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Bailong Tao,Chuanchuan Lin,Ai Guo,Yonglin Yu,Xian Qin,Kai Li,Hongchuan Tian,Weiwei Yi,Dengliang Lei,Lixue Chen 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.104 No.-
Infected wound healing remains a critical threat, which frequently delays the healing process and evenleads to severe life-threatening complications. Herein, we reported an effective anti-infection approach,which was based on copper ions-releasing hydroxyapatite/polydopamine (HA-Cu/PDA) nanocompositeswith photothermal effect. The HA-Cu/PDA nanocomposites was fabricated through a co-precipitationreaction between polydopamine (PDA)-coated hydroxyapatite nanoparticles (HA)-loaded Cu2+ (HA-Cu). Through a synergistic effect of released Cu2+ and photothermal efficiency of PDA coating, and the HACu/PDA nanocomposites exhibited extraordinary antibacterial capacities against Escherichia coli (E. coli)and Staphylococcus aureus (S. aureus). The nanocomposites presented good biocompatibility for mouseembryonic fibroblast (NIH-3T3) cells and promoted NIH3T3 cells to migrate toward wound sites. Additionally, this nanocomposite could stimulate the tissue remodeling-related gene expression toinduce the blood vessels formation, granulation tissues and collagen deposition, and eventually enhancewound healing. In vivo study further verified that HA-Cu/PDA nanocomposites with NIR irradiation couldsignificantly improve bacterial infected wound healing through the prominent antibacterial property,reduced inflammatory response, the formation of granulation tissue, collagen deposition, and angiogenesisability. Thus, this study develops a versatile strategy for a broad range of wound healing and skinreconstruction caused by bacterial infection.
Yuanyun Wei,Yaqi Gong,Shuang Wei,Yonglin Chen,Jian Cui,Xiang Lin,Yueqiu Yu,Hongxia Yan,Hui Qin,Lan Yi 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.8
Sometimes, people can be exposed to moderateor high doses of radiation accidentally or through the environment. Radiation can cause great harm to several systemswithin organisms, especially the hematopoietic system. Severaltypes of drugs protect the hematopoietic system againstradiation damage in diff erent ways. They can be classifi edas “synthetic drugs” and “natural compounds.” Their cellularmechanisms to protect organisms from radiation damageinclude free radical-scavenging, anti-oxidation, reducinggenotoxicity and apoptosis, and alleviating suppression ofthe bone marrow. These topics have been reviewed to providenew ideas for the development and research of drugsalleviating radiation-induced damage to the hematopoieticsystem.