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후두 및 하인두 암종에서 p53단백 발현과 Espstein-Barr Virus 검출
최영환,도남용,나한조,이도용,노용훈,김완수,최종선 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2
Background and Objectives : When p53 cancer suppressor gene, occurs gene deletion or point mutation, malignancy develops by loss of p53 function with abnormal p53 protein. The Epstein-Barr virus (EBV) is the causative agent of certain type of lymphoma and undifferentiated nasopharyngeal carcinoma. However, the role of EBV as a causative factor in other head &eck tumors is not fully elucidated except nasopharyngeal carcinoma. This study, the author examined that p53 expression and detection rate of EBV correlate to development of laryngeal and hypopharyngeal squamous cell carcinoma(SCC) and play the possible role of prognostic indicators. Materials and Methods : Formalin-fixed, paraffin-embedded tissue specimen from 32 cases of larynx and hypopharyngeal squamous cell carcinomas were studied by immunohistochemical staining for p53 and EBV. The results of analysis were compared with clinicopathological parameters. Results : p53 expression was 56.3% (18 cases) and the detection rate of EBV was 43.6% (14 cases) of 32 cases in laryngeal and hypopharyngeal squamous cell carcinomas. p53 expression was correlate with histologic grade (p<05) only. Detection of EBV was not correlate with clinicopathological parmeters. Conclusion : These results suggest p53 expression and the detection of EBV may be related with development of laryngeal and hypopharyngeal squamous cell carcinoma. And, the expression of p53 protein can be used as a prognosticator in laryngeal and hypopharyngeal squamous cell carcinoma under certain limitation.
金煥起,梁奉龍,李正元 全北大學校 附設 都市및環境硏究所 1990 都市 및 環境硏究 Vol.5 No.-
This paper was the study on the change of the water quality an water quality management of reservior when Yong-dam dam constructed. The results obtained are as follows, water quality of river in surroundings area was BOD 1-2 ㎎/ℓ, TKN 1 ㎎/ℓ, T-P 0.03-0.013 ㎎/ℓ. Results from calculatin of the pollution loading of conteminations according to environmental factor, water quality was calculated to BOD 0.87 ㎎/ℓ, T-N 0.07 ㎎/ℓ. Because of increased of inlet nutrient, nutrient conditions in Yong-dam reservior will generated to eutrophication. Therefore, methods for control and management nutrition conditions are must be intercept and control to inflow of nutrient that included to water and wastewater.
M/G/1 RETRIAL QUEUE with ERLANG RETRIAL TIME
이용완 안동대학교 기초과학연구소 1990 基礎科學 硏究論文集 Vol.1 No.1
In the retrial queueing system, it is always assumed that retrial time has exponential distribution, In this paper, we will extend exponential retrial time to Erlang retrial time. We investigate M/G/1 retrial queue where the retrial has generalized Erlang distribution of order 2. It is still unknown how to find mean queue size of retrial queue when the retrial time is Erlang distribution of order n (n≥3)or uniform distribution. In the next section, we decribe our model in detail and find mean queue sizes of the first and second retrial groups when the server is busy and idle.
중학생들의 논리적 사고 발달에 미치는 신경심리학적 요인의 분석
정완호,김영신,권용주 한국교원대학교 과학교육연구소 1998 청람과학교육연구논총 Vol.8 No.1
Piaget의 이론은 인간의 인지 발달이 성숙, 물리적 경험, 사회적 상호작용과 평형화(equilibrium)의 4가지 요인에 밀접하게 의존한다고 제시하였다. 논리적 사고의 발달에 관련된 4가지 주된 요인들의 하나인 성숙은 바로 ‘신경적 성숙(neurological maturation)’으로 여겨진다고 주장하였다. 신경적 성숙 요인에 대해서는 일반적 범위의 성숙이라는 표현에서 보다 정교화된 설명이 거의 이루어지지 않았다. 즉, 인간의 논리적 사고에 대한 연구의 대부분은 심리학적 또는 행동학적 관점에서 설명한 연구에 치중되어 있으며, 극히 일부만이 신경구조적 관점에서 인간의 고등한 추론적 또는 논리적 사고에 대한 연구가 진행되고 있다. 따라서 본 연구는 논리적 사고 발달에서 인간의 신경인지적 기능이 미치는 영향을 뇌의 인지적 기능에 대한 다양한 측면에서 분석하고자 하였다. 이를 위해서 중학교 1, 2, 3학년 학생 725명을 대상으로 뇌분화 기능, 전두엽연합령의 주요기능, 정보처리 유형이 논리적 사고 발달에 어떤 영향을 주는지를 분석하였다. 본 연구의 결과는 논리적 사고력과의 상관을 보이고 있는 변인으로는 정보처리 유형, 억제기능, 설계기능, 연령, 뇌기능 분화로 나타났다. 또한, 이들 변인들이 논리적 사고력 형성을 예언해주는 것으로 나타났다. 본 연구의 결과에 비추어보면, 인지 수준 발달 요인 중 성숙이 단순한 연령의 증가라는 의미를 넘어서 신경계의 발달과 깊은 관계가 있는 두뇌의 발달과 뇌의 정보처리 기능과 깊은 관계가 있는 것으로 사료된다. Piaget views intellectual development as the result of maturation, physical experience, social interaction, and equilibrium. Even he views the maturation as a neurological maturation, he never have been elaborated the maturation variable over the general possibility in intellectual development comparing to other variables. Therefore, the purpose of the present study was to investigate the effects of neurocognitive functions in logical thinking development. The study variables of neurocognitive functions investigated in this study were brain laterality, planning and inhibiting functions of prefrontal cortex, and information processing patterns. Seven hundred and twenty-five(725) junior high school students were enrolled in the present investigation of the effects. The results showed that information processing patterns and inhibiting function were two of the most predictable variables in logical thinking development. Planning function, chronological age, and brain laterality also were statistically significant variables of the logical thinking development. Therefore, the present study indicates that logical thinking development is strongly linked with the brain maturation and the information processing of the brain over Piagetian general and chronological maturation.