Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

개에서 동소성 간이식술시의 대사 및 혈역학적 변화

이창준,홍순용,신근만,최영룡,이영주,문종선 대한마취과학회 1993 Korean Journal of Anesthesiology Vol.26 No.3

Skilled and experienced anestheia is of great importance for patients undergoing orthotopic liver transplantation, because of multiple preexisting medical problems in such patients as well as the intraoperative problems of rapid hemodynamic, metabolic, and coagulation changes. In this study, the intraoperative hemodynamic and laboratory data were analyzed in ten dogs that underwent an orthotopic liver transplantation procedure by veno-venous bypass using Biopump. Liver transplantation can be divided into three distinct periods: stage I, or preanhepatic stage, which begins with the induction of anesthesia and continues until cross clamping of portal vein and IVC; stage II, or anhepatic stage, which begins at the anhepatic time and continues until the donor liver is reperfused by the recipients circulating blood; and stage III, or postanhepatic stage, which begins at the time of reperfusion and continues until the end of surgical procedure. The hemodynamic changes at the time of IVC and portal vein cross clamping were decreases in CVP, PCWP, and pulmonary artery pressure in spite of using Biopump. The significant metabolic alternations during anhepatic stage were decrease in blood glucose levels and increase in blood lactate levels. The more significant hemodynamic changes occurred at the time of reperfusion. Systolic pressure decreased suddenly to 58±6 mmHg and cardiac output decreased to 1.08±0.1l L/min. However heart rate, pulmonary artery pressure, CVP, and PCWP did not change significantly. During stage III, hyperglycemia occurred quite frequently. Significant abnormal coagulation chages could not be found, probably because the dogs were healthy. In conclusion, during anhepatic stage, we have to compensate for alternations of fluid balance. At the time of reperfusion, we should prevent severe hemodynamic changes and treat them immediately if they occur. However, it seems that glucose administration is not necessary to the liver recipient during stage II because there is no significant hemodynamic depression e to hypoglycemia at this time and hyperglycemia occurs later

General Equilibrium Model of Economic Growth and Structural Change in Agriculture

Park, Jung Keun,Kang, Chang Yong 전북대학교 농업과학기술연구소 1984 農大論文集 Vol.15 No.-

經濟構造의 變化는 最終需要나 中間財需要等 需要條件의 變化에 따라 說明되기도 하고 資源, 技術 等 供給條件의 變化에 따라 論明되기도 한다. 그러나 需要·供給條件의 相五聯關性을 따른 經濟購造變化의 說明이 가장 바람직하다고 할수 있다. Tolley-Smidt, Kelley- williamson, Yamaguchi-Binswanger等은 經濟構造 變化를 一般均衡模型에 의하여 分析하였다. 그들의 模型은 모두 農業部門의 二部門 模型에 基礎를 둔다. 그러나 開發途上國의 經濟成長에 따른 農業內部의 構造變化는 食糧部門과 非食糧部門의 特性을 뚜렷하게 區分짓기 때문에 經濟成長과 構造變化는 食糧部門, 非食糧部門, 非農業部門의 三部門模型에 의하여 接近할 必要가 있다. 本硏衆 이와 같은 問題點에 立脚하여 Yamaguchi-Binswanger 部門 模型을 三部門模型으로 延長, 擴大코저 한다. A selective review of the hypotheses purporting to explain the structural changes of economy reveals the structure of final or intermediate demand as a key explanation of structural change, while others suggest that any model purporting to explain this phenomenon should explore differences in production technologies, factor substitution possibilities and rate of technical change. However, the critical importance of interdependence between demand and supply condition naturally leades to general equilibrium model. Tolley-Smidt, Kelley-Williamson, and Yamaguchi-Binswanger analyzed the structural change with general equilibrium condition under the two sector (agriculture and industry) model. However, for most developing countries the structural change within agriculature can be observed as a result of the rapid economic growth. In the light of this point, this study is an attempt to analyze the economic development in terms of vital relationship within agriculatural sectors (food grain and non-food grain) and between these sectors and industry and to extend Yamaguchi-Binswanger model to three sector model.

Annual Change and C:N:P ratio in Particulate Organic Matter in Chinhae Bay, Korea

이필용,강창근,박종수,박주석,LEE, PIL-YONG,KANG, CHANG-KEUN,PARK, JONG-SOO,PARK, JOO-SUCK The Korean Society of Oceanography 1994 韓國海洋學會誌 Vol.29 No.2

An investigation of the annual change and C:N:P ratio in particulate organic matter (POM) in Chinhae Bay, a semi-enclosed bay of the southern coast of Korean Peninsula, was carried out for a period of 12 months between January and December, 1993. The concentrations of POM have a broad range: 198∼4,416 ugC/l, 24∼792 ugN/l and 4.5∼69.0 ugP/l, Marked seasonal changes of POM, particularly particulate organic carbon (POC) and nitrogen (PON), were observed in the surface water. Generally, the concentration of POM peaks in summer. The C:N:P composition ratio of particulate organic matter, which is high in summer, also shows a seasonal change. The C:N assimilation ratio is constant at 6.53, which is consistent with the Redfield ratio. The significant linear relationship between POM and chlorophyll-a in the surface water during the survey period (except for January and February) and the C:N ratio suggest that the concentration of POM is controlled by phytoplankton biomass. POM peaks in summer, a period characterized by high freshwater input and the strong stratification, as a result of the intense proliferation of phytoplankton by a large amount of nutrient loading from the tributaries. On the other hand, the high C:P and N:P ratios in summer indicate that P is limited for phytoplankton growth owing to N-enrichment from a high input of freshwater with a high dissolved inorganic N:P ratio.

COVID-19 확산 이후 한국사회 사회갈등 이슈와 미래신호 탐색: 국내 뉴스 기사 키워드를 중심으로

김용회 ( Kim Yong-hoi ),한창근 ( Han Chang-keun ) 한국사회복지연구회 2021 사회복지연구 Vol.52 No.1

본 연구는 코로나19 확산 이후 한국사회 사회갈등 양상의 강도와 범위, 그리고 변화를 포착하여 갈등이슈의 미래신호를 탐색하기 위해 수행되었다. 코로나19 확산이 시작된 2020년 1월부터 6월까지 ‘사회갈등’ 관련 이슈를 다룬 국내 뉴스 기사 8,897건을 수집하였다. 텍스트마이닝을 통해 주요 키워드 30개를 추출한 후, KEM(Keyword Emerge nce Map)과 KIM(Keyword Issue Map) 키워드 포트폴리오를 작성하였다. 주요결과, ‘약신호’ 영역에는 마스크, 북한, 교회, 대응책 키워드가 분포하였으며, ‘강신호’ 영역에는 경제, 대통령, 국가, ‘잠재신호’ 영역에는 혐오, 교육, 통합, ‘강하지만 증가율이 낮은 신호’ 영역에는 정치, 정부, 원내대표 등의 단어가 분포된 것을 확인하였다. 연구결과에 따라 코로나19 이후 한국사회 복합갈등 양상과 갈등이슈의 변화 및 미래신호를 해석하고 시시각각 변화하는 사회갈등에 대한 전략적 대응방안을 논의하였다. This study examines intensity and scopes of social conflicts and explores the future signal of conflict issues since COVID-19. For these purposes, this study collected 8,897 news articles related to ‘Social conflicts’ between January and June 2020. Analysis of text mining produced 30 key words which were reanalyzed by Keyword Emergence Map (KEM) and Keyword Issue Map (KIM). Key findings are as follows: The weak signal zone includes keywords such as mask, North Korea, church, and count measures; The strong signal includes economy, president, and nation; The latent signal zone reports hatred, education, and integration; The strong but slow growing zone includes politics, government, and floor leader. This study interprets the multiple social conflict phenomena and their changes. In addition, This study concludes with implications of strategic responses to changing social conflicts in Korea.

정원등(lanterns)용 태양전지셀의 온도특성 변화연구

이세현(Se-Hyun Lee),박창용(Chang-Yong Park),조미령(Mee-Ryoung Cho),신상욱(Sang-Wuk Shin),황명근(Myung-Keun Hwang),양승용(Seong-Yong Yang) 대한전기학회 2006 대한전기학회 학술대회 논문집 Vol.2006 No.7

In this paper, I try to measure the electrical characteristics of PV cell for lanterns with solar simulator and simulated with PCID software. I keep my eye on the characteristics variation of PV cell as a temperature change. Therefore, I try to increase a temperature of controlled block from 10℃ to 50℃ while measuring the PV cell. As a result, A variation caused by voltage have an effect on the efficacy of PV cell. Hence, it is an important variable when a designer plan to make a solar cell for lanterns.

정원등(lanterns)용 태양전지셀의 온도특성 변화연구

이세현(Se-Hyun Lee),박창용(Chang-Yong Park),조미령(Mee-Ryoung Cho),신상욱(Sang-Wuk Shin),황명근(Myung-Keun Hwang),양승용(Seong-Yong Yang) 한국조명·전기설비학회 2006 한국조명·전기설비학회 학술대회논문집 Vol.2006 No.5월

In this paper, I try to measure the electrical characteristics of PV cell for lanterns with solar simulator and simulated with PC1D software. I keep my eye on the characteristics variation of PV cell as a temperature change. Therefore, I try to increase a temperature of controlled block from 10℃ to 50℃ while measuring the PV cell. As a result, A variation caused by voltage have an effect on the efficacy of PV cell. Hence, it is an important variable when a designer plan to make a solar cell for lanterns.

DRG 지불제도 도입에 따른 의료보험청구 행태 변화

강길원,박형근,김창엽,김용익,하범만,Kang, Gil-Won,Park, Hyoung-Keun,Kim, Chang-Yup,Kim, Yong-Ik,Ha, Beom-Man 대한예방의학회 2000 예방의학회지 Vol.33 No.4

Objectives : To evaluate the impacts of the DRG payment system on the behavior of medical insurance claimants. Specifically, we evaluated the case-mix index, the numbers of diagnosis and procedure codes utilized, and the corresponding rate of diagnosis codes before, during and after implementation of the DRG payment system. Methods : In order to evaluate the case-mix index, the number of diagnosis and procedure codes utilized, we used medical insurance claim data from all medical facilities that participated in the DRG-based Prospective Payment Demonstration Program. This medical insurance claim data consisted of both pre-demonstration program data (fee-for-service, from November, 1998 to January, 1999) and post-demonstration program data (DRG-based Prospective Payment, from February, 1999 to April, 1999). And in order to evaluate the corresponding rate of diagnosis codes utilized, we reviewed 820 medical records from 20 medical institutes that were selected by random sampling methods. Results : The case-mix index rate decreased after the DRG-based Prospective Payment Demonstration Program was introduced. The average numbers of different claim diagnosis codes used decreased (new DRGs from 2.22 to 1.24, and previous DRGs from 1.69 to 1.21), as did the average number of claim procedure codes used (new DRGs from 3.02 to 2.16, and previous DRGs from 2.97 to 2.43). With respect to the time of participation in the program, the change in number of claim procedure codes was significant, but the change in number of claim diagnosis codes was not. The corresponding rate of claim diagnosis codes increased (from 57.5% to 82.6%), as did the exclusion rate of claim diagnosis codes (from 16.5% to 25.1%). Conclusions : After the implementation of the DRG payment system, the corresponding rate of insurance claim codes and the corresponding exclusion rate of claim diagnosis codes both increased, because the inducement system for entering the codes for claim review was changed.

콤바인 HST 전자제어시스템 개발

서신원(Sin-Won Seo),허윤근(Yun-Kun Huh),이제용(Je-Yong Lee),이창규(Chang-Kyu Lee),배근수(Keun-Soo Bae) 충남대학교 농업과학연구소 2011 농업과학연구 Vol.38 No.1

I/An electro-hydraulic transmission having advantages of convenience, safety, simple linking and high power, and an electronic control system were designed and fabricated. In this study, characteristics of the control system were investigated through outdoor tests for evaluation of installation of the system on a combine. Major findings were as followings. 1. Experiment for performance evaluation of the control system was conducted on concrete road. With steering lever in neutral position, driving HST swash plate and left/right wheel speed increased in proportion to driving lever angle. In case of steering control, steering swash plate angle changed in proportion to steering lever angle. This should cause increase in outer wheel speed, but it was observed that HST swash plate was controlled toward neutral to maintain the speed before steering. As a result, speed before steering was maintained despite the change in outer wheel speed by steering HST swash plate angle change. 2. It was observed that the HST system enabled steering with outer wheel maintained at constant speeds while inner wheel speed decreased, which was more stable than conventional mechanical links. In addition, for the selected 5 criteria, experiment showed satisfactory results and it was judged that installation on real vehicle would be feasible. 3. The control system showed response property of appropriate forward/reverse movement and lift/right steering, without causing any problems during experiment on concrete. Result of response property experiment on field operation also showed appropriate control over forward/reverse movement and left/right steering

RESIN 취급 주물공장 근로자들의 호흡기 건강에 관한 연구

최정근,이창옥,백도명,최병순,신용철,정호근,Choi, Jung-Keun,Rhee, Chang-Ok,Paek, Do-Myung,Choi, Byung-Soon,Shin, Yong-Chul,Chung, Ho-Keun 대한예방의학회 1994 Journal of Preventive Medicine and Public Health Vol.27 No.2

The effects of resin on the respiratory health have been investigated in 309 workers from four iron and steel foundries and the results compared with those from 122 workers who were not significantly exposed to resin gas and silica dust at the same industries. Phenol-formaldehyde resin was used in the core making and molding processes and workers were exposed to their decomposition products as well as to silica dust containing particulates. The subjects were grouped according to formaldehyde, dust and other gas exposures, and smoking habits were considered also in thi analysis. Standardized respiratory symptom questionnaire was administered by trained interviewers. Chest radiograph, pulmonary funtion tests, and methacholine challenge tests were done. Environmental measurements at the breathing zone were carried out to determine levels of formaldehyde, respiable dust and total dust. Foundry workers had a higher prevalence of symptoms of chronic bronchitis with chronic phlegm and chronic cough when exposed to dust. Exposure to gas was significantly associated with lowered $FEV_1$ and obstructive pulmonary function changes. Exposure to formaldehyde and phenol gas was associated with wheezing symptom among workers, but $FEV_1$ changes after methacholine challenge were not significantly different among different exposure groups. When asthma was defined as the presence of bronchial hyperreactivity with more than 20% decrease in $FEV_1$ after methacholine challenge, 17 workers out of 222 tested had asthma. Fewer asthmatic welters were found among groups exposed to formaldehyde, gas and dust, which indicates a healthy worker effects ill a cross-sectional study. The concentration of formaldehyde gas ranged from 0.24 to 0.43 ppm among studied foundries. The authors conclude that formaldehyde and phenol gas from combusted resin is probably the cause of asthmatic symptoms and also a selection force of those with higher bronchial reactivity away from exposures.