Parathyroid carcinoma with lung metastasis in a thirteen-year-old girl

Yon Seon Kim 대한외과학회 2012 Annals of Surgical Treatment and Research(ASRT) Vol.82 No.6

Parathyroid carcinoma is a rare disease in pediatric patients. We present a case of a 13-year-old girl who presented to the Thyroid Department for an asymptomatic palpable neck mass for 1 year. The high levels of calcium, ionized calcium, and parathyroid hormone level along with parathyroid scintigraphy studies suggested primary hyperparathyroidism. Parathyroid carcinoma was confirmed by biopsy and pathologic examination after resection. Six months postoperatively, persistent hypercalcemia and multiple lung metastases were found on computed tomography. Bilateral lung wedge resection was performed. En bloc resection for primary parathyroid carcinoma and aggressive resection of metastatic disease is the most effective treatment to control hypercalcemia.

Right Paraesophageal Lymph Node Dissection Should Be Considered for Patients Who Have Presence of More than Three Metastatic Nodes in Right Paratracheal Lymph Node

Yon Seon KIM 대한외과학회 2019 대한외과학회 학술대회 초록집 Vol.2019 No.10

Impact of preserving the parathyroid glands on hypocalcemia after total thyroidectomy with neckdissection

Yon Seon Kim 대한외과학회 2012 Annals of Surgical Treatment and Research(ASRT) Vol.83 No.2

Purpose: The aims of this study were to determine the incidence and evaluate the risk factors for hypocalcemia after total thyroidectomy and to investigate how many parathyroid glands should be preserved to prevent postoperative hypocalcemia. Methods: From March 2007 to February 2011, a retrospective review of 866 patients who underwent total thyroidectomy and node dissection for thyroid cancer was performed. The incidence and predisposing factors for hypocalcemia were analyzed. Among them, a total of 191 cases had four of their parathyroid glands identified intraoperatively. These patients were then divided into one preserved parathyroid gland group (group I, n = 22) and two or more preserved parathyroid glands group (group II, n = 169). The incidence of hypocalcemia with regards to the number of preserved parathyroid glands was determined and the results between the two groups were compared. The total calcium, ionized calcium and parathyroid hormone levels were compared between the two groups. Results: The overall incidence of transient and permanent hypocalcemia was 9.2% and 0.5%, respectively. The decreased number of preserved parathyroid gland and increased number of removed central lymph node were the significant risk factors for developing postoperative hypocalcemia. In 191 cases identified with four parathyroid glands, the incidence of hypocalcemia was related to the number of preserved glands (group I, 22.7%; group II, 3.0%; P < 0.001). Conclusion: The insufficient number of preserved parathyroid glands is the only cause of hypocalcemia after total thyroidectomy and node dissection. At least one preserved parathyroid gland may prevent postoperative permanent hypocalcemia.

Incident dementia in kidney transplantation recipients: a matched comparative nationwide cohort study in South Korea

( Seon Ha Baek ),( Jina Park ),( Sehoon Park ),( Mi-yeon Yu ),( Ji Eun Kim ),( Sang Hyun Park ),( Kyungdo Han ),( Yong Chul Kim ),( Dong Ki Kim ),( Kwon Wook Joo ),( Yon Su Kim ),( Hajeong Lee ) 대한신장학회 2023 Kidney Research and Clinical Practice Vol.42 No.4

Background: Recent studies have shown that patients with end-stage renal disease (ESRD) are at elevated risk of dementia. However, whether kidney transplantation (KT) lowers the risk for incident dementia remains unclear. Methods: From the Korean National Health Insurance Service database, we identified incident KT recipients aged ≥40 years without any history of dementia between 2007 and 2015. We also established a pair of age-, sex-, and inclusion year-matched control cohorts of patients with incident dialysis-dependent ESRD and members of the general population (GP) without a history of dementia, respectively. Cases of incident all-cause dementia, including Alzheimer disease (AD), vascular dementia (VD), and other kinds of dementia, were obtained from baseline until December 31, 2017. Results: We followed 8,841 KT recipients, dialysis-dependent ESRD patients, and GP individuals for 48,371, 28,649, and 49,149 patient-years, respectively. Their mean age was 52.5 years, and 60.6% were male. Over the observation period, 55/43/19 KT recipients, 230/188/75 dialysis-dependent ESRD patients, and 38/32/14 GP individuals developed all-cause dementia/AD/VD. The risks of incident all-cause dementia, AD, and VD in KT recipients were similar to those in GP (hazard ratio: 0.74 [p = 0.20], 0.74 [p = 0.24], and 0.59 [p = 0.18], respectively) and significantly lower than those in dialysis-dependent ESRD patients (hazard ratio: 0.17 [p < 0.001], 0.16 [p < 0.001], and 0.16 [p < 0.001], respectively). Older age and diabetes mellitus at the time of KT were risk factors for incident all-cause dementia and AD in KT recipients. Conclusion: This is the first study to show a beneficial impact of KT on incident dementia compared to dialysis dependency.

Case Report : Primary omental yolk sac tumor

( Seon Hwa Lim ),( Yon Hee Kim ),( Ga Won Yim ),( Eun Ji Nam ),( Young Tae Kim ),( Sung Hoon Kim ) 대한산부인과학회 2013 Obstetrics & Gynecology Science Vol.56 No.6

Extra-ovarian yolk sac tumor arising in the omentum is extremely rare. As yolk sac tumor originated from the omentum has been rarely reported, its clinical information is very limited. The authors encountered a case of yolk sac tumor originated from the omentum, and reported the case herein. A 32-year-old woman was presented with developed low abdominal distension for a month. Magnetic resonance imaging findings were suggestive of ovarian malignancy with ascites and peritoneal seeding nodules. Explorative laparotomy was performed and then the findings from frozen biopsy of omentum were suggestive of poorly differentiated tumor though whether it was primary or metastatic was uncertain. Thus, staging laparotomy were performed. Histopathology confirmed that the tumor was a yolk sac tumor of omentum origin. Then, 6 cycles of postoperative adjuvant chemotherapy at intervals of 3 weeks were performed using bleomycin, etoposide, and cisplatin regimen. Four-year outpatient follow-up thereafter showed no relapse.

Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis

Kim, Min-Seon,Pak, Youngmi K,Jang, Pil-Geum,Namkoong, Cherl,Choi, Yon-Sik,Won, Jong-Chul,Kim, Kyung-Sup,Kim, Seung-Whan,Kim, Hyo-Soo,Park, Joong-Yeol,Kim, Young-Bum,Lee, Ki-Up Nature Publishing Group 2006 NATURE NEUROSCIENCE Vol.9 No.7

Insulin signaling in the hypothalamus plays a role in maintaining body weight. Studies suggest that the forkhead transcription factor Foxo1 is an important mediator of insulin signaling in peripheral tissues. Here we demonstrate that in normal mice, hypothalamic Foxo1 expression is reduced by the anorexigenic hormones insulin and leptin. These hormones' effects on feeding are inhibited when hypothalamic Foxo1 is activated, establishing a new signaling pathway through which insulin and leptin regulate food intake in hypothalamic neurons. Moreover, activation of Foxo1 in the hypothalamus increases food intake and body weight, whereas inhibition of Foxo1 decreases both. Foxo1 stimulates the transcription of the orexigenic neuropeptide Y and Agouti-related protein through the phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway, but suppresses the transcription of anorexigenic proopiomelanocortin by antagonizing the activity of signal transducer–activated transcript-3 (STAT3). Our data suggest that hypothalamic Foxo1 is an important regulator of food intake and energy balance.

Renal adverse effects of sunitinib and its clinical significance: a single-center experience in Korea

( Seon Ha Baek ),( Hyun Suk Kim ),( Jeong Hwan Lee ),( Dong Ki Kim ),( Kook Hwan Oh ),( Yon Su Kim ),( Jin Suk Han ),( Tae Min Kim ),( Se Hoon Lee ),( Kwon Wook Joo ) 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.1

Background/Aims: Sunitinib is an oral multitargeted tyrosine kinase inhibitor used mainly for the treatment of metastatic renal cell carcinoma. The renal ad-verse effects (RAEs) of sunitinib have not been investigated. The aim of this study was to determine the incidence and risk factors of RAEs (proteinuria [PU] and renal insuffi ciency [RI]) and to investigate the relationship between PU and anti-tumor effi cacy. Methods: We performed a retrospective review of medical records of patients who had received sunitinib for more than 3 months. Results: One hundred and fifty-five patients (mean age, 58.7 ± 12.6 years) were en-rolled, and the mean baseline creatinine level was 1.24 mg/dL. PU developed in 15 of 111 patients, and preexisting PU was aggravated in six of 111 patients. Only one patient developed typical nephrotic syndrome. Following discontinuation of sunitinib, PU was improved in 12 of 17 patients but persisted in five of 17 patients. RI occurred in 12 of 155 patients, and the maximum creatinine level was 3.31 mg/ dL. RI improved in two of 12 patients but persisted in 10 of 12 patients. Risk fac-tors for PU were hypertension, dyslipidemia, and chronic kidney disease. Older age was a risk factor for RI. The median progression-free survival was signifi-cantly better for patients who showed PU. Conclusions: The incidence of RAEs associated with sunitinib was lower than those of previous reports. The severity of RAEs was mild to moderate, and par-tially reversible after cessation of sunitinib. We suggest that blood pressure, uri-nalysis, and renal function in patients receiving sunitinib should be monitored closely.

Papillary thyroid carcinoma with thyroiditis

Yon Seon Kim,Hye-Jeong Choi,Eun Sook Kim 대한외과학회 2013 Annals of Surgical Treatment and Research(ASRT) Vol.85 No.1

Purpose: The aim of this study was to evaluate the clinicopathologic characteristics of papillary thyroid cancer with thyroiditis, and to determine the rate of its complications for it. Methods: A retrospective review of 1,247 patients with papillary thyroid cancer who underwent primary thyroidectomy was performed. Among them, 316 patients had thyroiditis (group I) while 931 patients had no thyroiditis (group II), as reflected in the final pathologic reports. The two groups’ clinicopathologic results and rate of complications were compared. Results: Female gender, preoperative hypothyroidism, total thyroidectomy, no extrathyroid extension, no lymphovascular invasion, and no perineural invasion were associated with group I. More central lymph nodes were removed in group I than in group II, but there were fewer central lymph nodes with metastasis in group I than in group II. For the lateral lymph nodes, the two groups had the same numbers of removed nodes and nodes with metastatic tumor. Multivariate analysis revealed female predominance, more cases of preoperative hypothyroidism, more dissected lymph nodes, and fewer lymph nodes with metastasis in group I. Among the patients who underwent lobectomy, postoperative hypothyroidism occurred more in group I than in group II (P < 0.001). There was no difference in postoperative complications between the two groups. Conclusion: Papillary thyroid cancer with thyroiditis showed less aggressive features. Postoperative hypothyroidism occurred more in the patients with thyroiditis.

Radical Scavenging Activities of Asterina pectinifera Fermented with Cordyceps militaris Mycelia

Yon-Suk Kim,Eun-Kyung Kim,Sithranga Boopathy Natarajan,Jin-Woo Hwang,Seon Geun Kim,Nam-Joo Jeon,Jae-Woong Lee,Jae-Hyun Jeong,김학주,박표잠 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.suppl1

Asterina pectinifera was fermented with Cordyceps militaris mycelia for improvement of anti-oxidant activities. DPPH, alkyl, hydroxyl, and superoxide radical scavenging activities were evaluated using electron spin resonance. Anti-oxidant activities were also determined based on the ferric reducing anti-oxidant power assays and the ABTS radical scavenging activity. The lipid peroxidation inhibition activity was confirmed using ferric thiocyanate and thiobarbituric acid assays. The free radical scavenging activity and anti-oxidative effects of A. pectinifera fermented with C. militaris mycelia (FACM) extracts were higher than for A. pectinifera and C. militaris mycelia extracts alone. FACM extracts contained different biochemical ingredients due to fermentation of A. pectinifera and provide a beneficial anti-oxidant activity. FACM extracts are a promising source of beneficial antioxidants for use in food industries.

Pre- and post-ESD discrepancies in clinicopathologic criteria in early gastric cancer: the NECA–Korea ESD for Early Gastric Cancer Prospective Study (N-Keep)

Kim, Joon Mee,Sohn, Jin Hee,Cho, Mee-Yon,Kim, Woo Ho,Chang, Hee Kyung,Jung, Eun Sun,Kook, Myeong-Cherl,Jin, So-Young,Chae, Yang Seok,Park, Young Soo,Kang, Mi Seon,Kim, Hyunki,Lee, Jae Hyuk,Park, Do Yo Springer Japan 2016 GASTRIC CANCER Vol.19 No.4

<P><B>Background</B></P><P>Discrepancies in the clinicopathologic parameters pre- and post-endoscopic submucosal dissection (ESD) sometimes necessitate additional surgical resection. The aim of this study was to assess such discrepancies in clinicopathologic parameters before and after ESD in the context of reducing the risk of failure of curative ESD.</P><P><B>Methods</B></P><P>Data on 712 early gastric cancer patients were prospectively collected from 12 university hospitals nationwide. The inclusion criteria were differentiated carcinoma <3 cm in size, no ulceration, submucosal invasion <500 μm, and no metastasis. Clinicopathologic factors were compared retrospectively.</P><P><B>Results</B></P><P>The discrepancy rate was 20.1 % (148/737) and the most common cause of discrepancy was tumor size (64 cases, 8.7 %). Ulceration, undifferentiated histology, and SM2 invasion were found in 34 (4.6 %), 18 (2.4 %), and 51 cases (6.9 %), respectively. Lymphovascular invasion (LVI) was observed in 34 cases (4.6 %). Cases with lesions exceeding 3 cm in size showed more frequent submucosal invasion, an elevated gross morphology, and upper and middle locations (<I>p</I> < 0.05). In the cases with ulceration, depth of invasion (DOI) was deeper than in the cases without ulceration (<I>p</I> = 0.005). Differentiation was correlated with DOI and LVI (<I>p</I> = 0.021 and 0.007). DOI was correlated with tumor size, ulceration, differentiation, LVI, gross type, and location. There were statistically significant differences between mucosal cancer cases and submucosal cancer cases in tumor size, differentiation, ulceration, LVI, and location.</P><P><B>Conclusions</B></P><P>The overall discrepancy rate was 20.1 %. To reduce this rate, it is necessary to evaluate the DOI very cautiously, because it is correlated with other parameters. In particular, careful checking for SM-invasive cancer is required due to the high incidence of LVI irrespective of the depth of submucosal invasion.</P>