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Fupeng Li,Kai Huang,Jinbing Wang,Kai Yuan,Yiqi Yang,Yihao Liu,Xianhao Zhou,Keyu Kong,Tao Yang,Jian He,Chunjie Liu,Haiyong Ao,Fengxiang Liu,Qian Liu,Tingting Tang,Shengbing Yang 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Although biomedical implants have been widely used in orthopedic treatments, two major clinical challenges remain to be solved, one is the bacterial infection resulting in biofilm formation, and the other is aseptic loosening during implantation due to over-activated osteoclastogenesis. These factors can cause many clinical issues and even lead to implant failure. Thus, it is necessary to endow implants with antibiofilm and aseptic looseningprevention properties, to facilitate the integration between implants and bone tissues for successful implantation. To achieve this goal, this study aimed to develop a biocompatible titanium alloy with antibiofilm and anti-aseptic loosening dual function by utilizing gallium (Ga) as a component. Methods A series of Ti-Ga alloys were prepared. We examined the Ga content, Ga distribution, hardness, tensile strength, biocompatibility, and anti-biofilm performance in vitro and in vivo. We also explored how Ga3+ ions inhibited the biofilm formation of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) and osteoclast differentiation. Results The alloy exhibited outstanding antibiofilm properties against both S. aureus and E. coli in vitro and decent antibiofilm performance against S. aureus in vivo. The proteomics results demonstrated that Ga3+ ions could disturb the bacterial Fe metabolism of both S. aureus and E. coli, inhibiting bacterial biofilm formation. In addition, Ti-Ga alloys could inhibit receptor activator of nuclear factor-κB ligand (RANKL)-dependent osteoclast differentiation and function by targeting iron metabolism, then suppressing the activation of the NF-κB signaling pathway, thus, showing their potential to prevent aseptic loosening. Conclusion This study provides an advanced Ti-Ga alloy that can be used as a promising orthopedic implant raw material for various clinical scenarios. This work also revealed that iron metabolism is the common target of Ga3+ ions to inhibit biofilm formation and osteoclast differentiation.
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Xinfu Zhao,Yihao Nie,Xibin Yi,Shimo Yu,Jing Zhang,Xiaochan Liu,Zhipeng Yuan,Sijia Liu,Jian Zhang,Guoliang Dou,Mengdi Wang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-
Design of efficient CO2 adsorbent is an effective way to capture CO2. Bamboo-derived activated carbon isa promising CO2 adsorbent. Inspired by this, carbonized unidirectional polyimide (CUPI) aerogels werenewly designed by the ice templating method using directional freezing technology. The pore propertyof CUPI aerogel can be tuned by changing the solidification velocity, and a series of CUPI aerogels weredesigned to explore the CO2 capture performance in view of pore morphology/topology. As a result,the obtained CUPI-8 exhibits higher CO2 adsorption capacity compared to carbonized polyimide aerogelsdue to the synergistic effect of micropores and lamellar pores. Specially, the CO2 adsorption capacity overCUPI-8 can be up to 5.75 mmol/g at 20 bar and 298 K. Furthermore, the adsorption isotherm of CUPI-8still shows an upward trend even nearly 20 bar. The isosteric adsorption heat (Qst) value of CUPI-8 isnearly in the ideal scope of 30–50 kJ mol1. The efficient CO2 adsorption performance and good chemicalstability of CUPI aerogel makes it a promising absorbent for practical application. This work provides anew opportunity for researching the effect of pore morphology/topology and the synergistic effect ofhierarchical pores on CO2 capture.
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