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- 저자 : Fupeng Li (검색결과 2 건)
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Fupeng Li,Kai Huang,Jinbing Wang,Kai Yuan,Yiqi Yang,Yihao Liu,Xianhao Zhou,Keyu Kong,Tao Yang,Jian He,Chunjie Liu,Haiyong Ao,Fengxiang Liu,Qian Liu,Tingting Tang,Shengbing Yang 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Although biomedical implants have been widely used in orthopedic treatments, two major clinical challenges remain to be solved, one is the bacterial infection resulting in biofilm formation, and the other is aseptic loosening during implantation due to over-activated osteoclastogenesis. These factors can cause many clinical issues and even lead to implant failure. Thus, it is necessary to endow implants with antibiofilm and aseptic looseningprevention properties, to facilitate the integration between implants and bone tissues for successful implantation. To achieve this goal, this study aimed to develop a biocompatible titanium alloy with antibiofilm and anti-aseptic loosening dual function by utilizing gallium (Ga) as a component. Methods A series of Ti-Ga alloys were prepared. We examined the Ga content, Ga distribution, hardness, tensile strength, biocompatibility, and anti-biofilm performance in vitro and in vivo. We also explored how Ga3+ ions inhibited the biofilm formation of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) and osteoclast differentiation. Results The alloy exhibited outstanding antibiofilm properties against both S. aureus and E. coli in vitro and decent antibiofilm performance against S. aureus in vivo. The proteomics results demonstrated that Ga3+ ions could disturb the bacterial Fe metabolism of both S. aureus and E. coli, inhibiting bacterial biofilm formation. In addition, Ti-Ga alloys could inhibit receptor activator of nuclear factor-κB ligand (RANKL)-dependent osteoclast differentiation and function by targeting iron metabolism, then suppressing the activation of the NF-κB signaling pathway, thus, showing their potential to prevent aseptic loosening. Conclusion This study provides an advanced Ti-Ga alloy that can be used as a promising orthopedic implant raw material for various clinical scenarios. This work also revealed that iron metabolism is the common target of Ga3+ ions to inhibit biofilm formation and osteoclast differentiation.
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Zhan Xinyuan,She Zhixiang,Yue Zhengbo,Hu Fupeng,Wang Guangcheng,Wang Shaoping,Li Wei,Liu Bing,Wang Jin 한국화학공학회 2024 Korean Journal of Chemical Engineering Vol.41 No.1
Fe-doped g-C 3 N 4 has been proven to have the potential of visible light photocatalysis, but its catalytic activity of peroxymonosulfate (PMS) is neglected. Herein, the complex advanced oxidation processes of Fe-g-C 3 N 4 mediated PMS and visible light photocatalysis was developed, named as Vis/Fe-g-C 3 N 4 /PMS system, whose eff ects and synergistic mechanism for decomposing Rhodamine B (RhB) was evaluated. The coupling of sulfate radicals and photocatalysis for RhB degradation showed that the synergistic effi ciency ( η Syn ) and factor ( S c ) were 20.1% and 4.82, respectively, with a degradation effi ciency of 99.8%. Iron species dispersed on g-C 3 N 4 provided active sites for PMS activation to generate sulfate radicals, simultaneously reduced the forbidden band, and separated the photo-generated charges of g-C 3 N 4 . h + , SO 4 · ‾ and 1 O 2 were the main active species, and the increase of 1 O 2 was the cause of the synergistic eff ect. The possible degradation path of RhB by this coupling system was proposed. Our fi ndings prove that Vis/Fe-g-C 3 N 4 /PMS system has a great potential to decompose dye wastewater, and also to be an environmental remediation perspective.
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