전신성 홍반성 낭창의 임상적 고찰

신영태,이정호,신승훈,이강욱 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

To elucidate the clinical feature and clinicopathologic correlation of systemic lupus erythematosus(SLE), the authors analized symptoms and signs, laboratory findings and kidney pathology in 25 patients with SLE who were admitted to the Department of Internal Medicine, Chungnam National University Hospital from My 1985 to October 1989. Kidny biopsy was performed in 15 patients out of 19 patients who showed lupus nephritis. The results were as follows: 1. The ratio of male of females was 1:11.5. They were 14 to 53 years old and mean age was 30.2 years old. The peak age incidence was 3rd and 4th decades. 2. The most frequent chief complaint on admission was fever and chills. Most patients had two or more symptoms such as arthralgia, malar rash, generalized edema or weakness. 3. In 84% of the patients, duration from onset of the disease to diagnosis of SLE was longer than 1 month, which suggested that diagnosis of SLE is not easy in early stage of SLE. 4. The positive anti -DNA was the most frequently observed ARA criteria of SLE. And positive ANA, malar rash, persistent proteinuria, leukopenia, positive LE cell preparation, arthritis and oral ulcer were observed in order of frequency. 5. The frequent and pertinent general symptoms, not included in ARA criteria were fever and chills, arthralgia and abdominal pain which were observed in more than half of the patients. 6. On immunologic test, serum concentrations of C3 and C4 were decreased in 96% of the patients, serum concentration of Ig G, Ig A were increased in 65%, 36.8% and 26.3% of the patients respectively. The RA test was positive in 25% of the patients. 7. Lupus nephritis represented 76% of all SLE patients and pathological classification on 15 patients with lupus nephritis revealed class IV lupus nephritis in 9 patients(60%), class II n 3 patients (21%), class V in 2 patients(13.3%) and class III in 1 patient. 8. 7 out of 9 patients with class IV lupus nephritis and 1 out of 2 patients with class V lupus nephritis showed nephrotic syndrome. Progressive azotemia were observed in 3 out of 9 patient with class IV lupus nephritis and in 1 out of 2 patients with class V lupus nephritis. There were no nephrotic syndroms or azotemia in class II and class III lupus nephritis. 9. Of 17 patients who can be followed up, 9 patients were improved, 5 patients became progressive azotemia and 3 patients resulted in death. The causes of death were myocarditis with pericarditis in 1 patients, pneumonia with acute respiratory failure in 1 patient and CNS involvement of SLE in 1 patient.

급성신우신염의 임상적 고찰

신영태,신승훈,이순구,이정호,이강욱 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

A clinical retrospective study was undertaken in 81 patients with acute pyelonephritis admitted to the Department of Internal Medicine, Chungnam National University Hospital from January 1983 to December 1989. The results were as follows : 1. Total number of patients studied was 81(M/F ratio, 1 : 4.4). The M/F ratio of 22 complicated patients (27.2%) was 1 : 2.7 2. The predisposing factors associated with complicated patients were as follows : 7 cases of urinary tract stone, 7 cases of pregnancy, 4 cases of neurogenic bladder and each one case of prostatic hypertrophy, ureter cancer, bladder diverticulum and polycystic kidney disease. 3. The common subjective symptoms on admission were fever and chills, frank pain, nausea and vomiting. High body temperature and CVA tenderness were noted in 61% and 95% of patients respectively. And 50.6% of patients revealed right CVA tenderness and 28.4% in left, 16% in both respectively. There was no difference in symptoms and signs between complicated and uncomplicated groups 4. In 50 patients(61.7%) microorganisms were isolated on the urine culture specimens. The most common organism was E. coli(80%), and followed by Staphylococcus aureus and Serratia odorifera. E coli was the most frequent pathogen in both female and male patients, and in complicated and uncomplicated groups. (In sensitivity test of complicated and uncomplicated groups). In sensitivity test of causative pathogens to antibiotics, E coli was sensitive to amikacin(93%), tobramycin(83.3%) and gentamycin(79.4%) and 88.9 percent of E coli were ressistant to ampicillin 5. In urinary examination on admission, pyuria was noted in 81% of patients, and proteinuria and microscopic hematuria were noted in 68% and 44% of patients respectively. 6. Within 3 days after antibiotics treatment deference was occured in 73.5% of total patients, and complicated patients revealed delayed defeverence compared to uncomplicated ones.

공리적 설계를 이용한 모니터용 EPS 완충 포장 설계 시스템 개발

이정욱(Jeong-Wook Yi),하대율(Dae-Yul Ha),이상우(Sang-Woo Lee),임재문(Jae-Moon Lim),박경진(Gyung-Jin Park) 대한기계학회 2002 대한기계학회 춘추학술대회 Vol.2002 No.5

The monitor product is packed by cushioning materials because the monitor can be broken during<br/> transportation. However, the addition of the cushioning material increased the volume of the product.<br/> Therefore, it is required that the usage of cushioning material be minimized. In practice, design engineers<br/> have followed the ad hoc design with experiences of predecessors. Automation of the design process is very<br/> important for the reduction of engineering cost, and can be achieved by an excellent design process and<br/> software development. A design flow is defined and a software system is developed for automated design.<br/> At first, a basic model is defined. A user can modify the model from menus and design is carried out<br/> according to the input from the user. Finite element models are automatically generated based on the design.<br/> A nonlinear finite element analysis program called LS/DYNA3D is linked for the impact analysis. The<br/> process of Design of Experiments using orthogonal array is installed to minimize the maximum acceleration<br/> in drop test. Therefore, a new design can be proposed by the system. The program is designed according<br/> to the Independence Axiom of Axiomatic design. FRs and DPs of the software system are defined and<br/> decomposed by zigzagging process. Independent modules can be generated by analysis of the full design<br/> matrix and each module is coded as class in Object Oriented Programming (OOP). Design results are<br/> discussed.

지상라이다 데이터를 이용한 건물 윤곽선 자동 추출 알고리즘 연구

노이주(Yi-Ju Roh),김남운(Nam-Woon Kim),정희석(Hee-Seok Jeong),정중연(Joong-Yeon Jeong),강동욱(Dong-Wook Kang),정경훈(Kyung-Hoon Jeong),김기두(Ki-Doo Kim) 대한전기학회 2008 대한전기학회 학술대회 논문집 Vol.2008 No.10

지상라이다는 고정도의 3차원 영상을 제공하고 레이저 빔을 현장이나 대상물에 발사하여 짧은 시간에 수백만점의 3차원좌표를 기록할 수 있는 최신 측량장비로서 다양한 응용분야에서 두각을 나타내고 있다. 본 연구에서는 지상라이다를 이용한 건축물의 3차원 자동 윤곽선 추출을 다룬다. 지상라이다는 건축물의 3차원 윤곽선을 신속하게 추출할 수 있지만 지상기반 시스템이므로 여러 가지 장애물 때문에 건축물의 하단부에서는 추출이 쉽지 않다. 기존 항공라이다를 이용한 알고리즘에서는 사진의 색상차나 모폴로지 특성에 의존하여 범위를 제한하고, 이를 기반으로 윤곽선을 추출하였다. 하지만 지상라이다의 경우 항공라이다에 비해 분해능이 월등히 높다. 또한, 지상라이다는 지상에서 측정하기 때문에 항공라이다에서 어려운 건축물의 측면이나 정면도 윤곽선 추출이 가능하기 때문에 본 논문에서는 사진을 이용하지 않고 전처리를 하지 않은 데이터를 직접 이용하여 건물의 정면 윤곽선을 추출하는 것을 제안한다. 건물의 크기와 데이터 수 즉, 라이다로 측정한 포인트 수를 고려한 효율적인 Decimation방법을 제안하고 또한, Decimation된 데이터에서 지역적으로 제일 큰 값과 작은 값을 찾아낸다. 그 중 많이 벗어난 점을 편차를 이용하여 제거한다. 이렇게 찾아낸 건축물의 외곽점들을 이어 만든 윤곽선을 최종적으로 보간하여 좀 더 현실과 가까운 윤곽선 추출 방법을 제안한다.

이산설계공간에서 직교배열표를 이용한 순차적 알고리듬의 국부해

이정욱(Jeong-Wook Yi),박경진(Gyung-Jin Park) 대한기계학회 2004 대한기계학회 춘추학술대회 Vol.2004 No.4

The structural optimization has been carried out in the continuous design space or in the discrete design space. Generally, available designs are discrete in design practice. But methods for discrete variables are extremely expensive in computational cost. In order to overcome this weakness, an iterative optimization algorithm was proposed for design in the discrete space, which is called as a sequential algorithm using orthogonal arrays (SOA). We focus to verify the fact that the local solution can be obtained throughout the optimization with this algorithm. The local solution is defined in discrete design space. Then the search space, which is the set of candidate values of each design variables formed by the neighborhood of current design point, is defined. It is verified that a local solution can be founded by moving sequentially the search space. The SOA algorithm has been applied to problems such as truss type structures. Then it is confirmed that a local solution can be obtained using the SOA algorithm.

Eliminating Potato Virus Y (PVY) and Potato Leaf Roll Virus (PLRV) Using Cryotherapy of in vitro-grown Potato Shoot Tips

Jung-Yoon Yi,Gi-An Lee,Jong-Wook Jeong,Sok-Young Lee,Young-Gyu Lee 한국작물학회 2014 Korean journal of crop science Vol.59 No.4

Potato virus Y (PVY) and potato leafroll virus (PLRV) are among the most damaging potato viruses and prevalent in most potato growing areas. In this study, cryopreservation was used to eradicate PVY and PLRV using two cryogenic methods. Potato shoot tips proliferated in vitro were cryopreserved through droplet-vitrification and encapsulation-vitrification using plant vitrification solution 2 (PVS2; 30% glycerol + 15% dimethyl sulfoxide + 15.0% ethylene glycol + 13.7% sucrose) and modified PVS2. Both cryogenic procedures produced similar rates of survival and regrowth, which were lower than those from shoot tip culture alone. The health status of plantlets regenerated from shoot tip culture alone and cryopreservation was checked by reverse transcription-polymerase chain reaction. The frequency of virus-free plants regenerated directly from highly proliferating shoot tips reached 42.3% and 48.6% for PVY and PLRV, respectively. In comparison, the frequency of PVY and PLRV eradication after cryopreservation was 91.3~99.7% following shoot-tip culture. The highest cryopreserved shoot tip regeneration rate was observed when shoot tips were 1.0~1.5 mm in length, but virus eradication rates were very similar (96.4~99.7%), regardless of shoot tip size. This efficient cryotherapy protocol developed to eliminate viruses can also be used to prepare potato material for safe long-term preservation and the production of virus-free plants.

지류하천의 유황분석을 통한 BOD5 농도변화 유형 분석

정우혁 ( Woo Hyeuk Jeong ),김영일 ( Young Il Kim ),김홍수 ( Hong Su Kim ),문은호 ( Eun Ho Moon ),박상현 ( Sang Hyun Park ),이상진 ( Sang Jin Yi ),정상만 ( Sang Man Jeong ),조병욱 ( Byung Wook Cho ),최정호 ( Jeong Ho Choi ) 한국물환경학회 2011 한국물환경학회지 Vol.27 No.4

We analyzed the variations of water quality with flow regime alterations to determine the characteristics of the stream where the stream management is considerably difficult due to the high variability of the flow rates. In this study, both flow rates and water qualities were monitored at the tributaries, 34 in count, of both Geum River and Sabgyo Lake Basins. The variation of water qualities were divided into 2 types, based on their stream flow rates, known as Type I and Type II. If the water quality of a stream increases during low flow rate periods compared with high flow rate periods, it is classified as Type I; if the water quality of the stream increases during high flow rate periods compared with low flow rate periods, it falls under Type II. The analysis for the variations of water qualities, of all 43 basins, resulted to 24 basins under Type I and Nineteen 19 basins under Type II. The variations of water qualities were analyzed first by using Regression Analysis followed by Statistical Analysis. The average slope of the variations of water qualities and the slope of the standard deviations were 0.00135 and 0.00477, respectively. The Probability Distributions of both Type I and Type II basins were 61.1% and 38.9%, respectively. The basin having a probability distribution of 61.1% and is also known as Type I, increases during periods of low flow rates, due to the presence of point sources. Therefore, the basin should be enforced with stream management. Before the stream management can be implemented in all streams falling under Type II, the sources of contaminants should first be estimated. These contaminants can be classified into two parts, the first is Point source pollution and the second is Non-point source pollution, where the Non-Point source pollution can be sub-divided into two types, with storm runoff and without storm runoff.

Poster Session : PS 0743 ; Rheumatology ; Predictors Useful When Deciding to Switch Anti-Tumor Necrosis Factor Therapy in Patients with Ankylosing Spondylitis

( Jeong Won Lee ),( Ji Hyoun Kang ),( Jung Ho Choi ),( Yi Rang Im ),( Li Hui Wen ),( Kyung Eun Lee ),( Dong Jin Park ),( Tae Jong Kim ),( Yong Wook Park ),( Shin Seok Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Anti-tumor necrosis factor (TNF) agents,have proven useful in the treatment of ankylosing spondylitis (AS). However, some patients do not respond to a particular anti-TNF agent, but do derive benefi t from a different agent, after therapy is switched. Although switching of anti-TNF agents is relatively common in clinical practice, it is not yet possible to identify patients who may need therapy-switching (switchers). Therefore, the characteristics of switchers, and predictors of the need to switch, must be defi ned, to establish effective anti-TNF treatment plans. Methods: A total of 369 AS patients who had been treated with anti-TNF agents for at least 3 months, in a single tertiary-care center, between January 2004 and April 2013, were studied. Patients were divided into two groups depending on whether their anti-TNF agentshad been switched or not. Demographic, clinical, laboratory, and treatment-related data at the time of initiation of treatment with anti-TNF agents were compared between switchers and non-switchers,and within switchers, with reference to the reasons for switching. Multivariate Cox`s proportional hazard models were used to assess the reliability of the switching predictors identifi ed. Results: Of the 369 AS patients, 85 (23%) switched anti-TNF agents once during a mean follow-up time of 32. 9 months. Switchers were more likely to be prescribed DMARDs, to treat concomitant disease, than were non-switchers. Upon multivariate Cox`s proportional hazard analysis, use of infi iximab as the fi rst anti-TNF agent was the independent predictor of switching. The principal reasons for switching were drug ineffi cacy and the occurrence of adverse events, but the clinical data on these two types of switchers did not differ signifi cantly. Conclusions: We found that use of infi iximab as the fi rst anti-TNF agent was the independent predictor of a need to switch that anti-TNF agent.

Magnetic Behavious of MnxZn0.22Fe 2.78-x (x=0.00~0.08) Thin Films Grown by Ferrite Plating Method

Jeong Sik Lee,Tae Wook Ha,Jung Hyun Jeong,Ill Won Kim,Soung Soo Yi 한국자기학회 2003 한국자기학회 학술연구발표회 논문개요집 Vol.13 No.2

The Association between Apolipoprotein A-II and Metabolic Syndrome in Korean Adults: A Comparison Study of Apolipoprotein A-I and Apolipoprotein B

Yi, Dong Won,Jeong, Dong Wook,Lee, Sang Yeoup,Son, Seok Man,Kang, Yang Ho Korean Diabetes Association 2012 Diabetes and Metabolism Journal Vol.36 No.1

<P><B>Background</B></P><P>Apolipoprotein A-II (apoA-II) is the second-most abundant apolipoprotein in human high-density lipoprotein and its role in cardio metabolic risk is not entirely clear. It has been suggested to have poor anti-atherogenic or even pro-atherogenic properties, but there are few studies on the possible role of apoA-II in Asian populations. The aim of this study is to evaluate the role of apoA-II in metabolic syndrome (MetS) compared with apolipoprotein A-I (apoA-I) and apolipoprotein B (apoB) in Korean adults.</P><P><B>Methods</B></P><P>We analyzed data from 244 adults who visited the Center for Health Promotion in Pusan National University Yangsan Hospital for routine health examinations.</P><P><B>Results</B></P><P>The mean apoB level was significantly higher, and the mean apoA-I level was significantly lower, in MetS; however, there was no significant difference in apoA-II levels (30.5±4.6 mg/dL vs. 31.2±4.6 mg/dL, <I>P</I>=0.261). ApoA-II levels were more positively correlated with apoA-I levels than apoB levels. ApoA-II levels were less negatively correlated with homocysteine and high sensitivity C-reactive protein levels than apoA-I levels. The differences in MetS prevalence from the lowest to highest quartile of apoA-II were not significant (9.0%, 5.7%, 4.9%, and 6.6%, <I>P</I>=0.279). The relative risk of the highest quartile of apoA-II compared with the lowest quartile also was not significantly different (odds ratio, 0.96; 95% confidence interval, 0.95 to 1.04; <I>P</I>=0.956).</P><P><B>Conclusion</B></P><P>Compared with apoA-I (negative association with MetS) and apoB (positive association with MetS) levels, apoA-II levels did not show any association with MetS in this study involving Korean adults. However, apoA-II may have both anti-atherogenic and pro-atherogenic properties.</P>