제4차 국민 학교 국어과 교육 과정의 분석 연구

이주호 釜山敎育大學 1982 부산교육대학 논문집 Vol.18 No.1

Having analysed the contents of the 4th revised elementary school curriculum of Korean language course, the writer concludes as follows: 1. It is different from any other curriculum which has ever existed in that it attaches great importance to intelligence. This is because its contents is based on the system and fundamental concepts of modern rhetoric, literary theory and linguistics. 2. Its domain, goal, contents and description of method are systematic and so we can find consistence and unity in its arrangement. 3. Explicating its original goal in teaching korean language it may contribute to the improvement of the linguistic faculty. 4. It seems to me that it payed due regard to the actual conditions of elementary school lessons.

일반 의미론 접근의 국어 교육의 방향

이주호 釜山敎育大學 1980 부산교육대학 논문집 Vol.16 No.1

국어과 교육의 2면적 성격에 관한 고찰

이주호 釜山敎育大學 1974 부산교육대학 논문집 Vol.10 No.1

In the teaching of our language there are two features scemingly incompatible with each other; we can see them in its aims, materials and methods. First, in its aims the following features can be observed: (1)teaching our language as forms and functions and at the same time as values containing meanings, (2)teaching our language as a practical means of communication and as a cultural accomplishment, and (3)teaching our language as a means of communal life and as a carrier of our national culture or heritage. Second, in its materials we can point out; (1)teaching our language not merely as a language but as a carrier of our national literature, (2)teaching our language both as speech and as a written language, (3)teaching our language with a view to improving the ability of learners to produce as well as to comprehend, and (4)teaching our language in its phase of 'langue' and 'parole'. Third, in the methods of our language teaching must we face the following problems: (1)language as having two sides 'logos' and 'pathos' and (2)its intensive and diffusive features etc. In analysing the above-mentioned two-sided features in this study, the writer believes that we can bring to light those important problems we encounter in our language teaching.

국어과 교육의 여러 문제점 : 글의 요소 지도의 경우 In the Case of Education for writing Component

이주호 釜山敎育大學 1977 부산교육대학 논문집 Vol.13 No.2

Inducing apoptpsis by the inhibition of c-myb in oral squamous carcinoma cell line, KB cell

Lee,Jung-Chang 대한구강생물학회 2007 International Journal of Oral Biology Vol.32 No.4

Oral squamous cell carcinoma (OSCC) is the most commonmalignancy and is a major cause of worldwide cancer mortality.The proto-oncogene c-myb plays an important role in regulationof cell growth and differentiation, and it is expressed at highlevels in hematopoietic cells and many other types of cancers.However, the function of c-myb is not well known in OSCC.The present study aimed to reveal the function of c-myb and totest the alternation of cell growth and signaling by c-myb inOSCC. In this study, c-myb and dominant-negatibe myb(DN-myb) were expressed in an adenovirus-mediated gene deliverysystem to KB cells. The over-expressed c-myb broughtincreased cellular proliferation compared with control cells.However, DN-myb infected KB cells showed significantreduction of cell growth and enhanced induction of apoptosis toactivate PARP and caspase 9. c-myb induced increase of IGF-I,-II and IGF-IR expressions while DN-myb down-regulatedthese expression. Activation of ERK and Akt/PKB pathwaywas shown only in c-myb transduced cells. These findingssuggest that the role of c-myb in cell growth of oral cancer cellsis partially mediated through the modulation of IGFs, ERK andAkt/PKB. From this results, DN-myb is strongly recommendedas a curable gene for the treatment of c-myb dependentmalignancies such as OSCC.

정신분열병 환자의 신경인지기능 결함 유형

백주희,이호택,장호균,박병관,이상연,김은경 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.2

연구목적 : 정신분열증의 인지기능장애가 전반적인 결함인지 아니면 특정한 결함인지 논란이 지속되고 있다. 본 연구에서는 표준화된 신경심리검사 도구인 벤튼 신경심리검사(Benton Neuropsychological Assessment. 이하 BNA)를 사용하여 정신분열병 환자에서 특정한 신경인지기능 결함 유형이 관찰되는지 평가하고자 하였다. 대상 및 방법 : 정신장애 진단통계편람 제4판(DSM-Ⅳ) 진단기중에 따라 분류된 (1) 편집성 정신분열병 입원 환자 30명과 (2) 연령, 성별, 교육정도를 일치시킨 정상 대조군 30명을 연구 대상으로 하여 정신분열병 환자의 임상 증상을 양성 및 음성증상척도(Positive and Negative Syndrome Scale, 이하 PANSS)로 평가하여 인지 결함과 임상 증상간의 상관관계를 검증하였다. 결 과 : BNA 12개 검사(시간지남력 검사, 좌우지남력 검사, 연속숫자학습, 얼굴재인 검사, 직선지남력판단, 시각형태변별 검사, 판토마임재인, 촉각형태지각, 손가락위치판단, 음소변별, 3차원토막구성, 운동지속력 검사)중에서 정신분열병 환자는 정상 대조군에 비해 연속숫자학습(이하 유의수준 p〈0.05), 얼굴재인 검사, 촉각형태지각, 손가락위치판단에서 통계적으로 유의하게 저하된 수행을 보였다. 또한 정신분열병 환자는 정상 대조군에 비해 손가락위치판단 하위 요인 중 오른손, 왼손, 이점역에서 저조한 수행을 보였고, 시각형태변별 검사의 주변오류에서 유의하게 많은 오류를 나타냈다. 정신분열병 환자군에서 PANSS 총점, 양성 및 음성증상척도도 점수와 각 검사, 하위 요인, 오류 점수간에는 유의한 상관관계가 나타나지 않았다. 결 론 : 정신분열병 환자군에서 임상증상과 독립적인 언어성 작동기억, 학습, 주의력 및 안면지각기술과 촉각정보처리 등 시각과 촉각 양식의 지각 과제에서 복잡한 감각정보처리의 결함을 보이며, 이러한 신경인지기능 결함 유형은 선행 연구에서 제시된 특정한 결함 유형과 최소한 부분적으로 일치되는 소견이다. 한편 정신분열병 환자가 대상 위치검사에서는 상대적으로 정상적인 수행을 보인 반면 대상 인식검사에서는 결함을 나타냈으며, 언어성 작동기억이 결함을 보인 결과는. (1) 전전두엽과 두정엽 피질간의 상호연결이나 (2) 전전두엽과 해마간의 상호연결의 기능 이상을 시사할 가능성이 있으나 후속 연구에서 확증이 필요하다. Objectives : Schizophrenic patients have been reported to be associated with abnormal performance on a broad range of neuropsychological tests. But it has been a persistent controversy in the neuropsychology of schizophrenia whether this disorder is characterized by generalized deficits or specific deficits. The purpose of this study was to investigate, using standardized Benton Neuropsychological Assessment(BNA), whether the specific pattern of neurocognitive deficits is found in schizophrenics. Methods : The subjects were composed of (1) 30 schizophrenic inpatients who were diagnosed as paranoid subtype according to DSM-Ⅳ diagnostic criterior and (2) 30 normal subjects with matching demographic variables(i. e. age, sex, educational level). All tests of BNA were given schizophrenic patients and normal subjects, and the performances of schizophrenic patients and normal subjects were compared on all aspects of BNA. Schizophrenic symptoms were assessed via Positive and Negative Syndrome Scale(PANSS) to determine the relationship between clinical symptoms and schizophrenic cognitive deficits. Results : Of 12 tests of BNA, schizophrenic patients performance on Serial Digit Learning (SDL), Facial Recognition Test(FR), Tactile Form Perception(TFP), Finger Localization(FL) were significantly lower than those of normal subjects. In addition, schizophrenic patients showed significantly lower performances than those of normal subjects on Right Hand, Left Hand, Identification of two simultaneously touched fingers of FL, and more Peripheral Error on Visual Form Perception Test(VFPT). Finally, no significant correlation was found with respect to the relationships between total scores, positive symptoms scores, negative symptoms scores of PANSS, and all scores of BNA tests in schizophrenic patients. Conclusion : These results suggest that schizophrenic patients may have a specific pattern of neurocognitive deficits in verbal working memory, learning, attention, and complex sensory information processing in visual and haptic modality such as facial perception skills, tactile information processing, independent of psychotic symptoms. The pattern of deifcits is at least in partial, in agreement with many previous study results. On the tests of linguistic functions, visuospatial perception, and constructional abilities, schizophrenic patients' performance were not significantly different from those of normal subjects. The findings on visuospatial perception and constructional abilities imply that some posterior cortical zones may be relatively uncompromised in schizophrenia. Both poor performances on object recognition tests relative to normal performances on object location tests and verbal working memory dysfunction may be associated with the putative dysfunction of the reciprocal connections either (1) between the prefrontal and parietal cortex or (2) between the prefrontal cortex and hippocampal formation. This tentative explanation remains to be confirmed.

Clozapine 투여후 발생한 급성 간염

장순주,이호택,백주희,이상연 대한신경정신의학회 1999 신경정신의학 Vol.38 No.1

Clozapine 투여 후에 급성 간염이 발생했던 두 명의 환자에 대한 증례로, 두 명 모두 이전에 약물에 이한 간염이 발생한 과거력이 있었던 환자로서 무증사의 급성 간염이 발생한 후에 보존적 치료 후에 호전 되었다. 간염이 발생한 후에 간효소수치에 대해 정기적으로 검사를 하면서, 사용하고 있던 clozapine의 용량을 낮춘 후 간장제를 투여함으로써 간효소수치는 정상화되었다. Clozapine과 비교하면 clozapine은 간세포의 cytochrome P450에 영향을 미치는 것으로 생각되고 있고 chlorpromazine은 간내 담즙저류에 영향을 미치는 것으로 생각된다. 과거 약물에 의한 간염을 경험한 환자는 clozapine에 의해 유도된 감염에 보다 취약성을 보일 가능성이 있으며, 이런 관점에서 이전의 간 기능 이상을 경험했거나 물질 사용 장애 등의 병발이 있을 경우 정기적인 간기능 평가가 임상적으로 중요할 것으로 판단된다. The authors report two cases of clzapine-induced acute hepatitis. Two patients developed asymptomatic hepatitis and got better with conservative care. We decreased the dosage of clozapine and added hepatic protections, resulting in normalized laboratory findings. The authors also reviewed side effects of clozapine in this report. We reviewed the suggested mechanism of either clozapine or chlorpromazine-induced hepatitis. clozapine influences the liver cell via cytochrome P 450 and chlorpromazine does so via mild cholestasis. There may be a possibility that a patient who has experienced drug-induced hepatitis is vulnerable to clozapine-induced acute hepatitis. In this respect, those who have experienced drug-induced hepatitis must be observed more closely.

대량 출혈을 유발한 공장게실 1예

전정현,이선영,이나란히,신정은,주미순,정성애,한호성,유권 梨花女子大學校 醫科大學 醫科學硏究所 2001 EMJ (Ewha medical journal) Vol.24 No.1

A case of massive intestinal bleeding from jejunal diverticulum is describe. A 62-year-old man was refered to our hospital because of melena and anemia. After admission, he showed massive hematochezia with unstable vital sign. Esophagogastroduodenocopy and colonoscopy, selective abdominal angiography, and RBC bleeding scanning were performed to seek the cause of the intestinal bleeding, but none of these studies revealed the source of bleeding. The examination of small bowel with methylcellulose showed multiple small jejunal diverticuli and a large diverticulum. Resection of the involved portion of jejunum was performed. On pathological examination, two mucosal loss lesions were detected, but ulcer or arteriovenous malformation were not seen in the resected jejunal diverticulum. The patient showed no more intestinal bleeding after operation. Although jejunal diverticuli are rare, the careful search for this complication in a patient with intestinal bleding is important.

Oxygen-loaded microbubble-mediated sonoperfusion and oxygenation for neuroprotection after ischemic stroke reperfusion

Yi‑Ju Ho,Hsiang‑Lung Cheng,Lun‑De Liao,Yu‑Chun Lin,Hong‑Chieh Tsai,Chih‑Kuang Yeh 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Background Ischemic stroke-reperfusion (S/R) injury is a crucial issue in the protection of brain function after thrombolysis. The vasodilation induced by ultrasound (US)-stimulated microbubble cavitation has been applied to reduce S/R injury through sonoperfusion. The present study uses oxygen-loaded microbubbles (OMBs) with US stimulation to provide sonoperfusion and local oxygen therapy for the reduction of brain infarct size and neuroprotection after S/R. Methods The murine S/R model was established by photodynamic thrombosis and thrombolysis at the remote branch of the anterior cerebral artery. In vivo blood flow, partial oxygen pressure ( pO2), and brain infarct staining were examined to analyze the validity of the animal model and OMB treatment results. The animal behaviors and measurement of the brain infarct area were used to evaluate long-term recovery of brain function. Results The percentage of blood flow was 45 ± 3%, 70 ± 3%, and 86 ± 2% after 60 min stroke, 20 min reperfusion, and 10 min OMB treatment, respectively, demonstrating sonoperfusion, and the corresponding pO2 level was 60 ± 1%, 76 ± 2%, and 79 ± 4%, showing reoxygenation. After 14 days of treatment, a 87 ± 3% reduction in brain infarction and recovery of limb coordination were observed in S/R mice. The expression of NF-κB, HIF-1α, IL-1β, and MMP-9 was inhibited and that of eNOS, BDNF, Bcl2, and IL-10 was enhanced, indicating activation of anti-inflammatory and anti-apoptosis responses and neuroprotection. Our study demonstrated that OMB treatment combines the beneficial effects of sonoperfusion and local oxygen therapy to reduce brain infarction and activate neuroprotection to prevent S/R injury.

HNBR compound와 RFL 처리된 Polyester 섬유의 접착 연구

이주희 ( Ju Hui Yi ),강윤희 ( Yun Hee Kang ),박득주 ( Deuk Joo Park ),김욱수 ( Wook Soo Kim ),손우정 ( Woo Jeong Son ),변영후 ( Young Ho Byun ),김원호 ( Won Ho Kim ) 한국화학공학회 2010 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.48 No.5