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1
The development of Taiwan Fracture Liaison Service network

Lo-Yu Chang,Keh-Sung Tsai,Jen-Kuei Peng,Chung-Hwan Chen,Gau-Tyan Lin,Chin-Hsueh Lin,Shih-Te Tu,I-Chieh Mao,Yih-Lan Gau,Hsusan-Chih Liu,Chi-Chien Niu,Min-Hong Hsieh,Jui-Teng Chien,Wei-Chieh Hung,Rong-S 대한골다공증학회 2018 Osteoporosis and Sarcopenia Vol.4 No.2
Osteoporosis and its associated fragility fractures are becoming a severe burden in the healthcare system globally. In the Asian-Pacific (AP) region, the rapidly increasing in aging population is the main reason accounting for the burden. Moreover, the paucity of quality care for osteoporosis continues to be an ongoing challenge. The Fracture Liaison Service (FLS) is a program promoted by International Osteoporosis Foundation (IOF) with a goal to improve quality of postfracture care and prevention of secondary fractures. In this review article, we would like to introduce the Taiwan FLS network. The first 2 programs were initiated in 2014 at the National Taiwan University Hospital and its affiliated Bei-Hu branch. Since then, the Taiwan FLS program has continued to grow exponentially. Through FLS workshops promoted by the Taiwanese Osteoporosis Association (TOA), program mentors have been able to share their valuable knowledge and clinical experience in order to promote establishments of additional programs. With 22 FLS sites including 11 successfully accredited on the best practice map, Taiwan remains as one of the highest FLS coverage countries in the AP region, and was also granted the IOF Best Secondary Fracture Prevention Promotion award in 2017. Despite challenges faced by the TOA, we strive to promote more FLS sites in Taiwan with a main goal of ameliorating further health burden in managing osteoporotic patients.
2
Oxygen-loaded microbubble-mediated sonoperfusion and oxygenation for neuroprotection after ischemic stroke reperfusion

Yi‑Ju Ho,Hsiang‑Lung Cheng,Lun‑De Liao,Yu‑Chun Lin,Hong‑Chieh Tsai,Chih‑Kuang Yeh 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Ischemic stroke-reperfusion (S/R) injury is a crucial issue in the protection of brain function after thrombolysis. The vasodilation induced by ultrasound (US)-stimulated microbubble cavitation has been applied to reduce S/R injury through sonoperfusion. The present study uses oxygen-loaded microbubbles (OMBs) with US stimulation to provide sonoperfusion and local oxygen therapy for the reduction of brain infarct size and neuroprotection after S/R. Methods The murine S/R model was established by photodynamic thrombosis and thrombolysis at the remote branch of the anterior cerebral artery. In vivo blood flow, partial oxygen pressure ( pO2), and brain infarct staining were examined to analyze the validity of the animal model and OMB treatment results. The animal behaviors and measurement of the brain infarct area were used to evaluate long-term recovery of brain function. Results The percentage of blood flow was 45 ± 3%, 70 ± 3%, and 86 ± 2% after 60 min stroke, 20 min reperfusion, and 10 min OMB treatment, respectively, demonstrating sonoperfusion, and the corresponding pO2 level was 60 ± 1%, 76 ± 2%, and 79 ± 4%, showing reoxygenation. After 14 days of treatment, a 87 ± 3% reduction in brain infarction and recovery of limb coordination were observed in S/R mice. The expression of NF-κB, HIF-1α, IL-1β, and MMP-9 was inhibited and that of eNOS, BDNF, Bcl2, and IL-10 was enhanced, indicating activation of anti-inflammatory and anti-apoptosis responses and neuroprotection. Our study demonstrated that OMB treatment combines the beneficial effects of sonoperfusion and local oxygen therapy to reduce brain infarction and activate neuroprotection to prevent S/R injury.
3
Solution-processable end-functionalized tetrathienoacene semiconductors: Synthesis, characterization and organic field effect transistors applications

Mamillapalli, Narendra Chary,Vegiraju, Sureshraju,Priyanka, Pragya,Lin, Chih-Yu,Luo, Xian-Lun,Tsai, Hsiang-Chi,Hong, Shao-Huan,Ni, Jen-Shyang,Lien, Wei-Chieh,Kwon, Guhyun,Yau, Shueh Lin,Kim, Choongik Applied Science Publishers 2017 Dyes and pigments Vol.145 No.-
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Abstract A series of dialkylated tetrathienoacene (TTAR)-based solution-processable small molecular organic semiconductors have been synthesized and characterized for organic field effect transistor (OFET) applications. The central dialkylated TTAR moiety was end-capped with thiophenylvinylthiophene (TVT), bithiophene (bT), and thienothiophene (TT) to afford new π-conjugated p-type active materials, DTVT-TTAR (1), DbT-TTAR (2), and DTT-TTAR (3), respectively. The physical and electrochemical properties and theoretical calculations as well as OFETs performance and thin film morphologies and microstructures of these new soluble TTARs are systematically studied. Using a solution-shearing method, DTVT-TTAR exhibits p-channel transport with the highest mobility of up to 0.18 cm2 V−1s−1 and current ON/OFF ratios of 104-106, which is one of the highest hole mobilities for the solution-processed TTAR-based small molecules. Highlights <UL> <LI> Synthesis and characterization of dialkylated tetrathienoacene derivatives as semiconductors. </LI> <LI> Various substituents as end groups for solution-processed p-type semiconductors. </LI> <LI> P-type transport with highest mobility up to 0.18 cm2 V−1s−1. </LI> <LI> One of the highest mobilities for dialkylated tetratheinoacene derivaties. </LI> </UL> Graphical abstract [DISPLAY OMISSION]