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최윤정,오영지,정동선 서울여자대학교 2010 자연과학연구논문집 Vol.22 No.-
Antioxidant activity and total phenolic contents of Punica granatum peels were investigated. The pomegranate peels were extracted with 70% methanol (ME) and then partitioned to hexane (HF), ethyl acetate (EAF) and water (WF) fractions. Total phenolic contents and radical scavenging activities of each extract and fraction from Punica granatum peels were measured. The ethyl acetate fraction showed the highest radical scavenging activity, followed by methanol extract, water fraction and hexane fraction. The IC50 values of EAF were 0.144 ㎍./mL and 0.50 ㎍./mL for DPPH and ABTS radicals scavenging activities, respectively. A strong antioxidant activity of the EAF from pomegranate peels was correlated with its high level of total phenolic contents (740.0 mg of tannic acid equivalent/g). ME and WF also exhibited relatively strong radical scavenging activities with IC50 values of 6.70 ㎍./mL and 7.25 ㎍./mL for DPPH radical, and 17.4 ㎍./mL and 18.33 ㎍./mL for ABTS radical, respectively. These results suggest that the pomegranate peels possess strong antioxidant activity, and can be a useful source of natural antioxidant.
( Ji Yeong Kwak ),( Sang Goon Shim ),( Kil Jong Yu ),( Dae Hyeon Cho ),( Ji Eun Oh ),( Chang Uk Jeong ),( Hyun Chin Cho ),( Kwang Min Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: The prevalence of colorectal adenoma(CRA) is rapidly increasing in average- risk population over 40 years of age in Korea. But, there was few available data about CRA in young adults under 40 years of age. Methods: This was a cross-sectional study to evaluate prevalence and risk factor of CRA in Korean young adults 20 to 39 years of age that included asymptomatic young adults who underwent colonoscopy screening at first time as part of employer-provided health wellness program at the Health Promotion Center, Samsung Changwon Hospital from January 2011 to December 2013. Finally, 4286 subjects with no risk of colorectal cancer (personal history of colorectal polyp, inflammatory bowel disease, or family history of colorectal cancer) were included and we analyzed prevalence and characteristics of CRA by classifying into two groups with CRA group (n=497) and CRA-free group (n=3789). Also, we performed logistic regression model to confirm risk factor of CRA in young adults. Results: Among 4286 subjects in young adults under 40 years of age, 497 (11.6%) subjects had one or more colorectal adenomas and advanced adenomas were found in 39 (0.9%) subjects. The prevalence of CRA in the each decade of age group was 5.4% (33/608) in 20 to 29 years of age and 12.6% (464/3678) in 30 to 39 years of age. In multivariable regression analysis, age over 30 years old (OR, 2.37; 95% CI, 1.64-3.43), current smoker (OR, 1.48; 95% CI, 1.15-1.92) and alcohol consumption (OR, 1.30; 95% CI, 1.03-1.64) were associated with increased risk of CRA in young adults. Conclusions: The prevalence of CRA and advanced adenoma in Korean young adults was 11.6% and 0.9%, comparable to those of previous small studies. Age, smoking and alcohol consumption were associated with CRA in young adults.