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- 저자 : Yanxia Chen (검색결과 11 건)
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Yanxia Chen,Xuedong Liu,Xiaoguang Yang,Yuhui Liu,Xiaomeng Pi,Qingzhen Liu,Dong Zheng 한국유전학회 2015 Genes & Genomics Vol.37 No.5
Deer antlers are the only mammalian appendages subject to an annual cycle of epimorphic regeneration. Within the rapid-growth stage, they display the fastest cartilage development in the animal kingdom. To identify microRNA (miRNA) profiling in red deer (Cervus elaphus) antler cartilage, we applied deep sequencing technology to a small RNA library constructed from pooled cartilage (three antlers from three individuals). We generated 9,520,645 mappable reads with a size distribution of between 15 and 30 nucleotides (miRNAs of 18 nucleotides were the most abundant group: 31 %). Bioinformatics data mining revealed 399 miRNAs in antler cartilage, of which 345 were highly conserved and expressed in 25 other mammals, including the cattle (Bos taurus) and in humans (Homo sapiens). The remaining 54 miRNAs we identified were novel and likely to be antler-cartilage specific, but were expressed at low levels. The identification of these known and newly identified miRNAs in antler cartilage significantly enhances our understanding of the miRNA profiling of regenerating antler cartilage. Further studies are necessary to better understand miRNAs-regulated antlerogenesis.
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Zeng, Yanxia,Zhu, Xiashi,Xie, Jiliang,Chen, Li Techno-Press 2021 Advances in nano research Vol.10 No.3
A new ionic liquid functionalized magnetic silica nanoparticle was synthesized and characterized and tested as an adsorbent. The adsorbent was used for magnetic solid phase extraction on ICP-MS method. Simultaneous determination of precious metal Au has been addressed. The method is simple and fast and has been applied to standard water and surface water analysis. A new method for separation/analysis of trace precious metal Au by Magnetron Solid Phase Extraction (MSPE) combined with ICP-MS. The element to be tested is rapidly adsorbed on CoFe2O4@SiO2@[BMIM]PF6 composite nano-adsorbent and eluted with thiourea. The method has a preconcentration factor of 9.5-fold. This method has been successfully applied to the determination of gold in actual water samples. Hydrophobic Ionic Liquids (ILs) 1-butyl-3-methylimidazole hexafluorophosphate ([BMIM]PF6) coated CoFe2O4@SiO2 nanoparticles with core-shell structure to prepare magnetic solid phase extraction agent (CoFe2O4@SiO2@ILs) and establish a new method of MSPE coupled with inductively coupled plasma mass spectrometry for separation/analysis of trace gold. The results showed that trace gold was adsorbed rapidly by CoFe2O4@SiO2@[BMIM]PF6 and eluanted by thiourea. Under the optimal conditions, preconcentration factor of the proposed method was 9.5-fold. The linear range, detection limit, correlation coefficient (R) and relative standard deviation (RSD) were found to be 0.01~1000.00 ng·mL-1, 0.001 ng·mL-1, 0.9990 and 3.4% (n = 11, c = 4.5 ng·mL-1). The CoFe2O4@SiO2 nanoparticles could be used repeatedly for 8 times. This proposed method has been successfully applied to the determination of trace gold in water samples.
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Magnetization dynamics induced by the Rashba effect in ferromagnetic films
Yu, Zhizhou,Chen, Jian,Zhang, Lei,Xing, Yanxia,Wang, Jian The Royal Society of Chemistry 2018 Nanoscale Vol.10 No.39
<P>Manipulating the magnetization of ferromagnets by the current-induced spin-orbit torque has great potential application in the design of low energy consumption spintronic devices. Normally, an external magnetic field is needed for the reversal of current assisted magnetization by the spin-orbit torque. Recently, the switching of magnetization driven by the spin-orbit torque in the absence of an external magnetic field was reported in a Ta/Co20Fe60B20/TaOxsystem with lateral structural asymmetry. To understand the physics behind this experiment, we performed first principles calculations on the potential profile at the interface between the ferromagnetic film and the wedge-shaped deposited metal oxide in the Ta/Co/TaO system. This revealed that the lateral structural asymmetry generates two additional Rashba interactions which can reduce the minimum external field required to reverse the magnetization. In addition, we derived the Landau-Lifshitz-Gilbert equation from a quantum transport perspective and numerically investigated the magnetization dynamics in ferromagnetic films induced by Rashba interactions including those generated by lateral asymmetry. Our theoretical simulation provides microscopic explanations of experimental observations of magnetization switching in the absence of an external field of devices with lateral structural asymmetry.</P>
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Wang Ting,Yuan Lingling,Chen Yanxia,Wang Jing,Li Na,Zhou Hong 한국유전학회 2023 Genes & Genomics Vol.45 No.8
Background MicroRNAs (miRNAs) can regulate expression of target genes at post transcriptional level, and mediate the pathophysiological process of many diseases. Objective The study will illuminate the miRNA expression profiles of diabetic cardiomyopathy (DCM), seeking probable biomarkers of DCM at early stage and determining a target for the treatment of DCM. Methods Db/db mice were used as an animal model of type 2 diabetes mellitus. At 22 weeks of age, cardiac function was evaluated by echocardiography, and the structural changes in myocardium were evaluated by HE staining and TEM. The miRNA expression profiles were detected using miRNA sequencing and differentially expressed miRNAs were validated by real-time PCR. Bioinformatic analysis was used to analyze target genes of these miRNAs and relevant pathways in DCM. Results The results showed that 40 miRNAs were differentially expressed, including 28 upregulated miRNAs and 12 downregulated miRNAs. GO and KEGG pathway analysis showed that the target genes of up-regulated miRNAs were involved in 66 pathways, including Wnt, p53 and calcium signaling pathways, as well as FOXO and apoptosis signaling pathways, etc. The target genes of down-regulated miRNAs were involved in 68 pathways, including mitophagy, Ras and MAPK signaling pathways, etc. Moreover, some differentially expressed miRNAs were found in myocardium of DCM for the first time, such as miR-7225-5p, miR-696, miR-3470a, miR-3470b, miR-6240, miR-6538, miR-5128, miR-1195, miR-203-3p and miR-330-5p. Conclusions It is hoped that a few novel molecular pathways or targets of treatment for DCM would be found through understanding the expression features of miRNAs in diabetic myocardium.
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Binjuan ZHAO,Chenghu ZHANG,Youfei ZHAO,Yanxia FU,Qi LIU,Huilong CHEN 한국유체기계학회 2018 International journal of fluid machinery and syste Vol.11 No.1
To improve the design of the splitter blade in the centrifugal pump impeller, inner flow numerical simulations are performed on the centrifugal pump impeller without splitter blades firstly, inner flow diagnoses are performed based on the theory of the boundary vorticity dynamics, and distributions of the boundary vorticity flux (BVF), friction force as well as vorticity on the inner walls of the impeller are carefully analyzed to find the location of bad flows and their dynamic sources. Later, according to the inner flow diagnosis results, splitter blades are designed and reformed for the original impeller. The inner flow filed in the impellers equipped with the preliminary splitter blade and reformed splitter blade are numerically simulated and diagnosed. Finally, comparisons are made among the three impellers, and it is found that, compared to the original impeller (impeller 0), the BVF, friction force and vorticity distribution in the impeller equipped with the preliminary splitter blade (impeller 1) has no obvious improvement, although the pump head increases, the efficiency decreases; the BVF, friction force and vorticity distribution in the impeller equipped with the reformed blade (impeller 2) has improved obviously, BVF peak decreases evidently and BVF distributes more uniformly, flow separation is inhibited, the hydraulic force acting on the impeller increases, with the pump head and efficiency increasing dramatically. It is proven that, flow diagnosis based on the theory of the boundary vorticity dynamics is an effective supplemental way for the design of the splitter blade in the centrifugal pump impeller, and will provide reference for the design of other turbo machinery as well.
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ZHAO, Binjuan,ZHANG, Chenghu,ZHAO, Youfei,FU, Yanxia,LIU, Qi,CHEN, Huilong Korean Society for Fluid machinery 2018 International journal of fluid machinery and syste Vol.11 No.1
To improve the design of the splitter blade in the centrifugal pump impeller, inner flow numerical simulations are performed on the centrifugal pump impeller without splitter blades firstly, inner flow diagnoses are performed based on the theory of the boundary vorticity dynamics, and distributions of the boundary vorticity flux (BVF), friction force as well as vorticity on the inner walls of the impeller are carefully analyzed to find the location of bad flows and their dynamic sources. Later, according to the inner flow diagnosis results, splitter blades are designed and reformed for the original impeller. The inner flow filed in the impellers equipped with the preliminary splitter blade and reformed splitter blade are numerically simulated and diagnosed. Finally, comparisons are made among the three impellers, and it is found that, compared to the original impeller (impeller 0), the BVF, friction force and vorticity distribution in the impeller equipped with the preliminary splitter blade (impeller 1) has no obvious improvement, although the pump head increases, the efficiency decreases; the BVF, friction force and vorticity distribution in the impeller equipped with the reformed blade (impeller 2) has improved obviously, BVF peak decreases evidently and BVF distributes more uniformly, flow separation is inhibited, the hydraulic force acting on the impeller increases, with the pump head and efficiency increasing dramatically. It is proven that, flow diagnosis based on the theory of the boundary vorticity dynamics is an effective supplemental way for the design of the splitter blade in the centrifugal pump impeller, and will provide reference for the design of other turbo machinery as well.
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Robust Design Optimization of Hydrodynamic Characteristics of Airfoil 791
Chenghu ZHANG,Binjuan ZHAO,Zhongfu HUANG,Yanxia FU,Qi LIU,Huilong CHEN 한국유체기계학회 2018 International journal of fluid machinery and syste Vol.11 No.3
In this paper, the influence of the continuous random variation of the flow velocity on hydrodynamic characteristics of airfoil 791 was discussed, and a robust design optimization method was proposed to reduce the influence of uncertain factors on the stability of hydrodynamic performance. Firstly, Bezier curve was used to parameterize the suction side of the airfoil, and its thickness was controlled by four points, which was then taken as the optimization variables. Secondly, the criterion of robustness was given, and then a robust mathematical model was established. Finally, two objective functions of robust optimization were gained on the basis of uncertainty analysis with surrogate model. Combined with multi-objective genetic algorithm, a robust optimal solution with better hydrodynamic characteristics was obtained. The results showed that compared with original case, the thickness near trailing edge altered more smoothly, the resistance and surface wave intensity were obviously decreased, and the maximum reduction of drag-lift ratio and wake unevenness were 6.89% and 25.04% respectively, which contributed to the improvement of wake quality. The change of surface pressure and resistance coefficients were also more stable under the variable inlet flow velocity conditions, and then the robustness was strengthened accordingly. In conclusion, the robust design optimization can obviously improve the hydrodynamic characteristics of the airfoil while reducing the sensitivity to uncertain factors, meanwhile, it can provide better stability during the operating process.
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Shijian Luo,Huiqing Li,Zhihuai Mo,Junjie Lei,Lingjuan Zhu,Yanxia Huang,Ruying Fu,Chunyi Li,Yihuan Huang,Kejia Liu,Wenli Chen,Lei Zhang 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
This study aimed to explore potential new drugs in the treatment of ischemic stroke by Connectivity Map (CMap) and to determine the role of luteolin on ischemic stroke according to its effects on matrix metalloproteinase-9 (MMP9) and PI3K/Akt signaling pathway. Based on published gene expression data, differentially expressed genes were obtained by microarray analysis. Potential compounds for ischemic stroke therapy were obtained by CMap analysis. Cytoscape and gene set enrichment analysis (GSEA) were used to discover signaling pathways connected to ischemic stroke. Cell apoptosis and viability were, respectively, evaluated by flow cytometry and an MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5- diphenyl-2-H-tetrazolium bromide) assay. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot analysis were used to test the expression of MMP9 and the PI3K/Akt signaling pathway-related proteins in human brain microvascular endothelial cells (HBMECs) and tissues. Additionally, the infarct volume after middle cerebral artery occlusion (MCAO) was determined by a TTC (2,3,5-triphenyltetrazolium chloride) assay. The microarray and CMap analyses identified luteolin as a promising compound for future therapies for ischemic stroke. Cytoscape and GSEA showed that the PI3K/Akt signaling pathway was crucial in ischemic stroke. Cell experiments revealed that luteolin enhanced cell viability and downregulated apoptosis via inhibiting MMP9 and activating the PI3K/Akt signaling pathway. Experiments performed in vivo also demonstrated that luteolin reduced the infarct volume. These results suggest that luteolin has potential in the treatment of ischemic stroke through inhibiting MMP9 and activating PI3K/ Akt signaling pathway.
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Sun, Xiaoming,Shen, Jinglin,Liu, Chang,Li, Sheng,Peng, Yanxia,Chen, Chengzhen,Yuan, Bao,Gao, Yan,Meng, Xianmei,Jiang, Hao,Zhang, Jiabao Asian Australasian Association of Animal Productio 2020 Animal Bioscience Vol.33 No.1
Objective: An experiment was conducted to determine the effects of L-arginine (L-Arg) and N-carbamoylglutamic acid (NCG) on the growth, metabolism, immunity and community of cecal bacterial flora of weanling and young rabbits. Methods: Eighteen normal-grade male weanling Japanese White rabbits (JWR) were selected and randomly divided into 6 groups with or without L-Arg and NCG supplementation. The whole feeding process was divided into weanling stage (day 37 to 65) and young stage (day 66 to 85). The effects of L-Arg and NCG on the growth, metabolism, immunity and development of the ileum and jejunum were compared via nutrient metabolism experiments and histological assessment. The different communities of cecal bacterial flora affected by L-Arg and NCG were assessed using high-throughput sequencing technology and bioinformatics analysis. Results: The addition of L-Arg and NCG enhanced the growth of weanling and young rabbit by increasing the nitrogen metabolism, protein efficiency ratio, and biological value, as well as feed intake and daily weight gain. Both L-Arg and NCG increased the concentration of immunoglobulin A (IgA), IgM, and IgG. NCG was superior to L-Arg in promoting intestinal villus development by increasing villus height, villus height/crypt depth index, and reducing the crypt depth. The effects of L-Arg and NCG on the cecal bacterial flora were mainly concentrated in different genera, including Parabacteroides, Roseburia, dgA-11_gut_group, Alistipes, Bacteroides, and Ruminococcaceae_UCG-005. These bacteria function mainly in amino acid transport and metabolism, energy production and conversion, lipid transport and metabolism, recombination and repair, cell cycle control, cell division, and cell motility. Conclusion: L-Arg and NCG can promote the growth and immunity of weanling and young JWR, as well as effecting the jejunum and ileum villi. L-Arg and NCG have different effects in the promotion of nutrient utilization, relieving inflammation and enhancing adaptability through regulating microbial community.
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Kuikui Jiang,Ruoxi Hong,Wen Xia,Qianyi Lu,Liang Li,Jianhao Huang,Yanxia Shi,Zhongyu Yuan,Qiufan Zheng,Xin An,Cong Xue,Jiajia Huang,Xiwen Bi,Meiting Chen,Jingmin Zhang,Fei Xu,Shusen Wang 대한암학회 2024 Cancer Research and Treatment Vol.56 No.2
Purpose This study aims to evaluate the efficacy and safety of a new combination treatment of vinorelbine and pyrotinib in human epidermal growth factor receptor 2 (HER2)–positive metastatic breast cancer (MBC) and provide higher level evidence for clinical practice. Materials and Methods This was a prospective, single-arm, phase 2 trial conducted at three institutions in China. Patients with HER2-positive MBC, who had previously been treated with trastuzumab plus a taxane or trastuzumab plus pertuzumab combined with a chemotherapeutic agent, were enrolled between March 2020 and December 2021. All patients received pyrotinib 400 mg orally once daily plus vinorelbine 25 mg/m2 intravenously or 60-80 mg/m2 orally on day 1 and day 8 of 21-day cycle. The primary endpoint was progression-free survival (PFS), and the secondary endpoints included the objective response rate (ORR), disease control rate (DCR), overall survival, and safety. Results A total of 39 patients were enrolled. All patients had been pretreated with trastuzumab and 23.1% (n=9) of them had accepted trastuzumab plus pertuzumab. The median follow-up time was 16.3 months (95% confidence interval [CI], 5.3 to 27.2), and the median PFS was 6.4 months (95% CI, 4.0 to 8.8). The ORR was 43.6% (95% CI, 27.8% to 60.4%) and the DCR was 84.6% (95% CI, 69.5% to 94.1%). The median PFS of patients with versus without prior pertuzumab treatment was 4.6 and 8.3 months (p=0.017). The most common grade 3/4 adverse events were diarrhea (28.2%), neutrophil count decreased (15.4%), white blood cell count decreased (7.7%), vomiting (5.1%), and anemia (2.6%). Conclusion Pyrotinib plus vinorelbine showed promising efficacy and tolerable toxicity as second-line treatment in patients with HER2-positive MBC.
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