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Wang Xianyao,Wang Huizhen,Lu Junhou,Feng Zhanhui,Liu Zhongshan,Song Hailiang,Wang Heng,Zhou Yanhua,Xu Jianwei 한국조직공학과 재생의학회 2020 조직공학과 재생의학 Vol.17 No.5
BACKGROUND: Mesenchymal stem cell (MSC)-based cell transplantation is an effective means of treating chronic liver injury, fibrosis and end-stage liver disease. However, extensive studies have found that only a small number of transplanted cells migrate to the site of injury or lesion, and repair efficacy is very limited. METHODS: Bone marrow-derived MSCs (BM-MSCs) were generated that overexpressed the erythropoietin (EPO) gene using a lentivirus. Cell Counting Kit-8 was used to detect the viability of BM-MSCs after overexpressing EPO. Cell migration and apoptosis were verified using Boyden chamber and flow cytometry, respectively. Finally, the anti-fibrosis efficacy of EPO-MSCs was evaluated in vivo using immunohistochemical analysis. RESULTS: EPO overexpression promoted cell viability and migration of BM-MSCs without inducing apoptosis, and EPO-MSC treatment significantly alleviated liver fibrosis in a carbon tetrachloride (CCl4) induced mouse liver fibrosis model. CONCLUSION: EPO-MSCs enhance anti-fibrotic efficacy, with higher cell viability and stronger migration ability compared with treatment with BM-MSCs only. These findings support improving the efficiency of MSCs transplantation as a potential therapeutic strategy for liver fibrosis.
Yanhua Cui,Lili Yang,Yan Yan,Zengkai Wang,Jian Zheng,Binrong Li,Yonghai Feng,Chunxiang Li,Minjia Meng 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.2
The photocatalytic efficiency of conventional blending photocatalytic membranes suffers a significant reduction due to effective photocatalyst embedded in membrane matrix. Therefore, in this study, inspired by the bioadhesive technology of polydopamine (pDA), a novel Ti doped bismuth oxyiodide (BiOI)-polydopamine (pDA)-coated cellulose acetate (CA) (Ti/BiOI-pDA/CA) photocatalytic nanocomposite membranes were successfully developed for effective removal of tetracycline (TC). The Ti/BiOI-pDA/CA nanocomposite membranes displayed very high photocatalytic activity toward TC (about 98% after 120 min) under visible light irradiation and superior photodegradation kinetics (k=0.03214 min1). The removal rate of Ti/BiOI/-pDA/CA nanocomposite membranes under dynamic cyclic degradation system could be further improved, giving TC removal efficiency of 91% in 60min. Remarkably, the permeate flux, flux recovery ratio (FRR), reversible fouling (Rr), irreversible fouling (Rir) and the total fouling ratio (Rt) revealed the Ti/BiOI-pDA/CA nanocomposite membranes had excellent antifouling performance. In addition, the Ti/ BiOI-pDA/CA nanocomposite membranes exhibited excellent stability and reusability. Therefore, this work gives insight into the effective removal of TC wastewater and has a great potential for new generation of high-performance photocatalytic membranes for practical wastewater treatment in the future.
Yanhua Guan,Jiajie Wu,Renjuan Sun,Hongzhi Zhang,Yanqiu Hu,Fei Wang 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.8
Orthotropic steel bridge deck system usually consists of an orthotropic steel deck and an asphalt overlay. Fatigue cracks of the orthotropic steel deck and premature damage of the asphalt overlay are frequently reported for such system. Engineering cementitious composites (ECC) was therefore proposed to replace the asphalt overlay to address the aforementioned issues. The current study presents an investigation on the transversal flexural behaviour of the ECC under bending forces. Influence of the bending force direction, cover thickness, the number of longitudinal reinforcement steel bars on the flexural performance was revealed. Responses with regard to the load-deflection curve, failure mode, the ultimate capacity, the cracking behaviour, the interfacial slip between ECC and steel deck and the nominal cracking stresses were analysed. The results showed that the load-deflection response under both negative and positive bending forces exhibits elastic stage, crack-developing stage and yield stage. Compared with the reinforcement ratio, cover thickness plays a more significant role on the flexural performances. When the cover thickness decreases from 35 mm to 25 mm, the peak load increases by 21% − 25%. ECC maintains its feature of being ductile, with high tensile and compressive strain capacity in the composite slab. From the design point of view, reducing the cover thickness and increasing the reinforcement ratio can improve the ultimate load and cracking stress, and reduce the internal slip, strain and crack width of the composite slab. It is expected that the current study can provide basic knowledge to the design and application of the steel-ECC composite deck system.
Investigation on effect of surface properties on droplet impact cooling of cladding surfaces
Wang, Zefeng,Qu, Wenhai,Xiong, Jinbiao,Zhong, Mingjun,Yang, Yanhua Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.3
During transients or accidents, the reactor core is uncovered, and droplets entrained above the quench front collides with the uncovered fuel rod surface. Droplet impact cooling can reduce the peak cladding temperature. Besides zirconium-based cladding, versatile accidental tolerant fuel (ATF) claddings, including FeCrAl, have been proposed to increase the accident coping time. In order to investigate the effect of surface properties on droplet impact cooling of cladding surfaces, the droplet impact phenomena are photographed on the FeCrAl and zircaloy-4 (Zr-4) surfaces under different conditions. On the oxidized FeCrAl surface, the Leidenfrost phenomenon is not observed even when the surface temperature is as high as 550 ℃ with We > 30. Comparison of the impact behaviors observed on different materials shows that nucleate and transition boiling is more intensive on surfaces with larger thermal conductivity. The Leidenfrost point temperature (LPT) decreases with the solid thermal effusivity (${\sqrt{k{\rho}C_p}}$). However, the CHF temperature is relatively insensitive to the surface oxidation and Weber number. Droplet spreading diameter is analyzed quantitatively in the film boiling stage. Based on the energy balance a correlation is proposed for droplet maximum spreading factor. A mechanistic model is also developed for the LPT based on homogeneous nucleation theory.
Yanhua Ma,Xinchen Wang,Wenjie Zuo 한국자동차공학회 2020 International journal of automotive technology Vol.21 No.5
At the conceptual design stage, thin-walled beams (TWBs) with the complex cross-sectional shapes are extensively used to compose the automobile frame. Thus, the performances of automobile frame are determined by crosssectional shapes of TWBs. Currently, the modifications of complex cross-sectional shapes depend on the experience of engineers, which often causes the design risk. Meanwhile, to our knowledge, the previous studies mainly focused on the regular cross sections and paid little attention for the complex cross-sectional shape for the automobile frame. Therefore, this paper proposes an analytical sensitivity analysis method to modify the complex cross-sectional shapes. This method regards the coordinates of points and the thicknesses of sheets as design variables to describe the cross-sectional shapes. The bending stiffness, torsional stiffness and frequency are used to evaluate the performances of automobile frame. Finally, an example of the RAV4 automobile frame verifies that the analytical sensitivity analysis method can effectively guide the modification of the cross-sectional shape and achieve the lightweight automobile frame.
One-Pot Synthesis of α-Fe2O3 Nanospindles as High-Performance Lithium-Ion Battery Anodes
Yanhua Ding,Bing Liu,Rongsheng Cai,Tuo Xin,Chen Li,Linhua Xia,Yiqian Wang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.2
Hematite nanospindles with a uniform size of ~270 nm in length and ~90 nm in width are prepared using a facile one-step hydrothermal method. Polyvinylpyrrolidone (PVP) serves as a structure-directing agent to control the primary morphology and aggregations. When evaluated as anode materials for lithium-ion batteries (LIBs), the electrode of sodium alginate (SA) binder exhibits a much better electrochemical performance than that with the polyvinylidene fluoride (PVDF) binder. Remarkably, the electrode using SA binder can deliver a high reversible specific capacity of 979mAh · g -1 after 50 cycles and prominent rate capability. The microstructural evolution of the nanospindles after the electrochemical cycling is investigated by scanning transmission electron microscopy (STEM). Our results may provide important mechanistic insights for the design of nanostructured anode materials for LIBs.
Joint Optimization Method Combining Genetic Algorithm and Numerical Algorithm Based on MATLAB
Yanhua Guo,Feifei Liu,Ning Zhang,Tao Wang 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.11
A two-bar plane truss is builtin MATLAB based on mathematical model. Then the authors use genetic algorithm toolbox to solve this problem. The parametric truss model is set up in the finite element analysis software ANSYS. It is analyzed by first-order algorithm. The comparison of two kinds results show the pure genetic algorithm doesn’t always have an advantage over other algorithms. In the end, a joint optimization method is put forward on the basis of genetic algorithm. It combines genetic algorithm based on MATLAB toolbox and numerical algorithm based on quasi-Newton method. This method is illustrated by the numerical example of the two-bar plane truss. The results show this joint optimization method can get the global optimal solution of this problem every time.