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- 저자 : Yanqiu Hu (검색결과 4 건)
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Li Hu,Shuyong Jiang,Yanqiu Zhang,Dong Sun 대한금속·재료학회 2017 METALS AND MATERIALS International Vol.23 No.6
Crystal plasticity finite element method based on a representative volume element model, which includes the effectof grain shape and size, is combined with electron backscattered diffraction experiment in order to investigate plasticdeformation of NiTi shape memory alloy during uniaxial compression at 400 °C. Simulation results indicatethat the constructed representation of the polycrystal microstructure is able to effectively simulate macroscopicallyglobal stress-strain response and microscopically inhomogeneous microstructure evolution in the case ofvarious loading directions. According to slip activity and Schmid factor in {110}<100>, {010}<100> and{110}<111> slip modes, <100> slip modes are found to play a dominant role in plastic deformation, while <111>slip mode is found to be a secondary slip mode. In addition, the simulation results are supported well by the experimentalones. With the progression of plastic deformation, the (001) [010] texture component gradually disappears,while the γ-fiber (<111>) texture is increasingly enhanced.
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Yanhua Guan,Jiajie Wu,Renjuan Sun,Hongzhi Zhang,Yanqiu Hu,Fei Wang 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.8
Orthotropic steel bridge deck system usually consists of an orthotropic steel deck and an asphalt overlay. Fatigue cracks of the orthotropic steel deck and premature damage of the asphalt overlay are frequently reported for such system. Engineering cementitious composites (ECC) was therefore proposed to replace the asphalt overlay to address the aforementioned issues. The current study presents an investigation on the transversal flexural behaviour of the ECC under bending forces. Influence of the bending force direction, cover thickness, the number of longitudinal reinforcement steel bars on the flexural performance was revealed. Responses with regard to the load-deflection curve, failure mode, the ultimate capacity, the cracking behaviour, the interfacial slip between ECC and steel deck and the nominal cracking stresses were analysed. The results showed that the load-deflection response under both negative and positive bending forces exhibits elastic stage, crack-developing stage and yield stage. Compared with the reinforcement ratio, cover thickness plays a more significant role on the flexural performances. When the cover thickness decreases from 35 mm to 25 mm, the peak load increases by 21% − 25%. ECC maintains its feature of being ductile, with high tensile and compressive strain capacity in the composite slab. From the design point of view, reducing the cover thickness and increasing the reinforcement ratio can improve the ultimate load and cracking stress, and reduce the internal slip, strain and crack width of the composite slab. It is expected that the current study can provide basic knowledge to the design and application of the steel-ECC composite deck system.
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Fatty Acid-Binding Protein 4 in Patients with and without Diabetic Retinopathy
Ping Huang,Xiaoqin Zhao,Yi Sun,Xinlei Wang,Rong Ouyang,Yanqiu Jiang,Xiaoquan Zhang,Renyue Hu,Zhuqi Tang,Yunjuan Gu 대한당뇨병학회 2022 Diabetes and Metabolism Journal Vol.46 No.4
Background: Fatty acid-binding protein 4 (FABP4) has been demonstrated to be a predictor of early diabetic nephropathy. However, little is known about the relationship between FABP4 and diabetic retinopathy (DR). This study explored the value of FABP4 as a biomarker of DR in patients with type 2 diabetes mellitus (T2DM).Methods: A total of 238 subjects were enrolled, including 20 healthy controls and 218 T2DM patients. Serum FABP4 levels were measured using a sandwich enzyme-linked immunosorbent assay. The grade of DR was determined using fundus fluorescence angiography. Based on the international classification of DR, all T2DM patients were classified into the following three subgroups: non-DR group, non-proliferative diabetic retinopathy (NPDR) group, and proliferative diabetic retinopathy (PDR) group. Multivariate logistic regression analyses were employed to assess the correlation between FABP4 levels and DR severity.Results: FABP4 correlated positively with DR severity (<i>r</i>=0.225, <i>P</i>=0.001). Receiver operating characteristic curve analysis was used to assess the diagnostic potential of FABP4 in identifying DR, with an area under the curve of 0.624 (37% sensitivity, 83.6% specificity) and an optimum cut-off value of 76.4 μg/L. Multivariate logistic regression model including FABP4 as a categorized binary variable using the cut-off value of 76.4 μg/L showed that the concentration of FABP4 above the cut-off value increased the risk of NPDR (odds ratio [OR], 3.231; 95% confidence interval [CI], 1.574 to 6.632; <i>P</i>=0.001) and PDR (OR, 3.689; 95% CI, 1.306 to 10.424; <i>P</i>=0.014).Conclusion: FABP4 may be used as a serum biomarker for the diagnosis of DR.
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Chen, Wuguo,Zhang, Jiamin,Dong, Changjin,Yang, Bo,Li, Yanqiu,Liu, Chuanfeng,Hu, Yuanyang Korean Society for Biochemistry and Molecular Biol 2006 Journal of biochemistry and molecular biology Vol.39 No.4
We examined the intracellular localization of NS5 protein of Dendrolimus punctatus cytoplasmic polyhedrosis virus (DpCPV) by expressing NS5-GFP fusion protein and proteins from deletion mutants of NS5 in baculovirus recombinant infected insect Spodoptera frugiperda (Sf-9) cells. It was found that the NS5 protein was present at the plasma membrane of the cells, and that the N-terminal portion of the protein played a key role in the localization. A transmembrane region was identified to be present in the N-terminal portion of the protein, and the detailed transmembrane domain (SQIHMVWVKSGLVFF, 57-71aa) of N-terminal portion of NS5 was further determined, which was accorded with the predicted results, these findings suggested that NS5 might have an important function in viral life cycle.
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