左則 上두骨 및 頰骨에 發生한 殲維性 骨異形成症의 治驗例

梁棟奎,朴相俊,金秉民,金基元,金鍾烈 大韓顎顔面成形再建外科學會 1990 Maxillofacial Plastic Reconstructive Surgery Vol.12 No.3

Fibrous dysplasia is an idiopathic skeletal disorder in which medullary bone is replaced and disturbed by poorly organized, structually unsound fibroosseous tissue, which may produce cortical expansion. When facial bones are involed, considerable esthetic deformity may result. The term monostotic fibrous dysplasia has been applied when one bone is involved : when more than one bone is affected, the term polyostotic used. The polyostotic form may be accomplished by pigmented skin lesion (Jaffe type), or by pigmented skin lesions with endocrine disturbance (Albright syndrome). No general agreement exists on the cause of fibrous dysplasia. A few authors have suggested that fibrous dysplasia arises as a resujlt of trauma. It occurs predominantly in infant, adolescent females and runs a variable clinical course. When several bones are involed, it tends to be unilateral. Involements of alveolar bone may produce displacement of teeth with malocclusion, or loss of teeth, or both. Radiographycally, ti shows an indistinctly delimited osteolytic defect with a bubble - like pattern, but without a sclerotic rim. The preferred treatment is almost always surgery. If the lesion is extensive, surgical intervention with use of recontouring procedures aimed at the correction of esthetic or funtional disturbances is preferred treatment. Now, we present a case of fibrous dysplasia on the left maxilla and the zygoma treated by bony contourign via hemicoronal flap and intraoral approach with good results.

유두체-시상로의 신경종말에 관한 연구

양남길,심동원,김종규,안의태 순천향대학교 1985 논문집 Vol.8 No.1

This experiment was performed to define the ultrastructural character of axon terminal of mammillothalamic tract. The rats weighing 250∼300 gm were stereotaxically lesioned in the mammillary body. 2,7 and 14 days following the lesion, animals were sacrificed and perfused with 1% glutaraldehyde-1% paraformaldehyde solution(pH 7.2∼7.4), and anterior thalamic nuclei were punched out from the successfully lesioned brain. Tissue punchings were fixed in the same fixative as perfusion liquid overnight, immersed in the 2% osmic acid (pH 7.2∼7.4), dehydrated through alhcohol series, and embedded in the Araldite mixture. Degenerated axon terminals within the anterior thalamic nucleus following the mammillary lesion show two kinds of patterns, i,e., dark degeneration and lucent degeneration. Boutons of both types were asymmetrically synapsed with dendritic spine. Some boutons were synapsed directly with dendritic body, but from the correlative serial readings they showed the impression that they were originally synapsed with the spine. The result was contrasted with the former report that the synaptic type was defined as axo-dendritic one. The evidence suggests that axon-terminals of mammillothalamic tract make asymmetric axo-spinous synapses within anterior thalamic nucleus.

에멀젼 연료의 성능평가에 관한 연구

양원호,이동원,김홍석,박윤범,현명택 제주대학교 공과대학 첨단기술연구소 2005 尖端技術硏究所論文集 Vol.16 No.2

Emulsified fuel (mixed fuels with a small quantity of water) is suggested as a way of simultaneously diminishing NO_(x) and particulate matter. It is, therefore, an eco-friendly fuel and economical energy source. In this research, a comparative analysis between diesel fuel and emulsified fuel on their characteristics and the performance was done.

데페록사민 전처치가 토끼 심근경색 크기의 감소에 미치는 효과

양관모,오동렬,박승현,박규남,이원재,김형국,황두영,최승필,채장성 대한응급의학회 1998 대한응급의학회지 Vol.9 No.4

Background: Reperfusion of ischemic myocardium has been postulated to result in a specific oxygen radical mediated tissue injury. Iron may liberate during ischemia and we hypothesized that administration of the iron chelator, deferoxamine during ischemia would result in improved recovery after postischemic reperfusion. Purpose: To test whether iron-catalyzed processes contribute to myocardial necrosis during ischemia and reperfusion, deferoxamine was administered to block iron catalyzed hydroxyl radical formation in rabbits. Methods: Eleven rabbits were divided into two groups : control group (n=5) and deferoxamine pretreatment group (n=6). The left circumflex coronay artery was ligated for 30 minutes and reperfused for 180 minutes. Area at risk (AR) was measured by non-stained area with methylene blue injection into left atrium after left circumflex coronary artery ligation. Infarct size was measured by weighing after triphenyltetrazolium chloride staining. Heart rate was measured using electrocardiographic recording and systemic blood pressure was monitored by pressure transducer connected to the catheter in the left ventricle. Results: 1. There was no significant difference of heart rate and blood pressure in deferoxamine pretreatment group compared with control group. 2. There was significant decrease of serum iron concentration after continuous infusion of deferoxamine compared with serum iron concentration before ligation of coronary artery(P<0.05). 3. There was no significant difference of area at risk between control and deferoxamine pretreatment group. 4. Area at necrosis to area at risk was significantly reduced in deferoxamine pretreatment group compared with control group(P<0.05). The results suggest that deferoxamine infusion prior to coronary artery occlusion has a significant benefit in reducing infarct size in this model.

주痛의 東西醫學的 考察

楊棟元,吳旼錫,宋泰元 대전대학교 한의학연구소 2002 한의학연구소 논문집 Vol.11 No.1

Objectives : Study Cause of Elbow pain. Methods : Literature Review on Elbow pain in view of oriental medicine and western medicine. Conclusions : In view of oriental medicine cause of elbow pain is yukum(六淫), Jangbu(臟腑), gunglak(經絡) and in western medicine, cause is inflammation, overworking, ankylosing, deformity, etc.

납에 의해 유발된 신경세포의 APOPTOSIS

양선희,신동훈,백원기 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.2

Lead is a major environmental and occupational neurotoxicant. It has been shown that long-term exposure to a low level of lead impairs the development of brain. For example, it was reported that lead exposure during the childhood causes a learning difficulty and a memory deficit of children. Neurotoxic agents including the lead are believed to cause neuronal death in developing brain by two mechanisms: apoptosis and necrosis. However, the exact mechanism of neuronal death caused by lead exposure is still not known explicitly. In this study, we conducted a study to clarify a mechanism of hippocampal neuronal cell death caused by lead acetate. Hippocampal neurons were cultured for 14-16days and treated with lead acetate of 1, 10, 100μM concentrations for 12 hours. With the MTT (methyl tetrazolium test)kit, the viability of neuronal cells was measured. Next, in order to examine apoptosis caused by lead acetate, TUNEL(TdT-mediated d-UTP Nick End Labelling ) assay was performed. It has been shown that lead acetate reduced the viability of neuronal cells in a dose dependent manner, especially at the concentration of 100 μM lead acetate. TUNEL immunostain showed brownish signals in the nucleus of apoptotic cells. The proportions of apoptotic cells in the lead-acetate treated group were more higher than those in the controls and increased as lead acetate concentration increased. From above results, it may be concluded that lead in the hippocampal neuronal cells reduced cell viability and one of mechanisms in neuronal cell death by lead appears to be apoptosis.

알쯔하이머병 환자의 뇌혈류 장애 : Statistical Parametric Mapping을 이용한 Tc-99m ECD SPECT 분석 Statistical Parametric Mapping analysis of Tc-99m ECD SPECT

양동원,김범생,손영민,박정욱,정용안,손형선,김상윤 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.2

Background and Objectives . Alzheimer's disease (AD) is the most common cause of the dementia Pathologic and functional changes of AD are known to be unevenly distributed in the brain. This study investigates changes of cerebral blood flow (CBF) in patients with AD to determine brain regions with hypoperfusion that reflects progression of disease. Methods. Tc-99m-ECD single photon emission computed tomography (SPECT) was performed to measure regional CBF and statistical parametric mapping (SPM) 99 soft ware was used for the automated and objective approach to analyze SPECT image data. Twenty-five patients with mild to moderate dementia who met NINCDS-ADRDA critena for AD (male 11 female 14) and 17 age-matched normal control subjects were studied. The severity of AD was measured by clinical dementia rating (CDR) scale Results. SPM analysis of SPECT images revealed that CBF in the anterior cingulate gyrus left superior panetal cortex left medial frontal cortex left infenor temporal cortex. right thalamus and left hippocampus was significantly decreased in AD patients compared with normal controls (corrected p<0.05). The reduction of CBF according to CDR was localized in the left hippocampus and infenor temporal cortex right antenor and postenor ciagulate cortex and right superior panetal cortex (uncorrected p<0.01). Conclusions : Our data suggest that the cognitive dysfunction of AD is strongly related with functional abnormality in discrete brain areas 99m-Tc ECD SPECT with SPM analysis could be used as a useful functional imaging tool in AD study.

피질하 혈관성 치매 환자에서 단광자방출단층촬영과 Statistical Parametric Mapping을 이용한 뇌혈류 흐름의 분석 : Adaptation of Statistical Parametric Mapping

양동원,김범생,김의녕,손형선,김상윤 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.1

Background: Subcortical vascular dementia(SVaD) is relatively homogeneous subtype of VaD, but the mechanisms of cognitive dysfunction of subcortical VaD are not completely understood yet This study investigated the changes of cerebral blood flow(CBF) in patients with SVaD and the contribution of the white matter hyperintensity(WMHI) and clinical severity to CBF changes. Methods: 99mTc-ethyl cysteinate dimer single photon emission computed tomography(SPECT) was performed to measure the regional CBF and statistical parametric mapping(SPM)99 software was applicated to automated and objective analysis of the SPECT image data Twenty three patients (male 12, female 11) of mild to moderate dementia who met both the criteria of the DSM-IV and probable or possible NINDS-AIREN for VaD and have subcortical white matter changes and lacunar infarction on brain MRI and seventeen normal control subjects (male 7, female 10) were evaluated The severity of the WMHI was measured by semi-quantitative scale method proposed by Mantyla. The seventy of dementia was measured by clinical dementia rating (CDR) scale Results: SPM analysis of SPECT image revealed significantly reduced regional CBF in the right thalamus, left caudatd nucleus, cingulate, bilateral superior temporal, and left ventral subcallosal gyri in SVaD patients when it compared to normal controls (corrected p<0 001). Among four WMHIs, only the WMHI was associated with the small CBF reduction in the left superior temporal gyrus (uncorrected p<0 01) The reduction of CBF according to the severity of dementia was noted in the anterior and posterior association areas (uncorrected p<0 01). Conclusions: our study suggests that cognitive dysfunction of SVaD may be related with CBF reduction in the above mentioned brain areas, which probable are not associated with the severity of periventncular WMHI and dementia.

하부가열 수평유체층에서 자연대류 유동에 관한 수치해석

양종훈,이동원,김양훈,현명택,김신 濟州大學校 産業技術硏究所 1998 산업기술연구소논문집 Vol.9 No.1

The natural convection driven by a thermal buoyancy force was investigated in a square cavity. The top and bottom walls are cold and hot. respectively. while the vertical boundaries are adiabatic. A control volume approach with a power-law scheme was used to formulate the finite difference equations. The results are presented isotherms. velocity vectors, Nusselt numbers and critical Rayleigh numbers for the ranges of Ra = 1750~20000 and Pr = 0.05~10.0. The critical Rayleigh number increases as Prandtl number decreases. There exists a clockwise unicell flow near critical Rayleigh number, while two cells appear for large Rayleigh number.

하부가열 수평유체층에서 자연대류 유동에 관한 수치해석

양종훈,이동원,김양훈,현명택,김신 濟州大學校 工科大學 産業技術硏究所 1998 尖端技術硏究所論文集 Vol.9 No.1

The natural convection driven by a thermal buoyancy force was investigated in a square cavity. The top and bottom walls are cold and hot, respectively, while the vertical boundaries are adiabatic. A control volume approach with a power-law scheme was used to formulate the finite difference equations. The results are presented isotherms, velocity vectors, Nusselt numbers and critical Rayleigh numbers for the ranges of Ra = 1750 ∼ 20000 and Pr = 0.05 ∼ 10.0. The critical Rayleigh number increases as Prandtl number decreases. There exists a clockwise unicell flow near critical Rayleigh number, while two cells appear for large Rayleigh number.