악교정 수술중 수액요법과 술후 합병증의 연관성

류정호,김대윤,배준수,양병은,유준영,김용관 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.5

Few topics in operative and perioperative patient management generate more controversy than that of appropriate fluid and electrolyte therapy. especially, controversy has swirled around colloid vs crystalloid therapy and the composition of administered fluids, agreement among clinicians as to what fluid therapy is appropriate, and in what amount, is rare. This controversy likely will be enhanced by Arieff' s provocative article. He described 11 adults and 2 pediatric patients. All developed fatal postoperative pulmonary edema, seemingly caused solely by excessive postoperative fluid administration. From January 1999 to December 1999, we investigated 24 patients, which were operated by orthognathic surgery, about the intraoperative fluid therapy and the associated effect in orthognathic surgery, which is regarded as one of the major surgery of oral and maxillofacial surgery. First, They were devided into two groups, that is one-jaw surgery and two-jaw surgery, and each groups were devided by intraoperative fluid volume of 8ml/kg/hr. Subjective assesment was collected through use of a series of 3 questionnaries. In each questionnaire, a 5-point Liekert scale was used far assessment of following parameters of recovery from anesthesia: headache, dizziness, drowsiness, nausea/vomiting, thirst. The patient completed questionnaire 1 at 4 hour after surgery, questionnaire 2 was completed at 24 hours after surgery, and questionnaire 3 was completed at 48 hours after surgery. This study demonstrated that appropriated perioperative rehydration decreases postoperative adverse outcomes and improved the patient's perception of the postoperative period.

S-상 심실중격의 임상적 고찰

이동민,장경식,양종태,장대용,김종오,서영욱,고영엽,홍순표 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

Background: The sigmoid septum described an anatomical variation in the contour of the left ventricular outlet. It is related to degenerative change with aging. We observed clinical significance of sigmoid septum in Korean. Methods: Echocardiographic examination was performed in 434 patients. Sigmoid septum is defined as discrete bulging of the proximal interventricular septum with that thickness is greater than 1.3cm or the thickness is grater 1.5 times than adjacent mid interventricular septum in apical 3 chamber view. Result: The incidence of patient with sigmoid septum(septum patient) is 24.8% (male 8.4%, female 16.3%) . The incidence increases with age and is more common in women. The patients with sigmoid septum were compared with targeted groups, there was no significant difference in blood pressure between them, but in height and weight, the former were lower. (p<001, p<03). In the patients with sigmoid septum, weight and the surface area of a body have an opposite correlation with increase of age (p<03, r=-0.34) (p<04, r=-0.31) , but no decrease of height was found according to age increase (p=0.47, r=-0.11) The main reason patients with sigmoid septum ask echocardiolography and its clinical symptoms were abnormal results of previous electrocardiography and/or usual chest pain. Compared with control group, interventricular septal thickness is larger in septum patients (p<001). The thickness of interventricular septum located in subaortic left ventricular outflow tract is 1.6±0.3cm. There is another web like structure that continued from interventricualr septum to anterior free wall of left ventricle and the width is 1.6±0.4cm. A sign of insignificant obstruction due to left ventricular outflow was observed from three sigmoid septum patients. Conculusion: Septum patient is largely found in older age group and the body weight and body surface area are lower than control group. The body weight and body surface area are opposite correlation with age. So sigmoid septum is considered as structural change by weight reduction with aging. It is assumed that septum patients are related with asymptomatic ischemia because they have more abnormal ECG finding such as T wave inversion on precordial leads or standard leads, nonspecific ST-T change, LBBB etc. Sigmoid septum is not only proximal interventricular septal bludging but also another web like structure continuing to anterior wall of left ventricle.

새마을 運動 實績評價模型 作成에 관한 硏究

黃明燦,玄斗日,梁始浩,朴英熙,金龍國,申大淳 건국대학교 1974 學術誌 Vol.17 No.1

The New Village (Sae-ma-eul) movement is Korean version of Community Development that has under-gone widespread exploration, experimentation and application in developing countries throughout the world in recent years. In most countries the national governments have undertaken the iniative in Community Development through appropriate ministries or special agencies. The New Village Movement was initiated in 1970 by Korean government. But it became a people's movement for self-development as more and more people participated in the developmental programs. The major objectives of the New Village movement are to redress the economic disparities between the rural and urban areas by improving the economic, social and cultural conditions of rural Communities, to reform the way of life in rural villages by encouraging the attitude of self-help, and to increase the income of the farmers and fisher man. Since 1971, An enormous amount of public and priate money has been invested into the New Village Movement. It seems that the time has arrived when some framework for evaluating the whole program is to be developed. Thus, The objective of this study is to develop an appropriate to evaluate the new village project at the village level. Ten major factors which are supposed to be relevant for evaluation of the project was selected. The evaluation model thus developed can be summarized in the following format. ◁표 삽입▷ (원문을 참조하세요)

자일리톨, 후노란, 제2인산칼슘 및 카제인포스포펩타이드배합껌이 법랑질의 광질재침착에 미치는 영향에 관한 실용실험연구

이병진,배광학,박우철,양준영,황수정,노정,백대일,김종배 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.4

The object of this study was to investigate caries preventive effect of chewing gum containing xylitol, funoran, calcium hydrogen phosphate and casein phosphopeptide by examining Vickers' hardness and surface roughness with confocal laser microscope. Early caries-like lesions were created using 0.1 M lactic acid-sodium hydroxide buffer(pH 4.0). 8 pieces of 3am diameter bovine enamel specimen with early caries-like lesions were mounted into the recesses of lingual surface of the acrylic mandibular removable appliance. 13 subjects were the appliance for daytime and chewed control and experimental gums 7 times in a day, for 3 days. In order to evaluate the remineralization effect of chewing gum on specimens, we measured vickers' hardness number after chewing gum, 1 day, 2 days, 3 days after and calculated surface roughness immediately after chewing gum. Vickers' hardness number of experimental chewing gum was significantly higher than control in 2 and 3 days after. Surface roughness of experimental chewing gum was significantly lower than control immediately after chewing gum. These results showed that experimental gum has more effective in remineralization of bovine tooth enamel, and it is more effective at immediately after chewing.

Epidermal Growth Factor가 人體纖維芽細胞 增殖에 미치는 影響

金友濟,鄭豆泳,金良均,梁鍾大 朝鮮大學校 附設 醫學硏究所 1985 The Medical Journal of Chosun University Vol.10 No.1

The effects of epidermal growth factor(EGF) on the cell proliferation were estimated in normal human fibroblast and established adenovirus type 12-simian murine sarcoma virus 40 hybrid virus-transformed human fibroblast. In the presence of culture medium containing 1.0ng per ㎖ epidermal growth factor had more effect on the cell proliferation of transformed cell lines than normal cell lines. The data suggest that epidermal growth factor stimulates cell proliferation in additive manner of virus-transformed human fibroblast.

IGF-1 from Adipose-Derived Mesenchymal Stem Cells Promotes Radioresistance of Breast Cancer Cells

Yang, Hui-Ying,Qu, Rong-Mei,Lin, Xiao-Shan,Liu, Tong-Xin,Sun, Quan-Quan,Yang, Chun,Li, Xiao-Hong,Lu, Wei,Hu, Xiao-Fang,Dai, Jing-Xing,Yuan, Lin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23

Purpose: The aim of this study was to investigate effects of adipose-derived mesenchymal stem cells (AMSCs) on radioresistance of breast cancer cells. Materials and Methods: MTT assays were used to detect any influence of AMSC supernatants on proliferation of breast cancer cells; cell migration assays were used to determine the effect of breast cancer cells on the recruitment of AMSCs; the cell survival fraction post-irradiation was assessed by clonogenic survival assay; ${\gamma}$-H2AX foci number post-irradiation was determined via fluorescence microscopy; and expression of IGF-1R was detected by Western blotting. Results: AMSC supernatants promoted proliferation and radioresistance of breast cancer cells. Breast cancer cells could recruit AMSCs, especially after irradiation. IGF-1 derived from AMSCs might be responsible for the radioresistance of breast cancer cells. Conclusions: Our results suggest that AMSCs in the tumor microenvironment may affect the outcome of radiotherapy for breast cancer in vitro.

Crystal facet engineering induced anisotropic transport of charge carriers in a perovskite

Yang, Hewei,Zhou, Yunzhan,Yang, Yijun,Yi, Ding,Ye, Tao,Lam, Tran Dai,Golberg, Dmitri,Bao, Bate,Yao, Jiannian,Wang, Xi The Royal Society of Chemistry 2018 Journal of Materials Chemistry C Vol.6 No.43

<P>Precise control of crystal orientations and macroscopic morphology of a perovskite crystal is crucial for various optoelectronic applications relying on charge carrier transport tuning along exposed crystal facets. Here, taking methylammonium lead bromide (CH3NH3PbBr3) as an example, and employing a novel crystal facet engineering method, we successfully construct two kinds of perovskite crystals with exposed {001} and {110} facets. We find that the free carriers’ photoluminescence lifetime on the {001} facets can be 3 times longer than that on {110} facets. The related mechanisms are investigated <I>via</I> fluorescence lifetime imaging microscopy and <I>in situ</I> transmission electron microscopy. These indicate that the different trap state density of exposed facets and crystal structure changing of CH3NH3PbBr3 under light and electron beam irradiation lead to the differences in carrier transport along different facets. By distinguishing the charge carrier transport on different CH3NH3PbBr3 exposed facets, micro-photodetectors have been constructed. A device fabricated with the {001} exposed facets exhibited two orders of magnitude higher photocurrent and half as much dark current as a {110} facet-based device. Thus, the crystal facet engineering of perovskites can be widely adopted for understanding physical/chemical properties of perovskite crystals and provides great potential for novel perovskite optoelectronic device applications.</P>

CDK1 promotes the proliferation of melanocytes in Rex rabbits

Dai Yingying,Hu Shuaishuai,Bai Shaocheng,Li Jiali,Yang Naisu,Zhai Pin,Zhao Bohao,Chen Yang,Wu Xinsheng 한국유전학회 2022 Genes & Genomics Vol.44 No.10

Background: The fur color constitutes one of the most important economic characteristics of fur animals and is determined by the content of melanin. A previous study has shown that the cyclin-dependent kinase 1 (CDK1) is a member of the protein kinase family, involved in forming the color of the fur in Rex rabbits. However, its effect on the melanocytes remains unclear. Objective: This study aimed to provide evidence for the role of CDK1 in melanogenesis. Methods: This study measured the expression of CDK1 in Rex rabbit skins of six coat colors using qRT-PCR. The CDK1-mediated regulation of the pigmentation-related genes and cyclin-dependent kinases were analyzed. The melanin content, proliferation, and apoptosis of the melanocytes were analyzed using the NaOH, CCK8, and Annexin V-FITC methods. Results: The CDK1 expression in the skin of the rex rabbits with different coat colors was found to be regular, and the expression level was found to be the highest in the skin of the black rex rabbits (P < 0.05). The overexpression/knockdown of CDK1 was found to significantly increase/decrease the melanin content in the melanocytes (P < 0.01). Besides, CDK1 was found to significantly promote the proliferation of the melanocyte and inhibit apoptosis (P < 0.01). Furthermore, the overexpression of CDK1 was found to significantly affect the expression of the other melanin-related genes like TYR, PMEL, DCT, as well as the mRNA expression of the cyclin-dependent kinases CDK4, CDK6, CDK8, CCNB1. Conclusions: The results indicated that CDK1 can serve as a key gene regulating melanogenesis, melanocyte proliferation, and apoptosis, providing a new theoretical basis for studying the mechanism by which the different colors of the fur evolve in mammals.

Quinoxaline-Based Wide Band Gap Polymers for Efficient Nonfullerene Organic Solar Cells with Large Open-Circuit Voltages

Yang, Jie,Uddin, Mohammad Afsar,Tang, Yumin,Wang, Yulun,Wang, Yang,Su, Huimin,Gao, Rutian,Chen, Zhi-Kuan,Dai, Junfeng,Woo, Han Young,Guo, Xugang American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.27

<P>We present here a series of wide-band-gap (<I>E</I><SUB>g</SUB>: >1.8 eV) polymer donors by incorporating thiophene-flanked phenylene as an electron-donating unit and quinoxaline as an electron-accepting co-unit to attain large open-circuit voltages (<I>V</I><SUB>oc</SUB>s) and short-circuit currents (<I>J</I><SUB>sc</SUB>s) in nonfullerene organic solar cells (OSCs). Fluorination was utilized to fine-tailor the energetics of polymer frontier molecular orbitals (FMOs) by replacing a variable number of H atoms on the phenylene moiety with F. It was found that fluorination can effectively modulate the polymer backbone planarity through intramolecular noncovalent S···F and/or H···F interactions. Polymers (P2-P4) show an improved molecular packing with a favorable face-on orientation compared to their nonfluorinated analogue (P1), which is critical to charge carrier transport and collection. When mixed with IDIC, a nonfullerene acceptor, P3 with two F atoms, achieves a remarkable <I>V</I><SUB>oc</SUB> of 1.00 V and a large <I>J</I><SUB>sc</SUB> of 15.99 mA/cm<SUP>2</SUP>, simultaneously, yielding a power-conversion efficiency (PCE) of 9.7%. Notably, the 1.00 V <I>V</I><SUB>oc</SUB> is among the largest values in the IDIC-based OSCs, leading to a small energy loss (<I>E</I><SUB>loss</SUB>: 0.62 eV) while maintaining a large PCE. The P3:IDIC blend shows an efficient exciton dissociation through hole transfer even under a small energy offset of 0.16 eV. Further fluorination leads to the polymer P4 with increased chain-twisting and mismatched FMO levels with IDIC, showing the lowest PCE of 2.93%. The results demonstrate that quinoxaline-based copolymers are promising donors for efficient OSCs and the fluorination needs to be fine-adjusted to optimize the interchain packing and physicochemical properties of polymers. Additionally, the structure-property correlations from this work provide useful insights for developing wide-band-gap polymers with low-lying highest occupied molecular orbitals to minimize <I>E</I><SUB>loss</SUB> and maximize <I>V</I><SUB>oc</SUB> in nonfullerene OSCs for efficient power conversion.</P> [FIG OMISSION]</BR>

H₂ sensing characteristics of SnO₂ coated single wall carbon nanotube network sensors

Yang, Myung,Kim, Dai-Hong,Kim, Won-Sik,Kang, Tae June,Lee, Byung Yang,Hong, Seunghun,Kim, Yong Hyup,Hong, Seong-Hyeon IOP Pub 2010 Nanotechnology Vol.21 No.21

<P>SnO<SUB>2</SUB> nanoparticle coated single wall nanotube (SWNT) network sensors were fabricated by forming a SWNT network on the Pt patterned SiO<SUB>2</SUB><I>/</I>Si substrate using a dip coating method and subsequently depositing SnO<SUB>2</SUB> nanoparticles on the SWNT network by rf magnetron sputtering. Their H<SUB>2</SUB> gas sensing properties were investigated. The SnO<SUB>2</SUB>–SWNT network sensors stably and reversibly responded to H<SUB>2</SUB> gas even at room temperature and could detect H<SUB>2</SUB> gas down to 100 ppm. In addition to the low temperature detection, a remarkable finding was that the gas sensing behavior of SnO<SUB>2</SUB>–SWNT network sensors was changed from p-type to n-type with increasing SnO<SUB>2</SUB> deposition time (i.e. surface coverage of SnO<SUB>2</SUB> on SWNT). A schematic model was proposed to explain the switching of sensing behavior depending on the surface coverage of SnO<SUB>2</SUB> nanoparticles on the SWNTs. </P>