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( Xiang E Long ),( Zhao Hui Gong ),( Lin Pan ),( Zhi Wei Zhong ),( Yan Ping Le ),( Qiong Liu ),( Jun Ming Guo ),( Jiu Chang Zhong ) 한국생화학분자생물학회 (구 한국생화학회) 2010 BMB Reports Vol.43 No.4
Cyclin-dependent kinase 2 (CDK2) is a member of serine/threonine protein kinases, which initiates the principal transitions of the eukaryotic cell cycle and is a promising target for cancer therapy. The present study was designed to inhibit cdk2 gene expression to induce cell cycle arrest and cell proliferation suppression. Here, we constructed a series of RNA interference (RNAi) plasmids which can successfully express small interference RNA (siRNA) in the transfected human cells. The results showed that the RNAi plasmids containing the coding sequences for siRNAs down-regulated the cdk2 gene expression in human cancer cells at the mRNA and the protein levels. Furthermore, we found that the cell cycle was arrested at G0G1 phases and the cell proliferation was inhibited by different siRNAs. These results demonstrate that suppression of CDK2 activity by RNAi may be an effective strategy for gene therapy in human cancers. [BMB reports 2010; 43(4): 291-296]
Tl2Ba2CaCu2O8 Thin Films on MgO and Sapphire Substrates
X.J. Zhao,S.L. Yan,C. Zhang,E. Chen,L. Fang,L. Ji,Q.L. Xie,S. Li,T.G. Zhou,X. Zhang,X. Zuo,Y.G. Li 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.5I
High quality Tl2Ba2CaCu2O8(Tl-2212) films were grown on MgO and sapphire substrates with CeO2 buffer layers. The CeO2 buffer layers were prepared by using an in-situ process with RF magnetron sputtering. The Tl-2212 thin films were then fabricated in a two-step process: deposition of the Tl-containing precursor film and low-temperature post-thallination of the precursor film. The resulting Tl-2212 films showed an excellent biaxial texture. The superconducting transition temperatures, Tc’s, of the films on MgO and sapphire were 103.4 and 104.2 K, respectively. The critical current densities Jc at 77 K and zero magnetic field were as high as 2.37 × 106 A/cm2 for the film on MgO and 1.76 × 106 A/cm2 on sapphire. A surface resistance of 725 μ at 10 GHz and 77 K was obtained in the Tl-2212 film on CeO2 buffered sapphire.
A Novel Multi-Path Routing Algorithm Based on Clustering for Wireless Mesh Networks
( Chun-xiao Liu ),( Yan Zhang ),( E Xu ),( Yu-qiang Yang ),( Xu-hui Zhao ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.4
As one of the new self-organizing and self-configuration broadband networks, wireless mesh networks are being increasingly attractive. In order to solve the load balancing problem in wireless mesh networks, this paper proposes a novel multi-path routing algorithm based on clustering (Cluster_MMesh) for wireless mesh networks. In the clustering stage, on the basis of the maximum connectivity clustering algorithm and k-hop clustering algorithm, according to the idea of maximum connectivity, a new concept of node connectivity degree is proposed in this paper, which can make the selection of cluster head more simple and reasonable. While clustering, the node which has less expected load in the candidate border gateway node set will be selected as the border gateway node. In the multi-path routing establishment stage, we use the intra-clustering multi-path routing algorithm and inter-clustering multi-path routing algorithm to establish multi-path routing from the source node to the destination node. At last, in the traffic allocation stage, we will use the virtual disjoint multi-path model (Vdmp) to allocate the network traffic. Simulation results show that the Cluster_MMesh routing algorithm can help increase the packet delivery rate, reduce the average end to end delay, and improve the network performance.
Yuan Xie,Yanjun Li,Jiqiu Wen,Xue Li,Zhe Zhang,Jianrui Li,Yan’e Zhao,Peng Wang,Jun Zhang,Ying Tian,Long Jiang Zhang,Guang Ming Lu 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.2
Objective: To determine the feasibility of reduced field-of-view diffusion-weighted imaging (rFOV DWI) with multi-b values to detect functional variability in transplanted kidneys. Materials and Methods: Using a 3T MRI scanner, multi-b rFOV DWI of transplanted kidney or native kidney was performed in 40 renal transplantation recipients and 18 healthy volunteers. The patients were stratified, according to an estimated glomerular filtration rate (eGFR): Group 1, eGFR ≥ 60 mL/min/1.73 m2; Group 2, eGFR ≥ 30 mL/min/1.73 m2 and < 60 mL/min/1.73 m2; Group 3, eGFR < 30 mL/min/1.73 m2. Total apparent diffusion coefficient (ADCT), perfusion-free ADC (ADCD) and perfusion fraction (FP) of kidneys were calculated and compared among the four groups. Correlations between the imaging results and eGFR were assessed. Results: All volunteers had eGFR ≥ 60 mL/min/1.73 m2, while 16, 16, and 8 patients were included in Groups 1, 2, and 3, respectively. In the renal cortex, ADCT was higher in Group 1 ([1.65 ± 0.13] x 10-3 mm2/s) than Group 3 ([1.44 ± 0.11] x 10-3 mm2/s) (p < 0.05), and the inter-group differences of FP values were significant (all p < 0.05) (0.330 ± 0.024, 0.309 ± 0.019, 0.278 ± 0.033, and 0.250 ± 0.028 for control group, Groups 1, 2, and 3, respectively). Renal cortical ADCT, ADCD, FP, and renal medullary ADCT and FP correlated positively with eGFR (r = 0.596, 0.403, 0.711, 0.341, and 0.323, respectively; all p < 0.05). When using 0.278 as the cutoff value, renal cortical FP had a sensitivity of 97.1% and a specificity of 66.7% for predicting decreased renal function. Conclusion: Multi-b rFOV DWI presents transplanted kidneys with high resolution, which is a promising functional tool for non-invasively monitoring function of transplanted kidneys.