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Chang Ya-Hui,Hou Wen-Hsuan,Ya-Hui Chang,Li Chung-Yi 한국역학회 2022 Epidemiology and Health Vol.44 No.-
OBJECTIVES: Limited information is available on whether diabetes increases the severity of injuries from motor vehicle crashes (MVCs). This study aimed to investigate the association of type 2 diabetes with injury severity among driver victims of MVCs. METHODS: This cohort study involved 75,737 adult driver victims with type 2 diabetes from Taiwan’s Police-Reported Traffic Accident Registry in 2015-2017, along with 150,911 sex-, age-, and calendar year-matched controls. The severity level of nonfatal injuries was derived from the International Classification of Diseases Programs for Injury Categorization based on the diagnostic codes of National Health Insurance claims within 3 days after an MVC. Information on fatal injuries within 3 days after an MVC was obtained from the Taiwan Death Registry. Logistic regression models were used to estimate the odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) of injury severity in association with type 2 diabetes. RESULTS: After adjusting for potential confounders, driver victims with type 2 diabetes experienced significantly higher risks of mild and severe non-fatal injuries than their counterparts without diabetes, with covariate-adjusted ORs of 1.08 (95% CI, 1.05 to 1.11) and 1.28 (95% CI, 1.20 to 1.37), respectively. By contrast, the adjusted OR for fatal injuries was not significantly elevated, at 1.02 (95% CI, 0.89 to 1.18). Similar results were found when car and scooter driver victims were analyzed separately. CONCLUSIONS: Type 2 diabetes was found to moderately increase the severity of non-fatal injuries from MVCs among car and scooter driver victims.
Hou-Yang Kang,Li-Juan Lin,Zhi-Jian Song,Jing-Ya Yuan,Mei-Yu Zhong,Hai-Qin Zhang,Xing Fan,Li-Na Sha,Yi Wang,Li-Li Xu,Jian Zeng,Yong-Hong Zhou 한국유전학회 2012 Genes & Genomics Vol.34 No.5
Semi-dwarfism is an agronomically important trait in breeding for resistance to damage by wind and rain (lodging resistance)and for stable high yields. Dwarf Polish wheat (Triticum polonicum L., 2n = 4x = 28, AABB AS304) is a potential donor of dwarfing and other traits for common wheat improvement. A genetic analysis using an F2 population derived from a cross of AS304 and tall cultivar AS302 and derived F2:3 lines indicated that AS304 carries a recessive dwarfing gene, temporarily designated Rht-dp. Molecular markers and bulked segregant analysis were used to characterize and map the gene. Eight polymorphic SSR markers (Xwmc511, Xgwm495, Xgwm 113, Xgwm192, Xgpw7026, Xgpw3017, Xgpw1108 and Xgpw7521) on chromosome arm 4BS and two AFLP markers (M8/E5 and M4/E3) were mapped relative to the dwarfing locus. The closest linked markers, Xgpw3017 and M8/E5 at 0.5 and 3.5 cM, respectively, from Rht-dp will enable its marker assisted transfer to wheat breeding populations. Allelic tests indicated that Rht-dp was allelic to Rht-B1b; hence it may be an alternative allele at the Rht-B1 locus.
Toxic Epidermal Necrolysis Induced by Sintilimab: A Case Report
Ya-lei Lye,Bin Shan,Chen-hong Jia,Jiang Liu,Juan Hou,Wen-li Du,Rui Feng,Ping Liang 대한피부과학회 2023 Annals of Dermatology Vol.35 No.-
Sintilimab is an anti-programmed cell death receptor-1 antibody. The phase III clinical trial ORIENT-12 confirmed the safety of sintilimab combined with pemetrexed/platinum in the treatment of advanced squamous non-small cell lung cancer. Skin reactions are the most commonly reported adverse events of immune checkpoint inhibitors and are rarely severe. We describe a case of toxic epidermal necrolysis related to sintilimab in an elderly oncologic patient. 3 weeks after immunotherapy, the patient developed an extensive rash and diffuse itching, rapidly evolving into macules, blisters, bullae and erosions. Causal evaluation was performed based on the algorithm of drug causality for epidermal necrolysis and national Food and Drug Administration qualitative analysis. The patient responded to high-dose glucocorticosteroid and supportive therapy, alongside with local wound care. If immune checkpoint inhibitors need to be extrapolated clinically, strictly following evidence-based research, promptly detecting and treating adverse reactions is crucial.
Bin He,Ya-Li Mao,Ya Zhang,WEI YIN,CHANGJUN HOU,DANQUN HUO,Huanbao Fa 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.4
A highly sensitive and selective biomimetic sensor based on zinc porphyrin molecularly imprinted Polymer microspheres (MIPMs), gold nanoparticles (AuNPs) and carboxyl graphene (CG) nanomaterials was successfully developed for direct electrochemical detection of methyl parathion (MP). The novel strategy emphasized the fabrication of a porphyrin zinc-based sensor via attaching MIPMs on AuNPs/CG nanocomposites. MIPMs was prepared by free radical polymerization using MP as the template, Zinc porphyrin as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as the cross-linking reagent and azobisisobutyronitrile (AIBN) as the initiator. The introduction of AuNPs/CG significantly increased the effective electrode area, and amplified the sensor signal. The modified electrode was characterized by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The parameters of the detection process were also optimized. The biomimetic sensor exhibits a much wider linear dynamic range between 1.0 x 10 -6 mol L-1 and 8.0 x 10 -9 mol L-1 and the limit of detection (LOD) down to 3.16 x 10 -10 mol L-1 based on S/N = 3. The sensor had good reproducibility, stability and selectivity for MP detection. The developed sensor was successfully employed for the detection of MP in real samples.
Dabao Fan,Daxing Zeng,Ya Liu,Wenjuan Lu,Yulei Hou,Zirong Zhou,Jianwen Guo 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.4
This study investigates the factors affecting the topology of Rubik’s cube mechanism (RCM) and presents the synthesis theory of RCM. First, the revolute axis symmetry of the RCM is described and analyzed, and the general expression needed for the revolute axis to meet the symmetry is introduced. Next, the symmetry expression of the revolute pair contact surface (RPCS) of the RCM is given. The intersection between the RPCSs is analyzed via the adjacency matrix, and the adjacency matrix characteristics are given along with the motion characteristics of RCM. After determining the RPCS intersection, its topology is studied. Finally, the synthesis theory of RCM is presented, and the synthesis process and flowchart are proposed. The regular hexahedron RCMs with different topological structures are obtained after applying the synthesis theory. Hence, the theory proposed in this study provides strong theoretical support for the synthesis of other new RCMs.
Li Qiqi,Zhang Yingnan,Song Ya,Yang Huawei,Yang Lixia,Bai Liangjiu,Wei Donglei,Wang Wenxiang,Liang Ying,Chen Hou 한국탄소학회 2023 Carbon Letters Vol.33 No.2
Biomass carbon materials with high rate capacity have great potential to boost supercapacitors with cost effective, fast charging–discharging performance and high safety requirements, yet currently suffers from a lack of targeted preparation methods. Here we propose a facile FeCl3 assisted hydrothermal carbonization strategy to prepare ultra-high rate biomass carbon from apple residues (ARs). In the preparation process, ARs were first hydrothermally carbonized into a porous precursor which embedded by Fe species, and then synchronously graphitized and activated to form biocarbon with a large special surface area (2159.3 m2 g−1) and high degree of graphitization. The material exhibited a considerable specific capacitance of 297.5 F g−1 at 0.5 A g−1 and outstanding capacitance retention of 85.7% at 10 A g−1 in 6 M KOH, and moreover, achieved an energy density of 16.2 Wh kg−1 with the power density of 350.3 W kg−1. After 8000 cycles, an initial capacitance of 95.2% was maintained. Our findings provide a new idea for boosting the rate capacity of carbon-based electrode materials.
Jiang, Xue-Yan,Chang, Fu-Hou,Bai, Tu-Ya,Lv, Xiao-Li,Wang, Min-Jie,Wang, Guang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13
Background: To study the relationship of susceptibility to lung cancer with the gene polymorphisms of CYP1A1, GSTM1, GSTM3, GSTT1, GSTP1 and smoking status in Han and Mongolian populations of Inner Mongolia, an autonomous region of China. Materials and Methods: PCR-RFLP, allele-specific and multiplex PCR were employed to identify the genotypes of CYP1A1, GSTM1, GSTM3, GSTT1 and GSTP1 in a case-control study of 322 lung cancer patients diagnosed by bronchoscopy and 456 controls free of malignancy. Results: There is a significant difference in genotypic frequency of GSTT1 of healthy Mongolian and Han subjects. A statistically prominent association was found between CYP1A1 Msp1 (vt/vt) (OR=4.055, 95%CI:2.107-7.578, p=0.000), GSTM1 (-) (OR=2.290, 95%CI:1.467-3.573, p=0.000) and lung cancer in Mongolians. Similarly, in the Han population, CYP1A1 Msp1 (vt/vt) (OR=3.194, 95%CI:1.893-5.390, p=0.000) and GSTM1 (-) (OR=1.884, 95%CI:1.284-2.762, p=0.001) carriers also had an elevated risk of lung cancer. The smokers were more susceptible to lung cancer 2.144 fold and 1.631 fold than non-smokers in Mongolian and Han populations, respectively. The smokers who carried with CYP1A1 Msp1 (wt/vt+vt/vt), exon7 (Val/Val+Ile /Val), GSTM1 (-), GSTM3 (AB+BB), and GSTT1 (-) respectively were found all to have a high risk of lung cancer. Conclusions: CYP1A1 Msp1 (vt/vt) and GSTM1 (-) are risk factors of lung cancer in Han and Mongolian population in the Inner Mongolia region. The smokers with CYP1A1 Msp1 (wt/vt+vt/vt), CYP1A1 exon7 (Val/Val+Ile /Val), GSTM1 (-), GSTM3 (AB+BB), and GSTT1 (-) genotypes, respectively, are at elevated risk of lung cancer.
Fang-Ming Chen,Hsueh-Wei Chang,Sheau-Fang Yang,Ya-Fang Huang,Pei-Yung Nien,Yao-Tsung Yeh,Ming-Feng Hou 생화학분자생물학회 2012 Experimental and molecular medicine Vol.44 No.5
The mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) belongs to the MAPK cascades which are central to cell proliferation and apoptosis. The carcinogenic role of MKP-1 has been reported in many types of cancer but it has rarely been investigated in breast cancer. The present study was designed to evaluate the MKP-1 mRNA expression and its possible regulation by methylation of MKP-1 promoter in the model of several breast cancer cell lines and tissues as well as controls. Our data demonstrate MKP-1mRNA expression significantly decreased in five breast cancer cell lines compared to breast controls (P <0.01). Using the methylation-specific PCR (MSP) analysis,the unmethylated reaction (U) is dominant in both normal cell lines and benign breast tumors (100% vs. 86.2%), whereas the methylated reaction (M) is dominant in both breast cancer cell lines and invasive breast tumors (100% vs. 57.2%). In terms of methylation ratio (M/M+U), methylation level in MKP-1 promoter is significantly higher in the invasive breast tumor tissues (n = 152) than in benign breast tumor tissues (n = 29)(P < 0.0001). Assessing the methylation ratio of the promoter of MKP-1 gene to diagnose the breast malignancy (invasive vs. benign), the area under the receiver-operating characteristic (ROC) curve was 0.809(95% CI: 0.711-0.906, P < 0.001). The best performance for this prediction has a sensitivity of 76.32% and a specificity of 82.76% at the cutoff value of 0.38. Taken together, we firstly demonstrated that the promoter methylation of MKP-1 gene is a potential breast cancer biomarker for breast malignancy.