http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( F. Mcphee ),( L. Wei ),( Q. Xie ),( Y. Suzuki ),( J. Toyota ),( Y. Karino ),( K. Chayama ),( Y. Kawakami ),( M. L. Yu ),( S. H. Ahn ),( N. Zhou ),( H. Kumada ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Daclatasvir (DCV) plus asunaprevir (ASV) has demonstrated highsustained virologic response (SVR) in HCV genotype (GT-)1b infection.NS5A-Y93H and NS5A-L31 resistance-associated polymorphisms(RAPs) to DCV are known to impact DCV+ASV response in GT-1b-infectedJapanese. The effect of RAPs on SVR at posttreatment week12 (SVR12) to DCV+ASV was explored in mainland Chinese, Korean,and Taiwanese.Methods: Pooled data from 2 studies of DCV (60 mg daily) + ASV(100 mg capsule, twice-daily) for 24 weeks in GT-1b-infected interferon/ribavirin-naive and -experienced patients from mainland China,Korea, and Taiwan. Similar Japanese data (4 studies; n=445) werepooled for comparison. SVR12 with versus without baseline Y93Hand/or L31 RAPs was compared by age (<65 vs ≥65 years), cirrhosisstatus, and baseline HCV-RNA.Results: SVR12 and baseline NS5A sequences were available for 282patients (126 mainland Chinese [45%〕, 80 Koreans [28%〕, 76Taiwanese [27%〕). NS5A-Y93H and/or -L31 RAPs were observed pretreatmentin 8% mainland Chinese, 14% Korean, and 18%Taiwanese patients, compared with 19% in Japanese. SVR12 in allnon-Japanese patients is shown (Figure); rates were broadly similarbetween countries and with Japanese data (Japanese: 96% overallwithout RAPs, 41% with RAPs). Responses were lower among patientswith baseline RAPs. By contrast, SVR12 in patients without RAPs washigh (92-100%), irrespective of cirrhosis, age, or baseline HCV-RNA.Conclusions: At least 95% of HCV GT-1b-infected patients from mainlandChina, Korea or Taiwan without baseline NS5A-Y93H or -L31polymorphisms who had HCV-RNA ≤7 log10 IU/mL achieved SVR12on DCV+ASV, regardless of cirrhosis status and age.
Yamaguchi, Y.,Nakano, M.,Nagao, H.,Okumura, M.,Yamanaka, S.,Kawakami, T.,Yamaki, D.,Nishino, M.,Shigeta, Y.,Kitagawa, Y.,Takano, Y.,Takahata, M.,Takeda, R. Korean Chemical Society 2003 Bulletin of the Korean Chemical Society Vol.24 No.6
A unified picture for magnetism, superconductivity, quantum optics and other properties of molecule-based materials has been presented on the basis of effective model Hamiltonians, where necessary parameter values have been determined by the first principle calculations of cluster models and/or band models. These properties of the matetials are qualitatively discussed on the basis of the spin and pseudo-spin Hamiltonian models, where several quantum operators are expressed by spin variables under the two level approximation. As an example, ab initio broken-symmetry DFT calculations are performed for cyclic magnetic ring constructed of 34 hydrogen atoms in order to obtain effective exchange integrals in the spin Hamiltonian model. The natural orbital analysis of the DFT solution was performed to obtain symmetry-adapted molecular orbitals and their occupation numbers. Several chemical indices such as information entropy and unpaired electron density were calculated on the basis of the occupation numbers to elucidate the spin and pair correlations, and bonding characteristic (kinetic correlation) of this mesoscopic magnetic ring. Both classical and quantum effects for spin alignments and singlet spin-pair formations are discussed on the basis of the true spin Hamiltonian model in detail. Quantum effects are also discussed in the case of superconductivity, atom optics and quantum optics based on the pseudo spin Hamiltonian models. The coherent and squeezed states of spins, atoms and quantum field are discussed to obtain a unified picture for correlation, coherence and decoherence in future materials. Implications of theoretical results are examined in relation to recent experiments on molecule-based materials and molecular design of future molecular soft materials in the intersection area between molecular and biomolecular materials.
Dual Partial Dye Doping for Chromaticity Tuning and Performance Enhancement of White OLEDs
Jongwoon Park,Suganuma, N.,Kawakami, Y. IEEE 2008 Journal of display technology Vol.4 No.1
<P>In general, a guest dopant is doped into a single host matrix for white-light emission with two complementary colors. In this work, however, we have fabricated a white organic light-emitting diode (WOLED) based on dual partial dye doping in which a guest dopant is partially doped into two different host emitters; namely, orange-red emitting 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminos-tyryl)-4H-pyran (DCM) is partially doped into both blue-emitting 4, 4'-bis(2,2'-diphenylvinyl)-1,1'-biphenyl (DPVBi) and green-emitting Tris-(8-hydroxyquinoline) aluminum (Alq<SUB>3</SUB>). We demonstrate that dual partial dye doping allows us to finely tune the Commission Internationale d'Eclairage (CIE) chromaticity coordinates to the equienergy white point (x = 0.33, y = 0.33). In addition, it enhances device performance further, compared to WOLEDs based on DCM partially doped into a single host matrix (either DPVBi or Alq<SUB>3</SUB>). Moreover, the dual partial doping scheme is shown to provide a way of suppressing the self-quenching effect (singlet-singlet annihilation). For a systematic study, we have implemented a comprehensive numerical model and performed simulations of the OLED structure, providing a clear understanding with regard to the underlying physics of OLEDs. We also carry out an investigation of the effects of key design parameters such as the doped layer position and thickness and dye.</P>