The Lymphatic Drainage Pattern of Internal Mammary Sentinel Lymph Node Identified by Small Particle Radiotracer (99mTc-Dextran 40) in Breast

Xiao-Shan Cao,Guo-Ren Yang,Bin-Bin Cong,Peng-Fei Qiu,Yong-Sheng Wang 대한암학회 2019 Cancer Research and Treatment Vol.51 No.2

Purpose The purpose of this study was to detect the lymphatic drainage pattern of internal mammary area and verify the concept of internal mammary sentinel lymph node (IM-SLN) in breast. Materials and Methods A small particle radiotracer (99mTc-Dextran 40) was prepared and tested. 99mTc-Dextran 40 was injected into intraparenchyma at the sound breast by a modified radiotracer injection technique. Subsequently, dynamic single-photon emission computed tomography (SPECT), computed tomography (CT), and SPECT/CT combination images were performed to identify the radioactive lymph vessels and internal mammary lymph nodes (IMLNs). The direction of lymph drainage and the location of the IMLNs were identified in the SPECT/CT imaging. Results The radiochemical purity of 99mTc-Dextran 40 was > 95%. 99mTc-Dextran 40 could drainage into first, second, and third lymph node and the radioactive lymph node could be detected by the  detector in the animal experiment. After 99mTc-Dextran 40 injecting into intraparenchyma, 50.0% cases (15/30) were identified the drainage lymphatic vessels and radioactive IMLNs by SPECT. The drainage lymphatic vessel was found from injection point to the first IMLN (IM-SLN) after 10.5±0.35 minutes radiotracer injection, and then 99mTc-Dextran 40 was accumulated into the IM-SLN. The combination imaging of SPECT/CT showed the second IMLN received the lymph drainage from the IM-SLN. The lymphatic drainage was step by step in the internal mammary area. Conclusion The lymph was identified to drain from different regions of the breast to IM-SLN, and then outward from IM-SLN to other IMLN consecutively. It demonstrated the concept of the IM-SLN and provided more evidences for the application of internal mammary sentinel lymph node biopsy.

An Efficient Algorithm for Dynamic Shortest Path Tree Update in Network Routing

Xiao, Bin,Cao, Jiannong,Shao, Zili,Sha, Edwin H.M. The Korea Institute of Information and Commucation 2007 Journal of communications and networks Vol.9 No.4

Shortest path tree(SPT) construction is essential in high performance routing in an interior network using link state protocols. When some links have new state values, SPTs may be rebuilt, but the total rebuilding of the SPT in a static way for a large computer network is not only computationally expensive, unnecessary modifications can cause routing table instability. This paper presents a new update algorithm, dynamic shortest path tree(DSPT) that is computationally economical and that maintains the unmodified nodes mostly from an old SPT to a new SPT. The proposed algorithm reduces redundancy using a dynamic update approach where an edge becomes the significant edge when it is extracted from a built edge list Q. The average number of significant edges are identified through probability analysis based on an arbitrary tree structure. An update derived from significant edges is more efficient because the DSPT algorithm neglect most other redundant edges that do not participate in the construction of a new SPT. Our complexity analysis and experimental results show that DSPT is faster than other known methods. It can also be extended to solve the SPT updating problem in a graph with negative weight edges.

BRCA1 Gene Exon 11 Mutations in Uighur and Han Women with Early-onset Sporadic Breast Cancer in the Northwest Region of China

Cao, Yu-Wen,Fu, Xin-Ge,Wan, Guo-Xing,Yu, Shi-Ying,Cui, Xiao-Bin,Li, Li,Jiang, Jin-Fang,Zheng, Yu-Qin,Zhang, Wen-Jie,Li, Feng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11

The prevalence of BRCA1 gene mutations in breast cancer differs between diverse ethnic groups. Relatively little information is known about patterns of BRCA1 mutations in early-onset breast cancer in women of Uighur or Han descent, the major ethnic populations of the Xinjiang region in China. The aim of this study was to identify BRCA1 mutations in Uighur and Han patients with early-onset (age <35 years), and sporadic breast cancer for genetic predisposition to breast cancer. For detection of BRCA1 mutations, we used a polymerase chain reaction single-stranded conformation polymorphism approach, followed by direct DNA sequencing in 22 Uighur and 13 Han women with early-onset sporadic breast cancer, and 32 women with benign breast diseases. The prevalence of BRCA1 mutations in this population was 22.9% (8/35) among early-onset sporadic breast cancer cases. Of these, 31.8% (7/22) of Uighur patients and 7.69% (1/13) of Han patients were found to have BRCA1 mutations. In 7 Uighur patients with BRCA1 mutations, there were 11 unique sequence alterations in the BRCA1 gene, including 4 clearly disease-associated mutations on exon 11 and 3 variants of uncertain clinical significance on exon 11, meanwhile 4 neutral variants on intron 20 or 2. None of the 11 BRCA1 mutations identified have been previously reported in the Breast Cancer Information Core database. These findings reflect the prevalence of BRCA1 mutations in Uighur women with early-onset and sporadic breast cancer, which will allow for provision of appropriate genetic counseling and treatment for Uighur patients in the Xinjiang region.

Protectin DX increases alveolar fluid clearance in rats with lipopolysaccharideinduced acute lung injury

Xiao-Jun Zhuo,Yu Hao,Fei Cao,Song-Fan Yan,Hui Li,Qian Wang,Bi-Huan Cheng,Bin-Yu Ying,Bin-Yu Ying,Sheng-Wei Jin 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

Acute respiratory distress syndrome is a life-threatening critical syndrome resulting largely from the accumulation of and the inability to clear pulmonary edema. Protectin DX, an endogenously produced lipid mediator, is believed to exert anti-inflammatory and pro-resolution effects. Protectin DX (5 μg/kg) was injected i.v. 8 h after LPS (14 mg/kg) administration, and alveolar fluid clearance was measured in live rats (n = 8). In primary rat ATII epithelial cells, protectin DX (3.605 × 10−3 mg/l) was added to the culture medium with LPS for 6 h. Protectin DX improved alveolar fluid clearance (9.65 ± 1.60 vs. 15.85 ± 1.49, p < 0.0001) and decreased pulmonary edema and lung injury in LPSinduced lung injury in rats. Protectin DX markedly regulated alveolar fluid clearance by upregulating sodium channel and Na, K-ATPase protein expression levels in vivo and in vitro. Protectin DX also increased the activity of Na, K-ATPase and upregulated P-Akt via inhibiting Nedd4–2 in vivo. In addition, protectin DX enhanced the subcellular distribution of sodium channels and Na, K-ATPase, which were specifically localized to the apical and basal membranes of primary rat ATII cells. Furthermore, BOC-2, Rp-cAMP, and LY294002 blocked the increased alveolar fluid clearance in response to protectin DX. Protectin DX stimulates alveolar fluid clearance through a mechanism partly dependent on alveolar epithelial sodium channel and Na, K-ATPase activation via the ALX/PI3K/Nedd4–2 signaling pathway.

An Analytical Model of Chip Heat-Carrying Capacity for High-Speed Dry Hobbing Based on 3D Chip Geometry

Xiao Yang,Huajun Cao,Yong-peng Chen,Li-Bin Zhu,Ben-jie Li 한국정밀공학회 2017 International Journal of Precision Engineering and Vol.18 No.2

High-speed dry hobbing is the dominating green technique for gear hobbing owing to its high productivity and environmental friendliness. However, a large amount of cutting heat is generated during the machining process due to the absence of metalworking fluids and the adoption of high cutting speed. A better understanding of chip heat-carrying capacity for high-speed dry hobbing is quite necessary when aiming to reduce the influence of cutting heat on machining precision. In this paper, an analytical model is established to quantitatively determine the chip heat-carrying capacity of high-speed dry hobbing. According to the progressive heat transfer characteristic of high-speed dry hobbing, cutting heat generation and transmission are analyzed. 3D chip geometry is numerically calculated by modeling the complex hob geometry and the interrelated kinematic relations of high-speed dry hobbing. Based on the 3D chip geometry and the specific cutting energy, chip heat-carrying capacity model is developed considering three heat sources. In this model, chip heat partition is experimentally determined by calorimetric method. With the help of the developed model, chip heat-carrying quantity and chip heat-carrying efficiency are discussed by investigating their influence factors (hob rotation speed, axial feed, feed method, chip removal time and hob geometry).

An Output Power Prediction Method for Multiple Wind Farms under Energy Internet Environment

Jianlou Lou,Hui Cao,Bin Song,Jizhe Xiao 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.11

Traditional wind power prediction is only applicable to a single wind farm. Aim at this isolated prediction method. In this paper, combing with the information sharing and Interconnection mechanism of energy Internet, we propose an output power prediction method for multiple wind farms based on DBPSO-LSSVM model. Firstly, collect SCADA data of multiple wind farms in different areas. Secondly, delete outliers of different farms based on DBSCAN algorithm and select multiple wind fields training samples. And searching the optimal input parameters of LSSVM based on particle swarm algorithm to construct every wind farm model. Thirdly, predict multiple wind fields power combined with numerical weather prediction system. The method we propose can be used to make the scheduling plan in advance to solve a large number of abandoned wind power rationing problem every year. In experiment, the method we propose has the lowest error rate compares to LSSVM and BP-neural network. It’s more suitable to predict wind fields in different areas.

An adaptive parameter optimization model and system for sustainable gear dry hobbing in batch production

Ying Zhang,Huajun Cao,Peng Chen,Li-Bin Zhu,Xiao Yang 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.6

Gear hobbing technology is one of the most widely used forming processes of gear teeth. And the development of dry hobbing technologyprovides a solution for realizing productive, economical, and ecological gear production. Since there is no cutting oil for coolingand lubrication in dry hobbing process, the hob tool life, thermal deformation errors of machine tool, and quality of workpiece are sensitiveto the cutting parameters, especially the cutting speed and tip chip thickness. Considering this situation, a dry hobbing parametersoptimization model with the hobbing efficiency as our objective, and the hobbing cost per piece, gear quality, tact time as constraints wasestablished, in which the cutting speed and tip chip thickness were considered as optimal variables and the material of workpiece, coatingof hob, and feed rate were considered comprehensively. An iterative test method is proposed to solve this model. And for the applicationin automated production line, an online adaptive application system was also developed based on SINUMERIK 840D NC system. Theparameters of five different kinds of material gear were optimized by applying this model and system, and the result showed the modeland the system were practical.

Realizing highly efficient multicolor tunable emissions from Tb³⁺ and Eu³⁺ co-doped CaGd₂(WO₄)₄ phosphors via energy transfer by single ultraviolet excitation for lighting and display applications

Huang, Xiaoyong,Li, Bin,Du, Peng,Guo, Heng,Cao, Renping,Yu, Jae Su,Wang, Kai,Sun, Xiao Wei Elsevier 2018 Dyes and pigments Vol.151 No.-

<P><B>Abstract</B></P> <P>In this paper, we reported on multicolor emission tuning in Tb<SUP>3+</SUP> and Eu<SUP>3+</SUP> co-doped CaGd<SUB>2</SUB>(WO<SUB>4</SUB>)<SUB>4</SUB> phosphors prepared by a traditional high-temperature solid-state reaction. Upon 380 nm ultraviolet excitation, the emission color of CaGd<SUB>2</SUB>(WO<SUB>4</SUB>)<SUB>4</SUB>:Tb<SUP>3+</SUP>,Eu<SUP>3+</SUP> phosphors can be readily tuned from green to yellow, orange and finally to pure red through varying the concentration ratio of Eu<SUP>3+</SUP> and Tb<SUP>3+</SUP> ions. The energy transfer mechanism from Tb<SUP>3+</SUP> to Eu<SUP>3+</SUP> was systematically investigated by photoluminescence spectra, luminescence decay times, and time-resolved spectra. The internal quantum efficiencies of these phosphors were measured, and their thermal stability was also studied. A prototype white light-emitting diode (LED) device was fabricated by using an ultraviolet chip combined with a blend of blue-emitting BaMgAl<SUB>10</SUB>O<SUB>l7</SUB>:Eu<SUP>2+</SUP> phosphors, green-emitting BaSrSiO<SUB>4</SUB>:Eu<SUP>2+</SUP> phosphors, and red-emitting CaGd<SUB>2</SUB>(WO<SUB>4</SUB>)<SUB>4</SUB>:50%Tb<SUP>3+</SUP>,50%Eu<SUP>3+</SUP> phosphors. All the results indicate that the CaGd<SUB>2</SUB>(WO<SUB>4</SUB>)<SUB>4</SUB>:Tb<SUP>3+</SUP>,Eu<SUP>3+</SUP> has great potential application in lighting and displays.</P> <P><B>Highlights</B></P> <P> <UL> <LI> CaGd<SUB>2</SUB>(WO<SUB>4</SUB>)<SUB>4</SUB>:Tb<SUP>3+</SUP>,Eu<SUP>3+</SUP> showed efficient energy-transfer from Tb<SUP>3+</SUP> to Eu<SUP>3+</SUP>. </LI> <LI> CaGd<SUB>2</SUB>(WO<SUB>4</SUB>)<SUB>4</SUB>:Tb<SUP>3+</SUP>,Eu<SUP>3+</SUP> exhibited tunable color emission under 380 nm excitation. </LI> <LI> The energy-transfer mechanism was studied in detail. </LI> <LI> Quantum efficiency and thermal stability were investigated. </LI> <LI> The proof-of-concept LED lamps were fabricated by employing phosphors and UV LEDs. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Functional Roles of Long Non-coding RNA in Human Breast Cancer

Ye, Ni,Wang, Bin,Quan, Zi-Fang,Cao, San-Jie,Wen, Xin-Tian,Huang, Yong,Huang, Xiao-Bo,Wu, Rui,Ma, Xiao-Ping,Yan, Qi-Gui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

The discovery of long noncoding RNA (LncRNA) changes our view of transcriptional and posttranscriptional regulation of gene expression. With application of new research techniques such as high-throughput sequencing, the biological functions of LncRNAs are gradually becoming to be understood. Multiple studies have shown that LncRNAs serve as carcinogenic factors or tumor suppressors in breast cancer with abnormal expression, prompts the question of whether they have potential value in predicting the stages and survival rate of breast cancer patients, and also as therapeutic targets. Focusing on the latest research data, this review mainly summarizes the tumorigenic mechanisms of certain LncRNAs in breast cancer, in order to provide a theoretical basis for finding safer, more effective treatment of breast cancer at the LncRNA molecular level.

The potential molecular effects of bursal septpeptide II on immune induction and antitumor activity

Guang Fang Zhou,Qing Tao Liu,Bin Zhou,Ya Feng Qiu,Xiao Dong Liu,Zhi Yong Ma,Xiu Li Feng,Rui Bing Cao,Pu Yan Chen 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.3

The bursa of Fabricius (BF) is the acknowledged central humoral immune organ in birds. Bursal septpeptide II (BSP-II) is animmunomodulatory bioactive peptide isolated from BF. To understand the effects of BSP-II on immune induction, gene expression profilesof hybridoma cells treated with BSP-II were evaluated. Pathway analysis showed that regulated genes were involved in cytokine-cytokinereceptor interactions, T cell receptor signaling pathway, and pathway in cancer. It was observed that BSP-II reduced tumor cells proliferationand stimulated p53 expression. These results indicate potential mechanisms underlying the effects of the humoral immune system on immuneinduction, including antitumor activities. Our study has provided a novel insight into immunotherapeutic strategies for treating human tumors.