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      • KCI등재

        Catalytic green energy production based on engineered active water innovatively prepared using sunlight-illuminated gold nanoparticles

        Shih-Hao Yu,Fu-Der Mai,Wei-Yu Kao,Hui-Yen Tsai,Yu-Chuan Liu 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.127 No.-

        Water is the most common solvent in our daily lives. This solvent has advantages of green environmentalprotection and low cost. Water is conventionally considered to be an inert solvent, yet it is relatively polarand can form a large number of hydrogen bonds (HBs). But this property also inhibits the dissolution ofmany non-polar gases, causing many important electrocatalytic reactions performed in it to have lowefficiencies. In this work, we propose an innovative application of solar energy-generated active purewater (APW) with reduced HBs to enhance chemical reactions and physical procedures. Compared toconventional deionized water (DIW), the generated APW possessed a lower specific heat of ca. 0.96. The swelling degree of artificial skin in APW significantly increased by ca. 29%. Moreover, the densityof an ethanol/APW solution significantly increased by 0.21% due to more free water molecules beingavailable in APW to form stronger HBs with ethanol. Encouragingly, efficiencies of hydrogen evolutionreactions performed in an APW-based acidic solution and oxygen evolution reactions performed in anAPW-based basic solution significantly increased by 42% and 17%, respectively, compared to DIWbasedsolutions. The developed APW based on utilizing solar energy can create a more-effective greenprocess.

      • KCI등재

        RNA sequencing reveals that Prx II gene knockout can down-regulate the allograft rejection of dermal mesenchymal stem cells

        Han Ying-Hao,Mao Ying-Ying,Yu Nan-Nan,Jin Mei-Hua,Jin Ying-Hua,Wang Ai-Guo,Zhang Yong-Qing,Shen Gui-Nan,Cui Yu-Dong,Yu Li-Yun,Lee Dong-Seok,Jo Yu-Jin,Sun Hu-Nan,Kwon Jeongwoo,권태호 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3

        In this study, we used RNA sequencing (RNA-seq) to analyze and compare bulk cell samples from wild-type (WT) dermal mesenchymal stem cells (DMSCs) (n = 3) and Prx II knockout DMSCs (n = 3). The purpose of the study was to elucidate the role of Prx II on allogeneic immune rejection of transplanted DMSCs. The results revealed differential expression of 472 genes (176 up-regulated and 296 down-regulated; p ≤ 0.05) between the PrxII+/+ (WT) and PrxII−/− sample groups. When highly regulated genes were categorized according to the Gene Ontology (GO) molecular function classification and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the PrxII−/− samples showed a robust downward trend in allograft rejection. The study identified 43 all immunologically rejected differentially expressed genes, of which 41 showed lower expression in the PrxII−/− vs. PrxII+/+ (WT) samples. These findings suggest that Prx II gene knockout may down-regulate the allograft rejection that occurs during DMSCs transplantation and improve the survival rate of DMSCs in the host. This study provides a new perspective on the clinical treatment of stem cell transplantation.

      • KCI등재

        Sublimable materials facilitate the TEM sample preparation of oil-soluble nanomaterials

        Yu-Hao Deng 한국현미경학회 2020 Applied microscopy Vol.50 No.1

        Sample preparation is significantly important to the high-resolution transmission electron microscopy (HRTEM) characterization of nanomaterials. However, many general organic solvents can dissolve the necessary organic polymer support layer in TEM grid, which causes it difficult to obtain high-quality samples of oil-soluble nanomaterials. In this study, a new sample preparation method for oil-soluble nanomaterials has been developed by using the sublimable material as a transition layer. Experiments also show that there is no damage to TEM grids and high-quality HRTEM images can be obtained via this method. This approach paves the way to applicable HRTEM sample preparation of oil-soluble nanomaterials.

      • KCI등재

        Evaluation of Emergency Management Capability in Chinese College Based on CMM Model

        Hao Yu 위기관리 이론과 실천 2015 Journal of Safety and Crisis Management Vol.5 No.2

        Emergencies occur in colleges from time to time in recent years, which disturbs teaching and campus life seriously and causes pressure to students and teachers’ mind and hurt of their life. With emergencies happening frequently, it is the need of social development and also the need of maintaining the development and stability of higher education to constantly improve emergency management capability and to prevent and deal with the emergencies scientifically and efficiently. Emergency management capability decides the response level of a university when they emergencies happen. The improvement of the capacity is a process step by step with many stages for different stage requires different capability. This paper constructs the maturity model and evaluation index system of emergency management capability according to CMM and examines it with real data of a university in Henan Province. Result shows that the level of emergency management capability of the university is initial. Correspond with the university’s situation, the result is accurate and reliable and is able to provide reference for finding questions in the process of emergency management, reducing the risk of emergency and improving emergency management capability.

      • KCI등재

        Comparing eight types of ginsenosides in ginseng of different plant ages and regions using RRLC-Q-TOF MS/MS

        Yu-Lin Dai,Meng-Dan Qiao,Peng Yu,Fei Zheng,Hao Yue,Shu-Ying Liu 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.2

        Background: This article aims to compare and analyze the contents of ginsenosides in ginseng ofdifferent plant ages from different localities in China. Methods: In this study, 77 fresh ginseng samples aged 2e4 years were collected from 13 differentcultivation regions in China. The content of eight ginsenosides (Rg3, Rc, Rg1, Rf, Rb2, Rb1, Re, and Rd) wasdetermined using rapid resolution liquid chromatography coupled with quadrupoleetime-of-flighttandem mass spectrometry (RRLC-Q-TOF MS/MS) to comparatively evaluate the influences of cultivationregion and age. Results: Ginsenoside contents differed significantly depending on age and cultivation region. The contentsof ginsenosides Re, Rc, Rg1, Rg3, and Rf increased with cultivation age, whereas that of ginsenoside Rb1peaked in the third year of cultivation. Moreover, the highest ginsenoside content was obtained fromChangbai (19.36 mg/g) whereas the lowest content was obtained from Jidong (12.05 mg/g). Ginseng fromJilin Province contained greater total ginsenosides and was richer in ginsenoside Re than ginseng of thesame age group in Heilongjiang and Liaoning provinces, where Rb1 and Rg1 contents were relatively high. Conclusion: In this study, RRLC-Q-TOF MS/MS was used to analyze ginsenoside contents in 77 ginsengsamples aged 2e4 years from different cultivation regions. These patterns of variation in ginsenosidecontent, which depend on harvesting location and age, could be useful for interested parties to chooseginseng products according to their needs.

      • Growth of Human Colon Cancer Cells in Nude Mice is Delayed by Ketogenic Diet With or Without Omega-3 Fatty Acids and Medium-chain Triglycerides

        Hao, Guang-Wei,Chen, Yu-Sheng,He, De-Ming,Wang, Hai-Yu,Wu, Guo-Hao,Zhang, Bo Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5

        Background: Tumors are largely unable to metabolize ketone bodies for energy due to various deficiencies in one or both of the key mitochondrial enzymes, which may provide a rationale for therapeutic strategies that inhibit tumor growth by administration of a ketogenic diet with average protein but low in carbohydrates and high in fat. Materials and Methods: Thirty-six male BALB/C nude mice were injected subcutaneously with tumor cells of the colon cancer cell line HCT116. The animals were then randomly split into three feeding groups and fed either a ketogenic diet rich in omega-3 fatty acids and MCT (MKD group; n=12) or lard only (LKD group; n=12) or a standard diet (SD group; n=12) ad libitum. Experiments were ended upon attainment of the target tumor volume of $600mm^3$ to $700mm^3$. The three diets were compared for tumor growth and survival time (interval between tumor cell injection and attainment of target tumor volume). Results: The tumor growth in the MKD and LKD groups was significantly delayed compared to that in the SD group. Conclusions: Application of an unrestricted ketogenic diet delayed tumor growth in a mouse xenograft model. Further studies are needed to address the mechanism of this diet intervention and the impact on other tumor-relevant parameters such as invasion and metastasis.

      • KCI등재

        Studies on China s Emergency Management Evaluation Based on Meta-analysis Method : Review and Prospect

        Hao Yu 위기관리 이론과 실천 2015 Journal of Safety and Crisis Management Vol.5 No.2

        Emergency assessment is an important field of the current emergency management research. Foreign related research started earlier and progress rapidly, has a wealth of practical experience, the domestic research is in the stage of exploration. This paper will be introduced to the Meta - analysis method for evaluation of emergency management research, from the perspective of the overall comprehensive analysis of emergency management evaluation and the research itself, the emergency management at home and abroad in the evaluation of excavated in a large number of research literature in the field of general trends and characteristics, by summing up experience and the existing research results, the theoretical research and practice of emergency management evaluation by weak links that exist in the analysis, in order to find the deficiencies in the study of emergency management assessment, for the future development strategy and establish and improve the basis for policy.

      • Die Design and Numerical Simulation for the Die Forging Forming of Shifting Fork

        Yu, Hao,Jung, Dong Won,Kim, Dong Hong Trans Tech Publications, Ltd. 2014 Advanced materials research Vol.909 No.-

        <P>At present, the domestic most use the traditional machining methods of production, such as general milling, drill, ground, etc. But the traditional processing method is low material utilization ratio, time-consuming power consumption, and low production efficiency. as the same time the product quality is difficult to meet the requirement of high strength. In contrast, shifting fork forming die forging can improve labor productivity, and can obtain the ideal parts surface roughness and size accuracy. And with the forming of die forging the variable speed fork general rarely cutting processing, just in require special high points will has fine grinding. This design has completed the variable speed fork of die forging shape of mold design giving the design plan and design process. This topic is about the design of the numerical simulation, getting the expected of the press one.</P>

      • KCI등재

        Analysis of Dangerous Chemical Accident Cause Based on Apriori Algorithm

        Hao Yu 위기관리 이론과 실천 2016 Journal of Safety and Crisis Management Vol.6 No.1

        In order to identify the association between causes of accidents due to hazardous chemicals, clear and definite the key points of safety supervision, and improve the efficiency of security supervision, this study researches 150 accident investigation report as data source by data mining technology, A priori algorithm, and finds out the relationship between factors such as time, step, type, severity and cause. By analyzing the 8 valuable rules, it proposes 4 suggestions for improving key safety supervision, thus to promote the optimization of safety supervision strategy of hazardous chemicals.

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