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        Individualized Concurrent Chemotherapy for Patients with Stage III–IVa Nasopharyngeal Carcinoma Receiving Neoadjuvant Chemotherapy Combined with Definitive Intensity-Modulated Radiotherapy

        Pengjie Ji,Qiongjiao Lu,Xiaoqiang Chen,Yuebing Chen,Xiane Peng,Zhiwei Chen,Cheng Lin,Shaojun Lin,Jingfeng Zong 대한암학회 2023 Cancer Research and Treatment Vol.55 No.4

        Purpose This retrospective study aimed to re-evaluate the effect of concurrent chemotherapy in patients with locally advanced nasopharyngeal carcinoma (NPC) in the era of intensity-modulated radiotherapy (IMRT). Materials and Methods A total of 498 patients who received neoadjuvant chemotherapy (NCT) combined with concurrent chemoradiotherapy (CCRT) or IMRT were retrospectively reviewed. The distribution of baseline characteristics was balanced using propensity score matching. Additionally, the results of NCT+IMRT and NCT+CCRT were compared using Kaplan-Meier survival analysis, and differences in survival rates were analyzed using the log rank test. Results There were no significant differences in overall survival (OS), progression-free survival (PFS), distant metastasis-free survival (DMFS), and local progression-free survival (LRFS) between the two groups. Patients were further categorized into risk subgroups based on pretreatment Epstein-Barr virus (EBV) DNA cutoff values using receiver operating characteristic curve analysis. There were no statistically significant differences in OS, PFS, DMFS, and LRFS between patients who received NCT+CCRT and NCT+IMRT in the high-risk group. In the low-risk group, although there were no differences between NCT+CCRT and NCT+IMRT in OS, PFS, and LRFS, patients who received NCT+CCRT had better DMFS than those who received NCT+IMRT. Conclusion Pretreatment EBV DNA level can be used to individualize concurrent chemotherapy for patients with locally advanced NPC. Patients with low pretreatment EBV DNA levels may benefit from concurrent chemotherapy, whereas those with high levels may not. Other treatment modalities need to be explored for high-risk patients to improve their prognosis.

      • KCI등재

        王國維境界涚說的現代美學意义

        莫先武 한중인문학회 2005 한중인문학연구 Vol.15 No.-

        왕국유는 중국 역사상 현대 미학을 체계적으로 연구한 첫 번째로 인물이다. 그의 境界涚은 중국의 전통적인 이론인 意境涚을 현대 미학의 범주로 이끌어 주었다. 그는 철저하게 중국 전통의 功利主义 미학관을 배격하고 이를 天功利主义 미학관으로 대체하였다. 또한 이러한 기초위에 詩學의 가치를 인생의 가치와 결합시키게 해주어 시학의 인문 가치를 높여 주었다. 무공리주의 미학관과 현대 미학 이론의 기초위에 왕국유는 독창적인 경계 미학을 창조해 내었으니, 이는 중국 미학사에서 미증유의 일이었다. 왕국유의 境界 미학은 중국 전통의 의경론과 서방 현대 미학에 대한 새로운 해석이니, 이는 중국 當代 문학 이론의 중요한 방법론이 되어 주었다. As the first person studying esthetics, WANG Guowei turned the traditional Artistic Conception into modern esthetics. He thoroughly abandoned the traditional utility esthetics and established modern no-utility esthetics. Based on no-utility esthetics, he opened poem-humanity value in china by contacting literature with humanity, created modern systematical Artistic-Conception-esthetics, based on his modern experience of human nature, he re-readed Chinese traditional Artistic Conception and modern esthetics of west.

      • 淸初中國朝鮮族的來源及去向

        李賢淑 韓國暻園大學校아시아文化硏究所 中國中央民族大學韓國文化硏究所 2002 亞細亞文化硏究 Vol.6 No.-

        Chinese Korean at the beginning of Qing Dynasty, besides few of who had resided in Northeast area China before China was unified by Qing Government, most of them were captured during two aggressive campaigns against Korea during the period of Qing Taizong Huang Taiji, some Korean came here initiatively during the period of Nurhachi and Huangtaiji. Unified by Qing Government, their positions were different, so function followed was utterly different. But they all were merged into the Manchu society finally. Their descendants almost don't have any continued relationship with Korean today in China.

      • 창면 불쾌글레어 평가실험의 조건설정 및 타당성 검토를 위한 기초실험

        김선화,김병수,이진숙 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

        The purpose of the study is to found the base experimental data by testing the adaptable time of eyes with administrating experimental conditions including source luminance, background illuminance and the position of subjects, by examining the appropriation of evaluating discomfort glare caused by actual window and simulated window. The process of the study is as follows: 1) In terms of the previous experiment, the large of Mock-up, evaluation values and subjective positions were administrated. 2) The experiment on the adaptable time of eyes is conducted with source luminance, background illuminance and the subjective position. 3) At the same Mock-up condition, the experiments for evaluating discomfort glare caused by actual window and by simulated window were conducted and contrasted. The adaptable time of eyes is rationally tested as 120 seconds with source luminance, background illuminance and the subjective position. And the difference on the boundary of evaluating values caused by actual window and simulated window ranges from 13% to 5%. On the basis of the result, the applicability of evaluating discomfort glare caused by simulated window is presented

      • KCI등재

        강제환우와 보존기간이 난질에 미치는 영향

        오홍록,이봉덕,이수기,류현덕,유동조 충남대학교 농업과학연구소 2006 농업과학연구 Vol.33 No.1

        An experiment was conducted to investigate the effects of forced molting and egg storage time on the various egg qualities. A total of 240 ISA Brown layers (60 wk of age) were employed as the unmolted treatment (Control). Two hundred and forty ISA Brown layers, molted at the age of 55 wk, were used as a forced molting treatment (T1), and the same number and strain of layers, molted at the age of 70 wk. were also used as the another forced molting treatment (T2). A total of 120 eggs were sampled from each treatment, and divided into six sets, 20 eggs per set. These six sets were stored for 1, 3, 6, 9, 12, and 15 days at 18℃ temperature, respectively. Eggs from T1 were collected from laying hens at the age of 68 wk, which started molting at 60 wk of age and achieved 50% egg production at 63 wk of age. Eggs from T2 were collected from hens at 82 wk of age, which started molting at 70 wk of age and achieved 50% egg production at 78 wk of age. The eggshell strength of T1 was significantly (p<0.05) higher than the Control and T2, and the storing periods did not affect the eggshell strength at all. Neither the forced molting nor the storing periods did not exert any consistent effect on the egg weight, eggshell thickness, eggshell color and egg yolk color. The albumin heights of T1 and T2 were significantly (p<0.05) lower than the Control, and it was remarkably reduced gradually as the storage periods increased in all three treatments. The Haugh unit showed very similar trends as the albumin height, indicating that both albumin height and Haugh unit were very much related to each other. In conclusion, the forced molting improves the eggshell strength, but decreases the albumin height and Haugh unit. The storage of eggs also decreases the albumin height and Haugh unit regardless of molting.

      • KCI등재

        창면불쾌글레어 평가를 위한 인공창 실험의 타당성 검토 연구

        이진숙,김병수,김선화 대한건축학회 2003 대한건축학회논문집 Vol.19 No.12

        The purpose of this study is to find the base experimental data by testing the recovery time of human eye with administrating experimental conditions, source luminance, background illuminance and the position of subjects, by examining the appropriateness of evaluating discomfort glare caused by actual window and by simulated window. The process of this study is as follows: 1) In terms of the previous experiment, the large of Mock-up, evaluation values and subjective positions were administrated. 2) The experiment on the recovery time of human eye is conducted by source luminance, background illuminance and the subjective position. 3) At the same Mock-up condition, the experiments for evaluating discomfort glare caused by actual window and by simulated window were conducted and contrasted. Rationally tested recovery time of human eye is 120 seconds with source luminance, background illuminance and the subjective position. And the difference on the boundary of evaluating values caused by actual window and by simulated window ranges from 13% to 5%. On the basis of the result, the validity of discomfort glare evaluation caused by simulated window is presented.

      • Combination of chitosan-coating and irradiation on nutritional and sensory quality of egg

        Xian De Liu,Aera Jang,Dong Ho Kim,Cheorun Jo 한국가금학회 2007 한국가금학회 정기총회 및 학술발표회 Vol.24 No.-

        An experiment was desi gned t o improve the safety of chicken egg by the combination of chitosan-coating and irradiation process. One-day old hen egg produced from Rohman Brown with 26-week old was collected and coated with 2% chitosan solution. The sample egg was then irradiated at 0 and 2.0 kGy by gamma ray to see the effect of combination of chitosan-coating and gamma irradiation on nutritional quality of egg. Nutritional quality characteristics of hen egg studied included proximate composition, amino acid profiles, water activity, and mineral content in egg yolk and white. Sensory evaluation of cooked egg with different treatments also conducted. Chitosan-coating of egg resulted in a little decrease of amino acid contents in both yolk and white but the effect of irradiation was not found. There was no change found in other nutritional quality characteristics including proximate composition, and mineral contents. Sensory score indicated that chitosan-coating, irradiation, and their combination was not changed. Therefore, it can be concluded that chitosan-coating, irradiation, and the combination of those may affect on the egg quality very limitedly.

      • KCI등재

        《為吏之道》書風及儒家思想考析

        Xian song Chen 한국서예학회 2018 서예학연구 Vol.33 No.-

        The Weili zhi dao 為吏之道 (The Way of Being an Official), as a part of the Qin bamboo slips from Shuihudi 睡虎地 (excavated in 1975) documents, is the first discovery of Qin bamboo slips in China, which is of great significance. From the analysis of the calligraphy features of the Weili zhi dao, we can divide it into three styles. But through the careful analysis of its handwriting, I believe that these bamboo slips were probably wrote by one person——Xi 喜, who was the owner of the Shuihudi Tomb. And he wrote these slips in different periods of time. From the analysis of calligraphy features, We can find the following obvious characteristics: the use of right-falling stroke and left-falling stroke, the use of point stroke, the change of stroke weight and the lateral tendency of the characters. These features indicate that the Weili zhi dao was a typical representative in the stage of Libian 隸變 (one phase of the changing of calligraphy which evolved from the ancient characters to the Lishu.) From the analysis of the content of its text, we could learn that there are many similarities with the Confucian classics, such as The Analects, and Confucianism. It shows that the introduction and absorption of Confucianism by the Shuihudi documents. 《为吏之道》为云梦县睡虎地秦简中的一部分。从书法风格上来说,可以分为三种,但通过字迹分析,认为其书手为一人,很可能是墓主人“喜”在不同时间段所书。书法特征上,其中波笔和掠笔的使用、点的运用、笔画粗细的变化以及横向取势等特征,说明其夹杂着篆书和隶书,是处于隶变阶段的一个典型代表。内容上,其中有很多与儒家经典和儒家思想相似之处,反映了睡虎地秦律对儒家思想的引用、吸收。

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