http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
이정호 ( Chung Ho Lee ),이길자 ( Kil Cha Lee ),이근배 ( Kun Bai Lee ),김기원 ( Ki Wun Kim ),김성진 ( Sung Chin Kim ) 대한내과학회 1969 대한내과학회지 Vol.12 No.9
This report describes a 70 year old female patient who had numerous bursts of ventricular fibrillation associated with syncope. There was no evidence of the precipitating factors except for chloroquine toxicity. Her serum K was found to be low (3.2mEq/L).
The effect of ovarian cancer related biomarkers on survival in IDS-HIPEC patients
( Ki Eun Seon ),( Yong Jae Lee ),( Eun Ji Nam ),( Sang Wun Kim ),( Sunghoon Kim ),( Young Tae Kim ),( Jung-yun Lee ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-
Objective: To analyze the effect of ovarian cancer related biomarkers and chemotherapy response score (CRS) on progression-free survival (PFS) and overall survival (OS) in advanced ovarian cancer patients who were treated with neoadjuvant chemotherapy (NAC) followed by interval debulking surgery (IDS) with hyperthermic intraperitoneal chemotherapy (HIPEC). Methods: We retrospectively analyzed the medical records of 63 advanced-stage ovarian cancer patients who received NAC and underwent IDS with HIPEC at the Yonsei Cancer Center from 2015 to 2022. PFS and OS were compared in patients with and without BRCA1/2 mutation, TP53 mutation and programmed cell death ligand 1 (PD-L1) expression. The effect of each biomarker and CRS on survival was evaluated. Results: BRCA 1/2 mutations were detected in 23 (37.7%) of the 61 patients. PFS and OS were not significantly associated with BRCA 1/2 mutation (P=0.522 and 0.052 respectively). TP53 mutation was detected in 32 (80.0%) of the 40 patients. TP53 mutation was not significantly associated with either improved PFS (P=0.868) or OS (P=0.427). PD-L1 expression was detected in 4 (10.8%) of the 37 patients (IHC cut-off value: 22C3 CPS 10, 22C3 TPS 1%, SP263 25%). PD-L1 expression was significantly associated with longer PFS (P=0.029) but not with OS (P=0.270). Thirty-seven patients had CRS 1/2 and 19 had CRS 3. PFS was significantly improved in CRS 3 patients than CRS 1/2 patients (P=0.032). However, OS was not different from each CRS group (P=0.451). Conclusion: PD-L1 expression and CRS were significantly associated with longer progression-free survival, but not with overall survival among patients with advanced ovarian cancer previously treated with IDS-HIPEC.
중환자실에서 기계적 환기를 시행받는 환자들의 기관내삽관 튜브의 기낭내압
이영주,윤장운,문봉기,이규완,박미미,이영석 아주대학교 1997 아주의학 Vol.2 No.2
Background and Objectives : High volume, low pressure (HVLP) cuffed tubes have been substituted for low volume, high pressure (LVHP) cuffed tubes in order to reduce complications created by the cuffed endotracheal tubes contact with the tracheal wall. Several physidans, however, prefer to use the LVHP cuff for habitual or economic reasons. Even so, careless cuff Inflation of the HVLP cuff could also induce complications. The purposes of this study were to see whether there are any differences between the usual intracuff pressure (UICP) and the Optimum intracuff pressure (OICP), to compare the OICP of three groups, and to study the correlation between the OICP and the peak inspiratory pressure (PIP) of three kinds of endotracheal tubes under mechanical Ventilation. Methods : 82 adult patients, upon admission of the ICU, were divided into 3 groups with different cuffed tube types according to the following: Portex Profile group (n=66), HVLP cuffed tube; Portex Regular group (n=11), LVHP cuffed tube; Rusch Red group (n=5), LVHP cuffed tube. We used the Portex cuff pressure manometer for Portex Profile group, the Hewlett-Packard pressure transducer for Portex Regular, and Rusch Red group to measure the intracuff pressure (ICP). The OICP was measured with the minimal leak technique (MLT). Intracuff pressure difference (ICPD) was calculated by subtracting OICP from UICP. Results : UICP and OICP of Portex Profile group were 33.12±22.25 ㎝H₂O, 22.02±12.5㎝H₂O, Portex Regular group, 70.09±30.88 ㎝H₂O, 69.45±30.41 ㎝H₂O and Rusch Red group, 378.40±38.60 ㎝H₂O, 337.60±74.45 ㎝H₂O. Significant difference was shown among the groups (p < 0.05). The significant difference of the PIP was not seen among the groups. Significant correlation between OICP and PIP (regression = 0.463, p < 0.01) was demonstrated only in Portex Profile group. ICPD of three groups were as high as 84 ㎝H₂O to as low as -56 ㎝H₂O. About 40% of the patients showed the allowable range. Conclusions : This study suggests that routine check-ups of ICP are needed when the patients are admitted to the ICU. The OICP of the HVLP cuffed tube is 1/3 -1/15 of the LVHP cuffed tube. Therefore, the routine use of the HVLP tube is highiy recommended. The OICP shows positive correlation with the PIP. This suggests to make every effort to reduce the PIP.