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Woosung Kim,Yoonyoung Jang,Youn-Hee Lim,Bung-Nyun Kim,Choong Ho Shin,Young Ah Lee,Johanna Inhyang Kim,Yun-chul Hong 대한예방의학회 2020 Journal of Preventive Medicine and Public Health Vol.53 No.1
Prenatal cadmium (Cd) exposure may be associated with attention-deficit/hyperactivity disorder (ADHD) in children. Therefore, the objective of this study was to examine the relationship between Cd exposure during gestation and ADHD at 6 years of age.
Kim, Woosung,Jang, Yoonyoung,Lim, Youn-Hee,Kim, Bung-Nyun,Shin, Choong Ho,Lee, Young Ah,Kim, Johanna Inhyang,Hong, Yun-Chul The Korean Society for Preventive Medicine 2020 예방의학회지 Vol.53 No.1
Objectives: Prenatal cadmium (Cd) exposure may be associated with attention-deficit/hyperactivity disorder (ADHD) in children. Therefore, the objective of this study was to examine the relationship between Cd exposure during gestation and ADHD at 6 years of age. Methods: As part of an ongoing cohort study (the Environment and Development of Children study), 479 mother-child pairs from Seoul, Korea were included for analysis between 2008 and 2011. The whole blood concentration of Cd was analyzed using atomic absorption spectrophotometry. The parents were surveyed about ADHD behaviors in their children at age 6. Multivariable linear regression models were used to investigate the relationship between prenatal exposure to Cd and ADHD at 6 years of age. Results: Increased prenatal Cd concentrations were associated with increased scores for ADHD for girls, but not for boys, at age 6. A 2-fold increase in the prenatal Cd level was significantly associated with a 22.3% (95% confidence interval, 11.6 to 34.1) increase in ADHD in girls at 6 years of age, as indicated by the linear regression model. Conclusions: Our results identified significant associations between prenatal Cd exposure and ADHD scores in 6-year-old girls.
단조 증가 성질을 지닌 데이터 도메인에서의 집합 유사 시퀀스 매칭 방법
황우성(Woosung Whang),임효상(Hyo-Sang Lim) 한국정보과학회 2021 정보과학회 컴퓨팅의 실제 논문지 Vol.27 No.3
데이터 도메인이 가진 단조 증가 성질이란 시간이 흐름에 따라 도메인의 존재하는 값들이 사라지지 않고 증가하여 도메인이 확장되는 성질을 뜻한다. 본 논문에서는 단조 증가 성질을 가진 도메인에서의 효율적인 집합 유사 시퀀스 매칭 방법을 제안한다. 단조 증가 성질을 활용해 매칭 수행 시 발생하는 후보의 개수를 크게 줄이고, 매칭 수행의 시간을 감소시킨다. 제안하는 방법은 1) 단조 증가 성질을 활용하여 두 집합의 교집합 크기가 허용치 이상일 가능성을 미리 확인하고, 2) 공통 원소 존재 여부를 미리 파악하여 교집합 크기 예측의 정확도를 높임으로써 유사 시퀀스 매칭의 검색 범위를 줄여서 성능을 높일 수 있다는 장점을 가진다. 성능 평가 결과 제안하는 방법이 기존 방법에 비해 약 1.7배의 수행 시간 단축과 후보감축을 보인다. The monotonically increasing nature of a data domain means that the domain expands as new elements are added over time if elements already existing in the domain are never removed. In this paper, we propose an efficient set-based similar sequence matching method that uses the monotonically increasing property. Specifically, by using the monotonically increasing property, the proposed method considerably reduces the number of candidates generated during matching and reduces the processing time needed to perform the matching. The proposed method improves the similar sequence matching efficiency by reducing the search spaces for the matching as follows: 1) determining if two given sets are likely to be above the threshold by utilizing the monotonically increasing property, 2) determining if the intersection size is likely to be above the threshold with higher accuracy by checking for the existence of common elements in the two sets. According to the experimental results, we show that the proposed method reduces the processing time and the number of candidates by about 1.7 times compared to the existing method.
Noh, Ha Lim,Park, Young Ki,Oh, Byeong M.,Zheng, Jian,Kim, Sung-Hoon,Lee, Woosung,Kim, Jong H. Elsevier Sequoia 2019 Sensors and actuators. B Chemical Vol.301 No.-
<P><B>Abstract</B></P> <P>In this this study, we present a new colorimetric chemosensor based on the isoindoline structure (<B>ID1</B>) for the detection of volatile organic compounds (VOCs), ethylamines. Spectral changes in the UV–vis absorption spectrum of <B>ID1</B> were observed upon exposure to mono-ethylamine, resulting in significant and fast (<1.0 s) color changes detectable by the naked-eye. The reaction and kinetics of detection of different ethylamines (mono-, di-, and tri- ethylamines) by <B>ID1</B> were investigated via <SUP>1</SUP>H NMR and LC–MS characterization, binding stoichiometry, and association constant analyses, combined with density functional theory (DFT)-based quantum calculations. From these investigations, it was found that the mechanism of the detection is based on the nucleophilic attack, which was further evidenced by color change of <B>ID1</B> when exposed to H<SUB>2</SUB>S likely due to the similar nucleophilicity to ethylamine. <B>ID1</B> showed an efficient response to mono-ethylamine under versatile conditions, i.e., in the solution and solid (thin-films and dyed nylon fabric) states, which suggests applicability of <B>ID1</B> to simple, effective, and practical sensors.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new isoindoline-based chemosensor (ID1) was synthesized for ethylamine detection. </LI> <LI> Ethylamine was efficiently detected based on clear color changes ID1. </LI> <LI> Sensing mechanisms and kinetics were systemically investigated. </LI> <LI> Efficient ethylamine detection under solution, thin-film, and dyed fabric was demonstrated. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
우주현,임우성 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.1
Selenium is an essential microelement in animals including human. Selenium plays an important role in cellular functions such as deoxygenation and detoxification. Also, it can be used in treatment of cardiac disease, hepatic disease, AIDS and various cancers. Recent meta-analysis showed that high selenium exposure was associated with decreased risk of several cancers. Selenium has an effect on anticarcinogesis through several mechanisms, which are regulation of cell cycles, apoptosis, DNA damage and repair, inhibition of cellular adhesion and migration, anti-angiogenesis and immune modulation. Even though many laboratory studies have provided convincing evidence of these mechanisms, results from epidemiologic and clinical studies of selenium does not coincide with each other. Well-designed trials considering dosage and chemical form of selenium supplement as well as confounding factors and long-term follow-up of them would be needed to use selenium in chemoprevention and therapy of cancers.