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Anti-oxidant activities of kiwi fruit extract on carbon tetrachloride-induced liver injury in mice
Kang, Wonyoung,Yang, Heekyoung,Hong, Hyun Ju,Han, Chang Hoon,Lee, Young Jae The Korean Society of Veterinary Science 2012 大韓獸醫學會誌 Vol.52 No.4
The kiwi (Actinidia deliciosa) is well known to contain anti-oxidants. In this study, we investigated the anti-oxidant effects of kiwi extract on carbon tetrachloride ($CCl_4$) induced liver injury in BALB/c mice. The radical scavenging effect of 80% methanol extract of Halla-Gold kiwi was observed. For the animal study, mice were randomly divided into four groups: normal group, $CCl_4$-induced model group, kiwi extract administered group, and silymarin treated group. The kiwi extract was provided daily for 10 days. At the 24 h after last administration, $CCl_4$ was injected. The kiwi extract showed strong inhibitory effect of DPPH radicals and superoxide scavenging. In animal study, administration of $CCl_4$ resulted in significantly elevated plasma levels of ALT and AST but they decreased in kiwi-extract pretreated group. Anti-oxidant enzymes such as GSH-px and GSH-rd were restored in the kiwi extract treatment group. Histopathological degeneration was also prevented in the kiwi extract treated group compared with of the control group, which exhibited $CCl_4$-induced hepatotoxicity. On the basis of the obtained results, it can be concluded that kiwi extract showed protective effects, not only as anti-oxidant effects, but also in the protection of hepatotoxicity in $CCl_4$-intoxicated mice.
Anti-diabetic effects of benfotiamine on an animal model of type 2 diabetes mellitus
Chung, Kang Min,Kang, Wonyoung,Kim, Dong Geon,Hong, Hyun Ju,Lee, Youngjae,Han, Chang-Hoon The Korean Society of Veterinary Science 2014 大韓獸醫學會誌 Vol.54 No.1
Although benfotiamine has various beneficial anti-diabetic effects, the detailed mechanisms underlying the impact of this compound on the insulin signaling pathway are still unclear. In the present study, we evaluated the effects of benfotiamine on the hepatic insulin signaling pathway in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which are a type 2 diabetes mellitus model. OLETF rats treated with benfotiamine showed decreased body weight gain and reduced adipose tissue weight. In addition, blood glucose levels were lower in OLETF rats treated with benfotiamine. Following treatment with benfotiamine, the levels of Akt phosphorylation (S473/T308) in the OLETF groups increased significantly compared to the OLETF control group so that they were almost identical to the levels observed in the control group. Moreover, benfotiamine restored the phosphorylation levels of both glycogen synthase kinase (GSK)-$3{\alpha}/{\beta}$ (S21, S9) and glycogen synthase (GS; S641) in OLETF rats to nearly the same levels observed in the control group. Overall, these results suggest that benfotiamine can potentially attenuate type 2 diabetes mellitus in OLETF rats by restoring insulin sensitivity through upregulation of Akt phosphorylation and activation of two downstream signaling molecules, GSK-$3{\alpha}/{\beta}$ and GS, thereby reducing blood glucose levels through glycogen synthesis.
Wonyoung Yun,Hyun-Kyung Lee,Minkyung Kang,Hamna Shahzad,Pelin Akkaya 한국디자인트렌드학회 2023 한국디자인포럼 Vol.28 No.4
Background This paper presents an alternative creative solution to relieve stress expressed among university students living in dorms. By implementing art workshops and fostering a sense of community. This alternative approach aims to address the stress experienced by these students. Currently, the university fails to provide proactive measures or support to effectively deal with the students' stress, which often remains unaddressed due to their disincline to seek help. Recognizing the necessity for a sustainable and accessible service, this study suggests the implementation of “Brush on Grass”, a series of art workshops as a means of reducing stress and promoting social connections, particularly in the context of the pandemic. Methods The workshops aim to provide students with a creative outlet to manage stress and enhance their overall well-being. The workshops will take place in the green spaces of the campus, providing an opportunity to revitalize the campus landscape. Result Based on data collected through questionnaires, the art workshop, and interviews, this study formed an outline of “Poolbit”, which expands and encourages participation in the art workshops. Conclusion Therefore, this study explores the potential of service design to promote art-based workshops for stress management among university students in dormitories.
The antibacterial effect of xanthorrhizol as an endodontic irrigant on Enterococcus faecalis
Wonyoung Yue,Minju Song,Si-Mook Kang,Baek-il Kim,Tai-Cheol Yoon,Euiseong Kim 대한치과의사협회 2016 대한치과의사협회지 Vol.54 No.3
Objectives The aim of this study was to evaluate the antibacterial effect of xanthorrhizol (XTZ) on E. faecalis, compared with 2% chlorhexidine (CHX). Materials and Methods Normal physiological state (NS), starvation state (SS), and alkalization state (AS) of E. faecalis were used. A solution containing 1% XTZ in 30% ethanol, 1% dimethyl sulfoxide (DMSO), and 100 mg/ml sodium methyl cocoyl taurate was used and is referred to as Xan in this study. To determine the minimal bactericidal concentration (MBC) of Xan and CHX, 500μl of E. faecalis (NS and two stress states) was added to a microtube containing 500μl of serial 2-fold dilutions of 1% Xan and 2% CHX (1:2-1:128). The MBC of each antimicrobial was determined by the plate count method. Results The antibacterial effect of Xan was more effective on E. faecalis in AS than in the other states (NS, SS) at 0.125% Xan and 0.03325% Xan (P<0.05). In contrast, the antibacterial effect of CHX was more effective against E. faecalis in SS than the other states (NS, AS) at 0.0625% CHX (P<0.05). In SS, the antibacterial effect of CHX was more effective than that of Xan at 0.125% and 0.0625% (P<0.05). However, in AS, the antibacterial effect of Xan was more effective than that of CHX at 0.0625% and 0.03325% (P<0.05). Conclusions In endodontic retreatment cases in which it is important to effectively remove E. faecalis from the infected root canal, Xan may be more suitable when combined with NaOCl than CHX.
The antibacterial effect of xanthorrhizol as an endodontic irrigant on Enterococcus faecalis
Yue, Wonyoung,Song, Minju,Kang, Si-Mook,Kim, Baek-il,Yoon, Tai-Cheol,Kim, Euiseong The Korean Dental Association 2016 대한치과의사협회지 Vol.54 No.3
Objectives The aim of this study was to evaluate the antibacterial effect of xanthorrhizol (XTZ) on E. faecalis, compared with 2% chlorhexidine (CHX). Materials and Methods Normal physiological state (NS), starvation state (SS), and alkalization state (AS) of E. faecalis were used. A solution containing 1% XTZ in 30% ethanol, 1% dimethyl sulfoxide (DMSO), and 100 mg/ml sodium methyl cocoyl taurate was used and is referred to as Xan in this study. To determine the minimal bactericidal concentration (MBC) of Xan and CHX, $500{\mu}l$ of E. faecalis (NS and two stress states) was added to a microtube containing $500{\mu}l$ of serial 2-fold dilutions of 1% Xan and 2% CHX (1:2-1:128). The MBC of each antimicrobial was determined by the plate count method. Results The antibacterial effect of Xan was more effective on E. faecalis in AS than in the other states (NS, SS) at 0.125% Xan and 0.03325% Xan (P<0.05). In contrast, the antibacterial effect of CHX was more effective against E. faecalis in SS than the other states (NS, AS) at 0.0625% CHX (P<0.05). In SS, the antibacterial effect of CHX was more effective than that of Xan at 0.125% and 0.0625% (P<0.05). However, in AS, the antibacterial effect of Xan was more effective than that of CHX at 0.0625% and 0.03325% (P<0.05). Conclusions In endodontic retreatment cases in which it is important to effectively remove E. faecalis from the infected root canal, Xan may be more suitable when combined with NaOCl than CHX.
Analysis of Construction Cost Fluctuation Trends and Features on Apartment Housing
Park, Wonyoung,Kang, Tai-Kyung,Baek, Seung-Ho,Lee, Yoo-Sub The Korean Institute of Building Construction 2012 한국건축시공학회지 Vol.12 No.6
Construction projects, including housing, are carried out over long periods of time. According to changes to the construction period, the cost of input materials and wages also changes. Therefore appropriate management is important in order to minimize cost risks caused by fluctuations in prices. In Korea, housing units are usually sold in lots prior to construction completion. Therefore, careful management of input elements such as materials and equipment that are sensitive to price fluctuations is very important. This study deals with how the price fluctuation of materials, labor, and equipment influences the change of housing cost and seeks a way for cost management through identifying key resources sensitive to price fluctuation. As a result, a change to the housing cost index multiplies depending on cost changes of materials and labor together. Labor costs are a major factor on the housing cost index. In addition, certain types of materials and labor input to housing construction greatly influence price fluctuations. Thus, it is found that managing those main cost factors is the key for effective cost management.