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USP1 targeting impedes GBM growth by inhibiting stem cell maintenance and radioresistance
Lee, Jin-Ku,Chang, Nakho,Yoon, Yeup,Yang, Heekyoung,Cho, Heejin,Kim, Eunhee,Shin, Yongjae,Kang, Wonyoung,Oh, Young Taek,Mun, Gyeong In,Joo, Kyeung Min,Nam, Do-Hyun,Lee, Jeongwu Oxford University Press 2016 Neuro-oncology Vol.18 No.1
<P>USP1-mediated protein stabilization promotes GSC maintenance and treatment resistance, thereby providing a rationale for USP1 inhibition as a potential therapeutic approach against GBM.</P>
Lee, Hyun Ho,Nam, Dongsik,Kim, Choon-Ki,Kim, Koeun,Lee, Yongwon,Ahn, Young Jun,Lee, Jae Bin,Kwak, Ja Hun,Choe, Wonyoung,Choi, Nam-Soon,Hong, Sung You American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.12
<P>Here, we report the first electrochemical assessment of organophosphonate-based compound as a safe electrode material for lithium-ion batteries, which highlights the reversible redox activity and inherent flame retarding property. Dinickel 1,4-benzenediphosphonate delivers a high reversible capacity of 585 mA h g<SUP>-1</SUP> with stable cycle performance. It expands the scope of organic batteries, which have been mainly dominated by the organic carbonyl family to date. The redox chemistry is elucidated by X-ray absorption spectroscopy and solid-state <SUP>31</SUP>P NMR investigations. Differential scanning calorimetry profiles of the lithiated electrode material exhibit suppressed heat release, delayed onset temperature, and endothermic behavior in the elevated temperature zone.</P> [FIG OMISSION]</BR>
An antifungal mechanism of curcumin lies in membrane-targeted action within Candida albicans.
Lee, Wonyoung,Lee, Dong Gun Published for the International Union of Biochemis 2014 IUBMB life Vol.66 No.11
<P>The aim of this study is to investigate the antifungal mechanism of curcumin. This polyphenolic compound has been used traditionally in Asia for medicinal, culinary, and other purposes. Although antifungal effect of curcumin has been reported, this is the first study for its mode of action underlying disruption of plasma membrane in Candida albicans. The leakage of potassium ion from the fungal cytosol and dissipation in membrane potential was detected by bis-(1,3-dibutylbarbituric acid)trimethine oxonol [DiBAC4 ] staining. We also investigated an increase in membrane permeability in curcumin-treated C. albicans with influx of propidium iodide assay. Fluorescence analysis with 1,6-diphenyl-1,3,5-hexatriene supported the membrane-targeted mechanism of action indicating membrane disruption. On the basis of these results, we studied the effects of curcumin treatment on model membrane to elucidate its antifungal mechanism. Using calcein leakage assays from curcumin-treated large unilamellar vesicles and giant unilamellar vesicles, we found that curcumin has membrane-active mechanism inducing leakage of intracellular component through the flappy membrane. Therefore, this study suggests that curcumin exerts antifungal activity via inducing disruption of fungal plasma membrane.</P>
Magainin 2 Induces Bacterial Cell Death Showing Apoptotic Properties
Lee, Wonyoung,Lee, Dong Gun Springer-Verlag 2014 Current microbiology Vol.69 No.6
<P>Magainin 2 is pore-forming antimicrobial peptide on lipid matrix of bacterial membrane, secreted from the skin of the African clawed frog Xenopus laevis. The aim of this study was to investigate a new concept for antibacterial mechanisms called bacterial apoptosis-like cell death. We examined the morphological changes induced by magainin 2 in Escherichia coli, regarding apoptosis. Specifically, phosphatidylserine externalization from the inner to outer membrane surface was detected by Annexin V staining, and DNA fragmentation and chromatin condensation was detected by TUNEL and DAPI assay. We also found much mechanistic evidence to support the hypothesis that magainin 2 induces bacterial apoptosis-like death-including disturbance of membrane detected by DiBAC4(3), caspase activation observed by FITC-VAD-FMK staining, and analyzing the role of RecA in bacterial apoptosis-like death through the RecA expression assay by Western blot-in E. Coli when treated with magainin 2. On the basis of these results, magainin 2 exerts antibacterial activity with a new mechanism which is bacterial apoptosis-like death. Searching antimicrobial agents with novel mechanisms of action can be an effective strategy to coping with the emergence of new resistance mechanisms. Magainin 2 deserves further research as a potential antimicrobial therapeutic agent.</P>
Nickel-based bilayer thin-film anodes for low-temperature solid oxide fuel cells
Lee, Yeageun,Park, Joonho,Yu, Wonjong,Tanveer, Waqas Hassan,Lee, Yoon Ho,Cho, Gu Young,Park, Taehyun,Zheng, Chunhua,Lee, Wonyoung,Cha, Suk Won Elsevier 2018 ENERGY Vol.161 No.-
<P><B>Abstract</B></P> <P>In this study, we investigate the possibility of using Ni-based anodes as alternatives to the Pt-based anodes for thin-film solid oxide fuel cells (SOFCs) operating at low temperatures. Anodes, electrolytes, and cathodes are sequentially sputtered onto a nanoporous substrate. The pure Ni anodes with modified nanostructures exhibit comparable performance as that of the optimized Pt anodes. Furthermore, a Ni/Ni-YSZ bilayer anode fabricated via a co-sputtering method exhibits approximately 37% higher peak power density than does the optimized Pt anode at 500 °C, demonstrating that noble metal anodes can be replaced by Ni-based anodes in low-temperature SOFCs by optimizing the anode nanostructure.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ni anodes with different nanostructures are fabricated for low-temperature SOFCs. </LI> <LI> The Ni anodes are inferior to an optimized Pt anode in terms of catalytic activity. </LI> <LI> A Ni/Ni-YSZ bilayer anode is introduced as an alternative to the Pt anode. </LI> <LI> The bilayer anode successfully substitutes the Pt anode with 37% higher performance. </LI> <LI> The full cell fabrication process is time-efficient and easy to scale-up. </LI> </UL> </P>