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Jin, Juyoun,Lee, Woo Sirl,Joo, Kyeung Min,Maiti, Kaustabh K.,Biswas, Goutam,Kim, Wanil,Kim, Kyong-Tai,Lee, Se Jeong,Kim, Kang-Ho,Nam, Do-Hyun,Chung, Sung-Kee Royal Society of Chemistry 2011 MedChemComm Vol.2 No.4
<P>The per oral administration of compound 1, prepared by covalently attaching paclitaxel to a molecular carrier, shows good anti-tumor activity in the orthotopic mouse model of glioblastoma. The anti-tumor effects may be attributable to the cytotoxicity as well as the anti-angiogenic activity of the paclitaxel conjugate or paclitaxel itself in the brain parenchyma.</P> <P>Graphic Abstract</P><P>The per oral administration of 1, prepared by covalently attaching paclitaxel to a molecular carrier, shows good anti-tumor activity in the orthotopic mouse model of glioblastoma. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0md00235f'> </P>
Jin, Juyoun,Joo, Kyeung Min,Lee, Se Jeong,Jo, Mi-Young,Kim, Yonghyun,Jin, Younggeon,Kim, Joong Kyu,Ahn, Ji Mi,Yoon, Mi-Jung,Lim, Jaeseung,Nam, Do-Hyun National Hellenic Research Foundation 2011 ONCOLOGY REPORTS Vol.25 No.1
<P>The presence of active immunity within the brain supports the possibility of effective immunotherapy for glioblastoma (GBM). To provide a clinically-relevant adoptive immunotherapy for GBM using ex vivo expanded cytokine-induced killer (CIK) cells, the treatment capability of CIK cells, either alone or in combination with temozolomide (TMZ) were evaluated. Human CIK (hCIK) cells were cultured from PBMC using activating anti-CD3 antibody and IL-2, which were 99% CD3+, 91% CD3+CD8+ and 29% CD3+CD56+. In vitro, hCIK cells showed tumor-specific cytotoxicity against U-87MG human GBM cells. When hCIK cells were injected into tail veins of immune-compromised mice bearing U-87MG tumors in their brains, numerous CIK cells infiltrated into the brain tumors. CIK treatments (1x10(5), 1x10(6) or 1x10(7), once a week for four weeks) inhibited the tumor growth significantly in a dose-dependent manner; 44, 54 and 72% tumor volume reduction, respectively, compared with the control group (P<0.05). Moreover, hCIK cells (1x10(7), once a week for four weeks) and TMZ (2.5 mg/kg, daily for 5 days) combination treatment further increased tumor cell apoptosis and decreased tumor cell proliferation and vessel density (P<0.05), creating a more potent therapeutic effect (95% reduction in tumor volume) compared with either hCIK cells or TMZ single therapy (72% for both, P<0.05). Taken together, CIK cell-immunotherapy and TMZ chemotherapy have synergistic therapeutic effects and could be combined for a successful treatment of GBM.</P>
Gray and white matter changes linking cerebral small vessel disease to gait disturbances
Kim, Yeo Jin,Kwon, Hun Ki,Lee, Jong Min,Cho, Hanna,Kim, Hee Jin,Park, Hee Kyung,Jung, Na-Yeon,San Lee, Jin,Lee, Juyoun,Jang, Young Kyoung,Kim, Sung Tae,Lee, Kyung Han,Choe, Yearn Seong,Kim, Yun Joong Ovid Technologies (Wolters Kluwer) - American Acad 2016 Neurology Vol.86 No.13
<P>Objective: To investigate the topographic changes of white matter (WM) integrity and cortical thickness related to gait disturbances and determine whether these neural correlates mediate the association between cerebral small vessel disease (CSVD) and gait disturbances. Methods: A total of 129 patients with subcortical vascular cognitive impairment were included. CSVD severity was quantified as global and regional WM hyperintensities (WMH) volume and lacune and microbleed numbers. Amyloid burdens were assessed using Pittsburgh compound B (PiB)-PET scanning. Gait score was measured using a standardized scale. WM integrity was assessed by applying tract-based spatial statistics. Cortical thickness was measured using surface-based methods. Path analysis for gait score was performed using regional CSVD markers as predictors and fractional anisotropy (FA) and cortical thickness as mediators. Results: Periventricular WMH (PWMH) volume was associated with gait score, regardless of other CSVD. PiB retention ratio was not associated with gait score. Gait score was correlated with FA in the frontal and parietal WM and bilateral corpus callosum and with cortical thinning in the bilateral frontal and lateral temporo-parieto-occipital regions. Path analysis for gait score showed that PWMH contributed to gait disturbances with the mediation of mean FA or cortical thickness. Conclusions: Our findings suggest that WMH-related cortical thinning as well as disrupted integrity of periventricular WM is linked to gait disturbances.</P>
DO MARKETING ACTIVITIES ENHANCE FIRM VALUE? EVIDENCE FROM M&A TRANSACTIONS
Jin Q Jeon,Juyoun Ryoo,Cheolwoo Lee 한국재무학회 2015 한국재무학회 학술대회 Vol.2015 No.11
In this paper, we use an event study approach and find that aggressive marketing activities of target firms prior to the M&A deal are not always compensated with greater premiums and favorable market reactions, which would represent the presence of a potential “window-dressing.” Further analysis shows that the positive association between marketing activities and deal performance is conditional on the change in institutional ownership prior to the deal, suggesting that institutional investors cherry-pick good targets with value-enhancing marketing activities. The results hold for both OLS and 2SLS after accounting for potential endogeneity. This paper contributes to the marketing-finance interface literature by providing more precise and direct evidence on how marketing strategies affect firm value.
Illness uncertainty, coping, and quality of life of colorectal cancer patients during chemotherap
Jin Ah, Kim,Juyoun Yu 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10
Aim(s): Colorectal cancer patients undergoing chemotherapy may experience uncertainty in the course of treatment process and their quality of life could be affected by how they cope with the situation. This descriptive study aimed to identify the relationships between uncertainty, coping, and quality of life among colorectal cancer patients undergoing chemotherapy. Method(s): Participants were 160 hospitalized colorectal cancer patients undergoing chemotherapy. The modified version of the Mishel Uncertainty in Illness Scale and the Cancer Coping Questionnaire was used for the scoring of uncertainty and coping respectively. With regard to scoring of quality of life, the EORTC QLQ-C30 was used. Data were collected from August to October of 2020, and analyzed using t-test/ANOVA and Pearson’s correlations. Result(s): Uncertainty showed negative correlations with general condition (r= -.521, p<.001) and functions (r= .410, p<.001) in quality of life, and positive correlation with symptom (r= .335, p<.001) in quality of life. Uncertainty and coping had negative correlation (r= -.456, p<.001), therefore, coping showed positive correlations with general condition (r= .678, p<.001) and functions (r= .542, p<.001) in quality of life, and negative correlation with symptom (r= -.440, p<.001) in quality of life. Conclusion(s): The findings of this study imply that it is required to reduce uncertainty in illness and to increase coping skills for improving the quality of life of colorectal cancer patients undergoing chemotherapy. Therefore, the nursing intervention for the assessment and management of uncertainty and coping skills should be needed to improve quality of life of colorectal patients undergoing chemotherapy.
( Juyoun Shin ),( Jin Yang Baek ),( Doo Ryeon Chung ),( Kwan Soo Ko ) 한국미생물생명공학회(구 한국산업미생물학회) 2017 Journal of microbiology and biotechnology Vol.27 No.9
In this study, we characterized the bla<sub>NDM-5</sub>-bearing plasmid in a Klebsiella pneumoniae isolate that had lost the plasmid during serial passage. We determined the complete sequences of the plasmid pCC1410-2, which was extracted from a K. pneumoniae ST709 isolate collected at a Korean hospital from which two NDM-5-producing K. pneumoniae isolates were subsequently isolated. As a result, the pCC1410-2 plasmid had a backbone structure that was similar to those of two plasmids previously reported from the same hospital, but lacked some antibiotic resistance genes (bla<sub>TEM-1</sub>, rmtB, mphR(A), mrx(A), and mph(A)). A 9-bp repeating unit encoding three amino acids (Gln-Gln-Pro) was inserted in TraD in pCC1410-2. Thus, the pCC1410-2 plasmid might be transferred from the previously identified carbapenem-resistant K. pneumoniae, but some delections and inversions might have occurred during the process. We compared the transfer frequency and stability of the plasmids. The relative frequency of conjugative transfer and stability in the host were significantly lower in pCC1410-2 than in previously reported bla<sub>NDM-5</sub>-bearing plasmids in Korea. A low transfer frequency and instability in the host may cause underestimation of carbapenemase-producing Enterobacteriaceae in the clinical setting and in surveillance studies.
Anti-aquaporin-4 antibody-positive dorsal midbrain syndrome
Lee, Juyoun,Jeong, Seong-Hae,Park, Sang Min,Sohn, Eun Hee,Lee, Ae Young,Kim, Jae-Moon,Jo, Hyun-Jin,Lee, Yeon-Hee,Kim, Ji-Soo SAGE Publications 2015 Multiple sclerosis journal: clinical and laborator Vol.21 No.4
<P>Neuromyelitis optica spectrum disorders (NMOSD) can cause various ocular motor disorders in addition to optic neuritis. Ocular motor findings associated with NMOSD include spontaneous vertical and gaze-evoked nystagmus, wall-eyed bilateral internuclear ophthalmoplegia, and trochlear nerve palsy. The association between dorsal midbrain syndrome and anti-aquaporin-4 antibody seropositivity has not been reported. Here, we report a patient displaying typical dorsal midbrain syndrome and anti-aquaporin-4 antibody seropositivity.</P>
Shin, Juyoun,Baek, Jin Yang,Cho, Sun Young,Huh, Hee Jae,Lee, Nam Yong,Song, Jae-Hoon,Chung, Doo Ryeon,Ko, Kwan Soo American Society for Microbiology 2016 Antimicrobial Agents and Chemotherapy Vol.60 No.3
<P>The two plasmids extracted from Klebsiella pneumoniae sequence type 147 (ST147) isolates were analyzed. The first isolate was obtained from a patient transferred from United Arab Emirates to South Korea. The second isolate was obtained from a Korean patient and was suspected to be transmitted from the first patient. Sequences of two plasmids were almost the same, and genetic structures, including bla(NDM-5), of these plasmids were similar to plasmids of NDM-1-producing Escherichia coli ST131 isolates found in Europe.</P>