다제내성 그람양성균에 대한 Linezolid(Zyvox^(�))의 시험관내 항균력 비교

박대원,정희진,엄중식,황병연,김성범,이재갑,이연주,정혜원,정성주,박재형,이진수,손장욱,김우주,김민자,박승철 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

배경 : MRSA, VRE, VRSA같은 다제 내성 그람 양성균의 등장에 따라 glycopeptide를 대체할 새로운 항생제의 개발이 필요하게 되었고 결과적으로 새로운 항생제인 linezolid라는 항생제가 개발되었다. Linezolid는 이전의 항생제와는 다른 새로운 계열의 oxazolidinone으로 경구 이용률이 우수하다. 원내 및 원외감염의 중요한 원인균이 되고 있는 MRSA, VRE에 대한 적절한 경구용 항균제가 없는 국내에서 폐렴 및 피부 연조직 감염에서 경구용으로 사용해 볼 수 있는 약제이다. 본 연구에서는 고대 구로 병원에서 분리된 MRSA, VRE 등을 대상으로 다른 여러 항균제와 비교한 linezolid의 시험관내 항균력을 조사하고자 하였다. 재료 및 방법 : 연구대상은 1998년 1월부터 2000년 12월까지 본원에서 입원 및 외래를 통하여 피부 연조직 감염증 및 호흡기 감염증, 요로감염증으로 진단된 환자들의 가검물로부터 분리된 MRSA 60균주, VRE 43균주, PRSP 25균주를 액체배지 또는 한천배지 희석법을 통하여 linezolid 및 기타 항균제에 대한 최소발육억제농도를 구하였다. 결과 : 실험에 사용한 S. aureus는 모두 MRSA였고 이들은 linezolid에 대해 MIC_(90) 2㎍/㎖(MIC 범위 1-2㎍/㎖), Enterococcus spp는 모두 VRE로 linezolid의 MIC_(90)은 2㎍/㎖로 MIC 범위는 1-4㎍/㎖였다. 한 개의 균주에서 MIC 4㎍/㎖로 중등도 감수성을 보였으나 MIC breakpoint가 (8㎍/㎖인 내성균주는 없고 모두 감수성을 보였다. S. pneumoniae의 경우 penicillin 내성이었고, linezolid MIC_(90) 1㎍/㎖ (MIC 범위 0.5-1㎍/㎖)로 전부 감수성을 보였다. 결론 : Linezolid는 MRSA를 위시한 VRE, PRSP 등의 다제 내성 그람 양성균에 대하여 우수한 시험관내 항균력을 보임을 알 수 있었다. Background : The emergence of multi-drug resistant Gram-positive cocci, such as MRSA, VRE, and VRSA, necessitated to develop new antibiotics, which could replace the glycopeptide. As a result, a new antibiotics named linezolid was developed. Linezolid is different line of oxazolidinones with a good oral bioavailability, compared to other antibiotics. Since appropriate oral antibiotics are not presently available for MRSA, which is a major cause of nosocomial and community acquired infections, the introduction of linezolid will have favorable effect on treatment of infections such as pneumonia or skin infections. In this study, we investigated the antibiotic effect of linezolid on MRSA and VRE isolated from patients who were treated in Korea University Guro Hospital. Material and Methods : By using broth microdilution and agar dilution method we measured minimum inhibitory concentration (MIC) with sixty S. aureus, forty three Enterococcus spp., and twenty five S. pneumoniae isolates from patients who were diagnosed as skin, soft tissue, respiratory, and urinary infections in Korea University Guro Hospital from January, 1998 to December, 2002. Results : All of S. aureus used in this study were MRSA, and MIG_(90) of linezolid was below 2 ㎍/㎖ (MIC ranged between 1-2 ㎍/㎖). All of Enterococcus spp. were VRE, and had MIG_(90) of 2 ㎍/㎖ (MIC ranged between 1 to 4 ㎍/㎖). One of the VRE showed intermediate susceptibility with MIC of 4 ㎍/㎖. However, none was resistant with MIC breakpoint above 8 ㎍/㎖. All of S. pneumoniae were resistant to penicillin, but they were susceptible to linezolid with MICao of 1 ㎍/㎖(MIC range 0.5-1㎍/㎖). Conclusion : In conclusions, linezolid has an excellent in vitro antibiotic effect on multi-drug resistant Gram-positive cocci, such as MRSA, PRSP, and VRE.

자궁근종에서 Phospholipase C 동종효소들의 발현에 관한 연구

윤혜원,류임주,김창미,심재철,서영석 대한해부학회 1995 Anatomy & Cell Biology Vol.28 No.4

근접센서를 이용한 자동 두께 측정 시스템

주해호,박현제,정길도,이재원 嶺南大學校 工業技術硏究所 1994 工業技術硏究所論文集 Vol.22 No.2

This paper describes the automatic thickness measurement of the surface grinder for a grinding wheel by application of a proximity sensor, a limit switch, and PLC. The control system is designed to provide feeding a workpiece on the turn-table and pressing it by the upper disk automatically. In the process, the automation of checking the thickness of a grinding wheel is most important. In order to measure the relative displacement, the proximity sensors were employed and the sensitivities of the sensors were investicated and discussed the superiority. It has been shown by model experiment that the automation system of the surface grinder is performed satisfactory.

1997學年度 新入生 實態調査

元俊載,朴州信,鄭永壽 인하대학교 학생생활연구소 1998 學生生活硏究 Vol.18 No.-

特定有害産業廢棄物의 適正管理에 關한 硏究

梁在崙,金元滿,朴在柱 한국환경독성학회 1991 환경독성보건학회지 Vol.6 No.1

The specified industrial wastes increased 26% annually during the last 5 years from 1984 to 1988 in Korea, and the special treatment and proper management are required. The effective methods are studied on the process of generation, keeping, transportation, and treatment/disposal for specified industrial wastes and materials. Also, in this paper, the author describes the plans to develop the public disposal facilities and manage specific industrial waste properly in Korea.

성형입력에 의한 유연한 조작기의 잔류진동제어

이재원,이지형,주해호 嶺南大學校 工業技術硏究所 1995 工業技術硏究所論文集 Vol.23 No.2

This paper discusses the control of one link flexible robot which can run in high speed with no residual vibration. The preshaped input command is produced by convoluting the impulse sequence with the step command. The impulse sequences is produced by Singer's method and Tuttle's method. The result show that Tuttle's method is more simple in terms of mathematical modeling and more general in terms of producing impulse sequences than Singer's method.

실험계획법을 이용한 능동형 미소혼합기의 근사최적화

박재용,이원구,유진식,김용대,한석영,맹주성 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

An active micro-mixer, which was composed of an oscillating micro-stirrer in the microchannel to provide rapid, effective mixing at high flow rates was analyzed. The effects of molecular diffusion and disturbance by the stirrer were considered with regard to two types of mixer models: the simple straight microchannel and microchannel with an oscillating stirrer. Two types of mixer models were studied by analyzing mixing behaviors such as their interactionafter the stirrer. The mixing was calculated by Lattice Boltzmann methods using the D2Q9 model, In this study, the time-averaged mixing index formula was used to estimate the mixing performance of time-dependent flow. The mixing indices of the two models were compared. From the results, it was found that the mixer with an oscillating stirrer was much more enhanced and stabilized. Therefore, an approximate optimization of an active micro-mixer with an oscillating stirrer was performed using Kriging method with OLHD(Optima1 Latin Hypercube Design) in order to obtain a optimum solution. The design parameters were established as the frequency, the length and the angle of the stirrer, and the optimal values were determined to be 1.0346, 0.66D and ±45°, respectively. It was found that the mixing index of the optimal design increased by 88.72% compared with that of the original design.

순천향의대에서 문제중심학습의 실행 및 평가

김주자,이경재,원종호,이동환,안의태 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.1

Background and Objects : Problem based learning (PBL) was practiced the 2nd grade students of Soonchunhyand medical school for two weeks from Dec. 10th through 24th, 2001. This is to evaluate the effect of the PBL practice Materials and Methods : On study module was discussed each week for 17 small groups. Each group had 6-7 students and 1 tutor. Questionnaire was applied to both students and 20 tutors. The questions were grouped in 6 categories, that is, understanding and satisfaction about the PBL, the process of small group discussion and group activity in self-learning method, PBL module and tools for study, opinion about tutors evaluation method etc. And advantages, disadvantages and other opinions were described in self-administration. Results : Both students and tutors had satisfied the PBL practice positively. Practices of "self-learning and active discussion instead of spoon-feeding methods", "problem-solving ability and medical reasoning" were described as advantages, "inefficiency and loss of time because of poor process during the discussion", "time consuming and much loading problems in self-learning practice because lack of training" "time consuming and mush loading problems in self-learning practice because lack of training" "lack of study room" were described as disadvantages.

신경회로망을 이용한 이면비드 폭 예측에 관한 연구

정재원,김일수,박창언,김학형,서주환,김인주,심지연 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

The development of robotic welding process is a very complex assignment because the system is affected by a number of process parameters which are very difficult to determine or predict in practice. The full automation welding has not yet been achieved partly because the mathematical model for the process parameters of a given welding task is not fully understood and quantified. Several mathematical models to control welding quality, Productivity, micro structure and weld properties in arc welding processed have been studied. However, it is not an easy task to apply them to the various practical situations because the relationship between the process parameters and the bead geometry is non-linear and also they are usually dependent on specific experimental result. Practically, it is difficult, but important to know how to establish a mathematical model that can predict the result of the actual welding process and how to select the optimum welding condition under a certain constraint. In this paper, an attempt has been made to develop an neural network model to predict the back-bead width as a function of key process parameters in the GMA (Gas Metal Arc) welding and to compare the developed models with the experimental results

남북한 및 중국 중재제도의 비교연구

신군재,이주원 한국중재학회 2007 중재연구 Vol.17 No.2

The legal systems and open-door policies to foreign affairs in North Korea have been followed by those of China. Whereas an arbitration system of South Korea accepted most parts of UNCITRAL Model Law, North Korea has succeeded to an arbitration system of a socialist country. China, under the arbitration system of socialist country, enacted an arbitration act reflected from UNCITRAL Model Law for keeping face with international trends. We have used these three arbitration system as a tool for analyzing an arbitration system in North Korea. With an open-door policy, North Korea and China enacted an arbitration act to provide a legal security. Therefore, the core parts of arbitration system in North Korea and China are based on a socialist system while those of South Korea is on liberalism. So, North Korea and China enacted an arbitration act on the basis of institutional arbitration, on the other side, South Korea is based on ad-hoc arbitration. Because of these characters, in terms of party autonomy, it is recognized with the order as South Korea, China and North Korea. Also North Korea enacted separate 'Foreign Economic Arbitration Act' to resolve disputes arising out of foreign economies including commercial things and investments. There are differences in arbitration procedures and appointment of arbitrators : South Korea recognizes parties' autonomy, however parties should follow the arbitration rules of arbitration institutes in North Korea and China. According to an appointment of arbitrators, if parties fail to appoint co-arbitrators or chief arbitrators by a mutual agreement, the court has the right to appoint them. In case of following KCAB's rules, KCAB secretariats take a scoring system by providing a list of candidates. A party has to appoint arbitrators out of the lists provided by arbitration board(or committee) in North Korea. If a party may fail to appoint a chief arbitrator, President of International Trade Arbitration Board(or Committee) may appoint it. In China, if parties fail to appoint a co-arbitrator or a chief arbitrator by a mutual agreement, Secretary general will decide it. If a arbitral tribunal fails to give a final award by a majority decision, a chief arbitrator has the right for a final decision making. These arbitration systems in North Korea and China are one of concerns that our companies take into account in conducting arbitration procedures inside China. It is only possible for a party to enforce a final arbitral award when he applies an arbitration inside North Korea according to International Trade Arbitration Act because North Korea has not joined the New York Convention. It's doubtful that a party might be treated very fairly in arbitration procedures in North Korea because International Trade Promotion Commission controls(or exercises its rights against) International Trade Arbitration Commission(or Board).