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Zhao Zijun,Wu Yue,Wang Zairan,Xu Jiayi,Wang Yizheng,Zhao Zongmao 한국유전학회 2022 Genes & Genomics Vol.44 No.1
Background: Gliomas, especially Glioblastoma multiforme, are the most frequent type of primary tumors in central nervous system. Increasing researches have revealed the relationship between autophagy and tumor, while the molecular mechanism of autophagy in glioma is still rarely reported. Objective: Our research aims to conform the autophagy-related genes (ARGs) implicated in the development and progression of glioma and improve our understanding of autophagy in glioma. Methods: 20 candidate ARGs were screened through the protein-protein interaction network. We also downloaded the publicly accessible glioma data for 665 individuals from TCGA and 970 individuals from CGGA with RNA sequences and clinicopathological information. Subsequently, univariate and multivariate Cox regression analysis identified 5 key ARGs among the 20 candidate genes as key prognostic genes for survival, GSEA and immune response analysis. Results: ATG5, BCL2L1, CASP3, CASP8, GAPDH were identified as key ARGs in our research. Further studies showed that the high-risk population was linked to a dismal prognosis and suggested an immune-inhibitory microenvironment. GSEA results demonstrated that high risk population was closely related to DNA repair, hypoxia pathways, implicated in immunosuppression and carcinogenesis. Through CMap, we finally identified 14 candidate drugs for the ARG high risk population. Conclusions: This study established and verified an ARG risk model, which can serve as an independent predictor for prognosis, reflect on the strength of the immune response and predict the potential drugs in glioma. Our findings offer new understandings of ARG molecular mechanism and promising therapeutic targets for glioma treatment.
Zijun Wu,Shuting Wang,Renbin Xiao,Lianqing Yu 한국CDE학회 2020 Journal of computational design and engineering Vol.7 No.4
This paper develops a new topology optimization approach for minimal compliance problems based on the parameterized level set method in isogeometric analysis. Here, we choose the basis functions as level set functions. The design variables are obtained with Greville abscissae based on the corresponding collocation points. The zero-level set boundaries are derived from the level set function values of the interpolation points in all knot spans. In the optimization iteration process, the whole design domain is discretized into two types of subdomains around the zero-level set boundaries, undesign area with void materials and redesign domain with solid materials. To decrease the size of equations and the computational consumptions, only the solid material area is recalculated and the void material area is discarded according to the high accuracy of isogeometric analysis. Numerical examples demonstrate the validity of the proposed optimization method.
Zhaoming Huang,Zijun Zheng,Tao Wang,Li Wang,Hongcheng Gan,Weiguo Chen 한국자동차공학회 2022 International journal of automotive technology Vol.23 No.4
On a single-cylinder gasoline engine test bench, the experimental study of the effects of polishing the combustion chamber wall and piston top surface on the indicated thermal efficiency and combustion characteristics were carried out, and the mutual influence of combustion phase, combustion duration and indicated thermal efficiency before and after polishing the wall of combustion system was systematically analyzed. The results show that when the single-cylinder gasoline engine operates at stoichiometric air-fuel ratio, low load and low compression ratio, the heat transfer loss of the polished combustion chamber is reduced and the fuel economy is improved, and the indicated thermal efficiency is increased from 40.8 to 42.2 %. With the increasing of load and compression ratio, the knock effect caused by the reduction of heat transfer loss after polishing is enhanced, and the combustion phase is delayed and the combustion duration is prolonged, which eventually leads to the decrease of the indicated thermal efficiency. After combustion chamber polishing, HC and NOx decrease by up to 70 %. With the increase of compression ratio, HC emission gradually increases, while NOx emission gradually decreases. There is no obvious change trend of CO emission before and after polishing. When the gasoline engine operates in lean combustion mode, the indicated thermal efficiency increases effectively, and the highest thermal efficiency exceeds 45 %; When the gasoline engine operates at indicated mean effective pressure of 1.05 MPa, the reduction of heat transfer loss in the combustion chamber after polishing enhances the knocking tendency, resulting in the overall decrease of the gross indicated thermal efficiency compared with that before polishing.
Vibration reduction design of the Hangzhou Bay cable-stayed bridges
Liu, Weiqing,Xu, Xiuli,Wang, Rengui,Wang, Zijun,Wu, Xiaolan Techno-Press 2006 Structural Engineering and Mechanics, An Int'l Jou Vol.24 No.3
Hangzhou Bay Bridge spans the Hangzhou Bay and is located at Zhejiang province in the southeast seacoast of China. The total length of the bridge is 36 km. The bridge is composed of bridge approaches made up of multi-span prestressed concrete box girders and two cable-stayed bridges over the north and south navigable spans respectively. The seismic response analysis of the bridge model shows that if the navigable spans are designed as the routine earthquake-resistance system, the displacements and internal forces in pylons, piers and deckes are too large to satisfy the anti-seismic requirement of the structure. Therefore, the seismic reduction design was carried out by using viscous dampers to dissipate the kinetic energy of the structure both longitudinally and transversely. Using the vibration reduction system and aiming at the reasonable optimal goal, the purpose to reduce the seismic responses in south and north navigable spans has been achieved.
Shen Tianli,Wu Yunhua,Wang Xingjie,Wang Zijun,Li Enmeng,Zhou Cancan,Yue Chenyang,Jiang Zhengdong,Wei Guangbing,Lian Jie,Xu Qinhong,Li Xuqi 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Peritoneal adhesions (PAs) are a serious complication of abdominal surgery and negatively affect the quality of life of millions of people worldwide. However, a clear molecular mechanism and a standard therapeutic strategy for PAs have not been established. Here, we developed a standardized method to mimic the pathological changes in PAs and found that sirtuin 3 (SIRT3) expression was severely decreased in adhesion tissues, which was consistent with our bioinformatics analysis and patient adhesion tissue analysis. Thus, we hypothesized that activating SIRT3 could alleviate postsurgical PAs. Sirt3-deficient (Sirt3−/−) mice exhibited many more PAs after standardized abdominal surgery. Furthermore, compared with wild-type (Sirt3+/+) mice, Sirt3-deficient (Sirt3−/−) mice showed more prominent reactive oxygen species (ROS) accumulation, increased levels of inflammatory factors, and exacerbated mitochondrial damage and fragmentation. In addition, we observed NLRP3 inflammasome activation in the adhesion tissues of Sirt3−/− but, not Sirt3+/+ mice. Furthermore, mesothelial cells sorted from Sirt3−/− mice exhibited impaired mitochondrial bioenergetics and redox homeostasis. Honokiol (HKL), a natural compound found in several species of the genus Magnolia, could activate SIRT3 in vitro. Then, we demonstrated that treatment with HKL could reduce oxidative stress and the levels of inflammatory factors and suppress NLRP3 activation in vivo, reducing the occurrence of postsurgical PAs. In vitro treatment with HKL also restored mitochondrial bioenergetics and promoted mesothelial cell viability under oxidative stress conditions. Taken together, our findings show that the rescue of SIRT3 by HKL may be a new therapeutic strategy to alleviate and block postsurgical PA formation.
Yanmin Shen,He Wang,Zijun Liu,Weikun Li,Yuhua Liu,Jingjing Li,Hong-Liang Wei,Huayun Han 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.93 No.-
A new type of water-retaining, slow-release fertilizer (WSF) based on double-network hydrogels wasfabricated via the ion-crosslinking of sodium carboxymethyl cellulose and the free radical polymeriza-tion of polymerizable β-cyclodextrin (MAH-CD), polyethylene glycol dimethacrylate (PEGDA), acrylamide(AM), and acrylic acid (AA) with urea-loaded halloysite as an additive. The effects of the AM to AAmonomer ratio, the halloysite content, the AlCl3 content and the MAH-CD content on the swelling ratiowere studied. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), andthermogravimetric analysis (TGA) were applied to characterize the structure and properties of the WSF. The swelling behavior and water retention capacity of the fertilizer were investigated using a classicgravimetric method. The experimental results indicated that the presence of halloysite nanotubes clearlyadjusted the swelling and release properties of the WSF. Kinetic modeling indicated that the swellingmechanism and slow release behavior were consistent with a Fickian diffusion mechanism. Form theconsiderations of its properties and raw materials, the fertilizer developed here has a good prospect ofapplication and extension.