Epigenetic Field for Cancerization

Ushijima, Toshikazu Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.2

Epigenetic alterations, represented by aberrant DNA methylation, are deeply involved in human cancers. In gastric cancers, tumor-suppressor genes are inactivated more frequently by promoter methylation than by mutations. We recently showed that H. pylori infection, a potent gastric carcinogenic factor, induces methylation of specific genes in the gastric mucosae. When the methylation levels were analyzed in the gastric mucosae of healthy volunteers, cases with a single gastric cancer, and cases with multiple gastric cancers, who have increasing levels of risks for gastric cancers, there was a significant increasing trend in the methylation levels among the individuals without current H. pylori infection. This finding unequivocally showed the presence of an epigenetic field for cancerization. The degree of the field defect was measured more conveniently using methylation levels of marker genes than using those of tumor-suppressor genes. The presence of an epigenetic field for cancerization has been indicated for liver, colon, Barrett's esophageal, lung, breast, and renal cancers. Since decreased transcription is involved in the specificity of methylated genes, it is likely that specific genes are methylated according to carcinogenic factors. These findings emphasize the usefulness of DNA methylation as a marker for past exposure to carcinogens and future risk of cancer development.

Sensitive and Mild Fluorogenic Reagents for Biogenic Carboxylic Acids in HPLC

Ushijima, Tamano,Saito, Mikihiko,Sasamoto, Kazumi,Ohkura, Yosuke,Ueno, Keiyu 한국분석과학회 1995 분석과학 Vol.8 No.4

Five acid hydrazides as precolumn fluorescence derivatization reagents for carboxylic acids in HPLC, which have the benzofuran or benzothiazole moiety conjugated to a furan, thiophene or oxazoline ring, were synthesized and examined in view of reactivity, separability and sensitivity. Of these hydrazides, 2-(5-hydrazinocarbonyl-2-oxazolyl)-5,6-dimethoxybenzothiazole (BTOH) was most favorable. The detection limit of lauric acid as a model acid was 0.1 pmol per $10-{\mu}l$ injection volume at S/N=3, which was roughly equal to that of an analogous compound, 2-(5-hydrazinocarbonyl-2-furyl)-5,6-dimethoxybenzothiazole. The reagent allowed rapid assays of carboxylic acids ($C_{12:0}-C_{20:4}$) within 20 min with satisfactory scparability. The method was applied to the determination of fatty acids in human sera from healthy volunteers as well as from patients with diabetes or thyroid dysfunction.

REHABILITATION OF CONCRETE STRUCTURE BY USING ELECTROCHEMICAL CORROSION CONTROL METHODS

Sakae Ushijima 대한토목학회 2003 대한토목학회 학술대회 Vol.2003 No.10

The Role of Epigenetics in the Development of Gastric Cancer

( Toshikazu Ushijima ) 대한소화기학회 2009 SIDDS Vol.10 No.-

총독부 검열관 니시무라 신타로 연구 ―니시무라의 저작에 드러난 총독부의 의도―

우시지마요시미 ( Ushijima Yoshimi ) 민족어문학회 2021 어문논집 Vol.- No.92

총독부 검열관 니시무라 신타로의 저작은 총독부의 내부적 교육에 활용되었을 뿐만 아니라 총독부 정책에 맞는 견해를 일반에게 제시하는 역할도 하고 있었다. 첫째, 『朝鮮の俤(조선의 모습)』는 재조선 일본인 경찰을 교육하기 위한 것으로, 새로 채택된 ‘문화정치’를 실천으로 옮기기 위한 시도의 일환으로 보인다. 둘째, 「정감록」 연구는 애초에는 일본인 경찰관을 위해 저술된 것이었다가, 후에 《삼천리》지에 발표되어 민족종교 탄압을 정당화하는데 이용되었다. 셋째, 니시무라는 언어의 유사성을 근거로 일본과 조선을 동원(同源)이라고 했다. 이는 니시무라의 새로운 주장이 아니라 1910년의 한일합병 당시 니시무라의 스승인 가나자와에 의해 이미 주장되었던 이론이었다. 그러나 가나자와는 비공식적으로는 조선을 ‘본가(本家)’로 생각하고 있었으며, 이것은 일본의 우월성을 부정할 뿐만 아니라 일본의 국체를 훼손시킬 위험성을 내포하고 있었다. 니시무라의 양어동원일체론은 가나자와의 이론을 무시하지 않으면서도 그러한 위험성을 제거하여 통제된 형태로 조선의 신문과 라디오에서 발표되었다. The works of Shintaro Nishimura, the censor of the Government-general, was not only used for internal education of the Government-general, but also used to present the Government general’s opinion to the public. First, View of Joseon (朝鮮の俤) was for educating Japanese police officers in Joseon, and seems to have been an attempt to put the newly adopted ‘cultural politics’ into practice. Second, the study of 「Jeonggamrok」 was originally written for the purpose of facilitating Japanese police officers’ supervisions. However, it was later published in the journal Samcheolli and used to justify the oppression of ethnic religions. Third, Nishimura referred to Japan and Joseon as homologous (同源) based on linguistic similarity. It was not a new argument by Nishimura, but a theory already claimed by Kanazawa, Nishimura’s teacher, at the time of the Korea-Japan annexation in 1910. However, Kanazawa was unofficially thinking of Joseon as the ‘home (本家)’, and it not only denies Japan’s superiority, but also carries the risk of developing into an ideology that will undermine Japan’s national supremacy. Nishimura’s theory was published in Joseon newspapers and radio, in the form of eliminating such risks without ignoring Kanazawa’s theory.

Current status of gynecologic cancer in Japan

Kimio Ushijima 대한부인종양학회 2009 Journal of Gynecologic Oncology Vol.20 No.2

To make an overview of the current status of gynecologic cancer in Japan, we reviewed the recent incidence of cervical, endometrial, and ovarian cancer in Japanese women. The incidence of all three cancers has increased, but trends differ respectively. In age specific cancer site distribution data, the uterus and ovary are leading sites of high incidence among Japanese women younger than 40 years of age. Therefore, fertility sparing cancer treatment has received much attention. Several multicenter clinical trials have been done by Japanese groups, and some excellent evidence has been collected for endometrial and ovarian cancer. A promising international collaboration trial for ovarian clear cell carcinoma is also underway at the present time. To make an overview of the current status of gynecologic cancer in Japan, we reviewed the recent incidence of cervical, endometrial, and ovarian cancer in Japanese women. The incidence of all three cancers has increased, but trends differ respectively. In age specific cancer site distribution data, the uterus and ovary are leading sites of high incidence among Japanese women younger than 40 years of age. Therefore, fertility sparing cancer treatment has received much attention. Several multicenter clinical trials have been done by Japanese groups, and some excellent evidence has been collected for endometrial and ovarian cancer. A promising international collaboration trial for ovarian clear cell carcinoma is also underway at the present time.

Epigenetic Field for Cancerization (Reviews)

Toshikazu Ushijima 한국생화학분자생물학회 2007 BMB Reports Vol.40 No.2

Plenary Lecture 1 : Epithelial ovarian borderline tumor, diagnosis and treatment strategy

( Kimio Ushijima ) 대한산부인과학회 2014 서울심포지움 Vol.19 No.-

Sensitive and Mild Fluorogenic Reagents for Biogenic Carboxylic Acids in HPLC

Tamano Ushijima,Mikihiko Saito,Kazumi Sasamoto,Yosuke Ohkura,Keiyu Ueno 한국분석과학회 1995 분석과학 Vol.8 No.4

최정희와 ‘군국의 어머니’ ―최정희 산문 「군국의 어머님들」, 「군국모성찬」과 일본문학보국회 『日本の母』 텍스트 비교를 중심으로―

우시지마요시미 ( Ushijima Yoshimi ) 고려대학교 민족문화연구원 2021 民族文化硏究 Vol.90 No.-

본고는 2004년에 발굴된 최정희의 친일작품 중 「군국의 어머님들」, 「군국모성찬」을 그 원작과 비교하여 분석한다. 해당 작품은 아들을 군대로 보낸 일본의 어머니들의 사연을 담고 있는데, 그 목적은 징병제 시행을 앞둔 시점의 조선 농촌 여성들에게 ‘군국의 어머니’의 마음가짐을 선전하려는 것이다. 그런데 5개의 사연 중 3개까지가 등장인물, 이야기 전개 등에서 일본문학보국회가 쓴 『日本の母』의 내용과 같다. 최정희의 글과 그 원작을 비교한 결과, 일본과의 역사적 원한 관계가 삭제되는 등 조선의 독자에 맞게 개작이 이루어지고 있다. 주목해야 할 것은 「군국의 어머님들」의 마지막 사연에는 아들을 잃은 어머니의 슬픔이 그려져 있는데, 제목을 바꾼 「군국모성찬」에서는 원문에 있는 ‘아들을 잃은 슬픔’은 삭제되어 죽음을 태연하게 받아들이는 어머니로 개작되어있는 점이다. 이것은 징병제를 앞둔 조선에서 아들을 잃은 슬픔을 그리는 것이 문제가 되어, 당국의 지도가 개입한 것으로 추정된다. This paper analyzes “Militaristic Mothers” and “Gungukseongmochan” among Choi Jeong-hee’s pro-Japanese works discovered in 2004 by comparing them with the original works. These works tell a story of Japanese mothers who sent their sons to the military, and the purpose is to promote the mindset of a ‘Militaristic Mother’ to rural women at a time when the conscription system is about to be implemented. However, up to three of the these five stories are the same as the content of Japanese Mother (日本の母) written by the Patriotic Association of Japanese Literature in terms of characters and storytelling. As a result of comparing Choi Jeong-hee’s writing with the original work, the historical resentment with Japan was deleted, and the adaptation is being made to suit the readers of Joseon. It should be noted that the last story of “Militaristic Mothers” depicts the grief of a mother who lost her son, but in “Gungukseongmochan”, of which the title has been changed, the sadness of losing her son has been removed, and it has been rewritten as a mother who accepts her son’s death unconcernedly. it is presumed that the guidance of the authorities intervened because it was a problem to write the sorrow of losing a son in Joseon ahead of the conscription system.