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Representation of Princely Power: the Case of the Flemish Comital Dynasty in the 11th Century
Masumi UEYAMA 한국서양중세사학회 2024 西洋中世史硏究 Vol.0 No.53
In French historiography, the 11th and 12th centuries are often portrayed as “the age of princes”. While the Capetian kings controlled only a very narrow territory surrounding Paris, many princes, namely dukes and counts, inheriting vast territories, were essentially independent from royal control. However, due to the scarcity of primary sources, the research of princely powers has not so been in the focus of historical studies. This paper examines the princely power in the 11th Century, zooming into the role of ‘rituals’ or ‘ceremonies’ : specially the dedication ceremony of Hasnon monastery, which was held by the Flemish Comital dynasty in 1070. Baldwin of Mons, Count of Flanders, who organised this dedication ceremony, also inherited the countship of Hainaut through his wife, and the Hasnon monastery was located at the boundary area between the counties of Flanders and Hainaut, that is, his old and new territories. He collected here a total of 26 relics for the dedication, almost half from each of the two counties, and opened this ceremony not only to the clergy and noble, but also to the people. By bringing together so many relics from all over its territories, the Flemish comital dynasty manifested the unification of two counties, and aimed at impressing visually its power to divers attendants.
Kim, Bong Jik,Ueyama, Takehiko,Miyoshi, Takushi,Lee, Seungmin,Han, Jin Hee,Park, Hye-Rim,Kim, Ah Reum,Oh, Jayoung,Kim, Min Young,Kang, Yong Seok,Oh, Doo Yi,Yun, Jiwon,Hwang, Sang Mee,Kim, Nayoung K D BMJ Publishing Group Ltd 2019 Journal of medical genetics Vol.56 No.12
<P><B>Background</B></P><P>Diaphanous-related formin 1 (DIA1), which assembles the unbranched actin microfilament and microtubule cytoskeleton, is encoded by <I>DIAPH1</I>. Constitutive activation by the disruption of autoinhibitory interactions between the N-terminal diaphanous inhibitory domain (DID) and C-terminal diaphanous autoregulatory domain (DAD) dysregulates DIA1, resulting in both hearing loss and blood cell abnormalities.</P><P><B>Methods and results</B></P><P>Here, we report the first constitutively active mutant in the DID (p.A265S) of humans with only hearing loss and not blood cell abnormality through whole exome sequencing. The previously reported DAD mutants and our DID mutant (p.A265S) shared the finding of diminished autoinhibitory interaction, abnormally upregulated actin polymerisation activity and increased localisations at the plasma membrane. However, the obvious defect in the DIA1-driven assembly of cytoskeleton ‘during cell division’ was only from the DAD mutants, not from p.A265S, which did not show any blood cell abnormality. We also evaluated the five DID mutants in the hydrophobic pocket since four of these five additional mutants were predicted to critically disrupt interaction between the DID and DAD. These additional pathogenic DID mutants revealed varying degrees of defect in the DIA1-driven cytoskeleton assembly, including nearly normal phenotype during cell division as well as obvious impaired autoinhibition, again coinciding with our key observation in DIA1 mutant (p.A265S) in the DID.</P><P><B>Conclusion</B></P><P>Here, we report the first mutant in the DID of humans with only hearing loss. The differential cell biological phenotypes of DIA1 during cell division appear to be potential determinants of the clinical severity of <I>DIAPH1-</I>related cytoskeletopathy in humans.</P>
Study of Pulse Shape Discrimination of Sub-MeV Neutrons From Gamma-Rays with Liquid Scintillator
M. Yoshioka,M. Ueyama,Y. Koba,Y. Nakamura,T. Kajimoto,D. Moriguchi,Y. Uozumi,N. Shigyo 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
We have studied pulse shape discrimination of sub-MeV neutron from spallation nuclear reactions. Neutron measurements were carried out with a 2-inch NE213 scintillator viewed by a phototube (HAMAMATSU H1949) for the carbon-carbon reaction at 290 MeV/n. Neuron energies were measured with the TOF technique by using a timing pick-up plastic scintillator. Output signals of detectors were digitized and stored with a digitizer (Acqiris DC282). The digital pulse shape discrimination (DPSD) has been investigated through comparison between three different analyzing algorithms. Effects on the neutron-gamma (n/g) discrimination were also investigated after the subtraction of background and abnormal events. Moreover, in order to realize better n/g discrimination the detector system was cooled down to about zero degrees centigrade by Peltier devices to suppress the dark current of the phototube which would be the main cause distorting pulse shapes. Experimental studies were made in terms of the temperature dependence of detector performance including pulse shape.
A. Mzhavia,M. Ueyama,Y. Uozumi,Y. Sawada,M. Yoshioka,G. Wakabayashi,H. Iwamoto,Y. Koba,Z. Tsamalaidze,P. Evtukhovitch,V. Kalinnikov,N. Khomutov,N. Kuchinskii,G. Macharashvili,A. Moiseenko,A. Molokanov 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
Double-differential cross section (DDX) data of nucleon-actinide reactions is crucial for the study of nuclear waste transmutation by accelerator driven systems. Charged particle emission data is strongly required as well as the neutron data up to several Gev. In the present study, we measured double-differential cross sections of light charged particle productions for proton induced reactions on ^(232)Th at 360 Mev. The experiment was carried out at the PHASOTRON facility of the Joint Institute for Nuclear Research (JINR) in Dubna.The light charged particles (LCPs) emitted from nuclear reactions were detected by ΔE-E counter telescopes. Eight detector systems were used. Four of them were comprised of two plastic scintillator plates and BGO crystal. The other four consisted of two silicon semiconductor detectors and two scintillation counters, a cubic CsI(TI) (40 mm long) crystal and plate plastic scintillator. The four identical detectors on each side were placed at laboratory angles of 20˚. 40˚, 70˚ and 105˚ with respect to the beam axis. Resultant DDX spectra of protons and deuterons were compared with intranuclear cascade (INC) model.
Fumiaki Ishibashi,Toshiaki Hirasawa,Hiroya Ueyama,Yohei Minato,Sho Suzuki 대한소화기내시경학회 2023 Clinical Endoscopy Vol.56 No.4
Background/Aims: Diagnosis of Helicobacter pylori-naïve gastric cancer (HPNGC) is becoming increasingly important. This study aimed to explore the quality indicators for HPNGC detection. Methods: We conducted a cross-sectional, nationwide, web-based survey of gastrointestinal endoscopists in Japan. In addition to questions about the number of HPNGC cases detected in a year and basic information, the questionnaire also consisted of 28 questions: (1) 18 about HPNGC awareness, (2) six about diagnostic proactiveness, and (3) four about interest in HPNGC. Results: Valid responses were obtained from 712 endoscopists. The Japan Gastroenterological Endoscopy Society-certified endoscopists had a significantly higher HPNGC detection rate than the nonspecialists (0.42% vs. 0.32%, respectively; p=0.008). The results of the multiple regression analysis showed that Japan Gastroenterological Endoscopy Society certification and high awareness and interest scores were independent predictors of the HPNGC detection rate (p=0.012, p<0.001, p=0.024, respectively). Principal component analysis showed that the endoscopists who attended conferences for collecting information on HPNGC had a higher level of awareness. Conclusions: To improve the detection of HPNGC, it is necessary to increase the awareness of the disease. It is hoped that relevant societies will play an important role in endoscopists’ education.
Dynamic Chest X-Ray Using a Flat-Panel Detector System: Technique and Applications
Hata Akinori,Yamada Yoshitake,Tanaka Rie,Nishino Mizuki,Hida Tomoyuki,Hino Takuya,Ueyama Masako,Yanagawa Masahiro,Kamitani Takeshi,Kurosaki Atsuko,Sanada Shigeru,Jinzaki Masahiro,Ishigami Kousei,Tomiy 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.4
Dynamic X-ray (DXR) is a functional imaging technique that uses sequential images obtained by a flat-panel detector (FPD). This article aims to describe the mechanism of DXR and the analysis methods used as well as review the clinical evidence for its use. DXR analyzes dynamic changes on the basis of X-ray translucency and can be used for analysis of diaphragmatic kinetics, ventilation, and lung perfusion. It offers many advantages such as a high temporal resolution and flexibility in body positioning. Many clinical studies have reported the feasibility of DXR and its characteristic findings in pulmonary diseases. DXR may serve as an alternative to pulmonary function tests in patients requiring contact inhibition, including patients with suspected or confirmed coronavirus disease 2019 or other infectious diseases. Thus, DXR has a great potential to play an important role in the clinical setting. Further investigations are needed to utilize DXR more effectively and to establish it as a valuable diagnostic tool.