PRIdictor: Protein-RNA Interaction predictor

Tuvshinjargal, N.,Lee, W.,Park, B.,Han, K. North-Holland Pub. Co 2016 Bio systems Vol.139 No.-

<P>Several computational methods have been developed to predict RNA-binding sites in protein, but its inverse problem (i.e., predicting protein-binding sites in RNA) has received much less attention. Furthermore, most methods that predict RNA-binding sites in protein do not consider interaction partners of a protein. This paper presents a web server called PRldictor (Protein-RNA Interaction predictor) which predicts mutual binding sites in RNA and protein at the nucleotide- and residue-level resolutions from their sequences. PRldictor can be used as a web-based application or web service at http://bclab.inha.ac.kr/pridictor. (C) 2015 Elsevier Ireland Ltd. All rights reserved.</P>

2,3,7,8-Tetrachlorodibenzo-P-Dioxin Induced Cell-Specific Drug Transporters With Acquired Cisplatin Resistance in Cisplatin Sensitive Cancer Cells

Tuvshinjargal Gotovdorj,이은일,임용철,차은정,권대호,홍은영,김윤정,오민영 대한의학회 2014 Journal of Korean medical science Vol.29 No.9

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can induce drug transporter genes such as theATP-binding cassette G member 2 (ABCG2), which contributes to multidrug resistance. Weinvestigated the effect of TCDD pretreatment on drug transporters induction from cancercells of various origins. Cell viabilities after treatment of cisplatin were measured toevaluate acquiring cisplatin resistance by TCDD. Acquring cisplatin resistance was foundonly in cisplatin senstivie cancer cells including gastric SNU601, colon LS180, brain CRTMGand lymphoma Jurkat cells which showed a significant increase in cell viability aftercombined treatment with TCDD and cisplatin. High increase of ABCG2 gene expression wasfound in SNU601 and LS180 cells with a mild increase in the expression of the ABCC3,ABCC5,and SLC29A2 genes in SNU601 cells, and of major vault protein (MVP) in LS180cells. The AhR inhibitor kaempferol suppressed the upregulation of ABCG2 expression andreversed the TCDD-induced increase in cell viability in LS180 cells. However, in CRT-MGcells, other transporter genes including ABCC1, ABCC5, ABCA3, ABCA2, ABCB4, ABCG1,and SLC29A1 were up-regulated. These findings suggested the acquiring cisplatinresistance by TCDD associated with cancer cell-type-specific induction of drug transporters.

Short Wave Solar Radiation Features in Eastern Mongolia

Tuvshinjargal, D Korea Association For Quaternary Research 2003 제사기학회지 Vol.17 No.2

This study is conducted to examine the solar radiation features of landscape in Eastern Mongolia and their space and time distribution characteristics. To many foreigners, the name Mongolia conjures up images of the vast steppes of Central Asia. And, indeed, the extensive grasslands of the steppe make up the heart of Mongolia-geographically and economically. Steppe covers nearly the entire far eastern part of Mongolia, extending west in a narrowing band just south of the Khangai and Khan Khokhii mountains all the way to the Depression of the Great lakes. Eastern Mongolia is recognized as one of the last remaining untouched grassland steppes in the world. Landscape of Eastern Mongolia divided by 19 types that belongs to High Mountain, Middle Mountain and low mountain steppe. Only 5.6% of the total land area is covered by forest. Eastern Mongolian steppe is homeland of migratory rare and endangered birds and about 2.0million freely migrating gazelles. According to Mongolian scientists, there is growing evidence of fundamental changes in the Eastern steppe ecosystems in terms of increasing aridity during the last 70 years. As estimated average annual temperature has increased by approximately 0.7oC, soil moisture, energy supply has been changing. These processes closely interrelated into water and energy cycle of steppe ecosystem.

Hybrid Motion Planning Method for Autonomous Robots Using Kinect Based Sensor Fusion and Virtual Plane Approach in Dynamic Environments

Tuvshinjargal, Doopalam,Dorj, Byambaa,Lee, Deok Jin Hindawi Limited 2015 Journal of sensors Vol.2015 No.-

<P>A new reactive motion planning method for an autonomous vehicle in dynamic environments is proposed. The new dynamic motion planning method combines a virtual plane based reactive motion planning technique with a sensor fusion based obstacle detection approach, which results in improving robustness and autonomy of vehicle navigation within unpredictable dynamic environments. The key feature of the new reactive motion planning method is based on a local observer in the virtual plane which allows the effective transformation of complex dynamic planning problems into simple stationary in the virtual plane. In addition, a sensor fusion based obstacle detection technique provides the pose estimation of moving obstacles by using a Kinect sensor and a sonar sensor, which helps to improve the accuracy and robustness of the reactive motion planning approach in uncertain dynamic environments. The performance of the proposed method was demonstrated through not only simulation studies but also field experiments using multiple moving obstacles even in hostile environments where conventional method failed.</P>

Efficient Reactive Path Planning Method for Mobile Robot, Using Kinect Based Sensor Fusion in Dynamic Environment

Doopalam Tuvshinjargal(두팔람 툽신자갈),Byambaa Dorj(비얌바 도리),Kil To Chong(정길도),Deok Jin Lee(이덕진) 대한기계학회 2014 대한기계학회 춘추학술대회 Vol.2014 No.4

Researching the success in Universiade of Mongolian teams and athletes

( Namjil. D. Tuvshinjargal ) 한국체육학회 2015 국제스포츠과학 학술대회 Vol.2015 No.1

키넥트 센서를 이용한 동적 환경에서의 효율적인 이동로봇 반응경로계획 기법

두팔람 툽신자갈(Doopalam Tuvshinjargal),이덕진(Deok Jin Lee) 대한기계학회 2015 大韓機械學會論文集A Vol.39 No.6

본 논문에서는 동적 움직임을 갖는 장애물이 위치한 주행환경에서 이동로봇의 충돌회피 기능을 포함하는 효율적인 반응경로계획 기법을 제안하고자 한다. 로봇의 동적 장애물과의 충돌회피 기능을 위해서 반응경로계획기법을 기반으로 키넥트센서를 이용한 센서융합기법의 보완을 통해서 자율주행의 강건성을 증대시키고자 하였다. 반응경로기법에서 사용된 접근방식은 동적장애물을 가상좌표평면에서 지역관측기개념을 이용하여 정적장애물로 좌표변환을 가능하게하며, 생성된 가상평면에서의 로봇과 장애물의 충돌 발생 가능한 속도와 경로의 운동학적 정보추출이 가능하게 된다. 또한 키넥트 센서 정보를 융합하여 장애물의 방향과 위치 정보를 추정하여 동적 환경에서의 주행성능의 정미도를 증대시키고자 하였다. 본 연구에서 제안 기술의 성능을 검증하기 위해서 임베디드 로봇플랫폼과 여러 개의 동적 장애물을 이용하여 시뮬레이션 해석 및 실험을 수행하였다. In this paper, an efficient dynamic reactive motion planning method for an autonomous vehicle in a dynamic environment is proposed. The purpose of the proposed method is to improve the robustness of autonomous robot motion planning capabilities within dynamic, uncertain environments by integrating a virtual plane-based reactive motion planning technique with a sensor fusion-based obstacle detection approach. The dynamic reactive motion planning method assumes a local observer in the virtual plane, which allows the effective transformation of complex dynamic planning problems into simple stationary ones proving the speed and orientation information between the robot and obstacles. In addition, the sensor fusion-based obstacle detection technique allows the pose estimation of moving obstacles using a Kinect sensor and sonar sensors, thus improving the accuracy and robustness of the reactive motion planning approach. The performance of the proposed method was demonstrated through not only simulation studies but also field experiments using multiple moving obstacles in hostile dynamic environments.

Multi-Sensor Fusion Based Effective Obstacle Avoidance and Path-Following Technology

Dorj, Byambaa,Tuvshinjargal, Doopalam,Chong, KilTo,Hong, Dong Pyo,Lee, Deok Jin American Scientific Publishers 2014 Advanced Science Letters Vol.20 No.10

탄소 중립을 위한 철도 건설 사업 온실가스 평가항목의 탄소흡수원 분야 환경영향평가 개선 방안 연구

황진후,Namuun Tuvshinjargal,원주희,김민정,박다혜,전성우 한국환경복원기술학회 2023 한국환경복원기술학회지 Vol.26 No.3

The railway project is an essential green transportation tool that is considered suitable for the domestic and foreign policy direction of carbon neutrality, but there are some limitations, such as damaging important carbon absorption sources during construction. This study analyzed the environmental impact assessment related to carbon absorption sources of greenhouse gas evaluation items conducted during the railway project, and limitations and implications were derived. The analysis of environmental impact assessment guidelines related to railway projects and carbon absorption sources dealt with prediction and reduction methods related to carbon absorption sources, but guidelines, including environmentally friendly railway construction guidelines, lacked descriptions. Since the greenhouse gas environmental impact assessment, 83 railway project environmental impact assessments have been reviewed, but in some cases, carbon absorption-related predictions have not been implemented, or carbon absorption-related reduction measures have been insufficient. In addition, there were cases where there was a limit to calculating emissions and reduction or where the reduction value was insignificant compared to emissions. In order to supplement the environmental impact assessment in the field of carbon absorption sources related to railway construction projects, alternatives such as quantitative emission and low reduction calculation, review of the no net loss system using the total environmental resource system, and linkage with climate change impact assessment are needed.

HBV : Prevalence and Genotype Distribution of Hepatitis B, C and D Viruses among Patients with Chronic Liver Diseases of Mongolia

( Oidov Baatarkhuu ),( N Tuvshinjargal ),( T Alimaa ),( B Tsatsralt Od ),( J Amarsanaa ),( H Okamoto ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background/aims: Mongolia is known for its high endemicity for HBV, HCV, and HDV infections among apparently healthy populations. However there are little or no data on the prevalence and genotype distribution of HBV, HCV and HDV among patients with chronic liver diseases in Mongolia. Materials and methods: Serum samples obtained in 2009 from 207 patients (51.0±1.9 years) including those chronic hepatitis (n=90), liver cirrhosis (n=41), and HCC (n=76) were tested for serological and molecular markers of HBV, HCV, and HDV infections. Results: Of the 207 patients, 144 (69.6%), 106 (51.2%), and 117 (56.5%) tested positive for HBsAg and HBV DNA , HCV RNA, and HDV RNA, respectively. Collectively, 172 patients (83.1%) were viremic for one or more of these viruses, including dual viremia of HBV/HDV (26.6%) or HBV/HCV (7.7%) and triple HBV/HCV/HDV viremia (30.0%). Of note, triple ongoing infection was significantly more frequent among patients with HCC than among those with chronic hepatitis (63.2%) vs. 14.4%, P≤0.0001). The distribution of HBV genotypes among the 116 HBV-viremic patients was: A (0.9%), B (0.9%), C (6.0%), D (88.8%), and C plus D(3.4%). All 117 HDV isolates were classified into genotype 1. The 106 HCV RNA positive samples were typed as genotype 1b (92.5%). Conclusions: The present study revealed that ongoing dual or triple infection of HBV, HCV and HDV is highly prevalent among patients with chronic liver diseases of Mongolia.