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Tumurbaatar Batgerel,Afeesh Rajan Unnithan,박찬희,김철생 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.4
This study introduces a new design of electromagnetic manipulation (EMM) system for wireless control of magnetic robots and magnetic nanoparticles for biomedical applications. It can generate a high-gradient magnetic field in the desired direction and forms the ponderomotive force distribution which allows the motion of magnetic robots in the specified direction. The real time microscopic-video supported by the LabVIEW vision system, the detection of object function through NI-Vision Assistant and tracking function through Math-Script node in the LabVIEW simulation. The motion speed and direction of the magnetic robotics/ nanoscale material can also be manipulated using EMM system and Joystick controller.
식도 스텐트 이동 및 내구성 시험을 위한 디자인과 실험적 분석
Tumurbaatar Batgerel,Ludwig Erik Aguilar,Felipe Vista IV,양승현,박찬희,김철생 제어·로봇·시스템학회 2019 제어·로봇·시스템학회 논문지 Vol.25 No.2
A stent fatigue and migration testing device was designed based on the mathematical analysis of fatigue mechanism of an esophageal stent and esophageal motility, in which the esophageal stent was assumed to be under simulated in vivo peristaltic movement. A system simulating an esophageal tube movement was developed using Arduino MEGA and LabVIEW LIFO interface. The precise detection of the esophageal stent migration model was done by combining camera image processing analysis and Flexible Pressure Sensor (FPS). An Arduino MEGA2560 was used as the control board for the real-time monitoring of non-vascular esophageal stents while a LabVIEW based software was designed to monitor in real time the FPS and Flexible Bend Sensor (FBS) as well as the image processing for the stent fatigue/migration testing. Experimental results verified that the system can test for a stent’s fatigue life and the corresponding recorded data can be used for optimizing esophagus design. The proposed system can be further upgraded to be able to evaluate other types of stents for non-vascular applications as well as stents that is made from experimental materials.
Obiweluozor, Francis O.,Tiwari, Arjun Prasad,Lee, Jun Hee,Batgerel, Tumurbaatar,Kim, Ju Yeon,Lee, Dohee,Park, Chan Hee,Kim, Cheol Sang Elsevier 2019 Materials science & engineering. C, Materials for Vol.99 No.-
<P><B>Abstract</B></P> <P>Here we developed a semi-interpenetrating network (IPN) hydrogel obtained by free radical polymerization to fabricate a coated stent with the aim of incorporating a natural topography present in the human body to improve biological activity. The method involves sandwiching a bare metal stent in the semi-IPN hydrogel via solution cast molding. The bio-functionality of the membrane could be tuned by incorporating Polydopamine into the matrix, and also the mechanical property was optimized by choosing an adequate concentration of acrylamide. The coating containing polydopamine hydrogel showed good mechanical stability under continuous flow condition, as demonstrated by crimping and deployment into a catheter without damage. Stent polymer bonding was enhanced via polydopamine incorporation in the matrix. The non-thrombogenicity of the coating containing hydrogel was confirmed through dynamic hemocompatibility studies in vitro. Vascular simulations, including other biomechanical performance, like durability testing, radial strength, and recoil, were demonstrated. The dopamine containing hydrogel membrane (DCHM) was found to promote cell material interaction due to the ability of the catechol to bind protein and induce HUVECs cytoplasmic spreading, proliferation, and migration, with reduced smooth muscle cell (SMCs) activity. SMCs inhibition correlated well with the amount of incorporated catechol in the matrix. Our results show that this material used as coated stent could be more effective in suppressing platelet aggregation with improved haemocompatibility/biocompatibility for faster re-endothelialization than bare metal stent (BMS).</P> <P><B>Highlights</B></P> <P> <UL> <LI> 2D modeling of hydrogel coated stent for improved hemodynamics in contrast to bare metal stent was proposed. </LI> <LI> Incorporating PU as a second network in the IPN hydrogel greatly improve the mechanical property. </LI> <LI> The fabricated membrane creates a stable coating that enable delivery via non-invasive approach (catheter). </LI> <LI> Incorporation of Polydopamine in the matrix enhance HUVECs viability/ proliferation and suppresses SMCs viability. </LI> </UL> </P>
Thomas, Reju George,Unnithan, Afeesh Rajan,Moon, Myeong Ju,Surendran, Suchithra Poilil,Batgerel, Tumurbaatar,Park, Chan Hee,Kim, Cheol Sang,Jeong, Yong Yeon Elsevier 2018 International journal of biological macromolecules Vol.110 No.-
<P><B>Abstract</B></P> <P>We prepared Janus microspheres based on sodium alginate for the encapsulation of mesenchymal stem cells (MSC) in one compartment and iron oxide nanoparticles (IONP) or a drug in the second compartment. 4% percent sodium alginate solution was allowed to pass through a septum-theta capillary device and react with 2.5% calcium chloride to allow crosslinking to occur in the solution, forming calcium alginate Janus microspheres. Physico-chemical characterization of microspheres was done by FTIR, TGA, and XRD after loading of stem cells and IONP/drug. The mechanical integrity of microspheres was tested at different time points, which showed that 4% alginate microspheres were mechanically stable for a long period of time. Live/dead staining of MSCs alone and the MTS assay of MSCs and DMSO co-loaded were performed, which showed less toxicity to MSC in the Janus configuration. IONP/MSC-loaded Janus microspheres were tested by magnetic manipulation for targeted MSC delivery for cartilage repair using an electromagnetic manipulation (EMM) device. Janus microspheres can be used for targeted stem cell/drug delivery using EMM for cartilage repair in the near future.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P> <P>Janus microsphere loaded with MSC’s and IONP/drug and injection to cartilage repair area.</P>
Ramachandra Kurup Sasikala, Arathyram,Unnithan, Afeesh Rajan,Thomas, Reju George,Batgerel, Tumurbaatar,Jeong, Yong Yeon,Park, Chan Hee,Kim, Cheol Sang The Royal Society of Chemistry 2018 Nanoscale Vol.10 No.41
<P>In order to meet the unmet medical needs for effective cancer treatment, multifunctional nanocarriers based on iron oxide nanoparticles hold tremendous promise. Here we report a superparamagnetic iron oxide nanoparticles based hexa-functional nanosystem for synergistic cancer theranostic applications by offering active tumour targeting, accumulation and complementary imaging capability by combining magnetic resonance imaging as well as near-infrared fluorescence, magnetophotothermia and chemotherapy. The uniquely designed nanosystem exhibited a paramount increase in the antitumour efficacy through the simultaneous application of multiple thermal effects called magnetophotothermia, which outweighed the therapeutic efficacy of the current thermo-chemo therapies or stand-alone therapies. The active tumour-seeking property with prolonged tumour accumulation and complementary imaging capability with improved sensitivity and resolution also augments the therapeutic efficacy of the proposed nanosystem. Additionally, the work proposes a deep-learning-based tumour cell nuclei detection technique from H&E stained images in anticipation of providing much inspiration for the future of precision histology.</P>