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Aguilar, Ludwig Erik,Thomas, Reju George,Moon, Myeong Ju,Jeong, Yong Yeon,Park, Chan Hee,Kim, Cheol Sang Elsevier 2018 EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEU Vol.129 No.-
<P><B>Abstract</B></P> <P>Chemothermal brachytherapy seeds have been developed using a combination of polymeric dual drug chemotherapy and alternating magnetic field induced hyperthermia. The synergistic effect of chemotherapy and hyperthermia brachytherapy has been investigated in a way that has never been performed before, with an in-depth analysis of the cancer cell inhibition property of the new system. A comprehensive <I>in vivo</I> study on athymic mice model with SCC7 tumor has been conducted to determine optimal arrays and specifications of the chemothermal seeds. Dual drug chemotherapy has been achieved via surface deposition of polydopamine that carries bortezomib, and also via loading an acidic pH soluble hydrogel that contains 5-Fluorouracil inside the chemothermal seed; this increases the drug loading capacity of the chemothermal seed, and creates dual drug synergism. An external alternating magnetic field has been utilized to induce hyperthermia conditions, using the inherent ferromagnetic property of the nitinol alloy used as the seed casing. The materials used in this study were fully characterized using FESEM, H<SUP>1</SUP> NMR, FT-IR, and XPS to validate their properties. This new approach to experimental cancer treatment is a pilot study that exhibits the potential of thermal brachytherapy and chemotherapy as a combined treatment modality.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Aguilar, Ludwig Erik,GhavamiNejad, Amin,Park, Chan Hee,Kim, Cheol Sang Elsevier 2017 NANOMEDICINE Vol.13 No.2
<P><B>Abstract</B></P> <P>A functional cover made up of core-shell nanofibers with a unique combination of thermoresponsive polymeric shell and stretchable polymeric core for non-vascular nitinol stents that uses an alternating magnetic field (AMF) to induce heat in the stent for hyperthermia therapy and simultaneously release 5-fluorouracil and/or paclitaxel was designed. Varying the ratios of NIPAAm to HMAAm monomer resulted in different LCST properties for the synthesized copolymer and further utilized for an on-demand drug release. Biocompatibility test using NIH-3T3 fibroblast cells indicates that the composite with drug content is biocompatible and the in-vitro cancer cytotoxicity test using ESO26 and OE21 cancer cells proved that the material shows cancer cytotoxic properties via combination of dual drug and hyperthermia therapy. With this functional material, we propose a tailorable and on-demand drug release with more control that can be employed for a combination drug therapy/single drug therapy combined with hyperthermia therapy for cancer cytotoxicity effect.</P> <P><B>Highlights</B></P> <P> <UL> <LI> First time in literature that poly(NIPAAm-co-HMAAm) nanofibers was used as a stent cover. </LI> <LI> Loading two different chemotherapeutic drugs on poly(NIPAAm-co-HMAAm) with two different LCST points creates an on-demand and tailorable drug delivery. </LI> <LI> Unique combination of Thermoresponsive polymer and Mechanically stable polymer on a core-shell nanofiber. </LI> <LI> Combination of Alternating Field Induced hyperthermia and Chemotherapy on a nitinol stent for cancer cytotoxic effects. </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>On-demand drug release and hyperthermia therapy applications of thermoresponsive poly-(NIPAAm-co-HMAAm)/polyurethane core-shell nanofiber mat on non-vascular nitinol stents.</P> <P>[DISPLAY OMISSION]</P>
Aguilar, Ludwig Erik,Unnithan, Afeesh Rajan,Amarjargal, Altangerel,Tiwari, Arjun Prasad,Hong, Seong Tshool,Park, Chan Hee,Kim, Cheol Sang Elsevier 2015 International journal of pharmaceutics Vol.478 No.1
<P><B>Abstract</B></P> <P>A nanofiber composite mat of PU and Eudragit<SUP>®</SUP> L100-55 was created using electrospinning process. The pH dependent release of paclitaxel was successfully done with the use of PU/EL100-55 nanocomposite mats as the controlling platform. The morphology of the nanofiber composites was surveyed using FESEM and ratios of the polymers affects the diameter of the nanofiber. Characterization of the nanofiber composite mat was done using FTIR, DSC-TGA method. The release rate of paclitaxel was determined and analyzed by in vitro drug release method. In order to mimic the condition of a human duodenum, the fibers were submersed on PBS of different pH levels (4.0, 6.0,) respectively, and then analyzed using high performance liquid chromatography (HPLC). Composite mats submersed in PBS with pH 4.0 showed lesser release profile compared to mats submersed in PBS with pH of 6.0. The composite mat has adequate mechanical properties and in vitro cell biocompatibility indicating that the material can be used for drug eluting stent cover application.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
식도 스텐트 이동 및 내구성 시험을 위한 디자인과 실험적 분석
Tumurbaatar Batgerel,Ludwig Erik Aguilar,Felipe Vista IV,양승현,박찬희,김철생 제어·로봇·시스템학회 2019 제어·로봇·시스템학회 논문지 Vol.25 No.2
A stent fatigue and migration testing device was designed based on the mathematical analysis of fatigue mechanism of an esophageal stent and esophageal motility, in which the esophageal stent was assumed to be under simulated in vivo peristaltic movement. A system simulating an esophageal tube movement was developed using Arduino MEGA and LabVIEW LIFO interface. The precise detection of the esophageal stent migration model was done by combining camera image processing analysis and Flexible Pressure Sensor (FPS). An Arduino MEGA2560 was used as the control board for the real-time monitoring of non-vascular esophageal stents while a LabVIEW based software was designed to monitor in real time the FPS and Flexible Bend Sensor (FBS) as well as the image processing for the stent fatigue/migration testing. Experimental results verified that the system can test for a stent’s fatigue life and the corresponding recorded data can be used for optimizing esophagus design. The proposed system can be further upgraded to be able to evaluate other types of stents for non-vascular applications as well as stents that is made from experimental materials.