Construction of DOPA-SAM multilayers with corrosion resistance via controlled molecular self-assembly

Ting Chen,Ming Yang,Hui Yang,Ruining Wang,Shujuan Wang,Hang Zhang,Xiaoyu Zhang,Zhijuan Zhao,Jinben Wang 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.69 No.-

Although nano “green” coatings with excellent corrosion resistance have attracted great attention, the inhibition efficiency is still limited due to the lack of knowledge about the correlation between molecular structure and anticorrosion performance. Here, we fabricated a series of 3,4-dihydroxy-l-phenylalanine adlayers on self-assembled monolayers (SAMs) with varying end groups. We found that both NH2 and CF3SAMs were more conducive to the adsorption of DOPA and a flat adsorption conformation was preferentially adopted, with the plane of the phenylene ring parallel to the surface via cation-π interactions or hydrophobic interactions, leading to a compact and dense adlayer. Such DOPA-SAM multilayers can effectively protect the substrate from corrosion by suppressing the diffusion of aggressive water and acid molecules as well as the electrodissolution of metals. The lowest corrosion current of adlayers reaches 6.96 μA cm−2 which is much lower than that of bare substrate and other anticorrosion surfaces reported previously. The results provide guidance on the design of green anticorrosion materials via selecting SAMs that bridge organic and metal interface.

Development and Validation of Nomograms to Provide Individualized Predictions of Sur-vival Benefits from Surgery in Patients with Intermediate/Advanced Hepatocel-lular Carcinoma

( Wen-tao Yan ),( Jia-he Wang ),( Ming-da Wang ),( Zheng Wang ),( Bing Quan ),( Ya-hao Zhou ),( Wei-min Gu ),( Hong Wang ),( Ting-hao Chen ),( Tian Yang ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: According to the BCLC treatment guidelines, surgery does not be recommended for intermediate/advanced hepatocellular carcinoma (HCC). In real world, however, liver resections are often performed in patients with intermediate/ advanced but resectable HCC, especially in the East. Methods: We retrospectively evaluated multicentric data of 1,325 patients newly diagnosed with intermediate/advanced HCC who underwent curative resection. We randomly divided the subjects into development (n = 875) and validation (n = 450) samples. Multivariate Cox proportional hazards models were developed and separately validated on the basis of patients’ clinicopathological variables assessed for associations with 1-year recurrence and 3-year mortality. The discriminatory accuracy of these models was compared with conventional tools by analyzing receiver operating characteristic (ROC) curves. Results: He statistical nomograms built based on performance status, Child-Pugh grade, portal hypertension, preoperative alpha-fetoprotein level, tumor rupture, largest tumor diameter, tumor number, macrovascular and microvascular invasion, and satellites had good calibration and discriminatory abilities, with c-indices of 0.70 (1-year recurrence) and 0.68 (3-year survival), respectively. These models showed satisfactory goodness-of-fit and discrimination abilities in the validation cohort (c-index, 0.68 for 1-year recurrence and 0.69 for 3-year survival). The areas under the ROC curve using these nomograms exceeded those of traditional staging systems, indicating superior discriminatory capability (c-indices, 0.60-0.63 and 0.56-0.62, respectively). Conclusions: Our proposed online nomograms, which present graphically postoperative prognostic models for recurrence and survival in patients with intermediate/advanced but resectable HCC, offer valuable guidance to surgeons and hepatologists for individually predicting survival benefits from surgery and planning recurrence surveillance and adjuvant therapy.

Preparation of Robust Aramid/Epoxy Composites through Enhancing the Interface Performance by Nanocoating Solution

Tingli Hu,Zengxiao Wang,Yutong Cao,Zu Ming Hu,Jun Rong Yu,Yan Wang 한국섬유공학회 2022 Fibers and polymers Vol.23 No.4

Aramid fiber reinforced composites (AFRC) have attracted considerable attention because of its high strength andmodulus. But the poor interface due to the smooth fiber surface and few active groups limits the application of the finalcomposites. In this study, robust AFRC was achieved via dip-coating approach. Instead of Kevlar fiber, sulfonefunctionalizedpoly(p-phthaloyl-p-phenylenediamine) (SPPTA) was served as precursor to prepare nanocoating solution. Byfurther grafting epichlorohydrin (ECH) and Shellac (SLC), the functional coating solution was obtained. After modification,the roughness and the polarity of the fiber were considerably improved. The modified AF/epoxy composites showedexcellent interfacial bonding and mechanical properties. For the sample grafted with SLC, the interfacial shear strength(IFSS) reached 43.7 MPa with a significant enhancement by 21.4 %; while the inter-laminar shear strength (ILSS) reached48.6 MPa with a reinforcement of 45.9 %. The flexural strength and tensile strength were increased to 283 MPa and831 MPa, indicating that the study provides an effective method to achieve high strength AFRC.

Process and product innovarions in vertically differentiated markets with network externalities

Ming-qing Xing,Lai-sheng Wang,Rui-ting Zhang 인하대학교 정석물류통상연구원 2009 인하대학교 정석물류통상연구원 학술대회 Vol.2009 No.10

We analyze product and process innovations in a vertically differentiated duopoly in market with externalities. Through assuming process innovation reduces marginal cost and product innovation improves product quality, we find that;(i) product and process innovations are complements (resp.substitutes) for the firm with low (resp. high) quality when the intensity of network externality is small; (ii) process innovation affects product innovation more intensely when exists network externality than not;(iii) network externality makes process R&D (resp. aggregate process R&D) outcome affected by the parameter of product innovation cost ;(iv) aggregate process R&D outcome in industry increases with network intensity; (v) the firm with higher initial efficiency invests more in process innovation and will obtain more demand and profit than the rival in equilibrium.

Localization and Size Estimation for Breaks in Nuclear Power Plants

Ting-Han Lin,Ching Chen,Shun-Chi Wu,Te-Chuan Wang,Yuh-Ming Ferng 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.1

Several algorithms for nuclear power plant (NPP) break event detection, isolation, localization, and size estimation are proposed. A break event can be promptly detected and isolated after its occurrence by simultaneously monitoring changes in the sensing readings and by employing an interquartile range-based isolation scheme. By considering the multi-sensor data block of a break to be rank-one, it can be located as the position whose lead field vector is most orthogonal to the noise subspace of that data block using the Multiple Signal Classification (MUSIC) algorithm. Owing to the flexibility of deep neural networks in selecting the best regression model for the available data, we can estimate the break size using multiple-sensor recordings of the break regardless of the sensor types. The efficacy of the proposed algorithms was evaluated using the data generated by Maanshan NPP simulator. The experimental results demonstrated that the MUSIC method could distinguish two near breaks. However, if the two breaks were close and of small sizes, the MUSIC method might wrongly locate them. The break sizes estimated by the proposed deep learning model were close to their actual values, but relative errors of more than 8% were seen while estimating small breaks’ sizes.

Enhancing antibacterial activity of geminized cationic amphiphilic polymer via structure control and self-assembly regulation

Ting Chen,Lianyu Zhao,Ziyuan Wang,Jishi Zhao,Yan Li,Hangyu Long,Ming Yang 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.90 No.-

A novel geminized amphiphilic polymer containing double cationic head groups and hydrophobic tails ineach structural unit (denoted as PAGBn), has been prepared in our study. The self-assembly behavior onthe solid/liquid interface was investigated by quartz crystal microbalance with dissipation (QCM-D),steady-statefluorescence, dynamic light scattering (DLS) and transmission electron microscope (TEM). Atwo-regime buildup can be observed, where thefirst regime is attributed to the rapid adsorption ofpolymers, while a rearrangements of pre-adsorbed molecules and their aggregation on the surfacedominate the second regime, exhibiting a formation of aggregates in large sizes due to the effect of thecharge density and hydrophobes on the self-assembly process. It exhibits a drastically enhanced killingefficiency of99.9% against both of Staphylococcus aureus and Escherichia coli bacteria for PAGBncompared with other traditional single-chained polymers, through the reinforced synergistic effect ofelectrostatic and hydrophobic interactions, and the formation of large-sized polymer aggregates,encompassing and killing the bacteria more efficiency. Ourfindings reveal the antibacterial mechanismand the correlation between antibacterial activity and aggregates structure, providing a basis for thedevelopment of super-antibacterial materials in the infection resistant applications.

Galangin Prevents Acute Hepatorenal Toxicity in Novel Propacetamol-Induced Acetaminophen-Overdosed Mice

Ming-Shiun Tsai,Chia-Chih Chien,Ting-Hui Lin,Chia-Chi Liu,Rosa Huang Liu,Hong-Lin Su,Yung-Tsung Chiu,Sue-Hong Wang 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.11

Acetaminophen (APAP) overdose causes severe liver and kidney damage. APAP-induced liver injury (AILI) represents the most frequent cause of drug-induced liver failure. APAP is relatively insoluble and can only be taken orally; however, its prodrug, propacetamol, is water soluble and usually injected directly. In this study, we examined the timedependent effects of AILI after propacetamol injection in mice. After analyses of alanine aminotransferase and aspartate aminotransferase activities and liver histopathology, we demonstrated that a novel AILI mouse model can be established by single propacetamol injection. Furthermore, we compared the protective and therapeutic effects of galangin with a known liver protective extract, silymarin, and the only clinical agent for treating APAP toxicity, N-acetylcysteine (NAC), at the same dose in the model mice. We observed that galangin and silymarin were more effective than NAC for protecting against AILI. However, only NAC greatly improved both the survival time and rate consequent to a lethal dose of propacetamol. To decipher the hepatic protective mechanism(s) of galangin, galangin pretreatment significantly decreased the hepatic oxidative stress, increased hepatic glutathione level, and decreased hepatic microsomal CYP2E1 levels induced by propacetamol injection. In addition, propacetamol injection also reproduced the probability of APAP-induced kidney injury (AIKI), appearing similar to a clinical APAP overdose. Only galangin pretreatment showed the protective effect of AIKI. Thus, we have established a novel mouse model for AILI and AIKI using a single propacetamol injection. We also demonstrated that galangin provides significant protection against AILI and AIKI in this mouse model.

Fatty Acid Profile of Muscles from Crossbred Angus-Simmental, Wagyu-Simmental, and Chinese Simmental Cattles

Ting Liu,Jian-Ping Wu,Zhao-Min Lei,Ming Zhang,Xu-Yin Gong,Shu-Ru Cheng,Yu Liang,Jian-Fu Wang 한국축산식품학회 2020 한국축산식품학회지 Vol.40 No.4

This study assessed breed differences in fatty acid composition and meat quality of Longissimus thoracis et lumborum (LTL) and semitendinosus (SE) of Angus× Chinese Simmental (AS), Wagyu×Chinese Simmental (WS), and Chinese Simmental (CS). CS (n=9), AS (n=9) and WS (n=9) were randomly selected from a herd of 80 bulls which were fed and managed under similar conditions. Fatty acid profile and meat quality parameters were analyzed in duplicate. Significant breed difference was observed in fatty acid and meat quality profiles. AS exhibited significantly (p<0.05) lower C16:0 and higher C18:1n9c compared with CS. AS breed also had a tendency (p<0.10) to lower total saturated fatty acid (SFA), improve C18:3n3 and total unsaturated fatty acid (UFA) compared with CS. Crossbreed of AS and WS had significantly (p<0.05) improved the lightness, redness, and yellowness of muscles, and lowered cooking loss, pressing loss, and shear force compared with CS. These results indicated that fatty acid composition and meat quality generally differed among breeds, although the differences were not always similar in different tissues. Fatty acid composition, meat color, water holding capacity, and tenderness favored AS over CS. Thus, Angus cattle might be used to improve fatty acid and meat quality profiles of CS, and AS might contain better nutritive value, organoleptic properties, and flavor, and could be potentially developed as an ideal commercial crossbreed.

Human-Oriented Recognition for Intelligent Interactive Office Robot

Chia-Ming Wang,Shin-Huan Tseng,Pei-Wen Wu,Yuan-Han Xu,Chien-Ke Liao,Yu-Chi Lin,Yi-Shiu Chiang,Chung-Dial Lim,Ting-Sheng Chu,Li-Chen Fu 제어로봇시스템학회 2013 제어로봇시스템학회 국제학술대회 논문집 Vol.2013 No.10

This paper presents our new intelligent interactive robot, which is constructed to eagerly provide multi-functional services in an office environment. In order to endow a full interactive capability of our robots for realizing so-called human-robot interaction (HRI), we propose sensor fusion based human detection and tracking system and human pose estimation to deal with a number of situations which may take place in the office environment. Not only by these perceptions, human interact with the robot also by some natural way, such as touching the interface screen and talking with the robot through microphone. Finally, the effectiveness of the proposed work is tested and validated by some of experiments.

Grain Size Effect on Multi-Stage Micro Deep Drawing of Micro Cup with Domed Bottom

Wen Ting Li,Ming Wang Fu,Ji Lai Wang,Bao Meng 한국정밀공학회 2016 International Journal of Precision Engineering and Vol.17 No.6

A two-stage micro deep drawing system was designed and developed to manufacture a micro cup with domed bottom. The copper blank was annealed at three different conditions to obtain different grain sizes in such a way to study the grain size effect on the deformation behavior and thickness variation of the micro part. To investigate the instantaneous effect and deformation behavior, finite element simulation was used to simulate the whole drawing process. It revealed that the fracture in the place with the thinnest thickness in the micro part drawn from a circle blank with residual stress induced in blanking can be easily happen and the deformation load in the first-stage decreases more than that in the second-stage with the increase of grain size. Moreover, the micro part with a larger grain size has more nonuniform thickness and severer thinning around the punch corner. The surface roughness at the bottom of micro part increases with the grain size. The surface roughness at the wall of it, however, decreases with the deformation stage mainly due to the ironing effect. The research promotes the understanding of grain size effect on multi-stage micro deep drawing and facilitates the development of microforming process.