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( Tian Zhou Liu ),( Bang Xing Wang ),( Jin Tao Guo ),( Yang Zhou ),( Mugweru Julius ),( Moses Njire ),( Yuan Yuan Cao ),( Tian Wu ),( Zhi Yong Liu ),( Chang Wei Wang ),( Yong Xu ),( Tian Yu Zhang ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.9
The combination of trimethoprim (TMP) and sulfamethoxazole (SMX) has been shown to be active against Mycobacterium tuberculosis (Mtb) in clinical tuberculosis (TB) treatment. However, the mechanism of action of TMP-SMX against Mtb is still unknown. To unravel this, we have studied the effect of TMP and SMX by deleting the folP2 gene in Mycobacterium smegmatis (Msm), and overexpressing the Mtb and Msm folP1/2 genes in Msm. Knocking out of the folP2 gene in Msm reduced the minimum inhibitory concentration of SMX 8-fold compared with wild type. Overexpression of the folP1 genes from Mtb and Msm increased the MICs by 4- and 2-fold in Msm for SMX and TMP, respectively. We show a strong correlation between the expression of folP1 and folP2 genes and TMP-SMX resistance in mycobacteria. This suggests that a combination of FolP2 inhibitor and SMX could be used for TB treatment with a better outcome.
Frequently Occurring Reconnection Jets from Sunspot Light Bridges
Tian, Hui,Yurchyshyn, Vasyl,Peter, Hardi,Solanki, Sami K.,Young, Peter R.,Ni, Lei,Cao, Wenda,Ji, Kaifan,Zhu, Yingjie,Zhang, Jingwen,Samanta, Tanmoy,Song, Yongliang,He, Jiansen,Wang, Linghua,Chen, Yaji American Astronomical Society 2018 The Astrophysical journal Vol.854 No.2
Tian Tan,Jinsong Dai,Shengye Lin,Yongjie Cao,Maosen Wang 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.6
Cabin opening attitude of prefabricated fragment projectiles has a great impact on target damage probability. To address this issue, this study proposed a method for calculating damage probability based on gridding the target, which can estimate target damage probability under different cabin opening attitudes of projectile. To obtain the optimal cabin opening attitude of the projectile, an improved PSO algorithm named S-ACPSO was proposed, which has adaptive adjustment ability predicated on the sigmoid function and the particle diversity. To verify this method, a UAV target example was analyzed. The numerical result showed that the maximum target damage probability was 0.6847 under the optimal attitude. Following this, the influence of attitude parameters on the target damage probability was analyzed, which showed that the method in this study was feasible.
Tian, Shu-Bo,Yu, Jian-Chun,Kang, Wei-Ming,Ma, Zhi-Qiang,Ye, Xin,Cao, Zhan-Jiang,Yan, Chao Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15
Our aim was to investigate the value of combined detection of serum carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9, CA 242 and CA 50 in diagnosis and assessment of prognosis in consecutive gastric cancer patients. Clinical data including preoperative serum CEA, CA 19-9, CA 242, and CA 50 values and information on clinical pathological factors were collected and analyzed retrospectively. Univariate and multivariate survival analyses were used to explore the relationship between tumor markers and survival. Positive rates of tumor markers CEA, CA 19-9, CA 242 and CA 50 in the diagnosis of gastric cancer were 17.7, 17.1, 20.4 and 13.8%, respectively, and the positive rate for all four markers combined was 36.6%. Patients with elevated preoperative serum concentrations of CEA, CA 19-9, CA 242 and CA 50, had late clinical tumor stage and significantly poorer overall survival. Five-year survival rates in patients with elevated CEA, CA 19-9, CA 242 and CA 50 were 28.1, 25.8, 27.0 and 24.1%, respectively, compared with 55.0, 55.4, 56.4 and 54.5% in patients with these markers at normal levels (p<0.01). In multivariate Cox proportional hazards analyses, an elevated CA 242 level was determined to be an independent prognostic marker in gastric cancer patients. Combined detection of four tumor markers increased the positive rate for gastric cancer diagnosis. CA 242 showed higher diagnostic value and CA 50 showed lower diagnostic value. In resectable gastric carcinoma, preoperative CA 242 level was associated with disease stage, and was found to be a significant independent prognostic marker in gastric cancer patients.
Research on Landing Impact Characteristic Of Multi-Wheel Bogie Landing gear's Truck
Cao, Xin,Jia, Yuhong,Tian, Jiajie The Society for Aerospace System Engineering 2015 International Journal of Aerospace System Engineer Vol.2 No.2
Taking the four-wheel bogie landing gear as an example, the force status of truck-like landing gear during the landing impact was analyzed and the simulation model of four-wheel bogie landing gear was established. Firstly, a landing gear prototyping model was established using CATIA and imported to LMS Virtual.lab. Secondly, dynamic analysis of the landing impact was simulated with the established model. Finally, with the help of LMS Virtual.lab's parametric design ability, the effects of landing approach and truck pitch angle on the landing performance, truck motion and truck beam strength were studied. These conclusions will be useful to the design and analysis of the truck.
Rui Tian,Chun-Hua Yang,Xiao-Fei Wei,Er-Na Xun,Ren Wang,Shu-Gui Cao,Zhi Wang,Lei Wang 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.2
Aeropyrum pernix esterase (APE1547) was successfully used to catalyze the enantioselective transesterification of (R/S)-2-methyl-1-butanol in an ionic liquid (IL). Effects of various reaction conditions on the synthetic activity of the enzyme as well as enantioselectivity, including the type of IL, acyl donor, temperature, water activity,and substrate molar ratio were inverstigated. APE1547showed good catalytic performance (activity > 0.8 μmol/min/mg, E > 25), and the enzyme-IL mixture was recycled five times with only a slight decrease in catalytic performance.
Xiaoyi Cao,Lin Chen,Lang Tian,Xiaolian Jiang 한국간호과학회 2015 Asian Nursing Research Vol.9 No.4
Purpose: The purposes of the study were to examine psychological distress and health-related quality of life (HRQoL) in relocated and nonrelocated survivors aged 60 years and older, and to analyze predictors for psychological distress and HRQoL in older survivors 5 years after the 2008 Sichuan earthquake. Methods: This was a cross-sectional descriptive study with 112 relocated older survivors and 156 nonrelocated older survivors. Our study used a multistage sampling method. The measurements used in the study included self-reporting questionnaire-20, medical outcomes study 36-item short form health survey, and an instrument measuring demographic and disaster-related characteristics. Descriptive and multiple linear regression analysis were performed to determine factors that contributed to psychological distress and HRQoL. Results: The prevalence of psychological distress in relocated group (20.5%) was significantly higher compared to those in nonrelocated group (4.8%). Scores for HRQoL in relocated older survivors was significantly lower than those in nonrelocated older survivors. Relocation from preearthquake residence was the most significant predictor for psychological distress and HRQoL in the total sample. Other predictors were advanced age, lower educational level, the loss of family members during the earthquake, and the presence of chronic illnesses as well as the death of a spouse after the earthquake. Conclusions: Strategies can be designed in postdisaster recovery program, particularly for older survivors at high risk for psychological distress and poor HRQoL.
Shuo Cao,Xin Chen,Shengfa Pan,Yinze Diao,Yanbin Zhao,Tian Xia,Weishi Li,Feifei Zhou,Yu Sun 대한척추신경외과학회 2022 Neurospine Vol.19 No.4
Objective: To report concave-side distraction technique to treat congenital cervical scoliosis in lower cervical and cervicothoracic spine. To evaluate and compare clinical and radiographic results of this procedure with classic hemivertebra resection procedure. Methods: This study reviewed 29 patients in last 13 years. These patients were divided into convex-side resection group (group R) and concave-side distraction group (group D). Radiographic assessment was based on parameter changes preoperatively, postoperatively and at last follow-up. Demographic data, surgical data and complications were also evaluated and compared between the 2 groups. Results: In group R, mean age was 8.9 ± 3.3 years and follow-up was 46 ± 18 months. Operation time and blood loss averaged 500 ± 100 minutes, 703 ± 367 mL. In group D, mean age was 9.9 ± 2.8 years and follow-up was 34 ± 14 months. Operation time and blood loss averaged 501 ± 112 minutes, 374 ± 181 mL. Structural Cobb angle was corrected from 29.4° ± 12.5° to 5.3° (2.1°–18.1°) (p = 0.001) and 33.7° ± 14.1° to 12.8° ± 11.4° (p < 0.001) in groups R and D. Compensatory Cobb angle had a spontaneous correction rate of 59.6% (40.0%–80.8%) and 59.7% ± 23.0% in groups R and D. Mandibular incline, clavicle angle and spine coronal balance were significantly improved at last follow-up in both groups. All correction rates were not statistically different between groups. However, group D had significant less blood loss (p < 0.001) and operation time (p = 0.004) per vertebra than group R. Seven patients developed C5 nerve root palsy and recovered by 6 months of follow-up. Conclusion: Both surgical procedures are safe and effective in correcting congenital cervical scoliosis. But concave-side distraction technique has less blood loss and time-consuming during surgery, which provides a better option for the treatment of congenital cervical scoliosis.
Catalytic transfer hydrogenation of 7-ketolithocholic acid to ursodeoxycholic acid with Raney nickel
He Tian,Xuejun Cao,Hongbin Zhao 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.2
Ursodeoxycholic acid was produced by the stereoselective reduction of 7-ketolithocholic acid. This hydrogenation reaction was catalyzed by the T-1 Raney nickel and potassium borohydride was used as hydrogen donor instead of inflammable hydrogen gas. Potassium tert-butoxide was introduced to improve yield of ursodeoxycholic acid from about 70% to a maximum of 94% by inducing the stereoselectivity on hydroxyl group at 40 8C and atmospheric pressure. Reduction reaction conditions such as amount of reactants, temperature and stirring speed were optimized. The whole process is safe and low-cost. Eventually, the product, ursodeoxycholic acid was characterized by IR, 1H NMR and 13C NMR spectra.