Simulation of a neutron imaging detector prototype based on SiPM array readout

Tang Mengjiao,Zhang Lianjun,Tang Bin,He Gaokui,Huang Chang,Zhao Jiangbin,Liu Yang 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.9

Neutron imaging technology as a means of non-destructive detection of materials is complementary to X-ray imaging. Silicon photomultiplier (SiPM), a new type of optical readout device, has overcome some shortcomings of traditional photomultiplier tube (PMT), such as high-power consumption, large volume, high price, uneven gain response, and inability to work in strong magnetic fields. Its application in the field of neutron detection will be an irresistible general trend. In this paper, a thermal neutron imaging detector based on 6 LiF/ZnS scintillation screen and SiPM array readout was developed. The design of the detector geometry was optimized by geant4 Monte Carlo simulation software. The optimized detector was evaluated with a step wedge sample. The results show that the detector prototype with a 48 mm 48 mm sensitive area can achieve about 38% detection efficiency and 0.26 mm position resolution when using a 300 mm thick 6 LiF/ZnS scintillation screen and a 2 mm thick Bk7 optical guide coupled with SiPM array, and has good neutron imaging capability. It provides effective data support for developing high-performance imaging detectors applied to the China Spallation Neutron Source (CSNS).

Comparative Evaluation of an Error Checking Approach for MPSoC

Tang Liu,Huang-Zhang Qin,Hou-Yi Bin,Fang-Feng Cai,Zhang-Hui Bing 보안공학연구지원센터 2013 International Journal of Multimedia and Ubiquitous Vol.8 No.5

AUTONOMOUS LAND VEHICLE PATH PLANNING USING TERRAIN DATABASE

Bin, Zhang Shi,Wei, Tang Guo,Yue, Ma,Wen, Zhang Tian,Xiong, Zhang Shi 대한전자공학회 1992 HICEC:Harbin International Conference on Electroni Vol.1 No.1

We describe a new path planning system using terrain database. The system is adapt to the navigation of autonomous land vehicle under known environment such as road network without unknown moving obstacles. We discuss the terrain database structure, terrain representation, global path planning, local path planning under the direction of global path planning.

Resonant Frequency Estimation of Reradiation Interference at MF from Power Transmission Lines Based on Generalized Resonance Theory

Tang Bo,Chen Bin,Zhao Zhibin,Xiao Zheng,Wang Shuang 대한전기학회 2015 Journal of Electrical Engineering & Technology Vol.10 No.3

The resonant mechanism of reradiation interference (RRI) over 1.7MHz from power transmission lines cannot be obtained from IEEE standards, which are based on researches of field intensity. Hence, the resonance is ignored in National Standards of protecting distance between UHV power lines and radio stations in China, which would result in an excessive redundancy of protecting distance. Therefore, based on the generalized resonance theory, we proposed the idea of applying model-based parameter estimation (MBPE) to estimate the generalized resonance frequency of electrically large scattering objects. We also deduced equation expressions of the generalized resonance frequency and its quality factor Q in a lossy open electromagnetic system, i.e. an antennatransmission line system in this paper. Taking the frequency band studied by IEEE and the frequency band over 1.7 MHz as object, we established three models of the RRI from transmission lines, namely the simplified line model, the tower line model considering cross arms and the line-surface mixed model. With the models, we calculated the scattering field of sampling points with equal intervals using method of moments, and then inferred expressions of Pade rational function. After calculating the zero-pole points of the Pade rational function, we eventually got the estimation of the RRI’s generalized resonant frequency. Our case studies indicate that the proposed estimation method is effective for predicting the generalized resonant frequency of RRI in medium frequency (MF, 0.3~3 MHz) band over 1.7 MHz, which expands the frequency band studied by IEEE.

Expression of the CXCL12/SDF-1 Chemokine Receptor CXCR7 in Human Brain Tumours

Tang, Tian,Xia, Qing-Jie,Chen, Jian-Bin,Xi, Ming-Rong,Lei, Ding Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10

Purpose: Receptor 7 (CXCR7) has recently been characterized as a novel receptor for CXCL12/SDF-1 (stromal cell derived factor-1). Given the demonstrated importance of CXCL12/SDF-1 in angiogenesis and tumour metastasis, we hypothesized that CXCR7 may also play a role in tumour pathogenesis. Located in the limited space of the intracranial cavity, any brain tumours can be inherently serious and life-threatening. However, the expression of CXCR7 in pituitary adenoma, neurilemmoma or hemangioblastoma remains to be elucidated. Therefore, we aimed to determine the potential contribution of CXCR7 in the development of brain tumours. Methods: In this study we examined and quantified the mRNA expression of CXCR7 in four different human brain tumours - 27 patients with neurilemmoma (8 patients), pituitary adenoma (7 patients), hemangioblastoma (6 patients), or meningioma (6 patients) undergoing surgical resection in the West China Hospital of Sichuan University. There were 15 females and 12 males aged from 28 to 70 years old. Total RNA was isolated and mRNA was measured by quantitative real-time RT-PCR. One-way analysis of variance (ANOVA) was performed using SPSS 11.0 statistical software to compare the mRNA levels of CXCR7 among four groups. Results: We found that CXCR7 mRNA was detected in all tumour samples. Quantitative results showed that the levels of CXCR7 mRNA in brain tissues from patients with neurilemmoma or meningioma were significantly higher than those with pituitary adenoma or hemangioblastoma. Conclusions: The results suggest that the CXCR7 may play a role in progression, metastasis and angiogenesis of brain tumours.

SUV39H1 is a New Client Protein of Hsp90 Degradated by Chaetocin as a Novel C-Terminal Inhibitor of Hsp90

( Bin Lian ),( Qian Lin ),( Wei Tang ),( Xin Qi ),( Jing Li ) 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.1

Hsp90 is often overexpressed with activated form in cancer cells, and many key cellular proteins are dependent upon the Hsp90 machinery (these proteins are called “client protein”). Nowadays, more client proteins and more inhibitors of Hsp90 are being discovered. Chaetocin has been identified as an inhibitor of histone methyl transferase SUV39H1. Herein, we find that Chaetocin is an inhibitor of Hsp90 which binds to the C-terminal of Hsp90α. Chaetocin inhibited a variety of Hsp90 client proteins including AMl1-ETO and BCL-ABL, the mutant fusion-protein in the K562 and HL-60 cells. SUV39H1 mediates epigenetic events in the pathophysiology of hematopoietic disorders. We found that inhibition of Hsp90 by Chaetocin and 17-AAG had ability to induce degradation of SUV39H1 through proteasome pathway. In addition, SUV39H1 interacted with Hsp90 through co-chaperone HOP. These results suggest that SUV39H1 belongs to a client protein of Hsp90. Moreover, Chaetocin was able to induce cell differentiation in the two cells in the concentration range of Hsp90 inhibition. Altogether, our results demonstrate that SUV39H1 is a new client protein of Hsp90 degradated by Chaetocin as a novel C-terminal inhibitor of Hsp90. The study establishes a new relationship of Chaetocin and SUV39H1, and paves an avenue for exploring a new strategy to target SUV39H1 by inhibition of Hsp90 in leukemia.

Product Model Integrated with Carbon Footprint for Lowcarbon Design

Bin He,Wen Tang,Jun Wang 한국정밀공학회 2015 International Journal of Precision Engineering and Vol. No.

Greenhouse gas emission has become a recent global concern for green manufacturing. As the production is one of the main greenhouse gas emission sources, more and more researches have recently begun to pay attention to product low-carbon design. However, the traditional product modeling is easy to produce an obstacle for low-carbon design and lack of an effective integrated modeling approach to support knowledge reuse in product low-carbon design. This paper is devoted to presenting product model integrated with carbon footprint. After the carbon footprint meta-model is proposed, the product model integrated with carbon footprint for low-carbon design is proposed. And the corresponding modeling principles for product model are also discussed in detail. The product model of a magneto-rheological fluid absorber integrated with carbon footprint is used to demonstrate the proposed methodology.

Synergistic Effects of Polypropylene and Glass Fiber on Mechanical Properties and Durability of Recycled Aggregate Concrete

Bin Lei,Wengui Li,Huajian Liu,Zhuo Tang,Vivian W. Y. Tam 한국콘크리트학회 2020 International Journal of Concrete Structures and M Vol.14 No.5

To better understand the synergistic effects of combined fibers on mechanical properties and durability of recycled aggregate concrete (RAC), different types of fibers with various lengths and mass ratios were adopted in this study. Experimental investigations were conducted to study the 28-day compressive strength and strength loss after exposed to salt-solution freeze–thaw cycles and the coupled action of mechanical loading and salt-solution freeze–thaw cycles. The microstructure was also characterized to evaluate the mechanism of this synergistic effect. To determine the effectiveness of the combined fibers on improving the mechanical properties and durability of RAC, the synergistic coefficient was proposed and applied for various combinations of fibers. The results indicate that the incorporation of fibers slightly decreased the 28-day compressive strength of RAC, but combining different sizes and types of fibers can mitigate this negative effect. Moreover, the incorporation of fibers greatly improves the freeze–thaw resistance of RAC. The combining different fibers exhibited a synergistic effect on the enhancement in properties of RAC, which could not be predicted with only one simplistic rule of fibre mixtures. In addition, microstructural characterization shows that the bonding strength of the interfacial transition zone (ITZ) between the fiber and cement matrix is mainly determined by the chemical bonding force which is due to the hydration reaction between fiber surface and cement matrix.

Identification of loci affecting teat number by genome-wide association studies on three pig populations

Tang, Jianhong,Zhang, Zhiyan,Yang, Bin,Guo, Yuanmei,Ai, Huashui,Long, Yi,Su, Ying,Cui, Leilei,Zhou, Liyu,Wang, Xiaopeng,Zhang, Hui,Wang, Chengbin,Ren, Jun,Huang, Lusheng,Ding, Nengshui Asian Australasian Association of Animal Productio 2017 Animal Bioscience Vol.30 No.1

Objective: Three genome-wide association studies (GWAS) and a meta-analysis of GWAS were conducted to explore the genetic mechanisms underlying variation in pig teat number. Methods: We performed three GWAS and a meta-analysis for teat number on three pig populations, including a White Duroc${\times}$Erhualian $F_2$ resource population (n = 1,743), a Chinese Erhualian pig population (n = 320) and a Chinese Sutai pig population (n = 383). Results: We detected 24 single nucleotide polymorphisms (SNPs) that surpassed the genome-wide significant level on Sus Scrofa chromosomes (SSC) 1, 7, and 12 in the $F_2$ resource population, corresponding to four loci for pig teat number. We highlighted vertnin (VRTN) and lysine demethylase 6B (KDM6B) as two interesting candidate genes at the loci on SSC7 and SSC12. No significant associated SNPs were identified in the meta-analysis of GWAS. Conclusion: The results verified the complex genetic architecture of pig teat number. The causative variants for teat number may be different in the three populations

RGS2 promotes estradiol biosynthesis by trophoblasts during human pregnancy

Tang Chao,Jin Meiyuan,Ma Bingbing,Cao Bin,Lin Chao,Xu Shouying,Li Jiayong,Xu Qiang 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

Production of estradiol (E2) by the placenta during human pregnancy ensures successful maintenance of placental development and fetal growth by stimulating trophoblast proliferation and the differentiation of cytotrophoblasts into syncytiotrophoblasts. Decreased levels of E2 are closely associated with obstetrical diseases such as preeclampsia (PE) in the clinic. However, the mechanisms underlying the inhibition of placental E2 biosynthesis remain poorly understood. Here, we report that regulator of G-protein signaling 2 (RGS2) affects E2 levels by regulating aromatase, a rate-limiting enzyme for E2 biosynthesis, by using human trophoblast-derived JEG-3 cells and human placental villus tissues. RGS2 enhanced the protein degradation of the transcription factor heart and neural crest derivatives expressed 1 (HAND1) by suppressing ubiquitin-specific protease 14 (USP14)-mediated deubiquitination of HAND1, resulting in the restoration of HAND1-induced trans-inactivation of the aromatase gene and subsequent increases in E2 levels. However, aromatase bound to RGS2 and repressed RGS2 GTPase activating protein (GAP) activity. Moreover, we observed a positive correlation between RGS2 and aromatase expression in clinical normal and preeclamptic placental tissues. Our results uncover a hitherto uncharacterized role of the RGS2-aromatase axis in the regulation of E2 production by human placental trophoblasts, which may pinpoint the molecular pathogenesis and highlight potential biomarkers for related obstetrical diseases.