기-액병류상향 고정층반응기에서 액체의 흐름과 축방향분산

함병호,조지훈,편무실,김태옥,손민일 明知大學校 産業技術硏究所 1996 産業技術硏究所論文集 Vol.15 No.-

For upward cocurrent gas-liquid flow in a fixed bed reactor, the flow and axial dispersion of liquid were investigated in an air-water-Zeolite particle system. Based on experimental residence time distributions, parameters of mixing models were evaluated with two proposed liquid mixing models: axial dispersion model with stagnant zone(DSM) and plug flow model with stagnant zone(PFM). Accordingly, the applicability and parameters of each mixing model were analyzed for various operating conditions. We found that the flow and axial mixing characteristics of liquid could be analyzed well by DSM and parameters were well estimated by curve fitting using trial and error method. Also, the fraction of stagnant zone was decreased with increasing liquid velocity, while the dimensionless mass transfer coefficient between dynamic and stagnant zones was increased, and these parameters estimated by DSM were lower than those by PFM. In dynamic zone, calculated Peclet number were increased with increasing liquid velocity and axial mixing characteristics of liquid tended to access to plug flow for the high liquid Reynolds number(about Re1>50). For the porous catalyst particle system the flow and axial mixing characteristics of liquid had nearly same tendency that for the nonporous particle(glass bead) system, while dimensionless mass transfer coefficient was lower value than that for it. In these conditions, correlations of these parameters were obtained for various operating conditions.

새로운 Ca^2+ 길항제의 혈압강하효과

함원훈,임태균,정윤성,정윤호,양재권,최원철 성균관대학교 약학연구소 1993 成均藥硏論文集 Vol.5 No.1

Diltiazem and nifedipine, have been used throughout the world as an effective antianginal and antihypertensive agent. In order to increase the activity of these drugs, we synthesized the diltiazem-nifedipine coupling compounds. These compounds^(1-8) were tested for antihypertensive effect. Unfortunately, these compounds didn't show any promising activities.

직업적 디메틸아세트아미드(Dimethylacetamide) 노출에 의해 집단적으로 발생한 독성간염

최태성,우극현,김진석,박완섭,함정오,정상재,유재영 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

목적 : DMAC에 노출된 후 집단적으로 발생한 독성 간염 7례보고. 방법 : 2000년 2월 신설된 스판덱스 섬유제조 공장에 근무하는 생산직 근로자 178명중 2000년 2월 부터 8월까지 7명이 간장질환이 발생하였다. 환례들의 나이는 23∼47세였고, 남자 5명, 여자 2명이었다. 이들에 대해 혈액검사, 간 초음파 검사 등의 임상검사와 작업장 조사를 실시하였다. 결과 : 근무 부서는 중합 1명, 방사 1명, 권취 4명, 그리고 포장 1명이며 평균근무기간은 10주였다. 주 호소 증상은 심한 피로감, 어지럼증 및 황달이었고, 검사실 소견상 독성간염의 소견을 보였다. A, B 및 C형 간염 표지자 검사는 모두 음성이었고, 간초음파 소견상 특이 소견이 없었다. 문진 상 알코올 성 간염을 일으킬 정도의 음주력이나 최근 약물 복용력을 가지고 있는 환례는 없었다. 입원 후 보존적인 치료로 모두 급속히 호전되었다. 초기에 발생했던 환례에서 퇴원후 DMAC에 재 노출되어 독성 간염이 재발되었다. 이후 모든 환례들은 퇴원 후 DMAC 비노출 부서로 전환하였고, 퇴원후 지속적인 추적검사에서 간 효소 수치가 완전히 정상화되었고, 정상화되는 기간은 1∼2개월 정도 소요되었다. 결론 : 환례들의 임상증상, 검사결파, 노출력 및 과거력상 DMAC에 의한 독성간염으로 추정된다. Dimethylacetamide is widely used in the production of plasics, resins, synthetic fibers, and gums and in purification and crystallization processes. Inhalation of the vapor or skin absorption of the liquid of dimethylacetamide (DMAC) can cause liver damage. Toxic hepatitis possibly attributable to DMAC exposure occurred in seven works among 178 employees who had worked on a new spandex-fiber production line. A large amount of DMAC is used as a spinning solvent for synthetic fibers in the factory. The patients were aged 23-47 years old and composed of five males and two females. They were involved in the process of polymerization(1 patient), spinning(1), take-up(4) and packaging(1). The mean duration of exposure was 10 weeks. They experienced fatigue, dizziness and jaundice. The patients showed elavated total bilirubln, alanlne aminotransferase (ALT), and aspartate aminotransferase (AST) levels. The serologic test for viral hepatitis A, B and C were negative, as were the abdominal ultrasonographic scans. Based on the presumptive diagnosis of DMAC-induced toxic hepatitis, they were removed from the workplaces. One or two months after removal from the work, the transaminase levels returned to normal. The patients had no history of significant alcohol use, blood transfusion, recent medication, and drug abuse. As a result, authors could not find any attributable cause of toxic hepatitis but the toxicity by DMAC exposure.

다공성 충전층반응기에서 기-액흐름양상의 전이와 액체체류량

손민일,함병호,조지훈,김태옥,장영준 明知大學校 産業技術硏究所 1996 産業技術硏究所論文集 Vol.15 No.-

For both downward and ward cement gas-liquid flow in a porous packed bed reactor the transition of gas-liquid flow pattern and liquid holdup were investigated experimentally in an air-water-Zeolite particle system. Experimental results showed that gas velocity at trickle-to-pulse flow transition boundary in the downflow system was decreased with increasing liquid velocity and that gas velocity at bubble-to-pulse flow transition boundary in the upflow system was nearly constant for lower liquid velocity, however, it was increased with increasing liquid velocity for turbulent flow region. We also found that the dynamic liquid holdup in the upflow system was higher than that in the downflow system and it was increased with increasing liquid velocity and with decreasing gas velocity. Furthermore,the dynamic liquid holdup was sensitively affected by liquid velocity at trickle flow in the downflow system while it was sensitively affected by gas velocity at bubble flow in the upflow system and at pulse flow in the downflow and upflow systems. For the porous particle system fluid velocities at gas-liquid flow transition boundaries and dynamic liquid holdup had nearly same that for the nonporous particle(glass bead) system.

점적상에서의 수력학 특성

조지훈,성기천,함병호,김태옥 明知大學校 産業技術硏究所 1991 産業技術硏究所論文集 Vol.10 No.-

Hydrodynamics was investigated in a trickle bed with spherical particles. Flow transition boundary, pressure drop, and liquid holdup were measured and analyzed in an air-water system. The results showed that liquid velocity at trickle-pulse transition boundary increased with increasing packing size and it decreased with increasing gas velocity, and that the theoretical model proposed was well applicable to predicted flow transition boundary. In the same operation conditions, flow characteristics was changed with operation mode because of liquid closslinking. Therefore, as the maximum gas velocity increased, pressure drop increased. Also, pressure drop increased with increasing fluid velocity and it increased with decreasing packing size, and the effect of gas velocity on pressure drop for higher liquid velocity was less than that for lower liquid velocity. Liquid holdup increased with increasing liquid velocity and it decreased with increasing packing size, and the influence of gas velocity on liquid holdup for pulse flow regime had larger than that for trickie flow regime. By contrast, the influence of packing size on liquid holdup for pulse flow regime had less that for trickle flow regime. In this conditions, correlations of pressure drop and liquid holdup were proposed in terms of Reynolds numbers of total fluids and liquid phase.

주요우울증이 근로자의 생산성에 미치는 영향 : WHO-HPQ(Health and Work Performance Questionnaire)를 이용한 예비연구

김원,황태연,함병주,이준석,최병휘,김세주,서용진,강은호,우종민 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

Objectives : Major depressive disorder (MDD) causes patients' distress and makes socioeconomic burden, both directly and indirectly. We used the concept of lost productive time (LPT) to estimate the indirect costs and calculated both absenteeism and presenteeism among workers with MDD. Mcthods : Depression group was recruited from workers visiting psychiatric outpatient clinic who had MDD without major physical or mental disorders (N= 106). Age and sex matched healthy control group was also recruited through advertisement (M=100). All participants completed a interview using WHO Health and Work Performance Questionnaire (HPQ), Job Stress Measurement Scale for Korean Employees, and Hamilton Rating Scale for Depression. Statistical analysis was performed with independent t-test or χ² test as characteristics of values (p=0.05). Results : The number of absence (0.94-day/month vs. 0.10-day/month, P=0.015) andthe numberofearly leaving (2.56-day/month vs. 0.24-day/month, P<0.001) were significantly higher in the depression group. Depression group evaluated their Perfor-mance level much lower than controls with significant value (5.16 vs. 7.62, P<0.001). In addition, depression group estimated their performance level during the last 4 weeks lower compared to the level of past 1-year (5.16 vs 6.63, P<0.001). The estimated costs of absenteeism in depression group were higher than controls by 2,520,000 Korean Won per year, and those of presenteeism were also higher by 4,880,000 Korean Won per year. The total costs of LPT in depression group were higher than controls by 7,400,000 Korean Won, which corresponds to 26% ofmean annual salary. In addition, the level of occupational stress, such as high demand and interpersonal conflict, was higher in the depression group. Conclusion : Major depressive disorder costs substantial productivity loss to workers and their company. Presenteeism imposes more time cost than absenteeism. Effectiveness trials are needed to devise cost-effective programs for the early detection and treatment of depression at the workplace.

저혈청 배지에서 인간 전골수세포(HL-60)를 이용한 tPA 생산과 세포사멸기작에 관한 연구

김현구,성기돈,김태호,안주희,함문선,박진서,이현용 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.1

tPA 생산과 세포 사멸의 연구를 하기 위해서 인간 전골수세포가 배양되었다. 연속 관류 배양하에서 최대 tPA 생산량은 324 ng/ml이며 최대 세포 농도는 5.27×10 exp (6) cells/ml였다. Phorbol ester를 넣었을 때 tPA 생산량은 420 ng/ml까지 향상되었다. 형광 현미경으로 관찰했을 때, apoptosis는 세포 배양 초기부터 중반까지 우세했고 빠른 교반 속도에서도 우세했다. 그러나 necrosis는 세포배양 말기와 동결된 세포가 해동 되었을 때 우세했다. HL-60 was cultivated to produce tPA (tissue-type plasminogen activator) and study the mechanism of cell death. Maximum cell density and tPA production were obtained as 5.27×10 exp (6) cells/ml and 324 ng/ml, respectively under perfusion cultivation. tPA production was enhanced to 420 ng/ml in adding 160 nM of phorbol ester. The cells were gradually differentiated to granulocytes rather than proliferation. By Fluorescent microscope, apoptosis was prevailed except the death phase and in high agitation speed, but necrosis was prevailed in thawed cells and during the latter periods of the cultivation. It was also proved that tPA was most produced in apoptosis. To obtain higher tPA productivity, the cells must be maintained in apoptosis, not necrosis phase when the cells were dying.

기-액병류상향 충전탑에서 액체체류량과 축방향혼합특성

조지훈,손민일,박용성,함병호,김태옥 明知大學校 産業技術硏究所 1993 産業技術硏究所論文集 Vol.12 No.-

For upward cocurrent gas-liquid flow in a packed column, holdup and axial mixing characteristics of liquid were investigated. In an air-water-glass bead system. liquid holdup and residence time distribution(RTD) were measured and Peclet number based on axial dispersion model was evaluated from experimental RTD. We found that liquid holdup was increased with increasing liquid velocity and size of packing material, and it was decreased with increasing gas velocity. Also, liquid holdup for the cocurrent up flow system was larger than that for the downflow system at the same experimental conditions. As increasing gas velocity, the in fluence of packing size and operation method on liquid holdup was reduced. The calculated Peclet number was not affected by gas velocity, and it was increased with increasing liquid velocity and with decreasing packing size. Furthermore, the effect of liquid velocity on Petlet number for higher liquid Reynolds number(Re1>70) was larger than that for lower Re1. In these conditions, correlations of the dynamic liquid holdup and the Bodenstein number were obtained.

Antioxidative Compounds from Quercus salicina Blume Stem

Jung-il Kim,Sungun Kim,Kyoung-tae Lee,In-hye Ham1,Ho-hyun Kim,Wan-Kyunn Whang 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.3

The chromatographic separation of MeOH extract from the Quercus salicina Blume Stem led to the isolation of five phenolic compounds. Using spectroscopic methods, the structures of these compounds were determined as D-threo-guaiacylglycerol 8-O- β-D-(6'-O-galloyl)glucopyranoside (1), 9-methoxy-D-threo-guaiacylglycerol 8-O- β-D-(6'-O-galloyl)glucopyranoside (2), 6"-O-galloyl salidroside (3), methyl gallate (4), quercetin (5). We measured radical scavenging activity with the DPPH method and the anti-lipid peroxidative efficacy on human LDL with TBARS assay, with the result that all these compounds exhibited the antioxidative activity.

[PE-0078] Study of Genome-wide association for fatty acid composition in Korean rice accessions

Tae-Ho Ham(Tae-Ho Ham),Ah-Rim Lee(Ah-Rim Lee),ByeongYong Jeong(ByeongYong Jeong),Soon-Wook Kwon(Soon-Wook Kwon),Joohyun Lee(Joohyun Lee) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-