Sertraline이 예측불가능한 경도의 만성적 스트레스를 가한 백서의 자당섭취량 및 체중에 미치는 영향

이기철,조선영,이정호,김현택 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 연구는 예측불가능한 경도의 만성적 스트레스를 백서에게 가하여 우울 상태에 준하는 상태를 유발한 후 sertraline을 투여하여 1% 자당용액 섭취량과 체중에 미치는 영향을 정상백서와 비교하고자 하였다. 연구방법 : 11가지 종류의 스트레스를 18마리의 백서에게 4주간에 걸쳐서 처리하여 우울상태에 준하는 자당섭취량의 저하를 확인하였다. 스트레스로 처리된 실험집단을 무작위로 sertraline 투여군(N=9)과 saline 투여군(N=9)으로 나누었으며 스트레스 처리를 하지 않은 18마리의 통제집단도 sertraline 투여군(N=9)과 saline 투여군(N=9)으로 나누었다. 실험집단과 통제집단은 이후 4주간에 걸쳐서 sertraline(4.29mg/Kg) 또는 saline(0.5cc)을 매일 복강내 주사하였다. 실험집단은 실험약물 주사 기간중 지속적으로 스트레스 처리를 하였다. 실험이 진행되는 전체기간중 매주마다 1% 자당섭취량과 체중을 8주간에 걸쳐서 측정하였다. 실험결과 : 1) 실험집단의 sertraline 투여군은 실험 1주와 4주사이에 자당섭취량의 유의한 증가가 있었다. 통제집단의 sertraline 투여군은 자당섭취량이 저하되는 경향을 보였으나 통계적으로 유의하지는 않았다. 2) 실험집단의 sertraline 투여군은 저하된 체중이 그대로 유지되었으며 통제집단이 sertraline 투여군은 실험 1주와 3주, 4주 사이에 유의한 체중의 증가를 보였다. 3) 실험집단과 통제집단은 자당섭취량과 체중사이에 유의한 상관을 보이지는 않았다. 결 론 : Sertraline은 만성적으로 예측불가능한 경도의 만성적 스트레스를 가한 백서에서 저하된 1% 자당섭취량을 원래상태로 회복시키는 소견을 보였으나 체중은 회복시키지 못하였다. 정상백서에서 sertraline은 1% 자당섭취량의 저하를 유발하였으나 체중에는 영향을 미치지 않았다. The study was designed to evaluate the effects of sertraline on 1% sucrose intake and weight change in rats with chronic unpredictable mild stress and normal controls. We applied 11 types of stress regimens and identified depressive behaviours in 18 Spraque-Dawley rats for 8 weeks. After 4 weeks of chronic unpredictable mild stress procedure, those 18 rats were stratified into a sertraline-treated subgroup and a saline subgroup. Also nonstressed 18 rats were stratified into the sertraline-treated subgroup and the saline subgroup and were started intraperitoneal injections of sertraline(4.29mg/Kg) or saline for rest of 4 weeks. The 1% sucrose intake and the body weight were checked on the 4th day of every week, over the 8 weeks of experiment. The results were as follows : 1). The sertraline-treated subgroup of chronic unpredictable mild stressed rats showed significant increase of 1% sucrose intake between the 1st week and the 2nd, the 3rd and 4th week, while the sertraline-treated subgroup of non-stressed rats showed decreasing trend for 1% sucrose intake. 2) The sertraline-treated subgroup of chronic unpredictable mild-stressed rats showed a sustained decrease of body weight, while the sertraline-treated subgroup of non-stressed rats showed a non-significant increase of body weight. 3) In the group subjected to chronic unpredictable mild stress, there were no significant correlations between 1% sucrose intake and body weight and also no correlations in the non-stressed group. In summary, sertraline had an effect on restoring the decreased 1% sucrose intake to normal condition but no effect on regaining the body weight in the chronic unpredictable mild stress-treated rats. Sertraline resulted in a decrease of 1% sucrose intake and no effect on body weight in the non-stressed rats.

비교언어학 및 유전학적 방법에 의한 한국어 기원의 탐구

이상억,이정빈,김선영,천종식 서울大學校 人文學硏究所 2003 人文論叢 Vol.48 No.-

In exploring the origins of the Korean language, there are three windows through which we may penetrate the mysteries of this difficult question: archaeological, genetic/ genomic, and linguistic. In this paper I will try to answer this question by looking mainly through the latter two windows. As many linguists have attempted to place the Korean language into the proper language family according to linguistic affinity, I also want to classify the Korean language with linguistically related languages, mainly the Altaic languages. The so-called Altaic linguistics is very unstable compared with the more rigorously documented Indo-European linguistics. The lack of sufficient evidence, such as a common indigenous lexicon, has made it difficult to ascertain the genetic relationships and origins of languages such as Korean, Japanese, Manchu-Tungusic (Man, Gold(i), Oroqen, Ewenke, Lamut, Nanay, etc.), Mongolian(Khalkha, Chakhar, Urat, Khorchin, Ordos, Buriat, Oirat, Kalmyt, Da(g)ur, Monguor, Yellow Uighur. etc.) and Turkish(Turkish, Turkmen(ian), Azerbaidjani, Uighur, Uzbek, Kumyk, Tatar, Kazakh, Kirg(h)iz, Yakut, Altai, and Chuvash, etc.), which are typically classified as Altaic. Recently Starostin(1991) claimed that Proto-Altaic had disappeared around the sixth century B.C. Other measures are needed to evaluate this hypothesis, though, since the intra-linguistic debate has not provided any clear evidence or breakthroughs. That is why we turn to genetics as an approach and incorporate the results to shed new light on the origins of the Korean language. It has been shown that analysis of mitochondrial DNA, transmitted through maternal lineage, can be used to test this kind of hypothesis. After collecting data from such ethnic groups as Korean, Japanese, Ewenke, Nanay, Khalkha, Buriat, and Turkish, we have investigated information on mtDNA(Mitochondrial DNA). While we do not use the popular STR markers on Y chromosomes, and other nuclear markers such as the gene encoding cytochrome B will b isolated by the polymerase chain reaction, as in the next study,. In reality, it was rather difficult to extract genes from hair-roots and saliva, especially when there were not many samples available for serious study. Yet, we could fill the void for Koreans in the map that shows the mitochondrial DNA types in Africans, Australian Aborigines, Caucasians, East Asians, Native Americans, and New Guineans. The nucleotide sequences were determined through phylogenetic analysis. If we can position the sequences from Koreans in the currently available genealogical tree based on mitochondrial DNA, we may be able to reassess the existing hypotheses on linguistic genealogy. However, because primordial remains or ancient fragment of linguistic evidence are not readily available in Korea due to special geo-political situations, the position of the Korean language has been left unattested in the genealogical tree based on languages. Nonetheless, there are some examples similar to the Altaic languages that are estimated to have been used in Korea, and using these we may draw the linguistic tree shown below. On the other hand, our investigation through which maternal lineage alone has well established a biological lineage can be reported as follows. Korean is not isolated from Japanese, and the sisterhood with Turkic is also strange because the similarity between Korean and Manchu-Tungusic is more convincing according to linguistic evidences. It looks to be difficult to conclude anything at this stage of research. However, we know the genetic methods are quite scientific, while the comparative linguistic study often relies on abstract reconstruction.

Quality characteristics of extruded meat analog from different soy protein sources supplemented with oyster mushroom and mealworm

Sunyoung Jung,Boram Park,Shinyoung Park,Jiho Choi,Chansoon Park 한국식품영양과학회 2022 한국식품영양과학회 학술대회발표집 Vol.2022 No.10

Obesity-related Behaviors and Health Outcomes in Middle-aged Men : A Structural Equation Modeling

Sunyoung Jung,Su-Jin Cho 한국간호과학회 2023 한국간호과학회 학술대회 Vol.2023 No.11

Challenges for future directions for artificial intelligence integrated nursing simulation education

Sunyoung Jung 한국여성건강간호학회 2023 여성건강간호학회지 Vol.29 No.3

Artificial intelligence (AI) has tremendous potential to change the way we train future health professionals. Although AI can provide improved realism, engagement, and personalization in nursing simulations, it is also important to address any issues associated with the technology, teaching methods, and ethical considerations of AI. In nursing simulation education, AI does not replace the valuable role of nurse educators but can enhance the educational effectiveness of simulation by promoting interdisciplinary collaboration, faculty development, and learner self-direction. We should continue to explore, innovate, and adapt our teaching methods to provide nursing students with the best possible education.

Erythroid Differentiation Regulator 1, an Interleukin 18-Regulated Gene, Acts as a Metastasis Suppressor in Melanoma

Jung, Min Kyung,Park, Yoorim,Song, Seok Bean,Cheon, So Young,Park, Sunyoung,Houh, Younkyung,Ha, Soogyeong,Kim, Hee Jung,Park, Jung Min,Kim, Tae Sung,Lee, Wang Jae,Cho, Byung Joo,Bang, Sa Ik,Park, Hyun The Society for Investigative Dermatology, Inc 2011 The Journal of investigative dermatology Vol.131 No.10

Erythroid differentiation regulator (Erdr1) was first discovered in mouse leukemia cell lines and functions as a stress-related survival factor. This study investigated whether Erdr1 regulates murine melanoma progression, as well as the mechanism involved in Erdr1-regulated metastasis. The expression of Erdr1 is negatively correlated with IL-18 expression, which has a pro-cancer effect in melanoma. To study the role of Erdr1 as an anti-cancer factor, cell migration, invasion, and proliferation were measured. Erdr1 overexpression markedly inhibited the level of cell migration, invasion, and proliferation in B16F10 cells in vitro. In addition, Erdr1 overexpression significantly suppressed melanoma lung colonization, metastasis, and tumor growth in vivo. To identify the factors involved in Erdr1-reduced metastasis, heat shock protein 90 (HSP90), a well-known stress protein and contributor to tumor metastasis, was examined. We found that HSP90 was significantly decreased in Erdr1-overexpressing cells. Functional analysis demonstrated that HSP90 small-interfering RNA transfection reduced the migration ability and metastasis of melanoma. In conclusion, Erdr1 shows a powerful anti-metastasis effect that leads to the ability to reduce the metastatic potential of murine malignant melanoma cells. Erdr1 is an anti-metastatic factor that may be a possible therapeutic target for treatment of melanoma.

Sleeping Beauty transposon system harboring HRAS, c-Myc and shp53 induces sarcomatoid carcinomas in mouse skin

JUNG, SUNYOUNG,RO, SIMON WEONSANG,JUNG, GEUNYOUNG,JU, HYE-LIM,YU, EUN-SIL,SON, WOO-CHAN D.A. Spandidos 2013 Oncology Reports Vol.29 No.4

<P>The Sleeping Beauty transposon system is used as a tool for insertional mutagenesis and oncogenesis. However, little is known about the exact histological phenotype of the tumors induced. Thus, we used immunohistochemical markers to enable histological identification of the type of tumor induced by subcutaneous injection of the HRAS, c-Myc and shp53 oncogenes in female C57BL/6 mice. The tumor was removed when it reached 100 mm<SUP>3</SUP> in volume. Subsequently, we used 13 immunohistochemical markers to histologically identify the tumor type. The results suggested that the morphology of the tumor was similar to that of sarcomatoid carcinoma.</P>

농산물 중 Spiropidion과 대사산물(SYN547435, SYN547305) 동시 시험법 개발

구선영 ( Sunyoung Gu ),이정미 ( Jung Mi Lee ),이한솔 ( Han Sol Lee ),이수정 ( Su Jung Lee ),신혜선 ( Hye-sun Shin ),강성은 ( Sungeun Kang ),정용현 ( Yong-hyun Jung ),문귀임 ( Gui Im Moon ) 한국환경농학회 2021 한국환경농학회 학술대회집 Vol.2021 No.-

Spiropidion은 tetramic acid 계열 살충제로 acetyl-CoA carboxylase를 표적화하여 지질의 생합성을 저해하며 진딧물, 흰파리, 총채벌레, 진드기 등을 방제하는 데 사용한다. 코덱스(Codex), 유럽(EU), 미국(EPA), 일본(JECRF)에서 미등록 농약으로 별도로 기준과 잔류물의 정의가 설정되어 있지 않으나, 신규 농약 등록 신청으로 공정시험법 마련이 필요함에 따라 본 연구에서는 농산물 중 spiropidion과 대사산물 2종(SYN547435, SYN547305)의 잔류량을 분석하기 위한 공정시험법을 마련하고자 하였다. Spiropidion과 대사산물의 물리 화학적 특성을 고려하여 아세토니트릴을 추출 용매로 사용하는 QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe)법을 이용하여 추출 및 정제조건을 확립한 후 LC-MS/MS를 분석기기로 선정하였다. Spiropidion 및 대사산물 2종의 결정계수(r2)는 모두 0.99 이상으로 우수하였으며 정량한계는 0.01 mg/kg으로 나타났다. 대표 농산물 5종(현미, 감자, 대두, 감귤, 고추)에 대하여 정량한계, 정량한계 10배, 정량한계 50배 수준으로 처리하여 회수율 실험을 한 결과 평균 회수율은(5반복) spiropidion의 경우 79.4-98.5%, SYN547435의 경우 82.5-104.6%, SYN547305의 경우 85.4-108.4%이었으며, 상대 표준편차(RSD)는 모두 7.2% 이하로 나타났다. 본 연구는 국제식품규격위원회 가이드라인(Codex Alimentarius Commission, CAC/GL 40-1993, 2003)의 잔류농약 분석 기준 및 식품의약품안전평가원의 ‘식품등 시험법 마련 표준절차에 관한 가이드 라인(2016)’에 적합한 수준이며, 향후 공정시험법으로 활용될 예정이다.

프리틴 소비자 세대를 위한 휴대폰 디자인 요소 연구

정선영(Jung Sunyoung),윤정식(Yoon Jeongshick) 한국디지털디자인학회 2010 디지털디자인학연구 Vol.10 No.1

아동의 휴대폰 사용 인구는 시대의 변화에 따라 증가되고 있다. 저출산과 초혼연령의 증가 1가구 1자녀 맞벌이 부부의 증가 등 사회적 영향으로 아동들의 소비 수준이 성인만큼 높아지고 있다. 소비물품 중 휴대폰은 아동들의 필수품으로 자리 잡아가고 있으며 아동 세대 중 프리틴(10세~13세)의 점유율이 가장 높다. 그러나 프리틴 세대를 고려한 휴대폰 디자인 요소에 대한 연구는 부족한 실정이다. 본 연구는 프리틴 세대에서 휴대폰 사용율의 증가 원인인 사회적 요인과 프리틴 소비자의 특성을 바탕으로 휴대폰의 디자인 니즈(needs)를 분석하여 프리틴 계층을 고려한 아동용 휴대폰 디자인 요소를 제안하고자 한다. 설문조사는 1차 프리테스트 ,2차 SD7점 척도를 통한 설문 FGI(Focus group interview)의 방식으로 진행하였다. 1 2차 설문을 통해 프리틴은 바탕화면과 글씨 폰트 아이콘의 색상과 모양 요소에서 다양함과 귀여움을 원했다. 카메라나 DMB 화면을 장식하는 다양한 프레임을 원했다. 이런 요구를 아동들의 신체 및 인지 발단 단계 요소를 고려하면서 휴대폰 디자인을 재구성 한다면 미래 프리틴 세대가 친근하게 접근하고 선호하는 휴대폰을 디자인 할 수 있다. 이는 휴대폰뿐만 아니라 프리틴 세대를 겨냥한 다른 디자인 제품에도 다양하게 활용할 수 있을 것으로 판단된다. The population of using cell phones by children is increasing by the change of ages. By the influence of less childbirth and increase of first marriage age 1 child in 1 family and the increase of two-paycheck couple children's consumption level is getting higher as adults. Cell phone is being placed as a children's nessesities it shows the highest share of Pre-teens. However the research of the design of cell phone concerning for Pre-teens is lacking. This research is trying to suggest a cell phone design concerning Pre-teen by analizing cell phone's design needs based on social factor which is a cause of the increase of cell phone's use and Pre-teen customer's specialty. We used FGI(Focus Group Interview) by answering 1st Pre-test 2nd questionaire through SD7 score measure. Through the 1st and 2nd questionaire Pre-teen wanted the diversity and cute in basis screen letter font icon's color and shape elements. They wanted a diverse frame which decorates the camera and DMB screen. If we reorganize cell phones concerning Pre-teen's body and recognition development step element we can design a friendly accessing and prefering cell phone to Pre-teen generation. It is estimated that variously utilize not only cell phones but also other design products focused on Pre-teen generation.

음악활동을 통한 유아인성교육프로그램 적용 효과

정선영(Jung, SunYoung),김영연(Kim, YoungYoun),홍순옥(Hong, Soon Ohk) 학습자중심교과교육학회 2016 학습자중심교과교육연구 Vol.16 No.8

본 연구의 목적은 음악활동을 통한 유아인성교육프로그램이 유아의 도덕성, 사회성, 감성 영역의 인성에 미치는 효과를 검증하는 것이다. 이를 위해 유아인성, 음악, 인성평가도구 관련 문헌을 고찰하였으며 3~5세 연령별 누리과정 교사용 지도서의 음악관련 내용 및 인성교육의 하위내용을 분석하여프로그램을 개발하였다. 프로그램의 적용은 P시의 유치원에 다니는 4세반 유아 72명(실험집단 유아 36명, 비교집단 유아 36명)을 연구대상으로 하였으며, 유아인성을 측정하기 위한 유아인성평가 도구 는 선행연구를 고찰하여 연구자가 개발하였다. 자료분석은 연구도구의 신뢰도를 알아보기 위해 신뢰도 계수 Cronbach s α 를 산출하였으며, 독립표본 t-검정, 공분산분석(ANCOVA)을 실시하였다. 연구결과, 첫째, 음악활동을 통한 유아인성교육프로그램을 적용한 실험집단의 유아가 비교집단의 유아보다 도덕성, 사회성, 감성 영역의 모든 인성영역에서 통계적으로 유의하게 높게 나타났다. 둘째, 음악활동을 통한 유아인성교육프로그램을 적용한 실험집단의 유아가 비교집단의 유아보다 도덕성, 사회성, 감성 영역의 인성내용 및 하위내용에서 통계적으로 유의하게 높게 나타났다. 따라서 음악활동을 통한 유아인성교육프로그램은 유아의 도덕성, 사회성, 감성 영역의 인성을 증진시키는 효과가 있음이 검증되었다. The purpose of this research was to examine the effect of the early childhood character education program through thirty one music activities for four-years-old children developed by the researcher. The program applied to the seventy two preschoolers in P city for fifteen weeks from September 2014 to January 2015. Subjects were divided into experimental group and control group with same number of thirty six children. Collected data was analyzed using SPSS 19.0. Cronbach a coefficient was calculated for reliability verification of the pre- and post character test score for children and ANCOVA was used to determine the effect of music activities in the early childhood character education program to the formation of children s character. This research showed the following as a result: The early childhood character education through musical activity program was effective in terms of increasing the characters such as respect, public order, being a good son or daughter, caring for others, sharing, cooperation, self-awareness, and self-control.