http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Yeo, Seung-Gu,Kim, Dae Yong,Kim, Tae Hyun,Chang, Hee Jin,Oh, Jae Hwan,Park, Won,Choi, Doo Ho,Nam, Heerim,Kim, Jun-Sang,Cho, Moon-June,Kim, Jong Hoon,Park, Jin-hong,Kang, Min Kyu,Koom, Woong Sub,Kim, J Lippincott Williams Wilkins, Inc. 2010 Annals of surgery Vol.252 No.6
OBJECTIVE:: To investigate long-term outcomes of locally advanced rectal cancer (LARC) patients with postchemoradiotherapy (post-CRT) pathologic complete response of primary tumor (ypT0) and determine prognostic significance of post-CRT pathologic nodal (ypN) status. BACKGROUND:: LARC patients with post-CRT pathologic complete response were suggested to have favorable long-term outcomes, but prognostic significance of ypN status has never been specifically defined in ypT0 patients. METHODS:: The Korean Radiation Oncology Group collected clinical data for 333 LARC patients with ypT0 following preoperative CRT and curative radical resections between 1993 and 2007. Sphincter preservation surgery and abdominoperineal resection were performed in 283 (85.0%) and 50 (15.0%) patients, respectively. Postoperative chemotherapy was given to 285 (85.6%) patients. Survival was estimated by the Kaplan-Meier method, and the Cox proportional hazard model was used in multivariate analyses. RESULTS:: After median follow-up of 43 (range = 14–172) months, 5-year disease-free survival (DFS) was 84.6% and overall survival (OS) was 92.8%. The ypN status was ypT0N0 in 304 (91.3%), ypT0N1 in 22 (6.6%), and ypT0N2 in 7 (2.1%) patients. The ypN status was the most relevant independent prognostic factor for both DFS and OS in ypT0 patients. The 5-year DFS and OS was 88.5% and 94.8% in ypT0N0 patients, and 45.2% and 72.8% in ypT0N+ patients (both, P < 0.001). CONCLUSIONS:: LARC patients achieving ypT0N0 after preoperative CRT had favorable long-term outcomes, whereas positive ypN status had a poor prognosis even after total regression of primary tumor.
Yeo, Seung-Gu,Kim, Dae Yong,Kim, Tae Hyun,Kim, Sun Young,Hong, Yong Sang,Jung, Kyung Hae BioMed Central 2010 Radiation oncology Vol.5 No.-
<P><B>Background</B></P><P>To investigate whether whole-liver radiotherapy (RT) is beneficial in end-stage colorectal cancer with massive liver metastases and severe hepatic dysfunction.</P><P><B>Methods</B></P><P>Between June 2004 and July 2008, 10 colorectal cancer patients, who exhibited a replacement of over three quarters of their normal liver by metastatic tumors and were of Child-Pugh class B or C in liver function with progressive disease after undergoing chemotherapy, underwent whole-liver RT. RT was administered using computed tomography-based three-dimensional planning and the median dose was 21 Gy (range, 21-30) in seven fractions. Improvement in liver function tests, defined as a decrease in the levels within 1 month after RT, symptom palliation, toxicity, and overall survival were analyzed retrospectively.</P><P><B>Results</B></P><P>Levels of alkaline phosphatase, total bilirubin, aspartate transaminase, and alanine transaminase improved in 8, 6, 9, and all 10 patients, respectively, and the median reduction rates were 42%, 68%, 50%, and 57%, respectively. Serum carcinoembryonic antigen level decreased after RT in three of four assessable patients. For all patients, pain levels decreased and acute toxicity consisted of nausea/vomiting of grade ≤ 2. Further chemotherapy became possible in four of 10 patients. Mean survival after RT was 80 ± 80 days (range, 20-289); mean survival for four patients who received post-RT chemotherapy was 143 ± 100 days (range, 65-289), versus 38 ± 16 days (range, 20-64) for the six patients who did not receive post-RT chemotherapy (<I>p </I>= 0.127).</P><P><B>Conclusions</B></P><P>Although limited by small case number, this study demonstrated a possible role of whole-liver RT in improving hepatic dysfunction and delaying mortality from hepatic failure for end-stage colorectal cancer patients with massive liver metastases. Further studies should be followed to confirm these findings.</P>
S-94 A comparison of endoscopic treatments for rectal carcinoid tumors
( Sang Myung Yeo ),( Jae Kwang Lee ),( Hyun Soo Kim ),( Chang Keun Park ),( Jae Kwon Jung ),( Dae Jin Kim ),( Ji Hun Jang ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Background and Aims: Carcinoid tumor are slow growing neoplasms developing from enterochromaffin cells. The incidence of rectal carcinoid tumors has increased markedly and a recent study reported that the rectum is the most common site of carcinoid tumor in the gastrointestinal tract. This study aimed to compare the safety and efficacy of endoscopic mucosal resection (EMR) with endoscopic submucosal dissection (ESD) for rectal carcinoid tumor. Patients and Methods: Between January 2004 to December 2014, 153 patients undewent either EMR (n=85) or ESD (n=68) for rectal carcinoid tumors. The characteristics of the patients and tumors, the rate of complete resection and the rate of complications were analyzed retrospectively. Results: Baseline characteristics showed no significant difference between the 2 groups. Data on clinical outcomes also showed no significant difference between the 2 groups except the procedure time. The procedure time in EMR group was significantly shorter than in ESD group. Conclusions: Our study shows that the treatment of rectal carcinoid tumor with ESD is not superior to EMR.