인공 슬관절 전치환술에서 음압 배액법의 효과

손승원,이경재,김철용 대한슬관절학회 2003 대한슬관절학회지 Vol.15 No.1

목적 : 본 연구의 목적은 슬관절 전치환술 후 음압 배액법을 사용한 군과 사용하지 않은 군을 비교함으로서 관절 치환술 후 보편적으로 사용되고 있는 음압 배액법의 장단점 및 그 필요성에 대해 알아보고자 함에 있다. 대상 및 방법: 1998년 1월부터 2000년 12월까지 본원에서 골시멘트를 사용하여 동시에 양측 슬관절 전치환술을 시행 받은 환자 중 음압 배액법을 사용한 50예를 Ⅰ군으로, 사용하지 않은 50예를 Ⅱ군으로 하여 외래 및 입원 기록지, 수술 기록지 등을 역행적으로 분서하였다. 술전 및 술후 대퇴 둘레의 길이, 반상출혈의 정도, 술후 발생한 창상 감염의 빈도, 수혈량, 술전 및 술후 슬관절 점수 및 슬관절 운동범위를 비교하였다. 결과 : 대퇴 둘레의 길이는 Ⅰ군에서 술전 평균 42.9 ㎝, 술 후 평균 46.1 ㎝이었고 Ⅱ군에서 술전 평균 43.7 ㎝, 술후 평균 47.6 ㎝ 이었으며, 술후 반상출혈은 Ⅰ군에서 22%, Ⅱ군에서 58%의 빈도로 발생하였다. 두 군 모두에서 술후 창상 감염은 발생하지 않았으며, 술후 3일째까지의 수혈양은 Ⅰ군에서 평균 1.94(0-4)unit, Ⅱ군에서 평균 1.86(0-4)unit였다. 술전 및 술후에 측정한 슬관절 점수는 두 군 모두에서 술후 6주째 만족할 만한 증가를 보였으며 슬관절 운동 범위의 회복 역시 두 군에서 비슷한 경과를 보였다. 결론 : 본 연구에서 인공 슬관절 전치환술 후 음압 배액법을 시행한 군에서 술후 창상의 경과나 임상적 및 재활적 측면에서 음압 배액법을 시행하지 않은 군과 유의할 만한 차이가 없는 것으로 나타나 인공 슬관절 전치환술 후 음압 배액법은 선택적으로 사용되어져야할 것으로 사료된다. Purpose: To assess the clinical comparison of closed suction drainage group and non drainage group after simultaneous bilateral total knee arthroplasty. Methods & Materials : We analyzed the thigh circumference, ecchymosis, wound infection, transfusion amount, knee score and range of motion in 100 cases(50 patients) done with PFC of PFC-sigma model between 1998 and 2000. Fifty cases of them(group Ⅰ) were inserted hemo vac and the others(group Ⅱ) were not inserted hamo vac. Result : The average thigh circumference in group Ⅰ was 42.9 ㎝(preoperative), and 46.1 ㎝(postoperative), in group Ⅱ was 43.7 ㎝(preoperative). The knee that had no drains had a higher incidence of ecchymosis. However, the final result of knee score and range of motion of knee joint were not affected significantly by nonuse of closed suction draining. There were no infection sign in both groups. Conclusion : The clinical comparison of closed suction drainage group and non drainage group after simultaneous bilateral total knee arthroplasty was not significantly different in wound healing, clinical and rehabilitation course. The use of suction drainage must be carefully selected after primary total knee arthroplasty.

Bi₂Sr₂Ca(Cu_1-xNix)₂O_8+δ단결정의 전류 변화에 대한 활성화 에너지

손인호,김영국,전칠원,문성희,오재근 경남대학교 공업기술연구소 2000 硏究論文集 Vol.18 No.-

Bi□Sr□Ca(Cu□-□Ni□)□O□+δ (x=0, 0.003) 단결정을 개선된 방향성 응고법을 이용하여 성장시켰으며, 표준 4단자법으로 ab-면의 비저항을 측정하였고, Direct four-probe법을 이용해서 c-축의 비저항을 측정하였다. Arrhenius plot slopes의 기울기는 활성화 에너지를 나타내는데 이의 온도 의존성에 대하여 조사하였다. 자기장을 인가하여 활성화 에너지를 측정하면, 고온과 저온에 서로 다른 두개의 TAFF 영역이 나타나는 것을 볼 수 있고, 이들 활성화에너지는 고온 영역에서는 lnB에 비례하고, 저온 영역에서는 B□□ 에 비례하였다. By making use of the improved directional solidification method and, standard and direct four-prove methods respectively. We grow Bi□Sr□Ca(Cu1-□Ni□)2O8+δ (x=0, 0.003) single crystal and measure its resitivities in ab-plane and c-axis. The temperature at the activation energy, which is described by a slope in the Arrhenius plot, is examined. The activation energy measured by applying the external magnetic field, exhibits two different TAFF regimes at low and high temperatures. It is shown that the activation energy is propotional to lnB and B□□ at high and low temperature regimes, respectively.

양이온의 층간 반응에 의한 텅스텐 산화막과 전해질 계면에서의 전기화학적 특성에 관한 수치해석

孫太源,趙成鎭 弘益大學校 科學技術硏究所 1998 科學技術硏究論文集 Vol.9 No.2

In this study, optical density for tungsten oxide film is investigated by equation of diffusion derived for cation diffusion into film. Current is calculated for one case; reversible case that reaction rate is very fast. Dimensionless parameter ξ, ratio of diffusion coefficient in electrolyte and inside of film, and ζ, include exchange current density, are defined. Optical density is calculated with distribution of cation concentration that is calculated for dimensionless parameters in film. In reversible case, concentration of interfacial of electrolyte and film is very high and it takes long time to distribute uniformly. Change of optical density is great for change of diffusion coefficient.

미니동종 조혈모세포 이식에서 T림프구 수용체 단클론성 항체의 이용 가능성 및 혼합 림프구 배양에서 림프구 억제효과에 대한 연구

손상균,박성원,백진호,김동환,정진태,현동우,곽동석,이재태,이규보 대한조혈모세포이식학회 1999 대한조혈모세포이식학회지 Vol.4 No.2

연구배경: 조혈모세포이식 및 조건화 치료는 원발성 질환을 제거 후 새로운 조혈세포를 이용한 공간을 마련하고 세포의 생착을 이름으로써 치료의 목표를 달성하고자 하나 심한 부작용으로 인한 높은 조기 사망률은 극복하여야 할 점이다. 저독성 조건화 처치를 하면 불충분한 면역세포의 살해로 인한 거부반응이 큰 문제가 된다. 이에 거부반응 및 이식편대숙주반응의 중요한 역할을 하는 림프구에 대한 억제작용을 갖는 단클로성 항체의 생체 내에서 효과를 추측하기 위해 DLA(Dog lymphocyte Antigen) mismatched dog의 말초혈액을 이용한 MLC assay를 시행하였다. 방법: DLA typing의 결과와 비교하기 위해 단클론성 항체 첨가 없이 DLA가 서로 다른 3마리의 말초혈액을 이용하여 서로의 MLC 반응을 비교 실험하였다. T림프구 수용체에 대한 단클론성 항체의 농도에 따른 proloferation 억제효과를 보기 위해 2, 10, 20, 200ug/ml의 농도로 DM5 (antigranulocyte antbody: 음성 대조군)와 비교하였다. 항원에 감작된 림프구에서의 D5에 대한 효과를 보기위해 장기 골수 배양 배지에서 responder를 stimulator 및 D5와 함께 3일간 배양후 세척하고 2일간의 배양후 다시 stimulator로서 재자극 후 5일 뒤에 proliferation assay를 시행하였다. 실제 이식을 시행한 donor 및 recipient의 세포를 분리하여 proliferation assay를 하여 이식 전후를 비교하였다. 결과: T림프구 수용체에 대한 단클론성 항체의 농도를 달리한 실험에서 2, 10 ,20ug/ml 모두에서 같은 농도의 DM5는 억제효과가 없는데 비해상 당한 림프구증식 억제효과가 관찰되었다. In vivo 실험에서 중용량의 방사성 치료 및 면역 억제 요법으로 DLA matched 2마리 모두에서 성공적인 생착을 확인하였다. 공여자의 mismatched sample에 대해 G-CSF를 이용한 가동화 치료전 보다 낮은 proliferation score를 보였다. 결론: T림프구 수용체에 대한 단클론성 항체는 In vitro 실험에서 T림프구의 억제효과가 관찰되었고 동물 이식에서 부작용을 줄이는 저용량의 조건화 치료 후 생착을 유도하는 면역억제제로서 그 가능성을 확인하였고 향후 그 기전에 대한 연구 및 많은 생체 실험이 필요하다고 생각된다. 재생불량성 빈혈 같은 저세포 충실도의 골수 질환이나 과거에 방사선 치료를 심하게 받은 경우는 이미 골수 내 생착을 위한 공간이 마련된 상태이므로 특별한 면역억제 요법이 가능하다면 이러한 저독성의 조건화 처치가 유용하게 응용될수 있을 것으로 전망된다. Background: The objective of this study was to evaluate the effect of anti-TCR monoclonal antibody in mixed lymphocyte culture and as a part of immunosuppressive regimens in the allogeneic stem cell transplantation. Since marrow space is empty in the patients with aplastic anemia or previous radiation and no new space for allograft needs to be created, nontoxic imminosuppressive conditioning regimens should be feasible. These may include monoclonal antibody directed against T cell receptor other surface determinants on T cell. Moncoclonal antibody (MAb) 15.9D5 raised to canine TCR α β was found to induce hyporesponsiveness to allogeneic stimulator cells in primary and secondary mixed lymphocyte culture (MLC). Methods: Anti-TCR monoclonal antibody was tested to evaluate its suppressive effect of lymphocyte activity in vitro compared with anti- granulocyte anti body and used as an immuno-suppressive agent in two recipient dogs. Four different concentration of anti-TCR MAbs was tested in MLC to know the appropriate concentration for suppressing lymphocyte proliferation, and MLC assays were serially done from blood sample of recipient dogs and donor dogs before and after transplantation. Results: Anti-TCR monoclonal antibody had significantly suppressed H3-thymidine uptake in MLC compared with anti-granulocyte antibody(control). In two recipient dogs conditioned with non-myeloablative regimens and MAb, transplanted with DLA- matched donor dogs, successful mobilizing stem cells were less reactive to the stimulator lymphocytes than the lymphocytes from the dogs not treated before. Conclusion: The precise mechanism of immunosuppression induced by anti- TCR MAb needs to be elucidated. G-CSF had a role in suppressing lymphocyte activity of donor dogs and might have a role in preventing GVHD. Non-myeloablative conditioning strategy might be useful in patients with hypoplastic marrows who require immunosuppression only (e. g. aplastic anemia) and already has some spaces for engraftment in the marrow (e. g. irradiated marrows).

觸媒粒子 內에서 細孔擴散이 選擇度에 미치는 影響

孫太源,廉聖培 弘益大學校 1983 弘大論叢 Vol.15 No.2

The in fluence of pore diffusion on the yield and selectivity has been studied for a chemical reaction occuring in a catalyst particle. When a consecutive reaction (A???→R???→S) proceeds, mathematical formulation is performed by introducing Wheeler's classical work. Also the variation of the yield of intermediate product R due to conversion of reactant A was considered incase of plug flow reactor. By computations, favorable conditions to increase yield of desired product R with various values of parameters were obtained. The present results show that it is favorable when the reaction rate constant k₁is larger than k₂. And as a whole, the values of lower Thiele modulus for a nonporous catalyst and of higher effective diffusivity ratio tend to increase the yield of intermediate product.

일개 대학병원에서 치료중인 만성질환자의 금연,절주 및 운동 실천 정도

손혜숙,전진호,이종태,정귀원,김성준,엄상화,유병철 韓國保健敎育.健康增進學會 2001 보건교육건강증진학회지 Vol.18 No.3

Background: Many chronic diseases are associated with the lifestyle such as smoking, alcohol drinking and exercise. Attention is increasingly paid on the effect of exercise for the management of chronic disease these days. Objective: The purpose of this study was to evaluate the status of the smoking habit, alcohol drinking and physical exercise of the patients with chronic diseases. Methods: Total 793 persons(normal:422, chronic disease patients:371) in a hospital were questioned regarding the habits of smoking and alcohol drinking, and a practice of physical exercise in 1999. The patients with chronic illness were divided into three groups(Group I included the patients of hypertension and diabetes mellitus. Group II includes respiratory disease and cancer. Group III included liver disease ). The rate of exercise, the rate of smoking cessation and the rate of abstinence were assessed. In logistic regression analysis with each independent variables in each disease groups(I, II and III), odds ratio for the presence of disease was controlled for age and education. Results: The rate of exercise, the rate of smoking cessation and the rate of abstinence was 31.5%, 27.3% and 9.5% in the patients with chronic disease, respectively. In control group, those were 31.5%, 21% and 2.1%, respectively. In logistic regression analysis with exercise as independent variable, odds ratios(95% CI) for age and education were significantly high, with smoking cessation, odds ratio for age was high and with abstinence, odds ratio for disease was high in all disease groups. Conclusion : It was suggested that an effort for proper changes of lifestyle related to disease such as smoking, alcohol drinking and exercise should be intervened in the patients with chronic diseases.

메티실린 내성 황색 포도알균에 의한 연조직 및 골 감염에 대한 전환요법으로서의 경구 Rifampin의 유용성

손종원,김신우,하상우,이응갑,정덕원,장현하,이종명,김능수 대한감염학회 2005 감염과 화학요법 Vol.37 No.6

목적 : 메티실린 내성 황색 포도알균에 의한 연조직및 골 감염의 치료 시 glycopeptide약물의 정주 요법에 이은 경구 항생제로의 처방 전환이 요구되는 경우가 많으나 마땅한 경구 약제의 선택이 어려운 실정이다. 이에 경구 rifampin을 메티실린 내성 황색 포도알균에 의한 연조직 및 골 감염에 사용하여 치료한 경우를 분석하여 그 유용성 정도와 실패한 경우 실패의 위험인자를 알아보고자 하였다. 재료 및 방법 : 2001년 1월부터 2004년 9월까지 메티실린 내성 황색 포도알균에 의한 연조직 및 골 감염 환자를 대상으로 rifampin을 그 치료 목적으로 사용한 44명의 환자를 의무 기록과 X선 사진을 통해 후향적으로 분석하였다. 기초 자료를 분석하였고 감염이 재발하여 치료 실패로 판정된 환자들에 대해 치료 실패의 원인이 될 만한 주요 변수에 대한 Chi-square 검증과 로지스틱 회귀분석을 시행하였다. 결과 : 치료 후 재발은 20.5% (8/39)였으며 재발 예와 사망에 대한 위험요소에 대한 단변량 분석에서 고관절 보형물이 있는 경우 흔하였으나 통계적 차이에는 미치지 못하였다(P=0.065). 고관절 보형물 외에 동반된 질환들, 쇼크의 동반, 균혈증의 동반, 경구 시 ciprofloxacin과 rifampin의 병합 복용 기간 등을 혼란 변수로 사용한 다변량 로지스틱 회귀분석에서는 고관절 보형물 만이 통계적으로 유의하였다(P=0.044). 결론 : 메티실린 내성 황색 포도알균에 의한 연조직및 골 감염에 rifampin과 다른 약제를 병합하여 치료하는 경우 재발은 적었다. 치료 실패의 경우는 고관절 부위 감염과 같이 보형물을 쉽게 제거하기 어려운 상황과 관계되는 것을 보여준다. Background : Rifampin is sometimes used in combination with other anti-staphylococcal agents to treat methicillin-resistant Staphylococcus aureus (MRSA) infections but few reports are available about the usefulness of rifampin against MRSA infections, especially in soft tissue and bone infections. Thus, we evaluated the efficacy of rifampin as switch therapy for soft tissue and bone infections caused by MRSA and assessed the risk factors for treatment failure. Materials and Methods : We retrospectively studied 44 patients who had soft tissue and bone infections caused by MRSA and were treated with rifampin in combination or as monotherapy as switch therapy from January 2001 to September 2004. Results : The mean age of the subjects was 50.2 years and the number of male and female were 34 and 10, respectively. Median duration of rifampin use was 32 days and 25% of the patients had artificial prostheses. Thirty one patients (79.5%, 31/39) were cured with parenteral glycopeptide followed by rifampin in combination or as monotherapy. Eight patients (8/39) recurred after the completion of treatment. The presence of hip prosthesis was the only significant risk factor (P= 0.027) in multivariate logistic regression test. Rifampin was tolerable in all cases. Conclusion : Rifampin as switch therapy for soft tissue and bone infection caused by MRSA was effective in 79.5% (31/39) of sujects. The treatment failure seems to be associated with unremovable infected prosthesis.

RuxIr₁xO₂/Ti mesh 촉매전극에 의한 페놀의 전기화학적 산화특성에 관한 연구

孫太源,李相雄 弘益大學校 科學基術硏究所 1999 科學技術硏究論文集 Vol.10 No.2

One of the best ways of turning the characteristics of aromatic compounds the major anti-degradable compounds, into the one of bio-degradable is electrochemical oxidation. Among the aromatic compounds chlorine group on phenol has been chosen and the probabilities of electrochemical oxidation was researched by measuring Cyclic voltammogram(CV) and Tafel polarization curve for RUx.rxO₂/Ti mesh catalytic electrode. The value of HPP using Ru/Ir 7:3 electrode was smaller and i?? was larges than using Ru/Ir 3:7 electrode. Ru/Ir 7:3 electrode was better than Ru/Ir 3:7 electrode on the electrochemical oxidation of phenol.

피질하 혈관성 치매 환자에서 단광자방출단층촬영과 Statistical Parametric Mapping을 이용한 뇌혈류 흐름의 분석 : Adaptation of Statistical Parametric Mapping

양동원,김범생,김의녕,손형선,김상윤 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.1

Background: Subcortical vascular dementia(SVaD) is relatively homogeneous subtype of VaD, but the mechanisms of cognitive dysfunction of subcortical VaD are not completely understood yet This study investigated the changes of cerebral blood flow(CBF) in patients with SVaD and the contribution of the white matter hyperintensity(WMHI) and clinical severity to CBF changes. Methods: 99mTc-ethyl cysteinate dimer single photon emission computed tomography(SPECT) was performed to measure the regional CBF and statistical parametric mapping(SPM)99 software was applicated to automated and objective analysis of the SPECT image data Twenty three patients (male 12, female 11) of mild to moderate dementia who met both the criteria of the DSM-IV and probable or possible NINDS-AIREN for VaD and have subcortical white matter changes and lacunar infarction on brain MRI and seventeen normal control subjects (male 7, female 10) were evaluated The severity of the WMHI was measured by semi-quantitative scale method proposed by Mantyla. The seventy of dementia was measured by clinical dementia rating (CDR) scale Results: SPM analysis of SPECT image revealed significantly reduced regional CBF in the right thalamus, left caudatd nucleus, cingulate, bilateral superior temporal, and left ventral subcallosal gyri in SVaD patients when it compared to normal controls (corrected p<0 001). Among four WMHIs, only the WMHI was associated with the small CBF reduction in the left superior temporal gyrus (uncorrected p<0 01) The reduction of CBF according to the severity of dementia was noted in the anterior and posterior association areas (uncorrected p<0 01). Conclusions: our study suggests that cognitive dysfunction of SVaD may be related with CBF reduction in the above mentioned brain areas, which probable are not associated with the severity of periventncular WMHI and dementia.

減壓 貯藏中 Tomato果實의 Ribonucleic Acid와 Ribonuclease 活性의 變化

崔相源,崔鍾旭,孫泰華 COLLEGE OF AGRICULTURE KYUNGPOOK NATIONAL UNIVERSI 1984 慶北大農學誌 Vol.2 No.-

The process of ripening and senescence of tomato fruits has been studied in terms of storage temperature and pressure. Ribonucleic acid(RNA) content, Ribonuclease (RNase) activity, RNase properties and electrophoretic pattern of RNase were investigated during the storage. Total RNA content was decreased during ripening and senescence. The decreasing rate was greater at room temperature (R) than at low temperature (L), and under normal atmospheric pressure (NAP) than under sub-atmospheric pressure (SAP). RNase activity was increased during the period of climacteric rise and in accordance with developing color score. RNase activity was obviously higher at R than L, and under NAP than SAP. Consequently, RNase activity of NAP-R treatment was the highest among the treatments. The optimum temperature and pH of RNase activity were 70℃and pH 6.7, respectively. RNase activity was the most stable at pH 5.0 and retained 50% of its activity when treated at 90℃ for 10min. RNase activity was inhibited by cations and, markedly by zinc. Both treatment of NAP-R and SAP-L showed one band of RNase on gel electrophoresis in the early stage of storage. With the lapse of storage, the number of RNase band increased, showed 3 bands in the 7th day of NAP-R treatment and 2 bands in the 34th day of SAP-L treatment.