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Kim, Jung-Hee,Kim, Hee-Jong,Bak, Ye-Sol,Kang, Jeong-Woo,Lee, Dong-Hun,Kim, Man-Sub,Park, Yun-Sun,Kim, Eun-Jin,Jung, Kang-Yeoun,Lim, Yoong-Ho,Hong, Jin-Tae,Yoon, Do-Young The Korean Society for Applied Biological Chemisty 2012 Applied Biological Chemistry (Appl Biol Chem) Vol.55 No.1
Anti-cancer effects of naringenin derivative diethyl (5,4'-dihydroxy flavanone-7-yl) phosphate were evaluated in human lung cancer cells. The effect of diethyl (5,4'-dihydroxy flavanone-7-yl) phosphate (dEdHF-7-p) on A549 cell viability was measured using MTS assay and cell counting. Morphological changes were detected using phase-contrast microscopy. Apoptosis was analyzed using Hoechst staining. The influence of dEdHF-7-p on cell cycle distribution was determined using propidium iodide (PI) staining, and protein expression was determined by Western blot analysis. A newly synthesized naringenin derivative dEdHF-7-p suppressed cell growth of A549 though mechanisms including inhibition of cell cycle and increased apoptosis. Apoptotic and cell cycle modulators were changed by dEdHF-7-p in A549 cells; cyclins, ppRB, and anti-apoptotic factor Bcl-2 were down-regulated, whereas apoptotic factor Bax and cyclin-dependent kinase inhibitors p21 and p53 were enhanced, thereby releasing cytochrome c into the cytosol of dEdHF-7-p-treated-A549 cells. dEdHF-7-p treatment processed caspases-3/-8/-9 and cleavage of poly ADP-ribose polymerase. The dEdHF-7-p treatment enhanced Fas expression and decreased expression of cell survival factors such as PI3K and p-Akt in a dose-dependent manner. Taken together, dEdHF-7-p induces apoptosis by inhibiting the PI3K/Akt survival signaling pathway and modulating mitochondria-emanated intrinsic and Fas extrinsic pathways in A549 cells.
김진호,박종규,홍선희,강창성,나혜영,한윤종,안기범,왕영미 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.11
Congenital anomalies occur in 2-3% of neonates and have unknown and variable causes. It's occurance rate is higher in twin gestations than in singleton gestations, especially in monozygotic twins. In most cases of twin anomalies, one fetus is normal and the other fetus is not. When an anomaly is found in one fetus, various tests, such as chorionic villus sampling, amniocentesis, and umbilical cord aspiration are strongly recommended in high risk groups of chromosmal anomaly for accurate diagnosis and proper treatments. A case of congenital anomalies in both twins diagnosed in a 35 year old multiparous woman is presented with brief review of literatures.
주거환경의 변화에 따른 거실의장에 관한 조사 : 한옥과 대청과 아파트 거실
김선희,박승신,유용재,이채영,이미승,이영애,임진희 연세대학교 생활과학대학 1981 婦學 Vol.14 No.-
문화의 발달과 인구의 급증으로 대지가 부족하게 되어 주택난이 대두되자 일반적인 주거형태는 전통적 주거양식인 단독주택(한옥)에서 집합주택인 아파트로 변모하게 되었다. 이러한 주거형태의 변화는 온 가족이 사용하는 공동생활공간의 변화도 가져오게 되었다. 공동생활 공간의 대표적인 거실은 가족의 단란과 휴식을 위한 장소이며 생활습성이나 생활수준정도에 따라 내용을 달리할 수가 있다.
Short Communication : A Peptide Produced by Pseudomonas tolaasi, Tolaasin Binds to Metal Ions
( Sun Hee Lee ),( Geun Hyeong Jo ),( Do Seok Hwang ),( Yoon Kyung Woo ),( Young Giu Lee ),( Yeon Joong Yong ),( Kyung Rai Kang ),( Ji Ye Hyun ),( Young Kee Kim ),( Dong Woon Kim ),( Yoong Ho Lim ) 한국응용생명화학회(구 한국농화학회) 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.4
Brown blotch disease in mushrooms is caused by Pseudomonas tolaasin, which produces a peptide toxin, tolaasin I, and zinc ion inhibits the channel formed by tolaasin I. NMR experiments revealed that zinc, sodium, and calcium ions can bind to tolaasin I and their binding position on tolaasin I is the lactone ring.
김진윤,박선규,윤정수,김항중 대한마취과학회 1995 Korean Journal of Anesthesiology Vol.28 No.5
The proliferation of high-technology infusion devices has greatly influenced the practice of anesthesia by allowing precise delivery intraoperatively and postoperatively of intravenous anesthetics, analgesics, and vasopressors. During continuous drug administration to pediatric patients, unfavorable pharmacologic effects have occured. These effects were attributed to variations in flow from infusion devices. The intent of this investigation was to evaluate the influence of infusion devices on the accuracy and continuity effused fluid. Hartmann's solution was run through eight infusion pump at 5, 10, 15, 20, 25, 30, 40, 60, 80 and 100ml/hr. The volume of the fluid was measured for one hour at each flow rate using a infusion device analyzer(IDA-2) in vitro. Flow accuracy(ml/hr) was calculated by dividing the effused volume by the effusion time ; this value was subsequently expressed as a percentage of the desired flow rate. Flow continuity was expressed by the coefficient of variance(CV); analysis of variance with SAS was used for comparisons. Results were as follows ; 1) The flow accuracy values ranged from 98.8% to 114.2% of the desired rate. 2) Seven infusion pumps had flow rates within 5% of the desired rates at each flow rate but one pump had more than 10% of desired rate. 3) Each of the respective infusion pumps produced various levels of flow continuity and ranged from 0.7% to 2.5%(CV value). Conclusion , further evaluations are needed to differentiate continuity from other infusion devices(e.g., syringe infusion pump) in vitro and evaluations are needed to define the clinical significance in vivo. Future use of flow-rate data will likely be of significant value in establishing policies and procedures for the utilization of infusion devices and guidelines for product selection.
A Peptide Produced by Pseudomonas tolaasi, Tolaasin Binds to Metal Ions
Lee, Sun-Hee,Jo, Geun-Hyeong,Hwang, Do-Seok,Woo, Yoon-Kyung,Lee, Young-Giu,Yong, Yeon-Joong,Kang, Kyung-Rai,Hyun, Ji-Ye,Kim, Young-Kee,Kim, Dong-Woon,Lim, Yoong-Ho The Korean Society for Applied Biological Chemistr 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.4
Brown blotch disease in mushrooms is caused by Pseudomonas tolaasin, which produces a peptide toxin, tolaasin I, and zinc ion inhibits the channel formed by tolaasin I. NMR experiments revealed that zinc, sodium, and calcium ions can bind to tolaasin I and their binding position on tolaasin I is the lactone ring.