정신분열병에 대한 Risperidone의 효과 및 안전성에 관하여

신석철,왕성근,지익성,이선우,이규광,이봉희,이진영,황선희,신용재,배경도,김정란 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

In order to evaluate the efficacy and safety of risperidone, 10 patients with chronic schizophrenia were examined for 8 weeks in a silgle-open study. After the wash-out period of 1 week, risperidone was administered. Efficacy was evaluated by means of Positive and Negative syndrome Scale for Schizophernia(PANSS) and Clinical Global Impression(CGI). Safety assessment included the Extrapyramidal Symptom Rating Scale(ESRS), vital signs, body weight, ECG, and laboratory tests. The results were as follows 1) On the PANSS total score, there was significant improvement of total score after 1 week (P<.05) of administratiom. 2) On the PANSS positive and negative subscal, there were significant improvement of posotive and negative scores after 2 weeks (P<.05) of administration. 3) On the PANSS general psychopatholgy subscals, there were significant improvement of general psychopathologyscores after 1 week (P<.05) of administratiom. 4) On the CGI, there was significant decreasement of clinical impression of severity of schizophrenia score after 2 week (P<.05) of administration. 5) A statistically significant increase in body weight (P<.05) was observed after 8 weeks of administration. 6) EPS reached the peak at the end of the 1st week of administration of risperidone (11.8± 24.25) but they were easily relieved by addition of benztropine and clonazepam. There was not significant change in laboratory tests, vital sign, ECG after 8 weeks of administration. These results suggest that Risperidone is an effective antipsychotics and clinically safe except for increased body weight in chronic schizophrenia.

韓國産 개불(Urechis unicinctus) 前腸 上皮細胞 纖毛의 構造와 機能에 대하여

신길상,이순희 순천향대학교 기초과학연구소 1997 순천향자연과학연구 논문집 Vol.3 No.1

Urechis unicinctus is one of many tide animals known as a filter feeder. With filter, the animal effectively select plankton and debris from influxed sea warter into the fore gut. The filtering mechanism of this animal is yet not well understood, although ciliary movement of proboscis is in common filtering mechanism in some tide and water invertebrates. In this study with U. unicinctus it is revealed unusally that the filter is not in proboscis, but it is a part of unbranched hollow visceral organ which extend from proboscis to anal portion. The structural observation enable to analyze the filtering mechanism represented by ciliary movement in the fore gut. This results come from the structural considerations led to a possibility that the visceral organ is functionally compartmented into 3 parts, mid gut, hind gut and the fore gut. The hind gut as a respiratory organ and the mid gut as a digestive organ are already known but the 3 compartments consist exclusively with the fore gut as the filter in its function. The fore gut composed of pseudostrafied columnar epithelial cell with the cilia. The internal cilia are well differentiated kinocilia with the typical microtubule pattern, kinetosome and cilia roots. There are two kinds of striated cilia roots, main root extending perpendicularly from cell surface to basement membrane and short accessory root branching with an acute angle of 80°with the main root at basal plate of the kinetosome. The spacial approach of the main root to the large fused form of mitochondria is one of characteristic features which might be a intimate association between energy source and energy mass consuming cell organelles.

3차원 좌표 측정기의 측정 자동화 시스템 개발

신재혁,류영선,강희준 울산대학교 1998 공학연구논문집 Vol.29 No.2

본 논문은 10㎛ 정밀도를 가진 수동형 3차원 좌표 측정기(Coordinate Measuring Machine, CMM)에 다음의 기능을 부가함으로써, 자동화하고자한다. 그것들은 디스풀레이 제어, 키보드나 조이스틱을 통한 Man-Machine Interface 기능 그리고 서보 모터 제어 등이다. 이와같은 기능을 부가하기위하여, 8031 원칩 마이크로프로세서 시스템을 설계 제작하였고, Yasukawa 모터를 이용한 서보 제어 시스템은 일반적인 PID 알고리즘과 최종점에서 부가적인 Impulse 제어를 수행함으로써, 본 시스템의 요구 조건인 위치 오차 10㎛이내의 정밀 제어가 가능토록하였다. This paper works toward the development of an Automatic Coordinate Measuring Machine(CMM) by adding to a manually driven CMM machine with measuring accuracy of 10㎛ the following functions. a display control, man-machine interface with a joystick and a keypad, and servo motor control. 8031 one chip microprocessor system is designed to control the above functions and A servo motor control system with Yasukawa servo motors allows to control a probe with 10㎛ accuracy by using conventional PID control algorithm and an additional impulse control algorithm.

도시고형폐기물의 성분분석에 관한 연구

선정화,김희택,배성렬,강신춘 한양대학교 에너지·환경기술연구소 1994 에너지·環境技術論文集 Vol.1 No.-

도시지역에서 배출되는 일반폐기물에 대한 성분분석결과 밀도는 250∼300㎏/㎥, 수분함량은 중량비로 평균 51.83%, 가연성분 42.09%, 회분 6.08%로 각각 측정되었다. 한편, 저위발열량은 주거지역이 700∼1,700㎉/㎏, 상업지역이 2,000㎉/㎏이상으로 측정되어 상업지역이 주거 지역보다 발열량이 높은 폐기물이 배출됨을 알 수 있었는데 이는 수분함량이 높은 주개류의 배출이 상업지역이 주거지역보다 적으며 소비자 포장지로서 종이, 비닐, 플라스틱류 등의 사용이 많은데 기인하는 것으로 생각되어 진다. 한편, 분리수거, 유가품에 대한 자원 재활용, 연탄재 배출의 감소추세 등의 효과로 폐기물 중 불연성 함량은 줄어들고 반면 종이, 비닐, 플라스틱류 등의 가연성 폐기물의 함량은 크게 늘어 전체적으로 폐기물의 질이 향상되고 있음을 알 수 있다. The analysis results of components of municipal solid wastes are as follows : ① Density ranged from 250㎏/㎥ to 300㎏/㎥. ② Water content, combustible content and ash content measured 51.83%, 42.09%, 6.08% respectively. ③ Low calorific value was ranged from 700 to 1,700㎉/㎏ in residential area and measured 2,000㎉/㎏ in commercial one. Therefore, it was known that calorific value of wastes in residential area is smaller than that in commercial area. Also, the quality of wastes was improved by increase of combustible content which results from vitality of valuable recycling, reduction trend of briquette ash generation rate and increase of paper, plastic consumption as wrapping materials.

아동의 건강 및 질병개념 발달에 관한 탐색적 연구

신희선 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.1

This study examined the development of children's concepts of health and illness based on Piaget's cognitive developmental theory of children. Conceptions of health and illness of 72 children aged 3 to 12 were explored by interview, using interview guide developed by Bibace and Walsh. Six developmentally ordered categories of explanation of illness were utilized for data analysis. The results were as follows: The types of explanation of illness varied as a function of the developmental status of the subjects. Among preschool chidren, 79.2% gave the prelogical explanations including phenomenism and contagion. Among 7 year olds, 45.8% gave contamination explanations and 29.2% internalization explanations. Among 11 to 12 year olds explanations were classified as 58.3% internalization and 12.5% physiologic. The answers to the question "What does it mean to be healthy?" showed qualitative and quantitative changes with age. Among preschool children, "Strong body"(20.8%) and "Eating well"(12.5%)were the mostly mentioned categories. Among 7 year olds, "Not being sick" (41.7%) and "Strong body"(37.5%) were the mostly mentioned categories. Among 11 to 12 year olds, "Strong body" (41,7%) and "not being sick" (33.3%) were the mostly mentioned categories And, mental health was considered a part of health by 16.7 % of this age group children. When children were asked about specific illnesses, knowledge varied with the illness, Children were knowledgeable about headache and heart attack but knew little about cancer and measles.

간호사의 아동 통증 중재에 대한 지식 및 태도

신희선,김동희 대한간호학회 아동간호학회 2003 Child Health Nursing Research Vol.9 No.2

이온화에너지 처리 아이스크림 및 우유의 단회투여 독성시험

이희준,최현종,한선경,구본철,신명수,함준상,조철훈,이완규 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.1

본문참조

S Leadership 함양을 위한 숙명여대 의사소통센터의 교양교육 사례연구

신희선 숙명여자대학교숙명리더십개발원 2007 숙명리더십연구 Vol.6 No.-

숙명여대는 리더십 교양교육을 강화하면서 의사소통능력이 탁월한 여성 리더를 육성하고자 교양필수과정으로 <글쓰기와 읽기>, <발표와 토론> 강의를 개설하였다. 학제적이고 통합적인 리더십 교양교육의 차원에서 의사소통센터를 제도화하여 신입생들을 대상으로 사고와 표현능력을 키우는 교육을 실시하고 있다. 이는 아카데미즘에 충실한 대학 교육 본연의 자세를 견지한 기초교육이면서, 동시에 현대사회가 요구하는 실용적인 맞춤형 인재를 양성하기 위한 목적을 내포하고 있다. 본 연구는 2002년부터 시작된 <글쓰기와 읽기>, <발표와 토론> 수업 사례를 중심으로 의사소통교육의 현황을 소개하고 학생들의 리더십능력을 키워주기 위한 차원에서 실시되고 있는 의사소통센터의 다양한 프로그램들을 살펴보는데 있다. 학생들은 실습 비중이 큰 교양필수 과목을 1학년 시기에 이수함으로써 이러한 의사소통교육을 통해 사회현상에 대한 통찰력과 문제의식을 키우고, 자신의 생각을 구성하고 공적인 공간에서 설득력 있게 표현하고 전달하는 능력을 개발하고 있다. 이와 같은 의사소통능력은 숙명여대가 지향하는 S-리더십의 중요한 축인 미래형 기술(Skill)을 지닌 리더의 중요한 역량이자 자질이다. 이러한 방향에서 현재 진행되고 있는 의사소통교육이 갖고 있는 함의와 향후 S-리더십 교육의 방향에서의 시사점을 살펴보았다. Sookmyung Women's University set up "Writing and Reading" and "Presentation and Debate" courses as core electives of an educational program to foster women leaders who will practice gentle serving manner, and who will have excellent communication capabilities. Moreover, as a centralized and interdisciplinary educational program, Sookmyung Women's University has institutionalized the communication development center to educate the first year university students. This course is a fundamental education program which fulfills an intrinsic educational function of allowing students to cultivate their own ability. At the same time, an important goal is training pragmatic and talented people who best fit modern society. This paper analyzed current communication programs based on "Writing and Reading" and "Presentation and Debate" courses, and has looked over various other programs, which are dedicated to fostering students' leadership capabilities, which are operated by communication development center. Especially, this research highlighted the educational importance of campus competitions like "Sookmyung Debate Contest", started in 2002, and "Kyobo-Sookmyung the Whole Country University Students' Books discussion Contest", started in 2006, because these competitions were helpful enhancing students' communication capabilities. Through these effective education programs, students can cultivate their insight to social phenomenon and develop a critical mind to that, beyond her major. With the help of practical educational core courses which could stimulate students' thinking and expression ability, students' capability which was formulated by the communication education, will move toward S Leadership which is targeted by Sookmyung Women's University.

서울시 교직원의 고혈압 실태파악과 그 요인에 관한 연구

신선미,김종희,한규종,이희우 韓國學校保健學會 2004 韓國學校保健學會誌 Vol.17 No.1

Purpose : To describe epidemiological characteristics and related factors in school personnel with hypertension. Method : 5,384 school personnel (2,638 males and 2,746 females) received physical examination at the Seoul School Health Center in 2002. blood pressure(BP) was classified by JNC 7th report. Normal BP is systolic BP <120 and diastolic BP<80, prehypertension BP is 120-139 or 80-89mmHg, stage 1 hypertension BP is 140-159 or 90-99, and stage 2 hypertension >=160 or >=l00 mmHg. each group was evaluated by gender. We used multiple regression and logistic regression. Results : Normotension was 20.13% in d e s and 48.65% in female, prehypertension 43.4% in males and 3.06% in females, stage 1 hypertension 26.38% in males and 10.99% in females, stage2 hypertension 9.59% in males and 3.2% in females. the older age group had higher distribution of stage 1 hypertension and stage 2 hypertension. The means and abnormal rates of BMI, blood sugar, total cholesterol, GOT, GPT, and GTP was higher when their blood pressure was higher. However, an alcohol habit among lifestyle factors had an inverse effect. Higher Bp was correlated to a &her BMI, FBS, and cholesterol-like dose response. In stage 1 hypertension, the related factors of hypertension for males were BMI, amount of cigarettes smoked, exercise, blood sugar, total cholesterol, and GTP. In stage 1 hypertension, age, BMI, exercise, blood sugar, total cholesterol were related factors in female. In stage 2 hypertension, age and smoking were related factors in male, and age, BMI, and cholesterol in female. Conclusions : It is possible to intervene in all related factors of hypertension except age through life-style modification and appropriate medical management. Active health promotion is needed in School personnel.

교직원 중 비흡연자와 흡연자의 건강상태비교

신선미,이희우 韓國學校保健學會 2005 韓國學校保健學會誌 Vol.18 No.2

Purpose:This study estimated the prevalence of smoking among male and female school employees. This study also correlated key indicators of health with the number of cigarettes consumed per day by the male smokers. The indicators of health included health behavior, blood pressure (mmHg), BMI (kg/m2), diabetes, total cholesterol, GOT, GPT and GTP. Methods:Subjects included 2,640 male and 2,747 female employees working at elementary, middle, and high schools who received a physical check-up at the Seoul School Health Center in 2002. Data was obtained from the physical examinations, questionnaires, and laboratory results. Results:39.7% of males and 0.4% of females were current smokers. 60% of the male smokers consumed between 10 and 19 cigarettes per day, and39.6% of male smokers had been smoking between 10 and 19 years. Smokers who consumed more than one pack per day had a relatively higher BMI than the non-smokers (24.7 24.1, respectively). However, smokers had lower blood pressure than non-smokers. The mean systolic and diastolic blood pressure of current-smokers were 128.2 and 82.8, respectively, while the values among non-smokers were 129 and 84.5, respectively. The proportion of current smokers with severe obesity (over BMI 30) was 5.0%. This was considerably higher than the 1.3% of severely obese non-smokers. Current-smokers also had mean and abnormal rate of fasting blood glucose, total cholesterol, GOT, GPT, and GTP that were higherthan those of non-smokers. The frequency of red meat consumption, alcohol use, perceived incidents of stress were alsomore frequent in current-smokers than in non-smokers. Exercise frequency was also lower among smokers. In multiple regression after adjusting all possible confounding factors including age, BMI, diet, and drink, the parameter value of fasting blood glucose, cholesterol, GOT, GPT, and GTP increased relative to the level of cigarette consumption. Conclusion: Among school employees, health behavior, and general health status including BMI, total cholesterol, GOT, GPT, GTP, and fasting blood glucose were worse in smokers than in non-smoker.