Rational Design of Low Cost and High Energy Lithium Batteries through Tailored Fluorine-free Electrolyte and Nanostructured S/C Composite

Agostini, M.,Lim, D.-H.,Sadd, M.,Hwang, J.-Y.,Brutti, S.,Heo, J. W.,Ahn, J. H.,Sun, Y. K.,Matic, A. Wiley (John WileySons) 2018 ChemSusChem Vol.11 No.17

<P>We report a new Li-S cell concept based on an optimized F-free catholyte solution and a high loading nanostructured C/S composite cathode. The Li2S8 present in the electrolyte ensures both buffering against active material dissolution and Li+ conduction. The high S loading is obtained by confining elemental S (approximate to 80%) in the pores of a highly ordered mesopores carbon (CMK3). With this concept we demonstrate stabilization of a high energy density and excellent cycling performance over 500 cycles. This Li-S cell has a specific capacity that reaches over 1000 mA hg(-1), with an overall S loading of 3.6 mg cm(-2) and low electrolyte volume (i.e., 10 mu L cm(-2)), resulting in a practical energy density of 365 Wh kg(-1). The Li-S system proposed thus meets the requirements for large scale energy storage systems and is expected to be environmentally friendly and have lower cost compared with the commercial Li-ion battery thanks to the removal of both Co and F from the overall formulation.</P>

Effects of phosphorus on the δ-Ni₃Nb phase precipitation and the stress rupture properties in alloy 718

Sun,W.R.,Lee,J.H.,Guo,S.R.,Yoo,Y.S.,Choe,S.J.,Park,N.K.,Hu,Z.Q. 창원대학교 공작기계기술연구센터 1999 연구업적집 Vol.1 No.1

The effects of phosphorus on the phase transformation and stress rupture properties of alloy 718 were investigated. The nucleation of δ- phase, which does not contain phosphorus, was suppressed by the enrichment of phosphorus at grain boundaries. A low level of phosphorus resulted in the formation of faults-containing film-like δ- phase along the grain boundaries, while a higher level of phosphorus favored the long lath-like δ- phase precipitation. Phosphorus greatly prolonged the stress rupture life of the alloy in the range of 0.0008-0.013 wt.% while it reduced the stress rupture life in the range of 0.013-0.049 wt.% The effect of phosphorus in the stress rupture properties was closely related to its interaction with oxygen. Phosphorus atoms, in the range of 0.0008-0.013 wt.%, enhanced the resistance to oxygen intrusion along the grain boundaries, protected the grain boundaries from decohesion by oxygen atoms and oxidation, and subsequently prolonged the rupture life of the alloy. The protection effect of p is clearly demonstrated by the phenomenon that the crack initiation site was shifted from the surface to the center in the stress-ruptured samples with increasing addition of P. Over 0.013 wt.%, the protection effect of phosphorus is excessive and phosphorus began to display its inherent effect of damaging the grain boundary strength ; the stress rupture life of the alloy was reduced accordingly. Maximum stress rupture life was thus obtained at ∼0.013 wt.% P ⓒ 1998 Elsevier Science S.A. All rights reserved.

Expression of cancer-associated fibroblast-related proteins in thyroid papillary carcinoma

Sun, W. Y.,Jung, W. H.,Koo, J. S. Springer Science + Business Media 2016 TUMOR BIOLOGY Vol.37 No.6

<P>The purpose of this study was to evaluate the association between expression of cancer-associated fibroblast (CAF)-related proteins in papillary thyroid carcinoma (PTC) and clinicopathologic factors. Using tissue microarray (TMA) constructed from 339 cases of PTC (303 classic type, 36 follicular variant), we performed immunohistochemical staining for podoplanin, prolyl 4-hydroxylase, FAP alpha, S100A4, PDGFR alpha, PDGFR beta, NG2, 5-meC, and BRAF V600E and evaluated the association with clinicopathologic parameters. We classified the stroma of PTC as desmoplastic type, sclerotic type, pauci type, or inflammatory type. The expression of prolyl 4-hydroxylase (p = 0.042), FAP alpha (p = 0.044), PDGFR alpha (p < 0.001), and 5-meC (p = 0.030) in cancer cells differed according to the histologic subtype, higher in classic type than follicular type. The expression of FAP alpha (p = 0.034) and 5-meC (p = 0.021) in stromal cells was higher in the classic type than follicular type. PTC with BRAF mutation showed higher expression of podoplanin (p < 0.001), prolyl 4-hydroxylase (p = 0.013), FAP alpha (p < 0.001), S100A4 (p < 0.001), PDGFR alpha (p < 0.001), and 5-meC (p < 0.001) in the tumor cell compartment and of FAP alpha (p = 0.004), S100A4 (p < 0.001), PDGFR alpha (p = 0.002), PDGFR beta (p < 0.001), and 5-meC (p < 0.001) in the stromal cell compartment. There was also a difference in the expression of CAF-related proteins according to stromal phenotype; the expression of FAP alpha, S100A4, and PDGFR alpha was higher in desmoplastic type than in other subtypes, whereas NG2 expression was higher in inflammatory type (p < 0.001). Tumoral podoplanin negativity (p = 0.043) was associated with shorter DFS, and tumoral S100A4 positivity (p = 0.044) and stromal PDGFR beta positivity (p = 0.035) were associated with shorter OS. In conclusion, the expression of CAF-related proteins in cancer cells and stromal cells of PTC was different according to histologic subtype, BRAF V600E mutation, and subtype of stroma, and was related to prognosis.</P>

Azasiline-based thermally activated delayed fluorescence emitters for blue organic light emitting diodes

Sun, J.,Baek, J.,Kim, K. H.,Huh, J. S.,Kwon, S. K.,Kim, Y. H.,Kim, J. J. Royal Society of Chemistry 2017 Journal of Materials Chemistry C Vol.5 No.5

<P>Recently, the azasiline unit was introduced as a donor in thermally activated delayed fluorescence (TADF) emitters to realize efficient blue fluorescence from organic light emitting diodes (OLEDs). Utilizing the azasiline unit DTPPDDA in the formation of donor-connector-acceptor (D-C-A) materials resulted in deep blue emission with a Commission Internationale de l'Eclairage (CIE) coordinate of (0.151, 0.087), close to the blue standard of the National Television System Committee (NTSC) of (0.140, 0.080) with 4.7% External Quantum Efficiency (EQE). In the donor-acceptor-donor (D-A-D) type materials of BDAPM and SPDDA, carbonyl and sulfone units were used as the acceptors, respectively. The sulfonyl unit contributed to a large twist of the molecular structure while the carbonyl unit led to a small twist of the molecular structure. As a result, the blue fluorescent OLEDs containing BDAPM and SPDDA demonstrated 11.4% and 2.3% EQEs with CIE Y-values of 0.310 and 0.107, respectively.</P>

원발성 간암에서 PIVKA-II 및 Lens Culinaris Agglutinin-A 반응성 Alpha-fetoprotein(AFP-L3)의 임상적 유용성

배시현,박두호,양진모,박영민,차상복,최종영,성광용,조세현,정규원,선희식,김부성,최상욱,변병훈,한남익 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.2

Background/Aims: Des-γ-carboxy prothrombin(DCP), a protein induced by vitamin K absence or antagonist-II(PIVKA-II), and Lens culinaris agglutinin-A reactive AFP-L3 have been reported to be useful markers for the diagnosis of hepatocellular carcinoma (HCC). In the present study, both the PIVKA-II and AFP-L3 were analyzed and compared with a conventional AFP to determine its usefulness, specificity and sensitivity in the diagnosis of HCC. Methods: Sera were collected from 108 patients consisting of 17 patients with chronic hepatitis, 22 patients with liver cirrhosis and 69 patients with HCC. The AFP-L3 was determined by an lectin affinity electrophoresis coupled with an antibody-affinity blotting. Level of DCP was measured by an enzyme immunoassay with an anti-DCP monoclonal antibody. Results: The sensitivity and specificity of PIVKA-II and AFP L3 were 49.3% and 89.5%, and 32.5% and 85.7%, respectively. No significant correlation was found between the PIVKA-II or AFP L3 and serum AFP. No correlation was found etween the PIVKA-II or AFP L3 and the characteristics of HCC. Conclusion: The determination of plasma DCP and AFP L3 levels combined with AFP levels may be useful especially for the differential diagnosis between HCC and chronic liver diseases without HCC.(Korean J HepatoBackground/Aims: Des-γ-carboxy prothrombin(DCP), a protein induced by vitamin K absence or antagonist-II(PIVKA-II), and Lens culinaris agglutinin-A reactive AFP-L3 have been reported to be useful markers for the diagnosis of hepatocellular carcinoma (HCC). In the present study, both the PIVKA-II and AFP-L3 were analyzed and compared with a conventional AFP to determine its usefulness, specificity and sensitivity in the diagnosis of HCC. Methods: Sera were collected from 108 patients consisting of 17 patients with chronic hepatitis, 22 patients with liver cirrhosis and 69 patients with HCC. The AFP-L3 was determined by an lectin affinity electrophoresis coupled with an antibody-affinity blotting. Level of DCP was measured by an enzyme immunoassay with an anti-DCP monoclonal antibody. Results: The sensitivity and specificity of PIVKA-II and AFP-L3 were 49.3% and 89.5%, and 32.5% and 85.7%, respectively. No significant correlation was found between the PIVKA-II or AFP-L3 and serum AFP. No correlation was found etween the PIVKA-II or AFP L3 and the characteristics of HCC. Conclusion: The determination of plasma DCP and AFP-L3 levels combined with AFP levels may be useful especially for the differential diagnosis between HCC and chronic liver diseases without HCC.(Korean J Hepatol 2000;6:205-214)l 2000;6:205-214)

Effect of Lansoprazole on 24 Hour Intragastric pH and Acid Secretion in Peptic Ulcer Patients and Healthy Volunteers

Na, J. S 大韓臨床藥理學會 1997 臨床藥理學會誌 Vol.5 No.1

Impaired Sulfur-Amino Acid Metabolism and Oxidative Stress in Nonalcoholic Fatty Liver Are Alleviated by Betaine Supplementation in Rats

Kwon, Do Y.,Jung, Young S.,Kim, Sun J.,Park, Hee K.,Park, Jae H.,Kim, Young C. Oxford University Press 2009 The Journal of nutrition Vol.139 No.1

<P>Nonalcoholic fatty liver is involved in the development of nonalcoholic steatohepatitis and chronic liver injury. Impairment of hepatic transsulfuration reactions is suggested to be critically linked with alcoholic liver injury, but its role in nonalcoholic fatty liver remains unknown. We examined the early changes in sulfur-amino acid metabolism and their implication in nonalcoholic fatty liver disease (NAFLD). Male rats were provided with a standard liquid diet or a high-fat liquid diet (HF) for 3 wk. An additional group of rats received the HF diet supplemented with betaine (1%). HF diet intake elevated hepatic triglyceride and serum tumor necrosis factor-alpha (TNFalpha) concentrations. Antioxidant capacity of liver cytosol against hydroxyl and peroxyl radicals was reduced significantly. Hepatic S-adenosylmethionine (SAM) and glutathione (GSH) decreased, but hypotaurine and taurine concentrations increased. Methionine adenosyltransferase (MAT) activity, not its concentration, was depressed, whereas both activity and concentration of cysteine dioxygenase and GSH S-transferase were elevated. Betaine supplementation of the HF diet inhibited hepatic fat accumulation and serum TNFalpha elevation. The decrease in cytosolic antioxidant capacity was also prevented. MAT activity and its concentration were induced significantly. Hepatic SAM and GSH increased and elevation of hypotaurine and taurine was depressed. The results indicate that the metabolism of S-containing substances is significantly disturbed by the HF diet, suggesting a causal role of impairment of hepatic transsulfuration reactions in NAFLD. Betaine supplementation protects the liver from nonalcoholic steatosis and oxidative stress most probably via its effects on the transsulfuration reactions.</P>

칼슘급여수준· 급여방법·입자도·연령이 메추리의 진정이용칼슘가에 미치는 영향

김용식,선상수,명규호 ( Y . S . Kim,S . S . Sun,K . H . Myung ) 한국축산학회 1985 한국축산학회지 Vol.27 No.6

The relationships between calcium input level and excreta calcium, and true available calcium (TAC) values were Y=3.21 × 10^(-4)x²+ 0.52X-0.48 (r=0.9832^(**) and Y=-6.21 × 10^(-3)X² -0.03 (r=0.9738^(**)) respectively. The TAC values of limestone and oyster shell were the highest in the 40-80 mesh as 74.67%, and the lowest in the 10-30 mesh as 68.2% and 61.01% respectively. Excreted calcium from fed birds were significantly increased (p$lt;0.05) as the age of birds increased, however, excreted calcium from unfed birds were almost same in all the age of birds. The TAC value of calcium carbonate was the highest in that of 16 weeks old bird as 99.42±1.32%. The relationships between age of bird and excreta calcium, and TAC value were Y=0.578x-0.0475 (r=0.9960^(**)) and Y=-0.129X+100.0425 (r=-0.9850^(**)) respectively.

Brazing 과 Metallizing 에 의한 세라믹/금속 접합재 잔류응력의 유한요소 해석

최영택,박명균,박세만,선동주 명지대학교 대학원 1997 대학원논문집 Vol.1 No.-

In this study finite element method(FEM) is utilized to determine residual stress distributions induced by heat generated during joining processes of ceramics and metals. The finite element analysis is focused on the joining area, that comprises the interfacial area between a metal and a insert-layer, the insert-layer itself and adjoining area between the insert-layer and a ceramic. The residual stress distributions on the joining area are analyzed as function of thicknesses and yield stresses of the insert-layer(Brazing Filler Metal), and for different kinds of metals including SUS304 and SM45C. Two typical joining processes are considered in this investigation ; Active Metal Brazing and Metallizing. Stress distributions on the joining areas are computed for both processes and are compared with one another. This comparison can lead to the better joining method in reducing the residual stresses and consequently provide improved joining technologies.

原發性 肝癌의 1經驗例

朴鍾昇,鮮于鍈,李恩泰 최신의학사 1966 最新醫學 Vol.9 No.9