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최원호,안락선 忠州大學校 2002 한국교통대학교 논문집 Vol.37 No.4
This paper has Abstract studied calculating method to predict cutting resistance values under general cutting conditions.
치아우식활성에 의한 19세 청소년의 우식호발임계치 측정
최선락,장기완 全北大學校 齒醫學硏究所 1991 전북치대논문집 Vol.9 No.1
The author had sampled saliva and analyzed in order to investigate caries risk of Korean 19 years-old adolescence. The salivary flow rate(㎖/min) were calculated. By use of Dentobuff^?? strip(Orion Diagnostica, Espoo, Finland), buffering capacity of final pH after 5 minutes was observed. By use of Dentoculta^?? LB (Orion Diagnostica, Espoo, Finland), lactobacilli was selectively cultured. By use of Dentocult^?? SM strip(Orion Diagnostica, Espoo, Finland), Streptococcus mutans was selectively cultured. The obtained results were as follows ; 1. Simple Correlation Coefficients between DMFS and 4 each of caries risk factors was as follows ; salivary flow rate(r=-0.27, p<0.05), buffering capacity(r=-0.35, p<0.05), Streptococcus mutans(r=0.29, p<0.01), Lactobacilli(r=0.50, p<0.01). 2. Multiple Correlation between DMFS and 4 caries predisposing factors was statistically significant(r=0.47, p<0.01). 3. The border lines of 4 caries risk factors were as follows ; salivary flow rate 1.5㎖/min, buffering capacity pH 5.0 after 5 mins, S. Mutans 10^5 CFU/㎖, Lactovbacilli 10^4 CFU/㎖.
Lak Shin, Jeong,Dilip K. Tosh,Won Jun, Choi,Sang Kook, Lee,You-Jin, Kang,Sun, Choi,Jin Hee, Lee,Hankil, Lee,Hyuk Woo, Lee,Hea Ok, Kim 이화여자대학교 약학연구소 2010 藥學硏究論文集 Vol.- No.20
The first synthesis of 2'-deoxy-2'-fluoro-4'-selenoarabinofuranosyl pyrimidines as potent anticancer agents was accomplished using the DAST fluorination as a key step. It was first revealed that selenium atom participated in the DAST fluorination of 4'-selenonucleosides and that conformational bias induced by bulky selenium acted as a decisive factor in the DAST fluorination. Among compounds tested, 2'-F-4'-seleno-ara-C (4a) exhibited highly potent anticancer activity in all cancer cell lines tested and was more potent than ara-C (1).
하부식도 근육층 비후를 동반한 호두까기 식도 환자에서 발생한 Steakhouse 증후군
양선영 ( Sun Young Yang ),이오영 ( Oh Young Lee ),한성희 ( Sung Hee Han ),전대원 ( Dae Won Jun ),노병주 ( Byoung Joo Roh ),윤창옥 ( Chang Ok Yoon ),이항락 ( Hang Lak Lee ),윤병철 ( Byung Chul Yoon ),최호순 ( Ho Soon Choi ),함준수 대한소화기기능성질환·운동학회 2005 Journal of Neurogastroenterology and Motility (JNM Vol.11 No.2
Acute esophageal obstruction caused by the impaction of a large bolus of food has been called the `steakhouse syndrome`. Esophageal stenosis is usually found in adults suffering with steakhouse syndrome, but occasionally the syndrome occurs in the absence of any underlying organic abnormality. A 71-year-old male patient had complained of swallowing difficulty after ingesting meat two days previously. We performed endoscopy and found a meat bolus at 30 cm from the incisors, and we so removed the meat with a basket. No pathologic findings were observed endoscopically after the removal of the esophageal meat bolus. The esophageal manometry showed segmental, high amplitude esophageal pressure at the lower esophagus with normal peristalsis. We performed endoscopic ultrasonography with a high frequency catheter and we found thickening of the lower esophageal muscle layer. This case shows that nutcracker esophagus may be the cause of esophageal foreign body impaction and thickening of muscle layer may be associated with the symptom. (Kor J Neurogastroenterol Motil 2005;11:166-169)
임선욱,강규영,최용락 한국농화학회 1983 Applied Biological Chemistry (Appl Biol Chem) Vol.26 No.4
The effects of some soil conditions on the degradation rate and decomposing pattern of parathion were investigated and the obtained results are summarized as follows: Parathion degraded more rapidly in flooded soils than in non-flooded, in wet soils than in dry soils under non-flooded soils. The degradation rates in paddy and upland soils increased at high temperature than low temperature, higher pesticide concentration than low concentration and higher soil pH level. Parathion in paddy and upland soils was more persistent under soil sterilization than under non-sterilization and degraded rapidly in glucose application. Parathion was more persistent in upland soils than paddy soils under several factors described above. The metabolites identified from the paddy and upland soils by TLC include para-oxon (Rf 0.5), aminoparathion(Rf 0.27), p-nitrophenol(Rf 0.2), p-aminophenol(Rf 0.15). Soil enzyme, acid phosphatase activities decreased more at flooded soils than non-flooded, higher pesticide concentration than low concentration and higher soil pH level and the activity in glucose application was increased. Soil enzymes, urease and dehydrogenase activity decreased more at higher pesticide concentration than low concentration. Comparing with soil enzyme activity in paddy and upland soil, the former was higher than the latter.
Progress on the Development of Superconducting Magnet System for Cyclotron K120
Yeon Suk Choi,Dong Lak Kim,Hongming Tang,Hyung Suk Yang,Joon Sun Kang,Yu Seok Kim IEEE 2010 IEEE transactions on applied superconductivity Vol.20 No.3
<P>The Korea Basic Science Institute (KBSI) has targeted a 3.1 T superconducting magnet system to be used in a K120 superconducting cyclotron as one of the next cyclotron for medical application in the Korea Institute of Radiological and Medical Sciences (KIRAMS). The main superconducting magnet should be designed to accelerate various ions for the magnetic bending limit up to 120 MeV. Several ancillary requirements such as background field, space restriction due to ion beam line, and cryostat structure need technical attention. The conceptual design activities of main superconducting magnet system are completed. A quarter-scaled prototype is designed and fabricated in order to confirm the feasibility of our design. The design and fabrication of prototype superconducting magnet system is described in this paper. Also, the detail cryogenic cooling and cryostat structure are presented.</P>
Lee, Yoonji,Jeong, Lak Shin,Choi, Sun,Hyeon, Changbong American Chemical Society 2011 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.133 No.49
<P><I>S</I>-adenosylhomocysteine hydrolase (SAHH), a cellular enzyme that plays a key role in methylation reactions including those required for maturation of viral mRNA, is an important drug target in the discovery of antiviral agents. While targeting the active site is a straightforward strategy of enzyme inhibition, evidence of allosteric modulation of active site in many enzymes underscores the molecular origin of signal transduction. Information of co-evolving sequences in SAHH family and the key residues for functional dynamics that can be identified using native topology of the enzyme provide glimpses into how the allosteric signaling network, dispersed over the molecular structure, coordinates intra- and intersubunit conformational dynamics. To study the link between the allosteric communication and functional dynamics of SAHHs, we performed Brownian dynamics simulations by building a coarse-grained model based on the holo and ligand-bound structures. The simulations of ligand-induced transition revealed that the signal of intrasubunit closure dynamics is transmitted to form intersubunit contacts, which in turn invoke a precise alignment of active site, followed by the dimer–dimer rotation that compacts the whole tetrameric structure. Further analyses of SAHH dynamics associated with ligand binding provided evidence of both induced fit and population shift mechanisms and also showed that the transition-state ensemble is akin to the ligand-bound state. Besides the formation of enzyme-ligand contacts at the active site, the allosteric couplings from the residues distal to the active site are vital to the enzymatic function.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2011/jacsat.2011.133.issue-49/ja2066175/production/images/medium/ja-2011-066175_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja2066175'>ACS Electronic Supporting Info</A></P>