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Anti-Inflammatory Effect of By-Products from<i>Haliotis discus hannai</i>in RAW 264.7 Cells
Rho, Ho-Seok,Kim, Hyang,Kim, Jung-Ae,Karadeniz, Fatih,Ahn, Byul-Nim,Nam, Ki-Ho,Seo, Youngwan,Kong, Chang-Suk Hindawi Limited 2015 Journal of chemistry Vol.2015 No.-
<P>Several reports promoted the potential of shellfish due to their ability to act as antioxidant, anti-inflammatory, and antimicrobial agents. Pacific abalone,<I>Haliotis discus hannai</I>viscera is, reported to possess bioactivities such as antioxidative stress and anti-inflammatory. In this study, anti-inflammatory potential of mucus-secreting glands from shell-shucking waste of<I>H. discus hannai</I>was evaluated using RAW 264.7 mouse macrophage cell model. Results indicated that presence of<I>H. discus hannai</I>mucosubstance by-products (AM) significantly lowered the nitric oxide (NO) production along the expressional suppression of inflammatory mediators such as cytokines TNF-<I>α</I>, IL-1<I>β</I>, and IL-6 and enzymes iNOS and COX-2. Also, AM was shown to increase expression of anti-inflammatory response mediator HO-1. Presence of AM also scavenged the free radicals<I>in vitro</I>. In conclusion, by-products of<I>H. discus hannai</I>are suggested to possess notable anti-inflammatory potential which promotes the possibility of utilization as functional food ingredient.</P>
Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions
Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8
Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.
김용인,정갑석,장호중,김정묵,정석현 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.1
The purpose of this study was to examine the relationship between participation in leisure sport activities of leisure satisfaction. To accomplish this research purpose, there were two research questions; Firstly, Is there difference on leisure satisfaction according to the participation in leisure sport activities?, Secondly Will the degree of participation in leasure sport activities influence the leisure satisfaction? The population for this study was participants in Leisure sports activity program located in Seoul. The final 227 responses (participation 163, non-participation 114), collected by cluster random selecting method, were used in the data analysis procedure. The items for measuring leisure satisfaction were largely based on Lee(1992)s study, and the degree of participation in leisure sport activities was measured by the period and frequence of participation. To analyze the final data (277), the reliability analysis, analysis of covariance, multiple classification analysis, and multiple regression analysis were used. The conclusions for this study were as followings; Firstly, leisure satisfaction is partially different by participation yes or no of the leisure sports activity. That is, leisure satisfaction is higher participation of leisure sports activity than non-participation Secondly, leisure satisfaction is partially influence by the participation of degree of leisure sports. That is, period and frequence are influence on leisure satisfaction.
원위 대퇴골의 고립성 골연골종에서 발생한 속발성 연골 육종 1례 보고
정필현,황장수,강석,김용민,오형호,채동주,김종필 동국대학교 경주대학 1996 東國論集 Vol.15 No.-
연골육종은 비교적 서서히 자라며 늦게 전이하는 악성 연골 종양으로 알려져 있다. 골 연골종에서 발생한 속발성 연골육종은 발생빈도는 드물며 타부위로의 전이가 적고 악성도가 낮은 경우가 많아 적합한 수술적 치료로서 좋은 예후를 보이는 것으로 보고되고 있다. 본 동국대학교 정형외과학 교실에서는 우측 대퇴골 원위부 골간단부에 생긴 고립성 골 연골종에서 이차적으로 발생한 연골육종을 치험한 바 문헌고찰과 함께 보고하는 바이다. A case of Secondary Chondrosarcoma Arising from Solitary Osteochondroma of the Distal Femur Department of Orthopaedic Surgery, College of Medicine, DongGuk University Phil Hyun Chung M.D., Jung Su Hwang M.D., Suk Kang M.D., Yang Mln Kim M.D., Hyung Ho Oh M.D., Dong Ju Chae M.D., Jong Pil Kim M.D. Chondrpsarcoma is a malignant cartilage-forming tumor that grows slowly and metastasis of this tumor occurs in late stage. Secondary chondrosarcomas arising from a solitary osteocartilaginous exostosis are rare and those have a better prognosis than other chondrosarcomas, and they rarely metastasize. We present our experience with a case of secondary chondrpsarcoma arising in solitary osteochondroma of distal metaphysis of right femur with clinical details.
정원갑,최유식,서호철,이석규,이달해 영남대학교 공업기술연구소 1999 工業技術硏究所論文集 Vol.27 No.2
This paper proposes a fuzzy algorithm for cooperative behaviors of multiple autonomous mobile robots. Each robot makes decision of his behavior based on the information obtained by ultrasonic sensors to measure the position and angles of other robots. To enhance the industrial applicability of the suggested algorithm, we add disturbances of error angle caused by wheel steering when autonomous mobile robot navigates toward next destination point. This algorithm uses the position and velocity information of both the nearest robot and other robots within the detective radius of sensor with different weighting. Based on the fuzzy rule table and fuzzy inference, we obtain the rotational angle of the robots. The effectiveness of the proposed algorithm is shown by some computer simulations where a group of mobile robots encircles with equi-interval. In addition each robots is given weighting value to avoid the wall. Finally, the suggested algorithm shows that the more robots exist, the more effective it is.
NH₃TPD에 의한 SAPO-11 및 Pd/SAPO-11의 표면 산특성에 관한연구
정진호,정석진 慶熙大學校 材料科學技術硏究所 1991 材料科學技術硏究論集 Vol.4 No.-
In order to suggest an efficient catalyst system for methanol-to-olefin, variously prepared (Impregnation, Ion exchange) Pd/SAPO-11 catalysts were characterized using techniques of XRD, ICP, NH₃ TPD etc. From XRD results, it was found that Pd particles of impregnated Pd/SAPO-11 catalyst were found to be existed mainly on the outside of SAPO-11 cage as bulk clusters of large crystalline. On the other hand, ion exchanged Pd/SAPO-11 catalysts has some clue Pd that some portion exist within cage by the process of ion exchange, and the remained Pd exist outside of cage. The content of Pd outside of cage increased by the number of repeatation of ion exchange process as bulk clusters. From calculation of the mean particle size of Pd, the dispersion of Pd in ion exchanged catalyst was better than the impregnated one. From the ICP analysis, it was found that Pd was ion exchanged with Al, p, and Al-P except the cation in the lattice, especially Pd was exchanged with Al, P, and Al-P at 1st and 3rd ion exchange, and with cataion in the SAPO-11 at 2nd ion exchanging. By chemisorbed NH₃ TPD, we are found that the acid amount and strength can be controlled by the optimum mumber of ion exchange trials.
정의석,김선태,김선규,홍성민,정호성 大田大學校 環境問題硏究所 2002 환경문제연구소 논문집 Vol.6 No.-
From January through February 2000, the SO_2. NO_2, and VOCs (Volatile organic compounds) concentrations were measured at the total 15 sites (between 6213S and 6214S, between 5846W and 5848W) around the King Sejong Station located in King George Island. The badge type of SO_2 and NO_2 passive diffusion samplers impregnated with 5% Na_2CO_3 and TEA, respectively and VOC passive samplers including activated carbon filter were used. The samplers brought back to the laboratory were analyzed with IC or GC after extracting by distilled pure water, H_2O_2, or CS_2. Considering that the concentration level of each compound analyzed are very low in Antarctica, the blanks and instrumental detection limits were also determined. The blanks of SO_2 and NO_2 sampler were found to be 0.63 ppb and 0.49 ppb, respectively. Measured concentrations range from <LOD to 1.58 ppb for NO_2 and from <LOD to 0.44 ppb for SO_2. For ten species of VOCs investigated, on the other hand, most of compounds except for toluene and benzene could not be detected because of extremely low concentrations below the instrumental detection limits. Measured concentrations range from <LOD to 0.96ppb for toluene and from <LOD to 0.22 ppb for benzene. Although the concentrations of most gaseous contaminants investigated are observed to be very low, our results clearly show that anthropogenic emissions at King Sejong Station affect the concentrations of several of these compounds. The limited but valuable data presented in this study will be helpful to establish the systematic air monitoring system in the near future.