한국사회와 신사회운동: 운동조직 분석

임현진,공석기 서울대학교 사회과학연구원 1997 한국사회과학 Vol.19 No.2

생산시스템과 생산전략유형의 적합성 : 개념적 모형 A Concepual Model

林錫賢,鄭燦鎔 釜山 大學校 經營 經濟 硏究所 1994 經營 經濟 硏究 Vol.13 No.1

생산전략과 생산시스템 사이에는 일정한 연계가 있으며 양자간의 적합여부는 기업성과에 큰 영향을 미치는 것으로 생각되고 있다. 이 논문에서는 몇 가지 전략변수를 매개로 하 하여 생산시스템과 생산전략의 적합관계를 결정하는 상황론적 통합모델을 구성하였다. 이를 위하여 생산시스템은 공정유연성과 제품집중성, 생산전략은 제품수량, 제품다양성, 혁신성을 기준으로 하여 각각 여섯 가지로 분류하였다. 이와 같은 적합성모델은 생산시스템과 생산전략의 대응관계가 기업성과에 미치는 영향을 알아보기 위한 실증연구의 개념적 틀을 제공할 수 있을 것이다.

EDF 기대손실에 기초한 로버스트 공정능력지수

임태진,송현석 한국품질경영학회 2003 품질경영학회지 Vol.31 No.1

This paper presents a robust process capability index(PCI) based on the expected loss derived from the empirical distribution function(EDF). We propose the EDF expected loss in order to develop a PCI that does not depends on the underlying process distribution. The EDF expected loss depends only on the sample data, so the PCI based on it is robust and it does nor require complex calculations. The inverted normal loss function(INLF) is employed in order to overcome the drawback of the quadratic loss which may increase unboundedly outside the specification limits. A comprehensive simulation study was performed under various process distributions, in order to compare the accuracy and the precision of the proposed PCI with those of the PCI based on the expected loss derived from the normal distribution. The proposed PCI turned out to be more accurate than the normal PCI in most cases, especially when the process distribution has high kurtosis or skewness. It is expected that the proposed PCI can be utilized in real processes where the true distribution family may not be knwon.

EDF 기대손실에 기초한 공정능력지수의 붓스트랩 신뢰구간

임태진,송현석 한국품질경영학회 2003 품질경영학회지 Vol.31 No.4

This paper investigates bootstrap confidence intervals of the process capability index(PCI1 based on the expected loss derived from the empirical distribution function(EDF1. The PCI based on the expected loss is too complex to derive its confidence interval analytically, so the bootstrap method is a good alternative. We propose three types of the bootstrap confidence interval; the standard bootstrap(SB1, the percentile bootstrap(PB1, and the acceleration biased-corrected percentile bootstrap(ABC1. We also perform a comprehensive simulation study under various process distributions, in order to compare the accuracy of the coverage probability of the bootstrap confidence intervals. In most cases, the coverage probabilities of the bootstrap confidence intervals from the EDF PCI turned out to be more accurate than those from the PCI based on the normal distribution. It is expected that the bootstrap confidence intervals from the EDF PCI can be utilized in real processes where the true distribution family may not be known.

기업도산예측모형에 관한 실증연구

임석필,이현철 단국대학교 산업연구소 2002 산업연구 Vol.23 No.-

석면함유 슬레이트 지붕 물받이 퇴적물 중 석면 섬유 함유율

임지현,한솔민,김현석,신유민,박시은,허정윤,김민영,장봉기 순천향대학교 기초과학연구소 2022 순천향자연과학연구 논문집 Vol.28 No.1,2

This study attempted to determine the degree of asbestos release from the aging slate roof by comparing the asbestos content in the slate roof rain gutter with a colored steel plate (tin plate) over the slate roof. Four slate roof houses located in Haengmok-ri, Asan-si, Chungcheongnam-do, and one house constructed with a colored steel plate on the slate roof were selected to collect the sediment of the roof rain gutter. The asbestos fiber content was calculated by a point counting method using a polarization microscope after pretreatment with conversion treatment and hydrochloric acid treatment. The average asbestos content of the four slate roof rain gutter were 1.89%. However, asbestos was not detected in the Slate covering roof rain gutter, which were constructed on the slate roof. Asbestos fiber content was the highest at 2.89% in the slate roof rain gutter installed in 1976, followed by 2.44% in 1953. From the above results, it is necessary to minimize secondary damage as asbestos fibers released from slate roof houses to the surrounding atmosphere or leaked from slate roofs as rainwater may cause soil pollution and seriously affect residents' health. Although covering with colored steel plates (tin plates) has been shown to prevent the leakage of asbestos fibers to some extent, it is believed that a policy alternative to remove the slate roof as soon as possible is needed to solve the fundamental problem.

烏梅(Mume Fructus)水性엑스의 家兎 腸運動에 미치는 影響

高錫太,朴炫貞,任光楠 조선대학교 약학연구소 1994 藥學硏究誌 Vol.16 No.1

Effect of .Mume Fructus on intestinal function was investigated in rabbit, making use of its water extract. Mume Fructus water extract(MWE), of small doses(0.1, 0.3㎎/ml) produced contractile action but did not effect the spontaneous movement strips of high dose(1.0㎎/ml) elicited relaxative action and the inhibition of spontaneous movement in ileum strips. In lieum strips, MWE did not influence the contractile action but augmented the spontaneous movement to acetylcholine, MWE elicited the inhibition of contractile action and the agumentation of spontaneous movement to pilocarpine, MWE inhibited the both actions to histamine, did not affect to serotonin and blocked to dopamine. MWE exhibited the relaxation and the inhibition of spontaneous movement in longitadinal muscle of colon. In longitudinal muscle of colon, MWE inhibited both actions to acetylcholine, did not influence the contractile actions but augmented the spontaneous movement to histamine and serotonin. MWE elicited the increase of contractile actions and the decrease of spontaneous movement in circular muscle of colon. In circular muscle of colon, MWE augmented both actions to acetylcholine, inhibited both actions to serotonin, and then did not affect the contractile action but augmented the spontaneous movement to histamine.

Poly(ADP-ribose)Polymerase 억제제가 신생백서의 저산소성 허혈성 뇌손상에 미치는 영향/1H 자기공명분광법을 이용한 연구

황현숙,이정희,박평환,석은하,임근호,곽미정 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.42 No.2

Background : Poly (ADP-ribose) polymerase (PARP) has been described as an important candidate for mediation of neurotoxicity after brain ischemia. This study was purposed to evaluate the effects of a PARP inhibitor on hypoxic-ischemic injury in the neonatal rat brain. In this study, a highly potent inhibitor of PARP, 3, 4-Dihydro-5-[4-(1-piperidinyl) butoxy]-1 (2H)-isoquinolinone (DPQ) was investigated. Methods : Seven-day old Sprague-Dawley rat pups were used. The right common carotid artery was ligated under halothane anesthesia. After a recovery period of 3 hours, they were exposed to 8% oxygen at 37℃ for about 120 minutes. The animals were divided into four groups: the pre-treatment group (n = 13) and post-treatment group (n = 21) were given DPQ 10 ㎎/㎏ and the pre-control group (n = 7) and post-control group (n = 14) were given a vehicle for controls. Pre-treatment and pre-control groups were injected 30 minutes prior to the hypoxic injury while post-treatment and post-control groups were injected 30 minutes after the hypoxic period intraperitoneally. The right cerebral hemisphere of the rats were examined with localized ^1H magnetic resonance spectroscopy on day 1 and 7 after the hypoxic insult. Lipid/N-acetyl aspartate (Lip/NAA) and lipid/creatine (Lip/Cr) ratios were used as apoptotic markers. On day 14, the degree of brain injury was scored by morphological changes. Results : In the DPQ treated groups, the Lip/NAA and Lip/Cr ratios were lower than those of the control groups on day 1 after the hypoxic-ischemic injury (P < 0.05). However on day 7, only the ratios of the pre-treatment group were lower than those of the control group (P < 0.05). The degree of morphological changes of the brain injury on day 14 were lower in the DPQ treated groups (P < 0.05). Conclusions : These results suggest that DPQ exerts a neuroprotective effect in cerebral hypoxicischemic injury probably by inhibiting apoptosis especially in the early stage after an insult. Acute inhibiton of PARP can have a therapeutic value in preventing ischemic brain injury. (Korean J Anesthesiol 2002; 42: 228~240)

물질남용자의 유형화에 대한 예비적 연구

김현수,조선미,이용석,임기영,이호영 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.1

목 적: 본 연구는 물질남용자들의 인구학적 특성, 물질남용 특성, 인성특성을 파악하는 것을 통해 물질남용자들의 유형화를 하기 위하여 예비적으로 시행된 것이다. 방 법: 본 연구자가 수행하는 집단프로그램에 참여한 사람들을 직접 면접하고, MMPI, BDI, 이화방어기제검사 및 충동성검사 등을 시행하고 이에 대한 빈도분석과 Chi-square 검증 그리고 문항에 따라 F-검증을 실시하였다. 결 과: 1) 본 집단은 대마가 14명, 필로폰이 26명, 유해화학이 2명이었으며, 1년 이상 사용한자가 27명(64.35%) 이었고, 사회경제적으로 중이하가 많았으며 20-30대가 32명(76.5%)이었다. 학력 및 경제적 상태는 다양했으며, 직업도 다양했다. 전과는 15명이었다. 2) 발달력 상 부모관계가 나쁘거나 상실하거나, 이혼, 분리 등의 경험이 많으며, 상관분석상 전과는 비행력과 비행력은 부모약물, 부모관계, 전과와 유의미한 상관이 있었다(p<0.05). 3) MMPI 군집상 두 집단으로 분류가 되었으며 한 집단은 단순약물사용군으로, 다른 집단은 사회병질집단으로 명명하였다. 두 집단과 발달력과의 상관에서 사회병질집단은 부모관계, 부모약물과 통제적으로 유의미했다(p<0.05). 4) 물질종류에 따른 MMPI 척도에서 Mf, Si 척도가 유의미하게 상승했으며, 부모상실, 부모이혼, 부모학대가 있는 집단은 MMPI 척도에서 Pd 척도가 유의미하게 상승했다(p<0.05). 결 론: 이상의 결과로 볼 때 발달력, 물질종류에 따른 유형화의 가능성이 향후 더 연구되어져야 할 것으로 생각이 되며 이를 치료프로그램과 연결하는 연구가 앞으로 수행되어져야 할 것이다. Objectives: This preliminary study was performed to typify a group of substance abusers by their demographic data, developmental history, substance use patterns, and personality profiles. Methods: Forty-two substance abusers were assessed with Minnessota Multiphasic Personality Inventory(MMPI), Ehwa-Defense Mechanism Test, Beck Depression Inventory(BDI), Beck Anxiety Inventory(BAI), etc. They also participated in semi-structured interview by psychiatrists and social workers. Results: 1) This group consisted of 14 cannabis users, 26 methamphetamine users, and 2 inhalant users. Twenty-seven(64.35%) of this group abused drugs over one year. Thirty-two(76.5%) of the subjects were in their twenties or thirties. Many of them were less than low in their economic status. Their academic careers and occupations were various. Fifteen abusers had past criminal histories. 2) Among their developmental history, parental alcohol problem, poor relationship with parent, and criminal history were significantly correlated with one another(p<.05). 3) In the cluster analysis upon their MMPI profiles, two clusters emerged; one cluster presented low profiles, and the other showed high profiles. We named the former simple drug user group, and the latter `sociopathic drug abuser group`(p<.05). 4) There differences in MMPI profiles according to the kind of drugs and developmental problems. Methamphetamine group was higher in Mf and Si. The group with poor developmental history was higher in Pd profiles(p<.05). Conclusion: These results suggest that, for typology of substance abusers, more investigation should be made on developmental history and drug use patterns. This study presented two clusters of simple abuse group and sociopathic abuse group.

유한세프라딘 캅셀(세프라딘 500mg)에 대한 브로드세프 캅셀의 생물학적 동등성

조혜영,이석,강현아,오인준,임동구,문재동,이용복 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.3

Cephradine is a first generation cephalosporin and has broad spectrum antibacterial activity against gram-positive and gram-negative microorganisms, through inhibition of bacterial cell wall synthesis. Cephradine is useful for treatment of infections of the urinary and respiratory tract, skin and soft tissues. The purpose of the present study was to evaluate the bioequivalence of two cephradine capsules, Cefradine Yuhan(YuHan Corporation) and Broadcef (Ilsung Pharmaceuticals Co. Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The cephradine release from the two cephradine capsules in vitro was tested using KP Ⅶ Apparatus Ⅱ method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty normal male volunteers, 23.10±2.90 years in age and 67.69±8.04 ㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one capsule containing 500㎎ as cephradine was orally administered, blood was taken at predetermined time intervals and the concentrations of cephradine in serum were determined using HPLC method with UV detector. The dissolution profiles of two cephradine capsules were very similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_t and C_max and untransformed T_max. The results showed that the differences in AUC_t C_max and T_max between two capsules based on the Cefradine Yuhan were -2.87%, -0.96% and -4.85%, respectively. There were no sequence effects between two capsules in these parameter. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g.,log(0.93)∼log(1.02) and log(0.88)∼log(1.13) for AUC_t and C)max, respectively). The 90% confidence interval using untransformed data was within ±20% (e.g., -17.54∼7.78 for T_max). All parameters met the criteria of KFDA guideline for bioequivalence, indicating that Broadcef capsule is bioequivalent to Cefradine Yuhan capsule.