Enzymatic Synthesis of L-Theanine Using γ-Glutamylmethylamide Synthetase with Less ATP Consumption by ATP Regeneration System

Subin YUN,Taresh KHOBRAGADE,Sunga IM,Sangwoo JOO,Hyunsuk YOON,Younghwan GOH,Youkyoung KWON,Seohee JUNG,Sunga CHO,Pritam GIRI,Hyungdon YUN 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.10

리듬 태권도 프로그램이 발달장애 아동의 사회성 기술 향상과 문제행동 감소에 미치는 영향

윤수빈 ( Yun Subin ),정이루리 ( Jeong Irully ) 한국리듬운동학회 2020 한국리듬운동학회지 Vol.13 No.2

The purpose of this study is to see changes in social skills and problematic behaviors of children with developmental disabilities through this experimental study. We recruited twenty children diagnosed as having developmental disabilities aged between 6 and 13. Before this study started, the data were collected through interviews with their legal guardians and preparation of a preliminary examination. Ten participants were assigned to the experimental group, and other ten participants to the control group in order to examine differences in social skills and problematic behaviors before and after participating in the 12-week rhythmic Taekwondo program. The rhythmic Taekwondo program was provided three times a week and lasted for 1 hours per day. The results indicated that the experimental group shows significant differences in the social competence scale after participation in the program compared to before participation in the program, while the control group showed no significant differences in the scale. Another results indicated that the experimental group shows significant differences in all sub-categories of the problem behavior scale except the rule violation after the program, while the control group did not show significant differences in any sub-categories of the scale. Through this study, we believe that the rhythmic Taekwondo program seems to become a good opportunity to improve social competence and reduce problematic behaviors of children with developmental disabilities.

Incidence and Risk Factors of Vestibular Schwannoma in Korea : A Population-Based Study

Subin Kim,Yun-Hee Lee,Sumin Park,Junhui Jeong,장기홍 대한신경외과학회 2023 Journal of Korean neurosurgical society Vol.66 No.4

Objective : This study aims to investigate the incidence of vestibular schwannoma (VS) and demographic characteristics in Korea using population-based National Health Insurance Service data. Methods : This study analyzed Korean National Health Insurance Service data from 2005 to 2020, based on the International Classification of Diseases, 10th version, Clinical Modification codes D333 and D431. Only those patients who had undergone magnetic resonance imaging and audiologic tests were considered definitive cases. Demographic variables included age, sex, treatment modality, hypertension, diabetics, dyslipidemia, smoking history, alcohol history, and income status. Results : The total number of VS patients was 5751. The average incidence rate was 0.71 per 100000 from 2005 to 2020, and the annual incidence rate increased from 0.33 in 2005 to 1.32 in 2019 but decreased to 0.80 in 2020. Incidence was highest in those aged 60–69 years (1.791) and lowest in those younger than 20 years (0.041). Incidence was higher in females, and the number of patients who received radiosurgery (46.64%) was largest compared to the wait and scan group (37.96%), microsurgery group (12.85%), or the group who received both (2.56%). Diabetes, dyslipidemia, and alcohol consumption increased the risk of VS, while cigarette smoking reduced the risk of VS. Conclusion : The incidence of VS exhibited an increasing trend from 2005 to 2019. Radiosurgery (46.64%) was the most common treatment modality. Diabetes, dyslipidemia, and alcohol consumption increased the risk of VS, while cigarette smoking reduced the risk of VS.

Development of multiplex real-time PCR for the rapid detection of honeybee bacterial, fungal and parasitic pathogens

Subin Min,Mi-Sun Yoo,Hyun-Ji Seo,Doo Sung Cheon,Bang-Hun Hyun,Yun Sang Cho 한국양봉학회 2017 한국양봉학회 학술대회 자료집 Vol.2017 No.10

Identification of anthropogenically contaminated groundwater using fuzzy c-means clustering

Subin Choi,Kyoung-Ho Kim,Seong-Taek Yun 대한지질학회 2015 대한지질학회 학술대회 Vol.2015 No.10

에너지전환과 지속가능한 농촌사회를 위한 전략적 틈새로서 영농형 태양광 : 가능성과 쟁점들

오수빈(Subin Oh),신수민(Sumin Shin),윤순진(Sun-Jin Yun) 한국공간환경학회 2021 공간과 사회 Vol.31 No.4

영농형 태양광은 농업생산과 발전사업을 동시에 진행함으로써 농촌의 고령화와 농가 소득 감소라는 농촌사회의 경제위기와 기후위기를 동시에 해결하는 돌파구로 등장하였지만, 농민들에게 환영받지 못한 채 사회적 갈등의 대상이 되고 있다. 이 연구에서는 궁극적으로 영농형 태양광이 ‘지속 가능한 농촌사회 유지’와 ‘에너지전환’을 함께 해결할 수 있는 틈새로서의 가능성이 있는지, 틈새 확대를 위해서는 어떤 요소가 필요한지를 전략적 틈새 관리의 세 가지 과정인 ‘기대, 사회적 네트워크, 학습’을 통해 파악해 보았다. 분석 결과 영농형 태양광은 농가의 추가 수익 증대와 농민 주도의 에너지전환이라는 기대치가 여러 세미나와 공청회를 통해 이해관계자에서 광범위하게 논의·공유되고, 긍정적 측면을 경청하여 반영하고자 하는 노력이 보인다는 점에서 고무적이다. 하지만 여전히 해결되지 못한 쟁점들과 개선되어야 하는 부분이 존재하기에 이해당사자들의 지속적인 노력이 필요하다. 특히 학습 과정의 정책·제도와 경제적 논의에서 나타나는 표면적 갈등의 내면에 반대측 우려 지점이 내재해 있었다. 이에 각 지자체가 소규모 프로젝트로 영농형 태양광 사업을 시범적으로 설치하여 농민의 수용성을 함양하거나 주민참여형 협동조합 구성 및 공동 사업 절차 관리를 통한 우려 해소를 꾀할 수 있다. 영농형 태양광의 진정한 가치는 농지의 환경을 보전하면서 영농을 지속하고 재생에너지 전력을 생산하는 데 있다. 영농형 태양광이 에너지전환을 위한 전략적 틈새가 되기 위해서는 농민이 사업 주체임을 명확히 하고 임차농을 비롯한 다양한 상황에 놓인 농민 입장을 충분히 고려하면서, 에너지전환이란 방향성을 분명히 하고 보다 깊은 사회적 논의를 거쳐 농민이 혁신 주체로 활동할 공간을 열어주어야 한다. Agrophotovoltaics has emerged as a breakthrough in resolving both climate crisis and economic crisis of rural reality, such as aging and declining farm household income, by simultaneously carrying out agricultural production and power generation projects. However, they have not been welcomed by farmers and become subject to social conflicts. Thus, this study explored whether agrophotovoltaics have a possibility to be a strategic niche to achieve a ‘sustainable rural society’ and ‘energy transition’ and what factors are needed to expand the niche through three processes of strategic niche management, ‘expectation, social network, and learning.’ After conducting in-depth interviews with stakeholders surrounding agrophotovoltaics and analyzed the current issues concerning agrophotovoltaics, this study found that agrophotovoltaics are encouraging in that there is expectation of additional income increase for farmers and they are widely discussed through seminars and public hearings by stakeholders in various fields as a way of farmer-led energy transition. However, it was found that there are still unresolved issues and areas that need to be improved, so the stakeholders continuous efforts are needed. In particular, it was confirmed that there were points of concern for the opposite side within the surface conflict arising from the policy-system and economic discussions of the learning process. As a result, local governments can set up small-scale projects on a trial basis to foster farmers acceptance or form residents participatory cooperatives to resolve difficulties through the management of joint project process. The true value of agrophotovoltaic lies in the continuous farming and generation of renewable energy power while preserving the farmlands environment. In order to become a strategic niche for energy transition, it should be clear that farmers are main agents of the project, fully considering the position of farmers in various situations including tenant farmers and clarifying the direction of energy transition, and space for farmers need to be opened to make them as innovative agents.

Neurotrophin 3 genotype and emotional adverse effects of osmotic-release oral system methylphenidate (OROS-MPH) in children with attention-deficit/hyperactivity disorder

Park, Subin,Kim, Bung-Nyun,Kim, Jae-Won,Shin, Min-Sup,Cho, Soo-Churl,Kim, Ji-Hoon,Son, Jung-Woo,Shin, Yun-Mi,Chung, Un-Sun,Han, Doug-Hyun SAGE Publications 2014 Journal of psychopharmacology Vol.28 No.3

<P>Neurotrophin 3 (NTF3) has been studied in relation to the pathophysiology of attention-deficit/hyperactivity disorder (ADHD) and mood disorders as well as psychostimulant action. We hypothesized that the risk of an emotional side effect to methylphenidate (MPH) treatment may be associated with NTF3 genotypes. Ninety-six medication-naïve children with ADHD (mean age 8.70, standard deviation 1.41 years, 79 males) were genotyped and treated with MPH. At baseline, which was prior to MPH treatment, and after two weeks of medication, investigators asked children and their parents or caregivers about adverse events using a symptom rating scale. ADHD subjects with the A/A genotype at the NTF3 rs6332 polymorphism showed the highest ‘Emotionality’ and ‘Over-focus/euphoria’ factor scores, followed by those with the G/A genotype and those with the G/G genotype (<I>p</I>=0.042 and <I>p</I>=0.045, respectively). ADHD subjects with the A/A genotype at the NTF3 rs6332 polymorphism showed the highest ‘Proneness to crying’ and ‘Nail biting’ item scores, followed by those with the G/A genotype and those with the G/G genotype (<I>p</I>=0.047 and <I>p</I>=0.017, respectively). These data provide preliminary evidence that genetic variation in the NTF3 gene is related to susceptibility to emotional side effects in response to MPH treatment in Korean children with ADHD.</P>

지역정신보건센터의 균형성과관리시스템 구축

박수빈(Subin Park),홍진표(Jin Pyo Hong),용효중(Hyo Joong Yong),정희(Hee Jung),이은정(Eun Jung Lee),황윤정(Yun Jeong Hwang),박연옥(Yeon Ok Park),류진(Jin Ryu),이영(Young Lee) 대한사회정신의학회 2009 사회정신의학 Vol.14 No.1

연구목적: 최근 다양한 관점에서 성과를 설계하고, 조직전체의 성과를 강조하고, 성과에 의한 모니터링과 사후조치를 강화한 전략적 성과관리체계인 균형성과관리제(Balanced Scorecard, BSC)의 공공부문에 도입이 확대되어왔다. 본 연구에서는 지역정신보건센터 중 최초로 BSC를 도입한 강동구 정신보건센터의 BSC구축과정을 소개하고자 한다. 방 법: 강동구 정신보건센터 는 2008년 8월 BSC를 도입하기로 결정한 후, 전문가의 자문을 받으면서 조직구성원 전체가 참여하여 2008년 12월 강동구 정신보건센터 BSC를 구축하였다. 결 과: 강동구 정신보건센터는 '안전하면서도 역동적인 정신건강 네트워크를 통해, 지역주민들의 니즈(욕구)에 맞춤화된 최적의 정신 건강서비스를 제공함으로써, 지역주민들이 정신장애에 대한 편견 없이 함께 어울려 사는 삶' 이라는 비전 아래, 시민, 프로세스, 학습 및 성장 관점에서 전략목표를 수립하고 전략지도를 도출하였으며, 각각의 전략목표에 대한 성과목표 및 성과지표를 개발하 였다. 강동구정신보건센터 BSC의 특징과 의미는 다음과 같이 함축된다. 첫째, 강동구 정신보건센터 BSC 구축은 지역정신보건 사업의 성과를 다양하고 균형적인 관점에서 평가하고 관리하고자 한 최초의 시도이다. 둘째, 강동구 정신보건센터의 BSC 구축은 정신보건센터가 행정기관에 의해 수동적으로 업무평가를 받는 대상으로 머물지 않고, 능동적인 사업의 주체가 되겠다는 의지를 드러낸다. 셋째, 강동구정신보건센터의 BSC는 외부 용역에 의해 구축된 것이 아니라 조직구성원 전체의 참여에 의해 구축되 었다. 넷째, BSC구축 과정 동안 지속적으로 외부전문가의 자문을 받으면서 진행함으로써 내외부 시각의 균형을 담은 BSC체계를 구축할 수 있었다. 결 론: 본 연구는 지역정신보건센터에서 BSC를 도입한 최초의 연구로써, 정신보건센터나 관련시설에서 BSC를 도입하고자 할 때 유용한 정보로 활용될 수 있을 것이다.

A Preliminary Study of the Effects of an Arts Education Program on Executive Function, Behavior, and Brain Structure in a Sample of Nonclinical School-Aged Children

Park, Subin,Lee, Jong-Min,Baik, Young,Kim, Kihyun,Yun, Hyuk Jin,Kwon, Hunki,Jung, Yeon-Kyung,Kim, Bung-Nyun SAGE Publications 2015 Journal of child neurology Vol.30 No.13

<P>The authors examined the effects of arts education on cognition, behavior, and brain of children. Twenty-nine nonclinical children participated in a 15-week arts education program that was composed of either creative movement or musical arts. Children completed the Wisconsin Card Sorting Test, clinical scales, and brain magnetic resonance imaging before and after the intervention. Following program completion, performances on the Wisconsin Card Sorting Test, the Children’s Depression Inventory scores, and conduct disorder scores were significantly improved. Furthermore, cortical thickness in the left postcentral gyrus and superior parietal lobule were increased, and the mean diffusivity values in the right posterior corona radiate and superior longitudinal fasciculus were decreased. Positive correlations between changes in cognitive measurements and changes in cortical thickness were observed. This preliminary study suggests a positive effect of arts education on executive functions in association with brain changes. However, these findings must be interpreted with caution due to the noncomparative study design.</P>

Environmental Tobacco Smoke Exposure and Children’s Intelligence at 8–11 Years of Age

Park, Subin,Cho, Soo-Churl,Hong, Yun-Chul,Kim, Jae-Won,Shin, Min-Sup,Yoo, Hee Jeong,Han, Doug Hyun,Cheong, Jae Hoon,Kim, Bung-Nyun NLM-Export 2014 Environmental health perspectives Vol.122 No.10

<P>Background: Evidence supporting a link between postnatal environmental tobacco smoke (ETS) exposure and cognitive problems among children is mounting, but inconsistent.</P><P>Objectives: We examined the relationship between ETS exposure, measured using urine cotinine, and IQ scores in Korean school-aged children.</P><P>Methods: The participants were 996 children 8–11 years of age recruited from five administrative regions in South Korea. We performed a cross-sectional analysis of urinary cotinine concentrations and IQ scores obtained using the abbreviated form of a Korean version of the Wechsler Intelligence Scales for Children. Associations were adjusted for potential confounders, and estimates were derived with and without adjustment for mother’s Full-Scale IQ (FSIQ) score.</P><P>Results: After adjusting for sociodemographic and developmental covariates, urinary cotinine concentrations were inversely associated with FSIQ, Verbal IQ (VIQ), Performance IQ (PIQ), vocabulary, math, and block design scores. Following further adjustment for maternal IQ, only the VIQ scores remained significantly associated with urinary cotinine concentration (B = –0.31; 95% CI: –0.60, –0.03 for a 1-unit increase in natural log-transformed urine cotinine concentration; <I>p</I> = 0.03).</P><P>Conclusion: Urine cotinine concentrations were inversely associated with children’s VIQ scores before and after adjusting for maternal IQ. Further prospective studies with serial measurements of cotinine are needed to confirm our findings.</P><P>Citation: Park S, Cho SC, Hong YC, Kim JW, Shin MS, Yoo HJ, Han DH, Cheong JH, Kim BN. 2014. Environmental tobacco smoke exposure and children’s intelligence at 8–11 years of age. Environ Health Perspect 122:1123–1128; http://dx.doi.org/10.1289/ehp.1307088</P>