Solar urticaria in Korean patients

( Sung Min Kim ),( Young Ah Cho ),( Ji Su Lee ),( Ji Youn Hong ),( Jin Hee Kim ),( Joo Ran Hong ),( Hye In Cheon ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Solar urticaria (SU) is an uncommon type of photodermatoses characterized by erythematous wheal with pruritus after sunlight exposure, which shows a female predominance. Only a few studies to analyze the clinical features of SU were reported in Asia. Objectives: We aimed to analyze the clinical and photobiological characteristics of SU in Korea. Methods: We retrospectively investigated the medical records of patients with SU who visited the department of dermatology, Konkuk university medical center from January 2005 to January 2020. Results: Of a total of 44 patients, 36 (81.8%) were male and 8 (18.2%) were female. The mean age at onset was 17.6 years (range, 5-47) and the mean threshold time was 19.7 minutes. Among 32 patients who underwent phototesting, the action spectrum most commonly implicated was ultraviolet (UV) A only in 12 (37.5%), and then visible light (415nm) only was responsible for SU in 8 (25.0%). Three patients (9.4%) were induced by both UVA and visible light (415nm). Even 4 patients (12.5%) were triggered by only natural sunlight. Serum immunoglobulin E levels were measured in 33 patients, and 17 (51.5%) showed values higher than normal. The treatment most widely used were oral antihistamine (43.2%), followed by phototherapy (13.6%). Conclusion: SU is a rare photodermatosis in Korea, which shows a male preponderance. In this study, UVA and visible light (415nm) were predominant action spectrum of SU.

국내에서 분리된 Vancomycin 내성 장구균에 대한 분자역학적 연구

김수정,이남용,배직현,이경원,이위교,김의종,최명식,백경란,김성민,송재훈 대한감염학회 1998 감염 Vol.30 No.1

목 적 : 장구균은 병원 감염의 원인균으로서 최근 그 빈도와 중요성이 증가하고 있다. 특히 vancomycin에 내성을 보이는 장구균(VRE)은 효과적인 치료약제가 드물고, 그 내성 유전자가 vancomycin에 감수성을 보이는 다른 장구균이나 그람양성 구균에 전달될 수 있어 임상적인 중요도가 더욱 크다. 본 연구에서는 국내 5개 병원에서 분리된 VRE 균주의 표현형과 유전형을 결정하고, 분자역학적 방법을 이용하여 유전적 연관성 여부를 밝히고자 하였다. 방 법 : 각 병원에서 수집된 균주는 환자의 임상 검체에서 또는 VRE 집락화에 대한 선별검사에서 분리된 균주였다. 이들을 대상으로 vancomycin과 teicoplanin의 MIC를 측정하여 표현형을 결정하였으며, PCR로 vancomycin 내성 유전자를 증폭하여 유전형을 결정하였다. 또한 이들중 vanA와 vanB 유전자를 갖는 균주들을 대상으로 플라스미드 분석과 PFGE를 시행하였다. 결 과 : VRE로 최종 동정된 균주들은 42균주(E. faecium 21주, E. faecalis 6주, E. avium 2주, E. casseliflavus 13주)였으며, 항균제 감수성 양상으로 결정한 표현형은 VanA, VanB, VanC형이 각각 14주(33%), 7주(17%), 21주(50%)였다. PCR로 결정한 유전형은 vanA 12주(E. faecium), vanC 16주 였으며, 이중 VanA의 표현형을 보인 E. faecium 2주가 VanB의 유전형으로 판명된 것을 제외하면 표현형과 유전형은 모두 일치하였다. 플라스미드 분석과 PFGE 결과, 병원내 동일 균주의 전파 가능성이 5개 병원중 3병원에서 증명되었다. 결 론 : 국내 병원에서도 vancomycin 내성 유전자를 갖는 VRE가 다수 분리되고 있음을 확인할 수 있었으며, 연구 결과 일부 병원에서 내성균주의 병원내 전파 가능성을 시사하였다. 아직까지 국내에서 VRE로 인한 감여보고는 적지만 곧 임상적으로 문제가 될 것으로 판단되며, 따러서 내성균의 발생이나 확산을 억제하기 위한 노력과 감시가 필요할 것으로 생각된다. Background : Enterococci have emerged in recent years as a frequent cause of life-threatening nosocomial infections. The emergence of vancomycin-resistant enterococci(VRE) presents as an increasingly important problem particularly in the treatment and the potential dissemination of vancomycin-resistance. The purpose of this study is to determine the phenotypes and genotypes of VRE isolated from five hospitals and to study the genetic relatedness among them. Methods : Antimicrobial susceptibility patterns and amplification of vancomycin resistance genes were used for phenotyping and genotyping of 42 VRE isolates respectively. For 21 isolates with vanA or vanB gene, plasmid profiles and pulsed field gel electrophoresis(PFGE) patterns were analyzed for molecular epidemiologic study. Results : Out of 42 isolates, 21 were identified as E. faecium, 6 as E. faecalis, 2 as E. avium, and 13 as E. casseliflavus. Phenotyping showed 14 isolates as VanA(33%), 7 as VanB(17%) and 21 as VanC(50%). Genotyping resulted in 12 isolates as VanV(5 of E. faecalis and 7 of e. faecium) and 9 as VanB(all E. faecium). Genotyping results were concordant with phenotyping results except for the two E. faecium isolates of VanA which had VanB genotype. Intrahospital spread of the same strains was proven in three hospitals by plasmid profiles and PFGE analysis. Conclusion : The study demonstrated a considerable number of VRE isolates in Korea and intrahospital spread proven by molecular epidemiologic methods. Although VRE infection has been considered very are in Korea, practical guidelines including restriction of vancomycin usage and surveillance, are warranted to prevent infection and dissemination of VRE.

주간보호시설과 재가 치매노인 주간호자의 삶의 만족과 부담감

이수진,박호란,,김남초 노인간호학회 2005 노인간호학회지 Vol.7 No.1

Purpose: To investigate the level of life satisfaction and burden for primary caregivers of patients with dementia in day care centers and in their homes. Method: From August to September 2003, 56 caregivers of patients with dementia in day care centers and 54 caregivers in their homes were surveyed through three questionnaires: Life Satisfaction Index-Z and Korean Dementia Caregiver Burden. Result: Life satisfaction of caregivers in day care centers was significantly higher than that of caregivers in their homes(p<.005). Also, the sense of burden of caregivers in day care centers was significantly lower than that of caregivers in their homes(p<.005). Caregivers in day care centers showed significantly lower levels in four subdimensions of burden than those of caregivers in their homes. The level of life satisfaction of caregivers in day care centers and in their homes were also negatively correlated with the sense of burden(p<.005, p<.005). Conclusion: Using day care centers for patients with dementia will be a good way to take care of them because their primary caregivers can have more rest time and less burden. Therefore, using day care centers for patients with dementia should be recommended and the number of the facility should be increased nationwide.

생활치 표백술 후 수종의 자유 산소기 제거제 처리가 복합 레진-법랑질 전단 접착 강도 및 파절 양상에 미치는 영향

임경한,금기연,김애리,장수미 대한치과보존학회 2001 Restorative Dentistry & Endodontics Vol.26 No.5

Tooth bleaching has been prevailing recently for its ability to recover the color and shape of natural teeth without reduction of tooth material. However, it has been reported that bleaching procedure adversely affects the adhesive bond strength of composite resin to tooth. At the same time the bond strength was reported to be regained by application of some chemical agents. The purpose of this in vitro study was to investigate the effect of the removal of residual peroxide on the composite- enamel adhesion and also evaluated fracture mode between resin and enamel after bleaching. Sixty extracted human anterior and premolar teeth were divided into 5 groups and bleached by combined technique using office bleaching with 35 % hydrogen peroxide and matrix bleaching with 10% carbamide peroxide for 4 weeks. After bleaching, the labial surfaces of each tooth were treated with catalase, 70% ethyl alcohol, distilled water and filled with composite resin. Shear bond strength was tested and the fractured surfaces were also examined with SEM. Analysis revealed significantly higher bond strength values. (p<0.05) for catalase-treated specimens, but water-treated specimens showed reduction of bond strength, alcohol- treated specimens had medium value between the two groups(p<0.05). The fracture mode was shown that the catalase group and the alchohol group had cohesive failure but the water sprayed group had adhesive failure. It was concluded that the per-oxide residues in tooth after bleaching seems to be removed by gradual diffusion and the free radical oxygen from peroxide prevents polymerization by combining catalyst in the resin monomer. Therefore it may be possible to eliminate the adverse effect on the adhesion of composite resin to enamel after bleaching by using water displacement solution or dentin bonding agent including it for effective removal of residual per-oxide Key words : Vital tooth bleaching, Shear bond strength, Composite resin, Fracture mode catalase, Ethylalcohol, Free oxygen radical, Adhesive failure, Cohesive failure

다제 내성 폐렴구균에 대한 항균제 병합시의 시험관내 항균효과

김수정,이남용,양지원,백경란,김성민,배직현,송재훈 대한감염학회 1997 감염 Vol.29 No.2

목적: 페니실린 및 다제 내성 폐렴구균은 선택할 수 있는 치료제가 제한되어 임상적으로 문제가 되고 있다. 특히 다제 내성 균주에 의한 수막염의 치료에 cephalosporin제 단독요법의 치료 실패가 계속 보고 되면서, 기존 항균제의 병용요법이나 새로 개발되는 항균제에 관심이 모아지고 있다. 특히 국내에서 분리되는 폐렴구균의 페니실린 및 다제 내성율은 이미 세계 최고 수준으로 이러한 치료법의 개발이 더욱 필요한 상황이다. 저자들은 다제 내성 폐렴구균 감염증의 새로운 치료법을 찾고자 국내에서 흔히 사용되는 항균제를 대상으로 time-kill 방법을 이용한 시험관내 synergy 여부를 알아보고자 하였다. 방법 :대상균주는 국내에서 분리된 페니실린 감수성인 2균주와 모든 β-lactam 제제에 동시 내성을 보인 다제 내성 5균주이었다. 대상 병용요법은 penicillin+gentamicin, cefotaxime+gentamicin, vancomycin+gentamicin, vancomycin+cefotaxime, vancomycin+imipenem, ampicillin+cefotaxime 등이었다. 각 항균제의 시험 농도는 1/2 MIC로 하였으며, 균 집락수의 측정은 0,4,8,24시간에 시행하였다. 결과:Penicillin+gentamicin, cefotaxime+gentamicin, vancomycin+cefotaxime 등의 병합요법이 시험관내 synergy를 보였으며, vancomycin+gentamicin, vancomycin+imipenem, ampicillin+cefotaxime 등의 병용은 indifference의 결과를 보였다. 결론 본 연구를 통하여 penicillin+gentamicin, cefotaxime+gentamicin, vancomycin+cefotaxime 등의 병용요법이 다제 내성 균주에 대하여 시험관내 synergy를 보임으로써 새로운 치료요법의 대상이 될 수 있음을 확인하였다. 또한 이는 향후 생체 내에서의 약물 상호작용에 대한 동물실험시 응용될 수 있는 기본 자료로 의미가 있을 것으로 생각된다. Background: Penicillin-and multidrug-resistant Streptococcus pneumoniae became a global problem during recent decades. Multidrug resistance poses a serious threat to clinical medicine due to restriction of selecting appropriate antimicrobial agents to treat with. Current data suggest that any single antimicrobial agent cannot be a satisfactory option to treat pniemococcal infections caused by multidrug-resistant strains, particularly in meningitis. The aim of the study was to assess in vitro efficacy of several antimicrobial combinations which are commonly used in clinical practice, and to obtain reasonable regimens which can be applied to in vivo model. Methods: We performed time-kill studies of antimicrobial combinations including penicillin, cefotaxime, vancomycin, gentamicin, imipenem and ampicillin against five multidrug-resistant strains and two penicillin-susceptible strains. Penicillin, cefotaxime and vancomycin were combined with gentamicin, respectively. Cefotaxime plus vancomycin, imipenem plus vancomycin, and cefotaxime plus ampicillin combinations were also tested. Synergy was defined as a ≥100-fold or 2-log decrease in colony count at 24 h by the combination compared with that by the most active single agent. Result: Penicillin puls gentamicin, cefotaxime plus gentamicin, and vancomycin plus cefotaxime combinations were deminstrated to have in vitro synergistic activities against multidrug-resistant strains. Conclusion: Three combinations showed in vitro synergism against penicillin-resistant pneumococci. Experimental animal study is warranted to determine the clinical relevance of the in vitro results.

다변량 일반화가능도 이론을 통한 인식론적 신념 검사 타당화 연구

송인섭,김수란 한국교육방법학회 2012 교육방법연구 Vol.24 No.1

본 연구는 우리나라 대학생의 인식론적 신념 측정을 위해 기존 연구 결과를 통합하는 타당한 요인구조를 찾고 측정학적으로 신뢰로운 검사를 개발하는 것이 주된 목적이다. 이를 위하여 우선, 인식론적 신념에 대한 문헌 검토 후 본 연구의 개념모형 및 측정모형을 토대로 최초 63문항을 만들었으며 일차적으로 내용타당도를 거친 결과 총 56문항이 예비검사에 사용되었다. 우리나라 4년제 대학생 168명을 대상으로 예비검사를 실시한 결과 추출된 44문항으로 본검사를 진행하였다. 본검사는 437명(남학생 184명, 여학생 253명)을 대상으로 실시하여 요인분석을 통하여 최종적으로 7요인(지식의 확실성, 지식의 단순성, 앎의 원천, 앎의 정당화, 선천적 능력, 빠른 학습, 규제된 학습)으로 구성된 34문항을 선정했다. 이렇게 최종 문항이 선정된 후에는 보다 신뢰로운 검사인지를 규명하기 위해 다변량 일반화가능도 연구를 실시하였다. () 설계를 적용하여 G연구를 통해 오차원천에 대해 조사한 다음, D연구를 실시하여 일반화가능도계수(Generalizability Coefficients)와 phi 계수를 구하였다. G연구 결과, 문항 효과보다는 주로 피험자 효과와 문항과 피험자 상호작용 및 잔차의 분산 성분이 크게 나타났다. 이밖에도 D연구 결과 G계수는 .67에서 .85, phi 계수는 .64에서 .83 정도로 대체로 양호한 신뢰도 계수임을 확인 할 수 있었다. 본 연구는 기존 문헌에서 보여준 다양한 요인을 통합한 요인구조를 추출하였고, 신뢰도가 낮게 보고된 기존의 인식론적 신념 검사보다 비교적 높은 신뢰도를 확보했다는 것에 의의가 있다. 따라서 여러 대안적인 교육 방법을 통하여 인식론적 신념이 보다 세련(sophisticated)되게 변화 및 발달하는지에 대한 효과성 판단 연구에 유용하게 사용할 수 있을 것이다. The purpose of this study is to develop a valid and reliable examination on the measurement of the epistemological belief in the knowing and knowledge of Korean university students. Regarding the above, we initially selected 63 items through the review of literature on epistemological belief and then, based on content validity, 56 items were used for the primary test. With the result from the primary test tested on 168 Korean university students, we progressed onto the main test with only 44 items. The main test was conducted on 437(Male: 184, female: 253) Korean university students. Through the main test, we found 7 different kinds of factors and selected 34 items. The 7 factors are composed by certainty of knowledge, simplicity of knowledge, source of knowing, justification of knowing, innate ability, quick learning, and regulatory learning. After selecting the final items, we proceeded with the multivariate generalizability for investigation as to whether it is the more reliable examination. After investigating the source of error through the G study adjusted () design, we proceeded with the D-study for finding the generalizability coefficients and phi coefficient. With the result from the G-study, the effect are bigger than others. Besides, as a result of the D-study, we can confirm the reliability coefficient from the .67 to .85 of G-coefficient and .64 to .83 of phi-coefficient. This study has meant to synthesize diverse factor structure and secure a higher reliability than the past study. Thus, this measurement tool will be useful for judging the effectiveness that various alternative teaching methods makes the epistemological belief change and development more sophisticated.

다발성 뇌경색이 합병된 Pasteurella multocida 심내막염 1예

이남용,고재현,백경란,송재훈,천정학,김성민,이혁,김수정 대한감염학회 1997 감염 Vol.29 No.6

저자들은 평소 건강하였던 환자에서 동물과의 접촉없이 P.multocida에 의한 세균성 심내막염이 발생하여 임상 경과 중 다발성 뇌경색이 합병되었으나, 항균제 투여만으로 완치가 되었던 증례를 경험하였기에 문헌 고찰과 함께 이를 보고하는 바이다. In recent years, an increasing number of infections with Pasteurella multoida in human have been reported, causing a wide range of systemic illness. Infective endocarditis with P.multocida, however, is still quite rare. Recently we experienced a cases of P. multocida endocarditis in a 26-year old man who was admitted because of fever and headache. He denied any recent contact with animals. P. multocida was identified from blood cultures and echocardiography showed mitral regurgitation and vegetations on mitral valve area. He became stuporous on the fourth hospital day and the brain MRI showed acute cerebral infarction. He was treated with penicillin intravenously for six weeks, which successfully controlled clinical features of infections. To our knowledge, this is the first case of P. multocida endocarditis complicated with cerebral infarction in Korea.

대학생을 위한 예비 부모 교육 프로그램 개발을 위한 연구

윤기영,전효숙,박상임,이미숙,이석란,박수옥 서원대학교 학생생활연구소 1998 학생생활연구 Vol.16 No.-

The purpose of this study are to examine reference materials, existing lecture analysis, investigate how student response about new lecture model and to project the basic direction of pre-parent education program. The result of this study are as follows ; <Lecture Model : Parent and Child> Sequence Theme 1 Introduction, Positive Self-Concept 2 Love and Sex 3 Friends versus Lovers 4 Marriage 5 Parenting and Parent's Role 6 Pregnancy and Embriology 7 Brith 8 Middle Term Exam 9 Parent's Role for Infant and Toddler 10 Parent's Role for Child 11 Parent's Role for Youth 12 Society and Environment for Child Care 13 Communication for Parent-Child 14 Problem solving method for Child Care 15 Parent in Future 16 Final Exam

Structural Biology and Drug Targeting (Structural Basis of Protein Function and Regulation) : PRL-3 promotes tumor metastasis via down-regulation of MMP expression in human colorectal cell Line

( Su Kyung Lee ),( Young Ran Ha ),( Dong Cho Han ),( Byoung Mog Kwon ) 한국생화학분자생물학회 (구 한국생화학회) 2008 생화학분자생물학회 춘계학술발표논문집 Vol.2008 No.-

Effects of Seasonal Defoliation Treatment on Fruit Development and Tree Growth of Apple ‘Fuji’

Su-Hyun Ryu,Seong-sig Hong,Jeom Hwa Han,Hyun Hee Han,Gyung Ran Do,Ji-Hye Yim,In Myung Choi 한국원예학회 2014 한국원예학회 학술발표요지 Vol.2014 No.10