Arterial stiffness is inversely associated with a better running record in a full course marathon race

( Su Jeen Jung ),( Jae Hyoung Park ),( Se Won Lee ) 한국운동영양학회 2014 Physical Activity and Nutrition (Phys Act Nutr) Vol.18 No.4

[Purpose] Arterial stiffness is an independent predictor of cardiovascular risk and may contribute to reduced running capacity in humans. This study investigated the relationship between course record and arterial stiffness in marathoners who participated in the Seoul International Marathon in 2012. [Methods] A total of 30 amateur marathoners (Males n = 28, Females n = 2, mean age = 51.6 ± 8.3 years) were assessed before and after the marathon race. Brachial-ankle pulse wave velocity (ba-PWV) was assessed by VP-1000 plus (Omron Healthcare Co., Ltd., Kyoto, Japan) before and immediately after the marathon race. Pearson`s correlation coefficient was used to determine the relationship between race record and ba-PWV. In addition, Wilcoxon signed rank test was used to determine the difference in ba-PWV between before and after the race. [Results] There was no significant change in the ba-PWV of marathoners before and after the race (1271.1 ± 185 vs. 1268.8 ± 200 cm/s, P=0.579). Both the full course record (Pearson`s correlation coefficient = 0.416, P = 0.022) and the record of half line (Pearson`s correlation coefficient = 0.482, P = 0.007) were positively related with the difference in ba-PWV, suggesting that reduced arterial stiffness is associated with a better running record in the marathon. [Conclusion] These results may suggest that good vascular function contributes to a better running record in the marathon race.

Immune Responses to Varicella Zoster Virus and Effective Vaccines

Su Jeen Lee,Hun Kim,Kee-Jong Hong,Jae-Hwan Nam 대한미생물학회 2021 Journal of Bacteriology and Virology Vol.51 No.3

The effects of exercise training and carnosine on mitochondria-mediated apoptotic signaling in atorvastatin-treated rat skeletal muscle

Su-Zi Yoo,Mi-Hyun No,Jun-won Heo,Dae-Yun Seo,Su-Jeen Jung,Hyo-Bum Kwak 한국운동재활학회 2019 한국운동재활학회 학술대회 Vol.2019 No.05

The purpose of this study was to determine the effects of in vivo atorvastatin, L-carnosine, and resistance exercise training on mitochondria-mediated apoptotic signaling in the rat skeletal muscle. Male Wistar rats were randomly assigned to control (CON), 5 mg atorvastatin treated group (STAT), 5 mg atorvastatin plus resistance (ladder climbing) exercise training group (STAT + EX), 5 mg atorvastatin plus L-carnosine treatment group (STAT + CAR), and 5 mg atorvastatin treatment plus resistance exercise training plus L-carnosine treatment group (STAT + EX + CAR) (n=12 rats/group). Animals were administered via oral gavage with a vehicle, 5 mg/kg/day atorvastatin, and 250 mg/kg/day L-carnosine dissolved in 0.25 % w/v hydroxypropyl methylcellulose for 12 weeks. Also, animals were trained for 12 weeks on a ladder with a gradient of about 80 degrees. Mitochondria-mediated apoptotic signaling (e.g., Bax, Bcl-2, mPTP opening, cytochrome c, cleaved caspase-3) were measured in skeletal muscles (e.g., soleus, white gastocnemius). Bax , pro-apoptotic protein, was increased in STAT in both soleus and white gastrocnemius and decreased in STAT + EX, STAT + CAR, and STAT + EX + CAR in both soleus and white gastrocnemius. In contrast, Bcl-2, anti-apoptotic protein, was elevated in STAT + EX, STAT + CAR, and STAT + EX + CAR in both soleus and white gastrocnemius and reduced in STAT in both soleus and white gastrocnemius. Also, mPTP opening, cytochrome c, and cleaved caspase-3 showed the same patterns like Bax in both soleus and white gastrocnemius. These data demonstrated that skeletal muscle mitochondria-mediated apoptotic signaling was impaired by atorvastatin treatment for 12 weeks. However, L-carnosine and resistance exercise training protected against statin-induced mitochondria-mediated apoptotic signaling in the rat skeletal muscle, suggesting that both L-carnosine and resistance exercise training play a pivotal role in ameliorating apoptosis in statin-induced myopathy.

Effects of a single bout of exercise on mitochondria-mediated apoptotic signaling in rat cardiac and skeletal muscles

Su-Zi Yoo,Mi-Hyun No,Jun-Won Heo,Eunwook Chang,Dong-Ho Park,Ju-Hee Kang,Dae-Yun Seo,Jin Han,Su-Jeen Jung,Kwan Hwangbo,Hyo-Bum Kwak 한국운동재활학회 2019 JER Vol.15 No.4

일회성 농구운동이 청소년의 혈압과 혈관경직도에 미치는 영향

정수진(Su-Jeen Jung),박상현(Sang-Hyun Park) 한국생활환경학회 2017 한국생활환경학회지 Vol.24 No.2

This study was to investigate the effects of acute basketball program on blood pressure and arterial stiffness in adolescent. The subjects of this study were twenty-two male students in a middle school and they were divide into two groups(athletes: n=11, control: n=11). Both group conducted basketball training program for 60 min(warm-up: 5 min, main exercise: 50 min, cool down: 5 min). The result of this study is following : systolic and diastolic blool pressure show the no change in athletes group but control group significantly decreased compared to baseline. In the changes of arterial stiffness, ABI(R) and ABI(L) significantly decreased in control group and exercise group respectively compared to baseline. Both group PWV(R) significantly decreased more than baseline, while there was no difference between the groups. In conclusion, regardless of blood function and ages, physical activity can contribute to improvement of blood health. Therefore, aerobic exercise will be able to prevent metabolic syndrome(include cardiovascular disease, type 2 diabetes, obesity) in adult.

관상동맥질환자에게 일시적 레크리에이셔널댄스운동이 혈관 경직도와 중심동맥압에 미치는 영향

정수진(Su-Jeen Jung) 한국생활환경학회 2014 한국생활환경학회지 Vol.21 No.5

Arterial stiffness and central blood pressure are the surrogate markers of non invasive method anticipating cardiovascular disorders to the patients with coronary artery disease. Its numerous merits to the patients with coronary artery disease in relatively older age, research results of recreational dance are still insufficient. Thus, this study implemented acute recreational dance to 10 patients with coronary artery disease, who underwent coronary intervention, and analyzed the effects 20 minutes before and after exercise respectively. We measured brachial-ankle pulse wave velocity (ba-PWV) and central blood pressure. The ba-PWV was measured using VP-1000 plus (Omron Healthcare Co., Ltd., Kyoto, Japan)and central blood pressure was HEM-9000AI(Omron Healthcare Co., Ltd., Kyoto, Japan). As a result, pulse wave velocity, which indicates arterial stiffness, reduced positively, but it was not statistically significant. Nevertheless, it showed positive and statistically significant change in blood pressure of brachial artery, pulse pressure and central arterial pressure.

Effects of Acute Exercise on Mitochondrial Function, Dynamics, and Mitophagy in Rat Cardiac and Skeletal Muscles

Yoo, Su-Zi,No, Mi-Hyun,Heo, Jun-Won,Park, Dong-Ho,Kang, Ju-Hee,Kim, Joon-Hee,Seo, Dae-Yun,Han, Jin,Jung, Su-Jeen,Kwak, Hyo-Bum Korean Continence Society 2019 International Neurourology Journal Vol.23 No.S1

<P><B>Purpose</B></P><P>This study aimed to investigate the effects of single-bout exercise on mitochondrial function, dynamics (fusion, fission), and mitophagy in cardiac and skeletal muscles.</P><P><B>Methods</B></P><P>Fischer 344 rats (4 months old) were randomly divided into the control (CON) or acute exercise (EX) group (n=10 each). The rats performed a single bout of treadmill exercise for 60 minutes. Mitochondrial function (e.g., O<SUB>2</SUB> respiration, H<SUB>2</SUB>O<SUB>2</SUB> emission, Ca<SUP>2+</SUP> retention capacity), mitochondrial fusion (e.g., Mfn1, Mfn2, Opa1), mitochondrial fission (e.g., Drp1, Fis1), and mitophagy (e.g., Parkin, Pink1, LC3II, Bnip3) were measured in permeabilized cardiac (e.g., left ventricle) and skeletal (e.g., soleus, white gastrocnemius) muscles.</P><P><B>Results</B></P><P>Mitochondrial O<SUB>2</SUB> respiration and Ca<SUP>2+</SUP> retention capacity were significantly increased in all tissues of the EX group compared with the CON group. Mitochondrial H<SUB>2</SUB>O<SUB>2</SUB> emissions showed tissue-specific results; the emissions showed no significant differences in the left ventricle or soleus (type I fibers) but was significantly increased in the white gastrocnemius (type II fibers) after acute exercise. Mitochondrial fusion and fission were not altered in any tissues of the EX group. Mitophagy showed tissue-specific differences: It was not changed in the left ventricle or white gastrocnemius, whereas Parkin and LC3II were significantly elevated in the soleus muscle.</P><P><B>Conclusions</B></P><P>A single bout of aerobic exercise may improve mitochondrial function (e.g., O<SUB>2</SUB> respiration and Ca<SUP>2+</SUP> retention capacity) in the heart and skeletal muscles without changes in mitochondrial dynamics or mitophagy.</P>

관상동맥질환 환자에게 실시한 수영운동과 걷기운동이 혈류매개 확장반응과 혈관내피전구세포 발현에 미치는 영향

정수진(Su-Jeen Jung) 한국생활환경학회 2017 한국생활환경학회지 Vol.24 No.2

The aim of this study is to effects of swimming exercise and walking exercise for 10 weeks in patients with a coronary-artery disease on their flow mediated dilation (FMD) and the expression level of endothelial progenitor cells (EPCs). A patient group of 18 subjects were recruited, a walking exercise was carried out (n =10), and a swimming exercise was carried out (n = 8). The two exercises are types of the same aerobic exercise preferred by a lot of patients, but there are very insufficient grounds for scientific studies of swimming exercise as compared to those of the walking exercise. For measurement, this study measured their body composition, FMD and EPCs. As a result of this study, it turned out that there were no statistically significant changes in the expression level of EPCs and FMD in the patients with a coronary-artery disease, who carried out the swimming exercise than in those who carried out the walking exercise, but there was an effect between the times after carrying out the two exercises. In this result, since the swimming exercise and the walking exercise are the same aerobic exercises, there were no statistically significant differences, but both exercises had positive effects, so the importance of the exercises was confirmed.

한(韓) · 미(美) · 일(日) 유통(流通) 시스템의 비교연구(比較硏究) -수학적(數學的) 모델을 중심(中心)으로-

林晋洙 ( Jeen-su Lim ) 숭실대학교 인문과학연구소 1979 인문학연구 Vol.9 No.-

The importance of the distribution segment in national economy is recognized with the achievement of the economic progress together with the increased level of income. The pattern of consumption is changed and consumption segment also achieved great progress in the same with production segment. But distribution segment remained still in the state of inefficiency. As distribution can be an important obstacle in achieving the economic development and national welfare, many paid a keen attention and interest to that segment. In accordance with the increased interest in distribution, no succession and policy was made to activate the development of distribution segment. Therefore this thesis aims to build theoretical distribution system model by theoretical analysis and description, and to build a mathematical model by empirical analysis of distribution system of the three countries, Korea, Japan & U. S. After testing the validity of this mathematical model as a forecasting model, basic suggestions are made with the results of the research. Distribution is defined as the economic activities to connect supply and demand of economic materials and services. With these activities, distribution can deliver and create standard of living and increase consumer satisfaction. In studying the distribution, there are many traditional approach to mention, but these approaches are not satisfactory method to explain distribution. Therefore system approach is adapted to build the analytical frame work of the distribution. We can conceive system either entity or method. The basic definition of system as entity was made by optner. His definition is “a set of object with a given set of relation between the objects and their attributes.” On the other hand, system conceived as method is called as system approach. Any kind of features in reality can be grasped as system of some level. The idea to understand some features as a system is system approach in distribution. System approach was a dapted to describe the structure and function of distribution system more accurately. By doing this, we can understand distribution more clearly and can build distribution system model. In macro level, the distribution system was described by sign and mathematics. With the background of the basic model, mathematical model was built by the empirical analysis. In empirical analysis, factor analysis and multiple regression analysis was used. By the factor analysis, 22 variables are classified into 3 factors, consumption factor, production factor, and internal factor of dirstribution industry. With the result of the factor analysis, two kinds of regression models were built. One was by factor loading and the other was by theoretical consideration among high factor loading varibles. The data used for empirical analysis was the statistical data of three countries. The data was chosen for 20 years when the personnel income is lower than thousand dollars, The mathematical models built by multiple-regression analysis were following. These models were convinced to be significant by the T-test, F-test and Durbin-'Watson-test. So these models canbe used as forecasting model. Further comparative study of the model of Japan was made to make sure that the model of korea can be a good forecasting model. By the results of the forecasts, the sales volume will increase almost four times in the year of 1991 and the efficiency of the distribution segment should be nearly three times more than now. In order to make distrinbution system more efficient, the active reseasch and long term plan for the development of the distribution should be made by the government. Also policies to aid the distribution industry should be acted on the basis of the forecasts of the distribution system activities.

BMB Reports : Enhancement of UVB radiation-mediated apoptosis by knockdown of cytosolic NADP+-dependent isocitrate dehydrogenase in HaCaT cells

( Su Jeong Lee ),( Jeen Woo Park ) 생화학분자생물학회(구 한국생화학분자생물학회) 2014 BMB Reports Vol.47 No.4

Ultraviolet B (UVB) radiation induces the production of reactive oxygen species (ROS) that promote apoptotic cell death. We showed that cytosolic NADP+-dependent isocitrate dehydrogenase (IDPc) plays an essential role in the control of cellular redox balance and defense against oxidative damage, by supplying NADPH for antioxidant systems. In this study, we demonstrated that knockdown of IDPc expression by RNA interference enhances UVB-induced apoptosis of immortalized human HaCaT keratinocytes. This effect manifested as DNA fragmentation, changes in cellular redox status, mitochondrial dysfunction, and modulation of apoptotic marker expression. Based on our findings, we suggest that attenuation of IDPc expression may protect skin from UVB-mediated damage, by inducing the apoptosis of UV-damaged cells. [BMB Reports 2014; 47(4): 209-214]