Arterial stiffness is inversely associated with a better running record in a full course marathon race

( Su Jeen Jung ),( Jae Hyoung Park ),( Se Won Lee ) 한국운동영양학회 2014 Physical Activity and Nutrition (Phys Act Nutr) Vol.18 No.4

[Purpose] Arterial stiffness is an independent predictor of cardiovascular risk and may contribute to reduced running capacity in humans. This study investigated the relationship between course record and arterial stiffness in marathoners who participated in the Seoul International Marathon in 2012. [Methods] A total of 30 amateur marathoners (Males n = 28, Females n = 2, mean age = 51.6 ± 8.3 years) were assessed before and after the marathon race. Brachial-ankle pulse wave velocity (ba-PWV) was assessed by VP-1000 plus (Omron Healthcare Co., Ltd., Kyoto, Japan) before and immediately after the marathon race. Pearson`s correlation coefficient was used to determine the relationship between race record and ba-PWV. In addition, Wilcoxon signed rank test was used to determine the difference in ba-PWV between before and after the race. [Results] There was no significant change in the ba-PWV of marathoners before and after the race (1271.1 ± 185 vs. 1268.8 ± 200 cm/s, P=0.579). Both the full course record (Pearson`s correlation coefficient = 0.416, P = 0.022) and the record of half line (Pearson`s correlation coefficient = 0.482, P = 0.007) were positively related with the difference in ba-PWV, suggesting that reduced arterial stiffness is associated with a better running record in the marathon. [Conclusion] These results may suggest that good vascular function contributes to a better running record in the marathon race.

일회성 농구운동이 청소년의 혈압과 혈관경직도에 미치는 영향

정수진(Su-Jeen Jung),박상현(Sang-Hyun Park) 한국생활환경학회 2017 한국생활환경학회지 Vol.24 No.2

This study was to investigate the effects of acute basketball program on blood pressure and arterial stiffness in adolescent. The subjects of this study were twenty-two male students in a middle school and they were divide into two groups(athletes: n=11, control: n=11). Both group conducted basketball training program for 60 min(warm-up: 5 min, main exercise: 50 min, cool down: 5 min). The result of this study is following : systolic and diastolic blool pressure show the no change in athletes group but control group significantly decreased compared to baseline. In the changes of arterial stiffness, ABI(R) and ABI(L) significantly decreased in control group and exercise group respectively compared to baseline. Both group PWV(R) significantly decreased more than baseline, while there was no difference between the groups. In conclusion, regardless of blood function and ages, physical activity can contribute to improvement of blood health. Therefore, aerobic exercise will be able to prevent metabolic syndrome(include cardiovascular disease, type 2 diabetes, obesity) in adult.

관상동맥질환자에게 일시적 레크리에이셔널댄스운동이 혈관 경직도와 중심동맥압에 미치는 영향

정수진(Su-Jeen Jung) 한국생활환경학회 2014 한국생활환경학회지 Vol.21 No.5

Arterial stiffness and central blood pressure are the surrogate markers of non invasive method anticipating cardiovascular disorders to the patients with coronary artery disease. Its numerous merits to the patients with coronary artery disease in relatively older age, research results of recreational dance are still insufficient. Thus, this study implemented acute recreational dance to 10 patients with coronary artery disease, who underwent coronary intervention, and analyzed the effects 20 minutes before and after exercise respectively. We measured brachial-ankle pulse wave velocity (ba-PWV) and central blood pressure. The ba-PWV was measured using VP-1000 plus (Omron Healthcare Co., Ltd., Kyoto, Japan)and central blood pressure was HEM-9000AI(Omron Healthcare Co., Ltd., Kyoto, Japan). As a result, pulse wave velocity, which indicates arterial stiffness, reduced positively, but it was not statistically significant. Nevertheless, it showed positive and statistically significant change in blood pressure of brachial artery, pulse pressure and central arterial pressure.

관상동맥질환 환자에게 실시한 수영운동과 걷기운동이 혈류매개 확장반응과 혈관내피전구세포 발현에 미치는 영향

정수진(Su-Jeen Jung) 한국생활환경학회 2017 한국생활환경학회지 Vol.24 No.2

The aim of this study is to effects of swimming exercise and walking exercise for 10 weeks in patients with a coronary-artery disease on their flow mediated dilation (FMD) and the expression level of endothelial progenitor cells (EPCs). A patient group of 18 subjects were recruited, a walking exercise was carried out (n =10), and a swimming exercise was carried out (n = 8). The two exercises are types of the same aerobic exercise preferred by a lot of patients, but there are very insufficient grounds for scientific studies of swimming exercise as compared to those of the walking exercise. For measurement, this study measured their body composition, FMD and EPCs. As a result of this study, it turned out that there were no statistically significant changes in the expression level of EPCs and FMD in the patients with a coronary-artery disease, who carried out the swimming exercise than in those who carried out the walking exercise, but there was an effect between the times after carrying out the two exercises. In this result, since the swimming exercise and the walking exercise are the same aerobic exercises, there were no statistically significant differences, but both exercises had positive effects, so the importance of the exercises was confirmed.

The effects of exercise training and carnosine on mitochondria-mediated apoptotic signaling in atorvastatin-treated rat skeletal muscle

Su-Zi Yoo,Mi-Hyun No,Jun-won Heo,Dae-Yun Seo,Su-Jeen Jung,Hyo-Bum Kwak 한국운동재활학회 2019 한국운동재활학회 학술대회 Vol.2019 No.05

The purpose of this study was to determine the effects of in vivo atorvastatin, L-carnosine, and resistance exercise training on mitochondria-mediated apoptotic signaling in the rat skeletal muscle. Male Wistar rats were randomly assigned to control (CON), 5 mg atorvastatin treated group (STAT), 5 mg atorvastatin plus resistance (ladder climbing) exercise training group (STAT + EX), 5 mg atorvastatin plus L-carnosine treatment group (STAT + CAR), and 5 mg atorvastatin treatment plus resistance exercise training plus L-carnosine treatment group (STAT + EX + CAR) (n=12 rats/group). Animals were administered via oral gavage with a vehicle, 5 mg/kg/day atorvastatin, and 250 mg/kg/day L-carnosine dissolved in 0.25 % w/v hydroxypropyl methylcellulose for 12 weeks. Also, animals were trained for 12 weeks on a ladder with a gradient of about 80 degrees. Mitochondria-mediated apoptotic signaling (e.g., Bax, Bcl-2, mPTP opening, cytochrome c, cleaved caspase-3) were measured in skeletal muscles (e.g., soleus, white gastocnemius). Bax , pro-apoptotic protein, was increased in STAT in both soleus and white gastrocnemius and decreased in STAT + EX, STAT + CAR, and STAT + EX + CAR in both soleus and white gastrocnemius. In contrast, Bcl-2, anti-apoptotic protein, was elevated in STAT + EX, STAT + CAR, and STAT + EX + CAR in both soleus and white gastrocnemius and reduced in STAT in both soleus and white gastrocnemius. Also, mPTP opening, cytochrome c, and cleaved caspase-3 showed the same patterns like Bax in both soleus and white gastrocnemius. These data demonstrated that skeletal muscle mitochondria-mediated apoptotic signaling was impaired by atorvastatin treatment for 12 weeks. However, L-carnosine and resistance exercise training protected against statin-induced mitochondria-mediated apoptotic signaling in the rat skeletal muscle, suggesting that both L-carnosine and resistance exercise training play a pivotal role in ameliorating apoptosis in statin-induced myopathy.

Effects of a single bout of exercise on mitochondria-mediated apoptotic signaling in rat cardiac and skeletal muscles

Su-Zi Yoo,Mi-Hyun No,Jun-Won Heo,Eunwook Chang,Dong-Ho Park,Ju-Hee Kang,Dae-Yun Seo,Jin Han,Su-Jeen Jung,Kwan Hwangbo,Hyo-Bum Kwak 한국운동재활학회 2019 JER Vol.15 No.4

<i>Idh2</i> deficiency accelerates renal dysfunction in aged mice

Lee, Su Jeong,Cha, Hanvit,Lee, Seoyoon,Kim, Hyunjin,Ku, Hyeong Jun,Kim, Sung Hwan,Park, Jung Hyun,Lee, Jin Hyup,Park, Kwon Moo,Park, Jeen-Woo Academic Press 2017 Biochemical and biophysical research communication Vol. No.

<P><B>Abstract</B></P> <P>The free radical or oxidative stress theory of aging postulates that senescence is due to an accumulation of cellular oxidative damage, caused largely by reactive oxygen species (ROS) that are produced as by-products of normal metabolic processes in mitochondria. The oxidative stress may arise as a result of either increased ROS production or decreased ability to detoxify ROS. The availability of the mitochondrial NADPH pool is critical for the maintenance of the mitochondrial antioxidant system. The major enzyme responsible for generating mitochondrial NADPH is mitochondrial NADP<SUP>+</SUP>-dependent isocitrate dehydrogenase (IDH2). Depletion of IDH2 in mice (<I>idh2</I> <SUP>-<I>/</I>-</SUP>) shortens life span and accelerates the degeneration of multiple age-sensitive traits, such as hair grayness, skin pathology, and eye pathology. Among the various internal organs tested in this study, IDH2 depletion-induced acceleration of senescence was uniquely observed in the kidney. Renal function and structure were greatly deteriorated in 24-month-old <I>idh2</I> <SUP> <I>-/</I>-</SUP> mice compared with wild-type. In addition, disruption of redox status, which promotes oxidative damage and apoptosis, was more pronounced in <I>idh2</I> <SUP> <I>-/</I>-</SUP> mice. These data support a significant role for increased oxidative stress as a result of compromised mitochondrial antioxidant defenses in modulating life span in mice, and thus support the oxidative stress theory of aging.</P> <P><B>Highlights</B></P> <P> <UL> <LI> IDH2 is a major enzyme to maintain mitochondrial redox status. </LI> <LI> Depletion of IDH2 in mice shortens life span and accelerates aging. </LI> <LI> Renal function was greatly deteriorated in 24-month-old <I>idh2</I> <SUP>-<I>/</I>-</SUP> mice. </LI> </UL> </P>

Silibinin Ameliorates <i>O</i> -GlcNAcylation and Inflammation in a Mouse Model of Nonalcoholic Steatohepatitis

Lee, Su Jin,Nam, Min Jung,Lee, Da Eun,Park, Jeen-Woo,Kang, Beom Sik,Lee, Dong-Seok,Lee, Hyun-Shik,Kwon, Oh-Shin MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.8

<P>The mechanisms underlying the progression to non-alcoholic steatohepatitis (NASH) remain to be elucidated. In the present study, we aimed to identify the proteins involved in the pathogenesis of liver tissue inflammation and to investigate the effects of silibinin, a natural polyphenolic flavonoid, on steatohepatitis. We performed comparative proteomic analysis using methionine and choline-deficient (MCD) diet-induced NASH model mice. Eighteen proteins were identified from the two-dimensional proteomic analysis, which are not only differentially expressed, but also significantly improved, by silibinin treatment. Interestingly, seven of these proteins, including keratin cytoskeletal 8 and 18, peroxiredoxin-4, and protein disulfide isomerase, are known to undergo GlcNAcylation modification, most of which are related to structural and stress-related proteins in NASH model animals. Thus, we primarily focused on how the GlcNAc modification of these proteins is involved in the progression to NASH. Remarkably, silibinin treatment alleviates the severity of hepatic inflammation along with <I>O</I>-GlcNAcylation in steatohepatitis. In particular, the reduction of inflammation by silibinin is due to the inhibition of the <I>O</I>-GlcNAcylation-dependent NF-κB-signaling pathway. Therefore, silibinin is a promising therapeutic agent for hyper-<I>O</I>-GlcNAcylation as well as NASH.</P>

High Purity α”-Fe16N₂ Particles with Tunable Sphere Structures via Spray Drying Method

Kim, Su Gyeong,Jeon, Kwang-Won,Lee, Jung-Goo,Kong, Hyeongjun,Jeen, Hyoungjeen,Kwon, Se-Hun,Baek, Youn-Kyoung The Korean Magnetics Society 2017 Journal of Magnetics Vol.22 No.4

Effects of Acute Exercise on Mitochondrial Function, Dynamics, and Mitophagy in Rat Cardiac and Skeletal Muscles

Yoo, Su-Zi,No, Mi-Hyun,Heo, Jun-Won,Park, Dong-Ho,Kang, Ju-Hee,Kim, Joon-Hee,Seo, Dae-Yun,Han, Jin,Jung, Su-Jeen,Kwak, Hyo-Bum Korean Continence Society 2019 International Neurourology Journal Vol.23 No.S1

<P><B>Purpose</B></P><P>This study aimed to investigate the effects of single-bout exercise on mitochondrial function, dynamics (fusion, fission), and mitophagy in cardiac and skeletal muscles.</P><P><B>Methods</B></P><P>Fischer 344 rats (4 months old) were randomly divided into the control (CON) or acute exercise (EX) group (n=10 each). The rats performed a single bout of treadmill exercise for 60 minutes. Mitochondrial function (e.g., O<SUB>2</SUB> respiration, H<SUB>2</SUB>O<SUB>2</SUB> emission, Ca<SUP>2+</SUP> retention capacity), mitochondrial fusion (e.g., Mfn1, Mfn2, Opa1), mitochondrial fission (e.g., Drp1, Fis1), and mitophagy (e.g., Parkin, Pink1, LC3II, Bnip3) were measured in permeabilized cardiac (e.g., left ventricle) and skeletal (e.g., soleus, white gastrocnemius) muscles.</P><P><B>Results</B></P><P>Mitochondrial O<SUB>2</SUB> respiration and Ca<SUP>2+</SUP> retention capacity were significantly increased in all tissues of the EX group compared with the CON group. Mitochondrial H<SUB>2</SUB>O<SUB>2</SUB> emissions showed tissue-specific results; the emissions showed no significant differences in the left ventricle or soleus (type I fibers) but was significantly increased in the white gastrocnemius (type II fibers) after acute exercise. Mitochondrial fusion and fission were not altered in any tissues of the EX group. Mitophagy showed tissue-specific differences: It was not changed in the left ventricle or white gastrocnemius, whereas Parkin and LC3II were significantly elevated in the soleus muscle.</P><P><B>Conclusions</B></P><P>A single bout of aerobic exercise may improve mitochondrial function (e.g., O<SUB>2</SUB> respiration and Ca<SUP>2+</SUP> retention capacity) in the heart and skeletal muscles without changes in mitochondrial dynamics or mitophagy.</P>